The Lung Cancer Master Protocol, or Lung-MAP, is a precision medicine research study for people with advanced non-small cell lung cancer that has continued to grow after treatment. Patients are assigned to different study drug combinations based on the results of genomic profiling of their tumors.
Lung cancer
Lung cancer is one of the most frequently diagnosed cancers and the leading cause of cancer-related deaths worldwide with an estimated 2 million new cases and 1·76 million deaths per year. Substantial improvements in our understanding of disease biology, application of predictive biomarkers, and refinements in treatment have led to remarkable progress in the past two decades and transformed ...
Lung cancer
Lung cancer articles from across Nature Portfolio. Lung cancer arises in tissues of the lung, usually in the cells lining air passages. The two main types are small-cell lung cancer and non-small ...
Lung cancer
Read the latest Research articles in Lung cancer from Nature Reviews Clinical Oncology. ... Lung cancer is a disease typically associated with tobacco smoking; however, lung cancer in individuals ...
Advances in Lung Cancer Research
The NCI-sponsored National Lung Screening Trial (NLST) showed that low-dose CT scans can be used to screen for lung cancer in people with a history of heavy smoking. Using this screening can decrease their risk of dying from lung cancer. Now researchers are looking for ways to refine CT screening to better predict whether cancer is present.
Recent advances in lung cancer research: unravelling the future of
Lung cancer, a multifaceted disease, demands tailored therapeutic approaches due to its diverse subtypes and stages. This comprehensive review explores the intricate landscape of lung cancer research, delving into recent breakthroughs and their implications for diagnosis, therapy, and prevention. Genomic profiling and biomarker identification have ushered in the era of personalised medicine ...
The global burden of lung cancer: current status and future trends
Lung cancer is the leading cause of cancer-related death worldwide. However, lung cancer incidence and mortality rates differ substantially across the world, reflecting varying patterns of tobacco ...
Lung Cancer
Lung Cancer is an international publication covering the clinical, translational and basic science of malignancies of the lung and chest region.Original research articles, early reports, review articles, editorials and correspondence covering the prevention, epidemiology and etiology, basic biology, pathology, clinical assessment, surgery ...
Lung cancer
Lung cancer is one of the most frequently diagnosed cancers and the leading cause of cancer-related deaths worldwide with an estimated 2 million new cases and 1·76 million deaths per year. Substantial improvements in our understanding of disease biology, application of predictive biomarkers, and ref …
Top advances in lung cancer, 2021
The treatment paradigm and outcomes for patients with lung cancer have vastly evolved over the last several decades, ... Nisha A. Mohindra is supported by grant AHRQ-K12HS02638 from the Agency for Healthcare Research and Quality, US Department of Health and Human Services. Jyoti D. Patel is supported by a Cancer Center Core Grant from the ...
Epidemiology of lung cancer
According to the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) program, there were an estimated 229,000 new cases of lung cancer in the US in 2020, accounting for 12.7% of all cancer diagnoses. The current incidence of 45.6/100,000 is down from a peak of 69.5/100,000 in 1992, largely due to smoking cessation.
Advances in lung cancer: a ground-breaking decade
Lung cancer persists as the main cause of cancer death in people globally, driven by the ongoing tobacco epidemic and the emergence of risk factors such as ionising radiation exposure and ambient pollution. Nearly 2 million people die of lung cancer each year, a far higher death rate than other common cancer types. However, developments over the past 10 years have dramatically improved the ...
Current and Future Development in Lung Cancer Diagnosis
1. Introduction. Lung cancer is the most common cause of cancer-related deaths in North America and other developed countries. According to the 2020 special report on lung cancer, this disease is the most commonly diagnosed cancer and the leading cause of cancer death in Canada [].The impact imposed is highlighted by statistics reporting a higher number of Canadians dying of lung cancer than ...
Lung cancer treatment: 20 years of progress
Up until 2000, lung cancer was a highly lethal disease. Treatment options were extremely limited, with only platinum-based chemotherapy agents available, resulting in a 1-year survival rate of 33% in patients with advanced disease. The approval of the first breakthrough EGFR-targeted therapy in 2003 and the identification of specific somatic driver mutations on the EGFR gene in 2004, which ...
Seasonal influences on the efficacy of anti-programmed cell death
Cancer is an international interdisciplinary journal publishing articles on the latest clinical cancer research findings, spanning the breadth of oncology disciplines. Abstract Background Seasonal variations in systemic immunity have been reported. ... A total of 604 patients with lung cancer receiving single anti-programmed cell death ...
Lung cancer
Read the latest Research articles in Lung cancer from Nature Medicine ... In vivo screening of pro-metastatic factors in a genetically engineered mouse model of lung cancer uncovered the CD109 ...
The N6-methyladenosine Epitranscriptomic Landscape of Lung
Abstract. Comprehensive m6A epitranscriptome profiling of primary tumors remains largely uncharted. Here, we profiled the m6A epitranscriptome of 10 non-neoplastic lung (NL) tissues and 51 lung adenocarcinoma (LUAD) tumors, integrating the corresponding transcriptome, proteome and extensive clinical annotations. We identified distinct clusters and genes that were exclusively linked to disease ...
Lung Cancer Screening: Review and 2021 Update
Lung cancer screening with low-dose CT (LDCT) scans has been widely accepted within the last decade. Our knowledge and ability to implement screening has greatly increased because of significant research efforts and guidelines from multiple professional societies. The purpose of this review is to summarize some of the significant findings ...
Top advances in lung cancer, 2021
Cancer is an international interdisciplinary journal publishing articles on the latest clinical cancer research findings, spanning the breadth of oncology disciplines. Despite a global pandemic that continued to inflict chaos and confusion on the world, resulting in fewer cancer screenings and delayed surgeries, remarkable lung cancer treatment ...
Lung Cancer: Wiley Online Library Virtual Issues
Lung cancer ranks as the leading cause of cancer death in 2020 worldwide. Approximately 85% of newly diagnosed lung cancers are non-small cell lung cancer (NSCLC). However, the benefit of Endostar used in treating patients with advanced NSCLC of different ages is still unclear in real-world clinical settings. ... RESEARCH ARTICLES. Open Access ...
Inhibition of PKA/CREB1 pathway confers sensitivity to ferroptosis in
Epidemiological data has revealed that lung cancer is one of the most prevalent types of malignant neoplasm and the leading cause of cancer-related death globally, in which non-small cell lung cancer (NSCLC) accounts for 85% of cases [1, 2].Despite advances in diagnosis and treatment, the prognosis of NSCLC remains dismal, highlighting the need for novel therapeutic strategies [].
Significant Advances in Lung Cancer Treatment Bring Hope
The U.S. Preventive Services Task Force recommends annual lung cancer screening with low-dose CT for people who: Have a 20 pack-year or more smoking history, and. Smoke now or have quit within the past 15 years, and. Are between 50 and 80 years old. This screening often finds tumors before they spread outside the lung or cause any symptoms.
A comprehensive analysis of lung cancer highlighting ...
Lung cancer is the leading cause of cancer-related mortality in the United States. Investigating epidemiological and clinical parameters can contribute to an improved understanding of disease ...
Study supports precision radiation therapy in lung cancer
Results from a new study led by researchers at The University of Texas MD Anderson Cancer Center support standard use of the more precise intensity-modulated radiotherapy (IMRT) over the ...
Recent advances in the management of lung cancer
Introduction. For several decades lung cancer has been the most common cancer in the world. 1 In 2014 there were 46,403 new cases of lung cancer diagnosed in the UK. 2 It is the third most common cancer after breast and prostate, but has the largest proportion of all cancer-related deaths (22%). 2 The overall age standardised incidence has declined slightly over the past 40 years, which is a ...
Study: Less Than 1 in 5 Eligible Americans Are Getting Screened for
Bandi said previous research indicated that lung cancer screening rates within this high-risk population group were between 6.5% and 15% in 2020. That number has bumped up to 18.1%. While Bandi said this jump was a "pleasant surprise" to her and her team, the marked difference between states is still a problem.
Lung Cancer: Epidemiology, Etiology, and Prevention
Lung cancer is the leading cause of cancer death in the United States and around the world. Almost as many Americans die of lung cancer every year than die of prostate, breast, and colon cancer combined ( Fig. 1 ). 1 Siegel and colleagues 1 reviewed recent cancer data and estimated a total of 239,320 new cases of lung cancer and 161,250 deaths ...
Research round-up: lung cancer
Among the screen-detected lung cancers, only 9.4% were at stage IV, whereas in the non-screened group, 45.7% of lung cancers diagnosed were at stage IV. The authors reported that adherence to ...
Gallic Acid: A Potential Anti-Cancer Agent
This review discusses two aspects, one is the anti-cancer potential of GA against different types of cancer and the underlying molecular mechanisms, the other is the bibliometric analysis of GA in cancer and tumor research. The results indicated that lung cancer, prostate cancer, stomach cancer, and colon adenocarcinoma may become a hot topic ...
Lung cancer: biology and treatment options
Lung cancer remains the leading cause of cancer mortality in men and women in the U.S. and worldwide. About 90% of lung cancer cases are caused by smoking and the use of tobacco products. ... Medical research council lung cancer working party. Br J Cancer. 1993; 68 (6):1157-1166. [PMC free article] [Google Scholar] 125. Scagliotti G, Hanna N ...
COMMENTS
The Lung Cancer Master Protocol, or Lung-MAP, is a precision medicine research study for people with advanced non-small cell lung cancer that has continued to grow after treatment. Patients are assigned to different study drug combinations based on the results of genomic profiling of their tumors.
Lung cancer is one of the most frequently diagnosed cancers and the leading cause of cancer-related deaths worldwide with an estimated 2 million new cases and 1·76 million deaths per year. Substantial improvements in our understanding of disease biology, application of predictive biomarkers, and refinements in treatment have led to remarkable progress in the past two decades and transformed ...
Lung cancer articles from across Nature Portfolio. Lung cancer arises in tissues of the lung, usually in the cells lining air passages. The two main types are small-cell lung cancer and non-small ...
Read the latest Research articles in Lung cancer from Nature Reviews Clinical Oncology. ... Lung cancer is a disease typically associated with tobacco smoking; however, lung cancer in individuals ...
The NCI-sponsored National Lung Screening Trial (NLST) showed that low-dose CT scans can be used to screen for lung cancer in people with a history of heavy smoking. Using this screening can decrease their risk of dying from lung cancer. Now researchers are looking for ways to refine CT screening to better predict whether cancer is present.
Lung cancer, a multifaceted disease, demands tailored therapeutic approaches due to its diverse subtypes and stages. This comprehensive review explores the intricate landscape of lung cancer research, delving into recent breakthroughs and their implications for diagnosis, therapy, and prevention. Genomic profiling and biomarker identification have ushered in the era of personalised medicine ...
Lung cancer is the leading cause of cancer-related death worldwide. However, lung cancer incidence and mortality rates differ substantially across the world, reflecting varying patterns of tobacco ...
Lung Cancer is an international publication covering the clinical, translational and basic science of malignancies of the lung and chest region.Original research articles, early reports, review articles, editorials and correspondence covering the prevention, epidemiology and etiology, basic biology, pathology, clinical assessment, surgery ...
Lung cancer is one of the most frequently diagnosed cancers and the leading cause of cancer-related deaths worldwide with an estimated 2 million new cases and 1·76 million deaths per year. Substantial improvements in our understanding of disease biology, application of predictive biomarkers, and ref …
The treatment paradigm and outcomes for patients with lung cancer have vastly evolved over the last several decades, ... Nisha A. Mohindra is supported by grant AHRQ-K12HS02638 from the Agency for Healthcare Research and Quality, US Department of Health and Human Services. Jyoti D. Patel is supported by a Cancer Center Core Grant from the ...
According to the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) program, there were an estimated 229,000 new cases of lung cancer in the US in 2020, accounting for 12.7% of all cancer diagnoses. The current incidence of 45.6/100,000 is down from a peak of 69.5/100,000 in 1992, largely due to smoking cessation.
Lung cancer persists as the main cause of cancer death in people globally, driven by the ongoing tobacco epidemic and the emergence of risk factors such as ionising radiation exposure and ambient pollution. Nearly 2 million people die of lung cancer each year, a far higher death rate than other common cancer types. However, developments over the past 10 years have dramatically improved the ...
1. Introduction. Lung cancer is the most common cause of cancer-related deaths in North America and other developed countries. According to the 2020 special report on lung cancer, this disease is the most commonly diagnosed cancer and the leading cause of cancer death in Canada [].The impact imposed is highlighted by statistics reporting a higher number of Canadians dying of lung cancer than ...
Up until 2000, lung cancer was a highly lethal disease. Treatment options were extremely limited, with only platinum-based chemotherapy agents available, resulting in a 1-year survival rate of 33% in patients with advanced disease. The approval of the first breakthrough EGFR-targeted therapy in 2003 and the identification of specific somatic driver mutations on the EGFR gene in 2004, which ...
Cancer is an international interdisciplinary journal publishing articles on the latest clinical cancer research findings, spanning the breadth of oncology disciplines. Abstract Background Seasonal variations in systemic immunity have been reported. ... A total of 604 patients with lung cancer receiving single anti-programmed cell death ...
Read the latest Research articles in Lung cancer from Nature Medicine ... In vivo screening of pro-metastatic factors in a genetically engineered mouse model of lung cancer uncovered the CD109 ...
Abstract. Comprehensive m6A epitranscriptome profiling of primary tumors remains largely uncharted. Here, we profiled the m6A epitranscriptome of 10 non-neoplastic lung (NL) tissues and 51 lung adenocarcinoma (LUAD) tumors, integrating the corresponding transcriptome, proteome and extensive clinical annotations. We identified distinct clusters and genes that were exclusively linked to disease ...
Lung cancer screening with low-dose CT (LDCT) scans has been widely accepted within the last decade. Our knowledge and ability to implement screening has greatly increased because of significant research efforts and guidelines from multiple professional societies. The purpose of this review is to summarize some of the significant findings ...
Cancer is an international interdisciplinary journal publishing articles on the latest clinical cancer research findings, spanning the breadth of oncology disciplines. Despite a global pandemic that continued to inflict chaos and confusion on the world, resulting in fewer cancer screenings and delayed surgeries, remarkable lung cancer treatment ...
Lung cancer ranks as the leading cause of cancer death in 2020 worldwide. Approximately 85% of newly diagnosed lung cancers are non-small cell lung cancer (NSCLC). However, the benefit of Endostar used in treating patients with advanced NSCLC of different ages is still unclear in real-world clinical settings. ... RESEARCH ARTICLES. Open Access ...
Epidemiological data has revealed that lung cancer is one of the most prevalent types of malignant neoplasm and the leading cause of cancer-related death globally, in which non-small cell lung cancer (NSCLC) accounts for 85% of cases [1, 2].Despite advances in diagnosis and treatment, the prognosis of NSCLC remains dismal, highlighting the need for novel therapeutic strategies [].
The U.S. Preventive Services Task Force recommends annual lung cancer screening with low-dose CT for people who: Have a 20 pack-year or more smoking history, and. Smoke now or have quit within the past 15 years, and. Are between 50 and 80 years old. This screening often finds tumors before they spread outside the lung or cause any symptoms.
Lung cancer is the leading cause of cancer-related mortality in the United States. Investigating epidemiological and clinical parameters can contribute to an improved understanding of disease ...
Results from a new study led by researchers at The University of Texas MD Anderson Cancer Center support standard use of the more precise intensity-modulated radiotherapy (IMRT) over the ...
Introduction. For several decades lung cancer has been the most common cancer in the world. 1 In 2014 there were 46,403 new cases of lung cancer diagnosed in the UK. 2 It is the third most common cancer after breast and prostate, but has the largest proportion of all cancer-related deaths (22%). 2 The overall age standardised incidence has declined slightly over the past 40 years, which is a ...
Bandi said previous research indicated that lung cancer screening rates within this high-risk population group were between 6.5% and 15% in 2020. That number has bumped up to 18.1%. While Bandi said this jump was a "pleasant surprise" to her and her team, the marked difference between states is still a problem.
Lung cancer is the leading cause of cancer death in the United States and around the world. Almost as many Americans die of lung cancer every year than die of prostate, breast, and colon cancer combined ( Fig. 1 ). 1 Siegel and colleagues 1 reviewed recent cancer data and estimated a total of 239,320 new cases of lung cancer and 161,250 deaths ...
Among the screen-detected lung cancers, only 9.4% were at stage IV, whereas in the non-screened group, 45.7% of lung cancers diagnosed were at stage IV. The authors reported that adherence to ...
This review discusses two aspects, one is the anti-cancer potential of GA against different types of cancer and the underlying molecular mechanisms, the other is the bibliometric analysis of GA in cancer and tumor research. The results indicated that lung cancer, prostate cancer, stomach cancer, and colon adenocarcinoma may become a hot topic ...
Lung cancer remains the leading cause of cancer mortality in men and women in the U.S. and worldwide. About 90% of lung cancer cases are caused by smoking and the use of tobacco products. ... Medical research council lung cancer working party. Br J Cancer. 1993; 68 (6):1157-1166. [PMC free article] [Google Scholar] 125. Scagliotti G, Hanna N ...