phd pharmacy monash

PPSP01 - Pharmacy and pharmaceutical sciences PhD program

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Pharmacy and pharmaceutical sciences PhD program - 2017

Postgraduate research area

Commencement year

Unit codes that are not linked to their entry in the Handbook are not available for study in the current year.

Managing faculty

Faculty of Pharmacy and Pharmaceutical Sciences

Coordinator(s)

Associate Professor Philip Thompson

This program provides doctoral (PhD) students with the opportunity to develop expertise in their chosen discipline through the completion of a supervised research project.

Each student is also supported through a development program aimed at building the knowledge, skills and abilities that will help them to become more effective researchers, and develop the general professional skills of value to prospective employers in academia, industry, government and the broader community.d developing generic/transferable skills of value to prospective employers.

This program is also applicable to students studying externally.

Program requirements

All research students will be required to undertake compulsory training in the following areas:

• Monash Graduate Research Induction (online)
• Research Integrity (online)
• faculty induction, including occupational health and safety (where required).

Professional development component

Students must, in consultation with their supervisor(s), satisfactorily complete a minimum of 120 hours of graduate research professional development activities offered or recognised by the University:

• 60 hours (minimum) of professional development activities offered or recognised from the 'Excellence in research and teaching' category
• 60 hours (minimum) of professional development activities offered or recognised from the 'Professionalism, innovation and career' category.

Students will discuss with their supervisors which optional activities best suit their interests and area of study and complete any mandated activities. Students are required to update their supervisors on their progress toward achieving the required hours of professional development activities.

Students may be required to complete specific activities offered through the Monash Doctoral Program Monash Doctoral Program ( http://www.monash.edu/graduate-research/future-students/phd ) .

Attendance will be monitored to ensure hours are accurately recorded.

Students may also be directed or encouraged to attend and make presentations at various forums throughout their enrolment.

For detailed information about the options available in this PhD program, visit the Monash Doctoral Program Monash Doctoral Program ( http://www.monash.edu/graduate-research/future-students/phd ) webpage.

Relevant courses

2625 Doctor of Philosophy

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Krill Oil for Knee Osteoarthritis : A Randomized Clinical Trial

• 1 Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia
• 2 School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, Melbourne, Victoria, Australia
• 3 Department of Epidemiology and Biostatistics, Anhui Medical University, Hefei, Anhui, China
• 4 The Queen Elizabeth Hospital, University of Adelaide, Woodville, South Australia, Australia
• 5 Discipline of Medicine, University of Adelaide, Adelaide, South Australia, Australia
• 6 The University of Sydney, Kolling Institute and Royal North Shore Hospital, Sydney, New South Wales, Australia
• 7 Department of Rheumatology, School of Medicine and Pharmacology, Fiona Stanley Hospital, Murdoch, Western Australia, Australia
• 8 Medical School, University of Western Australia, Crawley, Western Australia, Australia
• Review Diagnosis and Treatment of Hip and Knee Osteoarthritis Jeffrey N. Katz, MD, MSc; Kaetlyn R. Arant, BA; Richard F. Loeser, MD JAMA

Question   In people with knee osteoarthritis who have significant knee pain and effusion-synovitis present on magnetic resonance imaging, does krill oil supplementation, compared with placebo, improve knee pain?

Findings   In this randomized clinical trial that included 262 adults, compared with placebo, 2 g/d of krill oil supplementation did not improve knee pain as measured on a visual analog scale (range, 0-100, with 0 indicating least pain) (mean difference, 0.30; 95% CI, −6.9 to 6.4; P  = .94) over 24 weeks.

Meaning   This study does not support 2 g/d of krill oil supplementation for improving knee pain in people with knee osteoarthritis who have significant knee pain and effusion-synovitis.

Importance   Knee osteoarthritis is disabling, with few effective treatments. Preliminary evidence suggested that krill oil supplementation improved knee pain, but effects on knee osteoarthritis remain unclear.

Objective   To evaluate efficacy of krill oil supplementation, compared with placebo, on knee pain in people with knee osteoarthritis who have significant knee pain and effusion-synovitis.

Design, Setting, and Participants   Multicenter, randomized, double-blind, placebo-controlled clinical trial in 5 Australian cities. Participants with clinical knee osteoarthritis, significant knee pain, and effusion-synovitis on magnetic resonance imaging were enrolled from December 2016 to June 2019; final follow-up occurred on February 7, 2020.

Interventions   Participants were randomized to 2 g/d of krill oil (n = 130) or matching placebo (n = 132) for 24 weeks.

Main Outcomes and Measures   The primary outcome was change in knee pain as assessed by visual analog scale (range, 0-100; 0 indicating least pain; minimum clinically important improvement = 15) over 24 weeks.

Results   Of 262 participants randomized (mean age, 61.6 [SD, 9.6] years; 53% women), 222 (85%) completed the trial. Krill oil did not improve knee pain compared with placebo (mean change in VAS score, −19.9 [krill oil] vs −20.2 [placebo]; between-group mean difference, −0.3; 95% CI, −6.9 to 6.4) over 24 weeks. One or more adverse events was reported by 51% in the krill oil group (67/130) and by 54% in the placebo group (71/132). The most common adverse events were musculoskeletal and connective tissue disorders, which occurred 32 times in the krill oil group and 42 times in the placebo group, including knee pain (n = 10 with krill oil; n = 9 with placebo), lower extremity pain (n = 1 with krill oil; n = 5 with placebo), and hip pain (n = 3 with krill oil; n = 2 with placebo).

Conclusions and Relevance   Among people with knee osteoarthritis who have significant knee pain and effusion-synovitis on magnetic resonance imaging, 2 g/d of daily krill oil supplementation did not improve knee pain over 24 weeks compared with placebo. These findings do not support krill oil for treating knee pain in this population.

Trial Registration   Australian New Zealand Clinical Trials Registry Identifier: ACTRN12616000726459 ; Universal Trial Number: U1111-1181-7087

Read More About

Laslett LL , Scheepers LEJM , Antony B, et al. Krill Oil for Knee Osteoarthritis : A Randomized Clinical Trial . JAMA. Published online May 22, 2024. doi:10.1001/jama.2024.6063

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