Free PowerPoint Templates

Free White PowerPoint Templates

presentation white background

Free Road Bicycle Race PowerPoint Template

presentation white background

Free Abstract Blue & White PowerPoint Template

presentation white background

Silverglow PowerPoint Template

Download free white PowerPoint templates and backgrounds for Microsoft PowerPoint presentations. Under this category you can find awesome white backgrounds and slide designs containing white and other colors.

presentation white background

Free Emergency Medical Response PowerPoint Template

Free unique Business PowerPoint Template

Simple & Unique Powerpoint Template for Presentations

presentation white background

Target Market PPT Template

presentation white background

Free Paint Artwork PowerPoint Template

presentation white background

Free Abstract Gray Structure PowerPoint Template

presentation white background

Free Productivity PowerPoint Template

presentation white background

Free White Mask PowerPoint Template

White is one of the best colors to use as a background in your PowerPoint presentations. By default, Microsoft PowerPoint will open a blank presentation with white background but you can create impressive slide designs combining the white color with other graphics. Here you can download free white PowerPoint PPT templates and backgrounds with original slide designs. Also you can find some nice white PPT templates with original effects applied, like the blur white background, shapes with white color, etc.

Download free presentation templates with white backgrounds and combining white with other colors. White backgrounds can help to bring good contrast to your presentation. Using a dark color over a white background you can make your text and content more visible and highlight the important parts and components of a presentation, be it a diagram, chart, table or text placeholder.

Alternatively, you can download other simple PowerPoint templates with white backgrounds or presentation designs containing other colors, like the yellow PowerPoint templates , blue PowerPoint templates or the dark presentation template backgrounds .

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Vintage Distressed Notebook Slides

Vintage Distressed Notebook Slides

presentation white background

Economic PowerPoint Template

Creative Solutions Workshop

Creative Solutions Workshop

Exotic Arabia

Exotic Arabia

Clean and Elegant Black & White Design

Clean and Elegant Black & White Design

Meeting Your Match

Meeting Your Match

Simple Social Media

Simple Social Media

Agency for the Automotive Sector

Agency for the Automotive Sector

Template for the 5G Wireless Era

Template for the 5G Wireless Era

Visualized Tour Company

Visualized Tour Company

Interior Design Catalogue

Interior Design Catalogue

Present with Assurance

Present with Assurance

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Background Presentation templates

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Futuristic Background presentation template

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Futuristic background.

When you need to impress everybody and stay relevant, you must look ahead and aim to be the first. Take a peek into the future with this new template Slidesgo has just designed. It’s free and perfect for techie topics or just for giving your presentation a futuristic vibe!

Spring Woods presentation template

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Spring Woods

Download the "Spring Woods" presentation for PowerPoint or Google Slides and start impressing your audience with a creative and original design. Slidesgo templates like this one here offer the possibility to convey a concept, idea or topic in a clear, concise and visual way, by using different graphic resources. You...

Simple Blackboard Background presentation template

Simple Blackboard Background

Download the Simple Blackboard Background presentation for PowerPoint or Google Slides and start impressing your audience with a creative and original design. Slidesgo templates like this one here offer the possibility to convey a concept, idea or topic in a clear, concise and visual way, by using different graphic resources....

Aqua Marketing Plan presentation template

Aqua Marketing Plan

For those times when a marketing plan needs to cause an impact, trust this template. You'll see instantly how appealing the watercolor details are when contemplating these slides. This design can be the perfect choice if your message has to do with water or the environment!

Notebook Lesson presentation template

Notebook Lesson

These are the last days before the Summer break! We know that there are some pending lessons that you need to prepare for your students. As they may be thinking about their friends and their holidays, catch their attention with this cool template!

Minimalist Aesthetic Slideshow presentation template

Minimalist Aesthetic Slideshow

When you combine a minimalist design with abstract shapes and a palette composed of pastel colors, you get a successful result. This template has all of the aforementioned, plus an elegant typography and some icons of plants. It's quite unique and works for any topic, so give it a try!

Team Building Class for Elementary presentation template

Team Building Class for Elementary

Your students spend most of their days at school, so building a good atmosphere in the class is vital for their happiness. Why don’t you dedicate a day to team building activities? This will help new students make friends and older students create deeper relationships with their classmates. It that...

Eco-Friendly Minitheme presentation template

Eco-Friendly Minitheme

Speaking about taking care of the environment is always a good idea, and with this Eco-Friendly Minitheme you can assure that your audience knows about recycling, bio products, the problems of plastic, and the solutions to lessen the impacts of global warming. The slides have cute abstract and floral illustration...

Leafy Green Color Palette Company Profile presentation template

Leafy Green Color Palette Company Profile

Download the "Leafy Green Color Palette Company Profile" presentation for PowerPoint or Google Slides. Presenting a comprehensive company profile can be a game-changer for your business. A well-crafted profile connects with potential clients and vendors on another level, giving them a deep understanding of your organization. This company profile template...

Minimalist Business Slides presentation template

Minimalist Business Slides

Minimalism is an art style that frees the canvas and that lets the content stand out for itself. It’s a way of conveying modernism, simplicity and elegance and can be your best ally in your next presentation. With this new design from Slidesgo, your business presentations will be as professional...

Pre-K Activities to Celebrate International Astronomy Day presentation template

Pre-K Activities to Celebrate International Astronomy Day

Download the Pre-K Activities to Celebrate International Astronomy Day presentation for PowerPoint or Google Slides and create big learning experiences for the littlest students! Dynamic and adorable, this template provides the visual stimuli that Pre-K students thrive on and makes your lessons more playful and exciting — after all, Pre-K...

Yellow Abstract Marketing Theme presentation template

Yellow Abstract Marketing Theme

Download the "Yellow Abstract Marketing Theme" presentation for PowerPoint or Google Slides and take your marketing projects to the next level. This template is the perfect ally for your advertising strategies, launch campaigns or report presentations. Customize your content with ease, highlight your ideas and captivate your audience with a...

Watercolor Company Profile presentation template

Watercolor Company Profile

Do you like watercolor painting and need to present your company profile? Combine your passion with your work with this Google Slides and PowerPoint template. The Slidesgo team has designed this presentation that looks like a canvas with all the watercolor strokes included. And not only that! All the resources...

Happy Drawing Day presentation template

Happy Drawing Day

Download the "Happy Drawing Day" presentation for PowerPoint or Google Slides. The education sector constantly demands dynamic and effective ways to present information. This template is created with that very purpose in mind. Offering the best resources, it allows educators or students to efficiently manage their presentations and engage audiences....

Mountain Backgrounds presentation template

Mountain Backgrounds

Be creative and feel free to adapt this template to the topic you need to talk about. It will feel like a little excursion to the mountains due to the wonderful backgrounds. All the layouts are easily editable—the only limit is your imagination!

Floral Pattern presentation template

Floral Pattern

Download the "Floral Pattern" presentation for PowerPoint or Google Slides and start impressing your audience with a creative and original design. Slidesgo templates like this one here offer the possibility to convey a concept, idea or topic in a clear, concise and visual way, by using different graphic resources. You...

Formal Meeting presentation template

Formal Meeting

When it comes to important decisions and discussions, a formal meeting is often necessary. These meetings are typically held in a structured setting and require a certain level of decorum and respect for all participants. Do you think that they also require a well-prepared presentation? We think so, because we've...

Vintage Paper Texture Style Newsletter presentation template

Vintage Paper Texture Style Newsletter

Are you planning on sending a newsletter? If you’re looking for a beautiful and elegant aesthetic maybe this template is for you! The vintage paper style over a soft blue and mecanograph font look absolutely stunning! Golden texts or spots and nice leaves all over… It looks so chic and...

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Free White Background PowerPoint & Google Slides

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Discover the best white background PowerPoint templates and Google Slides themes that you can use in your presentations.

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PowerPoint Presentation Download Free - Piano_6 slides

PowerPoint Presentation Download Free - Piano

Creative slides Smart and innovative presentation slides No animation template Easily editable data driven charts (pie, bar, line)

Overseas Dispatch Work - Free Professional PowerPoint Templates_6 slides

Overseas Dispatch Work - Free Professional PowerPoint Templates

Presentation photos are included; 1 aspect ratios (4:3) Landscape orientation style Format: PowerPoint (.pptx) - designed with Microsoft PowerPoint 2016

Free PowerPoint Template Download - Laptop Theme_6 slides

Free PowerPoint Template Download - Laptop Theme

Easy to edit in PowerPoint All images included Format: PowerPoint (.pptx) - designed with Microsoft PowerPoint 2016 Trend template

Work with Coffee - PowerPoint Templates Free Download_6 slides

Work with Coffee - PowerPoint Templates Free Download

Drag & drop image placeholders Non-animated 1 aspect ratios (4:3) Latest Templates support version

PowerPoint Free - Marketing Analysis_6 slides

PowerPoint Free - Marketing Analysis

Smart and innovative presentation slides Landscape orientation style Easily editable content Easy to change colors

Free Design Template - Work in a Life_6 slides

Free Design Template - Work in a Life

Modern, simple, and clean design Drag & drop image placeholders Free images and artwork All images included

Free Design Template - Telecommuting_6 slides

Free Design Template - Telecommuting

Modern, simple, and clean design Smart and innovative presentation slides Presentation photos are included; Non-animated

Business Supplies - Free PowerPoint Design_6 slides

Business Supplies - Free PowerPoint Design

Clean, modern, and creative slides Creative and innovative presentation slides Trend template Easy color change

Idea Note - Free Powerpoint Template_6 slides

Idea Note - Free Powerpoint Template

Modern and clean design Creative slides Easily editable content 4:3 slide size

Working day - PPT Design Free_6 slides

Working day - PPT Design Free

Modern, simple, and clean design Trend template Modern, attractive, and business-friendly colors Easy to change colors

Free PowerPoint Template Design - Business_6 slides

Free PowerPoint Template Design - Business

Modern and clean design Smart and innovative presentation slides Easy to edit in PowerPoint Format: PowerPoint (.pptx) - designed with Microsoft PowerPoint 2016

Deep-sea Fish - Free PPT Template_6 slides

Deep-sea Fish - Free PPT Template

Presentation photos are included; Landscape orientation style Modern, attractive, and business-friendly colors Easy to change colors

Kitty - Best PPT Template Free Download_6 slides

Kitty - Best PPT Template Free Download

Landscape orientation style Clean style Modern, attractive, and business-friendly colors Easy to change colors

Cute Puppy - PowerPoint Images Free Download_6 slides

Cute Puppy - PowerPoint Images Free Download

Modern and clean design Creative slides Non-animated Format: PowerPoint (.pptx) - designed with Microsoft PowerPoint 2016

PPT Design Free Download - Mobile Transaction Invoice_6 slides

PPT Design Free Download - Mobile Transaction Invoice

Free images and artwork Landscape orientation style Clean style Easily editable data driven charts (pie, bar, line)

Relaxing Beach - PowerPoint Presentation Download Free_6 slides

Relaxing Beach - PowerPoint Presentation Download Free

Free images and artwork Landscape orientation style Creative and innovative presentation slides Latest Templates support version

Highway in a Nature - Free Powerpoint Templates Design_6 slides

Highway in a Nature - Free Powerpoint Templates Design

Easy to edit in PowerPoint Clean style Easily editable content Image placeholders

Free PowerPoint - Badminton_6 slides

Free PowerPoint - Badminton

Professional business presentation Landscape orientation style Format: PowerPoint (.pptx) - designed with Microsoft PowerPoint 2016 Clean style

Free PowerPoint Backgrounds - Rock Climbing_6 slides

Free PowerPoint Backgrounds - Rock Climbing

Modern and clean design No animation template Easily editable content Easy color change

Free PowerPoint - The Top of the Snowy Mountain_6 slides

Free PowerPoint - The Top of the Snowy Mountain

Professional business presentation Creative slides All images included Easy color change

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White Background Simple PowerPoint Templates & Google Slides Themes

Unlock your presentation potential: explore our collection of professionally crafted free and premium powerpoint templates and backgrounds for instant download, black and white corporate background powerpoint template, simple business background powerpoint template, simple blue and white powerpoint template, simple infographics shapes, white flat squares on blue powerpoint template, sparkle background powerpoint template, yellow sparkle background powerpoint template, paper leaf on orange background powerpoint template, floral black and white border powerpoint template, background with ribbon powerpoint template, white paper style abstract powerpoint template, kipasin google slide, gogureng powerpoint presentation, kipasin powerpoint presentation, talento googleslide templates, talento powerpoint presentation, shopbag google slide templates, shopbag powerpoint presentation, in green google slides theme, in green powerpoint theme, urban - interior powerpoint template, seamless arrows background powerpoint template, goldfish on the black background powerpoint template, simple elegant powerpoint template, speech bubble on orange background powerpoint template, food doodles on chalkboard powerpoint template, buy n sell powerpoint presentation, bussines fox googleslide, tehsoe powerpoint presentation, tehsoe google slide presentation, corpor 0 1 powerpoint presentation, corporate 0 2 google slide templates, shuley googleslide templates, corporate 0 2 powerpoint presentation, modern google slide templates, corporate 0 3 powerpoint presentation, corporate 0 3 google slide templates, automotica powerpoint presentation, tatu university google slide templates, desta google slide templates, desta powerpoint presentation, insurance google slide templates, heyya powerpoint presentation, finance google slide templates, heyya google slide templates, zoom tech powerpoint presentation, diagram infographic googleslide templates, fish style googleslide templates.

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Download Free and Premium White Background Simple PowerPoint Templates

Choose and download White Background Simple PowerPoint templates , and White Background Simple PowerPoint Backgrounds in just a few minutes. And with amazing ease of use, you can transform your "sleep-inducing" PowerPoint presentation into an aggressive, energetic, jaw-dropping presentation in nearly no time at all. These from free or premium White Background Simple PowerPoint Templates and Backgrounds are a great choice for a wide variety of presentation needs.

Our Free and Premium PowerPoint Templates are "pre-made" presentation shells. All graphics, typefaces, and colors have been created and are pre-set by an expert graphic designer. You simply insert your text. That's it!

Free vs. Premium White Background Simple PowerPoint Presentation Templates

PoweredTemplate offers a wide range of free White Background Simple PowerPoint Presentation Templates. You can find them by filtering by “Free”, from the “Filters” option on the site, on the top left corner of the screen after you search. This content is completely free of charge.

If you download our free White Background Simple PowerPoint templates as a free user, remember that you need to credit the author by including a credits slide or add an attribution line “Designed by PoweredTemplate”, clearly and visibly, somewhere in your final presentation.

PoweredTemplate also offers premium PowerPoint templates, which are available only to Premium users. There is no difference in product quality between free and premium White Background Simple PowerPoint Presentation Templates.

Best White Background Simple PowerPoint Templates

Are you looking for professionally designed, pre-formatted White Background Simple PowerPoint templates so you can quickly create presentations? You've come to the right place - PoweredTemplate has created these templates with professionals in mind. At PoweredTemplates, we understand how busy you are and how you love to save time.

That's why we've created a set of PowerPoint design templates with a White Background Simple theme. These White Background Simple PowerPoint templates are a great choice for a wide variety of presentation needs. Spend your time wisely - download the White Background Simple PowerPoint Templates today.

White Background Simple PowerPoint Presentation Themes FAQ

What are white background simple powerpoint templates.

A PowerPoint template is a pattern or blueprint for your slides that you save as a .pptx or .potx file.

All the White Background Simple PowerPoint templates are natively built in PowerPoint, using placeholders on the slide master, color palettes, and other features in PowerPoint, and can contain layouts, theme colors, theme fonts, theme effects, background styles, and even content (according to Microsoft Office).

How to choose White Background Simple PowerPoint templates for presentations?

Choose after carefully studying the template features and viewing the big preview images. All the product information is on the product page in the description and a list of the features can be found in the horizontal scrolling bar under the Download button. You may download a few free templates before making the final decision.

Who are White Background Simple PowerPoint templates suitable for?

Why do i need white background simple powerpoint templates.

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PowerPoint Backgrounds Template

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Number of slides: 31

Plain white backgrounds are unappealing and unstimulating. To make your presentation pop and keep your stakeholders interested, use one of the backgrounds provided here. They can suit your specific business needs, regardless of whether you target a young, dynamic audience or you provide services to well-established, multinational corporations.

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Free PowerPoint Background Template

Embellish your slides with your company’s color pallet.

Nothing like a personal touch on your presentation by adding your company’s colors to the slides in a discreet way. Whether it’s just a few decorative elements across the slide’s borders or attention-grabbing graphics, you can make your presentation look more professional with this simple touch.

Reinforce your target market

Are you providing financial services for small to medium businesses or do you offer consulting to freelancers on digital marketing techniques? Whatever your niche is, you can have an associated graphic that can help you tailor your content for your customers.

Keep your stakeholders engaged

Grab your clients’ attention by creating a visually interesting and stimulating presentation. It can help your business look more professional and thoughtful at virtually no cost. It’s an easily implementable technique that can differentiate you from the rest of your competitors.

Engaged customers are satisfied customers

Those backgrounds can help you solve any engagement issues and let you focus on content

Easily brand your presentations

Make your interactions with customers memorable by discreetly branding them. People will be able to recall those distinguishing features.

Differentiate yourself

Here you can easily come in to show your passion and dedication in providing good services in all aspects of your business.

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69 beautifully designed slides 67 icons included PowerPoint and Keynote ready 16:9 full HD class="mobile-none"resolution

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How to change the background in Powerpoint

powerpoint best practices slide sorter view windows laptop

You can change the background to anything you like if you're using Powerpoint to create presentations: a picture, a color, a gradient, or even an in-motion video. You'll know the best background for your presentation, but whatever you want to change it to, we're here to help you do it.

How to change the background to a color or gradient

How to add a picture to the background, how to add a video to the background.

Here's how to change the background in Powerpoint to a few different styles.

What You Need

Don't have Powerpoint installed already? Here's how to download it.

Beyond an empty background, the most simple background you can add to your Powerpoint presentation is a flat color, or a gradient from one color to another. Here's how to do it.

Step 1: Open your Powerpoint document and select the slide that you want to change the background for, on the left-hand side. In this example, we're using the standard template for an architectural pitch presentation.

Step 2: Select Design in the top-menu bar.

Step 3: Select Format Background in the top right.

Step 4: From the menu that appears, select either Solid fill or Gradient fill depending on your needs.

Step 5: If you want a solid color, select the paint can icon and choose your color preference. You can select from a range of curated color options, select More colors for a greater array of options, or use the Eyedropper tool to grab a color from the presentation to use for your background.

You can also adjust the transparency using the slider, to fade the color in and out.

If you want a gradient from one color to another, you can select a Preset gradient between two colors — but you can also fine-tune it using the Gradient stops options to control the number and type of color changes within the gradient. You can also adjust the position, transparency, direction, and brightness of the colors and the gradient itself.

Step 6: Play around with the option until you're happy. If you want to start again at any point, select the Reset background button at the bottom of the Format Background menu.

When you're happy with the result, just close the menu down by selecting the X icon in the top-right corner of the Format Background menu. Alternatively, if you want to apply that gradient or solid-color background to every slide, select the Apply to all button at the bottom of the window.

Would you rather make an image the background for your presentation's slide(s)? You can do that too.

Step 1: Select the slide that you want to change the background for, on the left-hand side. Then select Format Background in the top-right.

Step 2: Select Picture or texture fill .

Step 3: If you want to use a texture for the background, select the box next to Texture and choose the texture you want for the background from the pop-out window.

Step 4: If you want to use an image, select the Insert button under the "Picture source" subheading. Then decide where you want to source the image from.

Step 5: Select From a file if you want to use a local image file, then choose it using the file explorer and select Open . If you'd rather source it online, stock images, or the stack of pre-installed logos, select those and follow the on-screen instructions to introduce the image.

Step 6: If you want the image or texture to appear in the background of all slides, select the Apply to all slides button at the bottom right of the screen.

You can embed a video in a PowerPoint presentation , but if you want to really spice up a slide, why not change the entire background to a video? Here's how to do it.

Step 1: Select Insert followed by Video . Choose whether you want to add a video from your local device or an online source. If the former, select it from the file explorer and select Open . If it's online, paste the URL and select Insert .

In this example, I'm using a clip from the 1988 sci-fi comedy Red Dwarf .

Step 2: Use your mouse to drag and move the video so that it covers the portion of the slide that you want it to play on (or the whole thing). You can resize it too, using the corner controls by clicking and dragging.

Step 3: Right-click the video and select Send to back .

You can also take this opportunity to use the built-in controls to trim the video if it needs it, choose when you want it to start (automatically, or when clicked on), and its style — whether you want it to appear at an angle or with a fade around it.

Step 4: When you're happy with the video's implementation, select Slideshow at the top, then select either From beginning or From current slide in the top left to check out the presentation to make sure the video is working correctly.

If it's not in the right position, starts at the wrong point, or isn't formatted how you'd like it, use the right-click controls on the video to make your adjustments.

Now that you've become a master of Powerpoint backgrounds, how about playing around with the new Copilot features? Here are five of the best things you can do with Copilot Pro right now.

Alternatively, hone your presentation creating skills with these Microsoft PowerPoint best practices .

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Jon Martindale

Online team collaboration is the new norm as companies spread their workforce across the globe. Gone are the days of primarily relying on group emails, as teams can now work together in real time using an instant chat-style interface, no matter where they are.

Microsoft Teams is one of many collaboration tools designed to bring company workers together in an online space. It’s not designed for communicating with family and friends, but instead provides a platform for video conferencing, real-time discussions, document sharing and editing, and more for companies and corporations. What is Microsoft Teams? Microsoft Teams is a chat-based workspace initially introduced in 2016 for customers subscribing to the Office 365 Enterprise and Business plans, serving as the successor to Microsoft’s Skype for Business platform. It also replaced the Microsoft Classroom service in Office 365 Education.

Double-spacing is a great way to organize your word processing, and an excellent optimization that is built into most word processing tools. And whenever we hear “word processing,” one of the first programs that comes to mind is Microsoft Word. Learning how to use Microsoft Word is usually straightforward, but it has various formatting features that aren't immediately obvious. Here, we’re going to teach you how to implement double spaces throughout your next Word doc.

Microsoft Word is one of the most feature-rich word processing tools gifted to us human beings. In fact, the very word “Word” has invaded nomenclature to the point where any discussion of this type of software, regardless of what the product is actually called, typically results in at least one person calling the software “Word.”

With each new release of the industry-lauded software, we get more and more capabilities. But this shouldn’t prevent us from knowing how to incorporate classic Word elements, such as the hanging indent. We understand how tough it can be to stay on top of how to use Microsoft Word though, so we’ve made this guide to teach you how to quickly and easily add a hanging indent to your next Word doc.

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Beautiful White Background PPT and Google Slides Themes

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Simple presentation background ideas: elevate your visuals with minimalistic designs

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Anete Ezera August 29, 2024

When you’re putting together a presentation, the background you select is key in setting the mood and making sure your content shines. While there are many different good presentation backgrounds that are bright and colorful, there’s a rising preference for simple presentation backgrounds. These clean designs can boost your message by minimizing distractions and making sure your content takes centre stage.

Bulb Concepts with Yellow Crumpled Paper Ball

In this article, we’ll delve into the advantages of using simple presentation backgrounds, specific scenarios where they shine, and how platforms like Prezi can elevate your presentations with their open canvas and dynamic tools.

The power of a simple presentation background

Choosing a backdrop for your presentation goes beyond selecting a color or a basic layout. It involves setting up an uncluttered environment that highlights your message effectively. Let’s explore the reasons why opting for a simple presentation background can improve your message.

Improved readability

A key advantage of using a simple presentation background is the readability it offers. Complicated or excessively intricate backgrounds can make the text challenging to read, leading your viewers struggling to comprehend your message. Conversely, a simplistic background guarantees that your text is easily readable, allowing your audience to concentrate on your content.

Reduced distractions

Having a simple presentation background can minimize distractions for your audience, which is crucial when sharing intricate details or holding their attention for a long time. Opting for a simple aesthetic background for presentation slides directs the focus toward the speaker and the content rather than on the background itself. 

Senior businesswoman giving presentation to team. Male and female professionals are planning strategy in meeting. They are in board room at office. She is showing a business presentation theme and using the power of visual storytelling to convey the message.

Versatility

Simple presentation backgrounds offer flexibility. They can be customized to suit various presentation topics. Whether you’re showcasing a business pitch, a school assignment or an imaginative idea, a clean background can serve as the perfect backdrop for your material.

Timeless appeal

Trends in design come and go, but simplicity is timeless. A simple background for presentation slides ensures that your presentation won’t look outdated in a few months. It also conveys professionalism and can be tailored to fit any industry or topic.

What is the best background for a presentation? 

When preparing a presentation, it’s best to opt for a background that’s straightforward, neat and doesn’t draw much attention. Opting for colors such as light grey or gentle blue is recommended as they offer a nice contrast with the text. It’s advisable to steer clear of designs or vibrant colors that may overshadow the content.

In case you decide to include images, make sure they’re subtle and relevant to the subject matter. Consistency plays a role here, so stick to the same background style across all slides to maintain a polished and coherent appearance.

Specific use cases for simple presentation backgrounds

Simple presentation backgrounds are suitable for a wide range of scenarios. Here are some specific instances where a minimalistic background works best:

Business presentations

In a corporate setting, professionalism is key. A simple, clean background helps maintain a professional tone and ensures that your data, graphs, and key points are easily readable.

Minimal empty brown beige 3d room background. Modern Studio showcase with copy space. Trendy place to advertise your products. Luxury stage concept for cosmetic, beauty, fashion, product mock-up design template presentation

For example, using a soft, neutral-toned background like this empty brown-beige studio room background can create a warm, welcoming atmosphere without distracting from the content.

Educational presentations

When students have to explain ideas, it’s important to keep things clear and straightforward. Using a simple background for presentations can make it easier for the audience to concentrate on the educational points without distractions.

presentation white background

A background with subtle textures, such as this simplistic aerial shot above Lake Dumbleyung, can provide a serene backdrop that doesn’t compete with the information being presented.

Creative and design presentations

When presenting creative work, such as design concepts or artistic projects, the background should complement rather than overshadow the content. A simple presentation background allows your creative elements to take center stage.

Simple presentation background

Consider using an abstract but subtle design like this abstract lights on a dark green background to add a touch of creativity without overwhelming your visuals.

Personal and inspirational presentations

Personal stories or inspirational talks benefit from backgrounds that evoke emotion without being overly complex. A minimalistic background with a hint of nature, like this colorful clouds at sunset, can create a peaceful and reflective atmosphere.

Simple presentation background that displays rosy clouds.

Product or service showcases

When showcasing a product or service, a simple presentation background can help highlight the subject without competing for attention.

Simple presentation background that displays a table in sunlight.

For example, a rendering product background with a clean, neutral design is ideal for presentations focused on product demonstrations, allowing the product itself to be the star of the show. This type of background is especially useful in marketing presentations where the goal is to create a clear and compelling visual representation of the product.

Science and nature-themed presentations

For presentations centered around scientific concepts or natural phenomena, a background that subtly reflects the theme can be very effective.

Simple presentation background of a steam.

The soft-focused image of steam provides a simple yet evocative backdrop that can complement discussions on topics such as geology, environmental science, or even metaphorical concepts like transformation and change. This type of background adds depth to your presentation without overwhelming the content.

Youthful and creative presentations

For presentations aimed at younger audiences or those with a creative edge, a playful and vibrant background can help set the tone. This single paper airplane on a yellow background offers a whimsical yet simple design that’s perfect for educational, inspirational, or creative projects.

A Single Paper Airplane on Yellow Background

This type of background is particularly effective in presentations for students, where the goal is to engage and inspire while keeping the design straightforward and accessible.

Technology and innovation presentations

For presentations focused on technology, innovation, or data-driven topics, a background that subtly suggests complexity while remaining visually clean can be very effective.

3d rendering futuristic Abstract background, Blue Color Motion Striped line texture for Business science and Technology advertising

This abstract background with dots is an excellent choice for such presentations. The modern and sleek design, suggests connections to networks, systems and digital technology. This makes it ideal for discussing AI, networking, or futuristic advancements. The background brings a contemporary tech vibe to your presentation while keeping things simple and clear, ensuring your message stays prominent.

Leveraging Prezi for dynamic presentations

Prezi is a tool that distinguishes itself from slide-based presentations by providing a flexible canvas method. This special feature enables you to craft engaging presentations where the background contributes significantly to shaping the story.

Open canvas for creative freedom

Unlike traditional presentations where each slide is a separate entity, Prezi allows you to work with an open canvas . This means the background isn’t merely a fixed element but an essential component of the narrative. You have the freedom to navigate the canvas crafting a cohesive storytelling journey.

Dynamic panning and zooming for engaging storytelling

One remarkable aspect of Prezi is its panning and zooming feature. In contrast to slide-based presentations, where transitions occur from one slide to another, Prezi allows for navigation across the canvas. You can zoom in on details, and then pan out to reveal the broader context, transforming your presentation into an engaging storytelling experience . This interactive journey lets you evolve the background as you lead your audience through layers of information. The panning and zooming effects not only enhance appeal but also highlight important points and foster a more immersive experience for your viewers.

Simple presentation backgrounds in Prezi templates

Prezi offers a variety of templates that incorporate simple presentation backgrounds , making it easy to get started with a minimalistic design. For instance, the Modular Dark AI-Assisted template uses a sleek, dark background that’s perfect for professional and technical presentations.

Prezi AI-assisted template

The Research Project Light template offers a clean, light background that’s ideal for academic and educational presentations.

Research template

Experimenting with backgrounds

With Prezi, you’re not limited to the backgrounds provided within the platform. You can experiment with your own images to create a unique and personalized presentation. The limitless canvas allows you to place and move elements in a way that’s visually appealing and tailored to your specific needs.

Professional and medical presentations

For presentations in the healthcare industry or any professional field where clarity and precision are paramount, Prezi offers templates like the Medicine Light .

presentation white background

This template features a clean, minimalistic background that reflects the seriousness and professionalism required in medical presentations. The light background ensures that important medical data, charts, and images are presented clearly, making it easier for the audience to focus on the critical information being conveyed.

Effective onboarding and training

When creating onboarding presentations or training sessions, it’s important to use a background that’s both engaging and non-distracting. Prezi’s Employee Onboarding AI-Assisted template is designed to facilitate effective learning by combining a simple presentation background with interactive elements.

Prezi AI template

The minimalistic design helps keep the focus on the training content, making it easier for new employees to absorb the information without being overwhelmed by visual clutter.

Educational and lesson plan presentations

Educators looking to present lesson plans or educational content will benefit from Prezi’s Lesson Plan Template .

Prezi simple background template

This template uses a simple background for presentations for students that’s ideal for structuring and organizing educational material. The simplicity of the background allows teachers to present information clearly, ensuring that students can easily follow along with the lesson. The open canvas format also enables educators to create dynamic and interactive presentations that can adapt to various teaching styles.

Free backgrounds in Prezi

Another key benefit of using Prezi is its variety of backgrounds accessible directly in the editor, saving you the hassle of hunting for the ideal background elsewhere. Whether you need a work desk setting for a professional presentation or a constellation-themed background for a creative project, Prezi has you covered.

Explore all available Prezi templates and get started!

Embrace the benefits of simplicity in your next presentation

Simplicity is not just a passing fad; it’s evolved into an essential element in presentation design. A simple presentation background improves readability, reduces distractions, and provides an enduring charm. Whether you’re giving a business pitch, teaching a class, or showcasing your creativity, opting for a simple presentation background ensures that your message remains the focal point.

Prezi’s open canvas approach takes this a step further by allowing you to integrate simple presentation backgrounds into a dynamic, visually engaging story. With Prezi, you have the freedom to experiment with creativity, using backgrounds as an essential element of your storytelling. So next time you’re preparing a presentation, consider the power of simplicity and explore the endless possibilities that a simple presentation background, especially in Prezi, can offer.

Remember, you don’t need to look far for the perfect background – with Prezi, a world of simple yet effective backgrounds is right at your fingertips. Looking for more background ideas? Find good presentation backgrounds here .

presentation white background

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How to Remove Background From Images in Word [Extremely Easy!]

I was working on a report once, and everything was going smoothly—the creative juices were flowing, my motivation was at its peak, and I had all the material ready. To add the final personalized touch, I decided to include my own picture. I had several photos I wanted to use, but I wasn’t sure how to frame them correctly and insert them into the presentation. It took me a while, but I finally figured out how to remove the background from images in Word. In this article, I'll show you how I did it.

Introduction to AI Background Removal in WPS Photos

In this article, I'll highlight how I use my favorite photo editing tool, WPS Photo, which is part of the WPS Office suite. As someone who frequently works on presentations and reports, I rely on the free WPS Office suite for its AI-powered solutions and robust office tools.

One of the standout features of WPS Photo is its ability to function offline, unlike many web-based photo editors. This means I'm not limited by internet connectivity, allowing me to freely edit photos with premium, AI-powered tools. These are some of the editing capabilities of WPS Photo!

AI Auto Background Removal

WPS Photo's AI Auto Background Removal tool is a game-changer for users who need to remove backgrounds quickly and effortlessly. This feature automatically detects and removes the background of an image, regardless of the complexity, saving you the hassle of manual selection. It’s perfect for creating clean, professional-looking images in seconds.

AI Custom Background Removal

For more detailed background removal, WPS Photo also offers an AI Custom Background Removal option. This feature allows you to tailor the removal process according to the specific needs of your image, whether it's a portrait, product, or document. You can switch between different modes based on the image type, ensuring precise and clean results. If needed, manual adjustments can further refine the outcome.

AI Integration in Other Features

WPS Photo doesn’t just stop at background removal; its AI capabilities extend to other editing tools, enhancing the overall user experience:

Image Enhancer: The AI-powered Image Enhancer dramatically improves the resolution of images, increasing clarity by 2X or 4X with a single click. This is especially useful for enhancing low-resolution or blurry photos.

Text Enhancement: When dealing with scanned documents that have dark backgrounds or unclear text, WPS Photo’s AI-enhanced Text Enhancement feature removes the background and sharpens the text, making it much easier to read and print.

Magic Eraser: The AI-driven Magic Eraser tool efficiently removes unwanted elements from your images, intelligently blending the background to give a seamless finish. It's perfect for cleaning up photos with distractions.

Color Adjustment and Filters: AI also powers WPS Photo's color adjustment tools, offering a variety of filters like portrait, landscape, food, and text. These filters are optimized to enhance the image's color tone, making it more visually appealing with just a few clicks.

Watermark Removal: The AI technology in WPS Photo can detect and remove watermarks from images. This feature uses advanced algorithms to recognize the watermark layer, making it easy to clean up images without leaving traces.

Core Editing Features

Alongside these AI-driven tools, WPS Photo also provides robust core editing features:

Crop, Rotate, and Straighten: You can easily crop, rotate, and straighten images, with options to set the crop size manually or by shape. The tool also supports image calibration to fix distortions caused by lens effects.

Annotation Tools: You can insert text, add images (like logos), select and copy specific areas, or crop the image as needed. These tools help you add detailed notes or brand elements directly to your photos.

Watermark Tool: If you need to protect your content or indicate the source, WPS Photo allows you to add both text and image watermarks. You can apply these as single elements or cover the entire screen.

How to Remove Background from Image in Word?

Often, when I sit down to create a document, I find the process of switching tabs to edit an image with complex image editors quite cumbersome. If you face the same challenge and are wondering "how to change the background of a picture in a Word document," you'll be pleased to know there's a straightforward solution.

As discussed throughout the article, WPS Photos—once just an image editor and viewer tool included with WPS Office—has now been integrated directly into WPS Office. This integration makes it easy to manage and edit images within your Word documents. Let’s explore how to remove the white background from an image in Word documents using WPS Office while uploading images.

Step 1: Insert Image in Word

To begin, we need to insert the image into our document in WPS Writer. Here’s how to do it:

Open your Word document using WPS Writer.

In WPS Writer, go to the "Insert" tab in the toolbar.

Click on the "Picture" button in the Insert ribbon, and from the drop-down menu, select "From File" to insert an image from your computer.

Simply browse for the image you want to insert into the Word document.

Step 2: Edit with WPS Photos

Now, let's edit the inserted images using WPS Photos without switching any tabs:

Simply right-click on the inserted image and then click on the "Edit" button in the context menu.

The image will now open in the WPS Photos Editor, where you can edit it using WPS AI tools such as the image enhancer, background removal, or try out some new filters.

Step 3: Remove and Change Background

Now that we have the image open in the WPS Photos Editor, let’s remove the background and make the image ready for your Word document:

On the WPS Photos Editor interface, click on the "BG Removal" button in the right-side pane toolbar.

Upon clicking, WPS AI will automatically start processing the image to remove the background.

Once the process is complete, the background will be removed, and your image will be ready for use in your document.

If you're wondering how to replace the background color in a Word image, it's quite straightforward. Simply use the "Background Fill" option to add a new background color. Alternatively, you can add an image as the background for an even more customized look.

Step 4: Save the Image

To finalize the image, there is one more step: saving the image to ensure your edits are preserved.

Simply click on the "Save" button to save the image. This will close the WPS Photos Editor and return you to the WPS Writer interface.

The image inserted now seamlessly blends with the Word document, without the background, and maintains the professionalism of your document.

This tool is truly amazing to work with, and its simplicity is something best understood through experience. I highly recommend using both WPS Writer and WPS Photos. Whether you are a student or a professional, these tools from WPS Office make your work a lot easier.

Bonus Tips: AI Enhancer in WPS Photos

The reason WPS Office has consistently been my favorite editing tool is due to its unwavering commitment to progress and innovation. It continuously improves and stays ahead of the game, all while offering a suite of powerful, free tools. The recent upgrade in July, which introduced AI-powered features, was a game-changer that took the market by storm. This update has made photo editing not only simpler but also smarter.

That's where WPS Photos steps in, integrated seamlessly within the WPS Office suite. This tool not only preserves the integrity of your images but also enhances them, ensuring they remain crisp and clear. Here's how you can enhance your photos to make them crisper and clear up any blurred visuals using WPS Photos' AI Enhancer.

Step 1: First, open the image you want to enhance using WPS Photos.

Step 2: Next, hover over the "Edit" button and select the "AI Enhancer" option from the drop-down menu.

Step 3: The image will now open in the WPS Photos Editor, where AI will assist in the enhancement process, making editing easier.

Step 4: To enhance your image, click on the "Image Quality Enhancer" tool in the right-side pane.

Step 5: AI will begin enhancing the image, improving its clarity and appeal without removing any pixelated details.

Step 6: Finally, save the enhanced image by clicking on the "Save" button.

Whether you're working on a detailed report, a vibrant presentation, or a creative project, WPS Photos takes your images to the next level. It transforms what could be a tedious task into an enjoyable and efficient process, allowing you to focus on your creative vision rather than technical limitations. This kind of attention to detail is what makes WPS Office not just a tool, but a trusted partner in achieving your best work.

1. Can I edit the image after removing the background?

Yes. After removing the background, you can continue to refine the image using WPS Photos' extensive editing tools. The platform allows for precise adjustments, including cropping, brightness and contrast modifications, filter applications, resizing, and rotation. Additionally, you can add text and make further enhancements to ensure your image meets your desired specifications.

2. Is it possible to save the image with the removed background for use outside of Word?

Yes. You can move the image with the removed background to other programs by copying and pasting it or exporting the document as a PDF. However, to save images with transparent backgrounds in formats such as PNG, you will need to utilize additional software, as Word does not offer this capability.

Effortless Background Removal with WPS Office:

Back in the day, learning how to remove the background from images in Word traditionally required manual effort, which was both time-consuming and prone to imperfections. Thankfully, WPS Office has revolutionized this process with its AI-powered background removal tool. This feature performs remarkably well, delivering precise and flawless results with minimal effort. As someone who has experienced its effectiveness firsthand, I can confidently say it’s a major life-saver. If you want to see just how impressive it is, download WPS Office and experience the results for yourself.

  • 1. How to remove background from picture in powerpoint(In Easy Steps)
  • 2. How to Remove Text from Images Using AI (Extremely Easy)
  • 3. How to Remove Background Using Pixlr (Extremely Easy!)
  • 4. How to Remove Background from Picture Using AI (Steps with Images)
  • 5. How to Add Text to an Image in Word/Excel/Powerpoint (Extremely Easy!)
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  • Case Report
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  • Published: 31 August 2024

Multiple sclerosis and amyotrophic lateral sclerosis: is there an association or a red flag? A case report and literature review

  • Raseel Aljthalin 1 ,
  • Rawan Albalawi 1 ,
  • Atheer Alyahya 1 ,
  • Rawabi Alhathlool 1 &
  • Moustafa Alhashemi 1 , 2  

BMC Neurology volume  24 , Article number:  307 ( 2024 ) Cite this article

Metrics details

Multiple sclerosis (MS) is an inflammatory disease of the central nervous system that causes damage to the myelin and axons and is caused by genetic or environmental factors. Amyotrophic lateral sclerosis (ALS) is characterized by rapidly progressive degeneration of the motor neurons resulting in the presence of upper and lower motor-neuron signs and symptoms.

Case presentation

A 46-year-old female patient presented with symmetrical weakness of the lower limbs and numbness that developed over weeks. Magnetic resonance imaging (MRI) of the brain exhibited typical demyelination features, high signal abnormality involving the periventricular and subcortical white matter, and an oval-shaped lesion. The patient was diagnosed with MS based on the clinical presentation and radiological examination. However, there was rapid progression of the symptoms, involvement of bulbar dysfunction, and muscle atrophy. Furthermore, the patient did not respond to acute therapy and immunotherapy, which made the diagnosis of MS less likely or suggested that it could be associated with another diagnosis. Her neurophysiological test met the criteria of ALS, and she was started on riluzole.

Literature review

We reviewed all articles from 1986 to 2023, and there were 32 reported cases describing the co-occurrence of ALS and MS in different populations. Our case is the 33rd, and to our knowledge, it is the only case reported in the Middle East and specifically in Saudi Arabia. The main proposed mechanism according to postmortem examinations is a combination of degenerative and inflammatory processes with a cascade of production of reactive oxygen species and nitric oxide, which lead to cell death and apoptosis during concomitant ALS with MS.

The co-occurrence of ALS and MS is extremely rare, but it can be explained by pathogenesis related to neurodegeneration, inflammation, or genetic susceptibility. Rapid progressive motor and bulbar symptoms could be red-flag symptoms, extensive evaluation might be needed for these patients.

Peer Review reports

Multiple sclerosis (MS) is an inflammatory disease of the central nervous system that causes damage to myelin and axons, influenced by genetic and environmental factors. The autoimmune process in MS leads to the degeneration of myelin sheaths. Common presenting symptoms include sensory, motor, and vision issues, as well as imbalance [ 1 , 2 ].

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease affecting the brain and spinal cord, characterized by the presence of upper and lower motor neuron signs and symptoms [ 3 ]. ALS impacts bulbar, cervical, lumbosacral, and thoracic motor neurons [ 4 ].

Both MS and ALS can exhibit non-motor symptoms. Neuropsychiatric symptoms in ALS most commonly include depression and anxiety, while cognitive impairment may arise due to frontal lobe dysfunction. Executive dysfunction is frequently reported in ALS [ 5 ]. In contrast, cognitive issues in MS can result from cortical lesions that lead to gray matter atrophy, causing a variety of cognitive symptoms. Other non-motor symptoms in both conditions include fatigue, pain, pseudobulbar affect, sialorrhea, and autonomic dysfunction [ 4 ]. Notably, autonomic dysfunction in ALS is an independent factor contributing to disease progression and is associated with more rapid rates of motor functional decline and shorter survival [ 6 ].

The co-occurrence of MS and ALS is rare; however, the proposed link involves genetic factors and demyelination activity affecting axon cells alongside the degeneration of anterior horn cells, leading to programmed cell death [ 3 ]. Activation of neuroinflammation and neurodegenerative processes due to environmental or genetic factors may explain the connection between these two diseases [ 7 , 8 ]. A notable case of co-occurrence involved a patient with ALS who exhibited features of MS, potentially driven by a hexanucleotide repeat expansion of C9ORF72 [ 1 ]. This case highlighted a challenging presentation of progressive bulbar symptoms, raising questions about whether the patient was experiencing a progressive form of MS or concomitant diseases.

We report on a middle-aged woman diagnosed with MS who was later found to have ALS, along with an overview of 32 additional cases and a description of the link between these two diseases.

The patient was a 46-year-old woman with a known case of type 2 diabetes mellitus. In April 2022, the patient started to have progressive symmetrical weakness of the lower limbs and numbness, which developed over weeks and was progressive in nature. She also started to have difficulty with walking and eventually required a wheelchair. She denied having any history of recent travel, raw-milk ingestion, vaccination, family history of the same presentation, illicit drug use, fever, or upper-respiratory-tract infection. She also denied having any gastrointestinal or genitourinary symptoms.

The patient was admitted to another facility, and the investigations performed included lumbar puncture and magnetic resonance imaging (MRI) of the brain. The MRI showed non-specific white-matter lesions, and the patient was diagnosed with demyelinating disease. She received pulse steroid therapy and was discharged, but there was minimal improvement regarding her muscle weakness after she went home.

In September 2022, her weakness progressed further with upper limb weakness, and she also developed difficulty in breathing and swallowing, along with worsening of her muscle weakness. Eventually, she was tracheostomized. During her admission to the other facility, she again received pulse steroid therapy, intravenous immunoglobulin, and one dose of ocrelizumab due to an impression of secondary progressive MS. Because she was not showing any improvement in functional status, she was eventually referred to our institution for further investigations and management (Fig. 1 ).

figure 1

Timeline of the patient’s events

Clinical findings

The patient was on a mechanical ventilator with a trachea tube, nasogastric tube, and indwelling Foley catheter. She was awake, alert, and responding to commands. The results of cranial nerve examination were normal except for atrophy and fasciculation of the tongue with an exaggerated jaw reflex. Motor examination revealed atrophied thenar muscles, hypertonia of the upper limbs, and hypotonic lower limbs.

The Medical Research Council (MRC) grade of limb power for the upper limbs was + 2 for proximal muscles and + 3 distally at the level of the wrist and fingers. For the lower limbs, the MRC was + 2 proximally and + 1 distally at the level of the ankle, feet, and toes. The score for deep tendon reflexes was + 2 for the upper limbs with spreading reflexes, and the lower limbs were areflexic with mute plantar reflex, no clonus, and negative Hoffman sign. Sensory examination revealed decreased pinprick sensation and an absence of proprioception in the lower limb, and no sensory level was detected. The cerebellar examination was limited because of severe weakness.

Laboratory findings

The patient’s vitamin levels were all within normal limits, including vitamin B12 and its metabolites methylmalonic acid and homocysteine. The results of a thyroid function test including thyroid antibodies were normal. Her cerebrospinal fluid (CSF) showed a normal cell count, normal levels of glucose, protein, and lactate, negative culture results, and an oligoclonal band. Moreover, the results of serological and CSF tests for Campylobacter jejuni , cytomegalovirus, Epstein-Barr virus, and Haemophilus influenzae infection were negative. Autoimmunological diagnostic including antinuclear antibody (ANA), complement fixing ANA (C-ANA), and perinuclear anti-neutrophil cytoplasmic antibodies (p-ANCA) were negative, as were tests for coeliac disease (antigliadin antibodies and antitransglutaminase antibodies). Moreover, paraneoplastic antibodies were sent through the serum and CSF, and the result was negative.

Radiological features

Brain and spine MRI showed evidence of scattered foci of hyperintense T2/FLAIR signal abnormality involving the periventricular and subcortical white matter in both cerebral hemispheres with limited involvement of the corpus callosum. Some of these lesions appeared perpendicular to the lateral surface of the lateral ventricle and suggested a demyelinating process. There was no pathological enhancement suggesting active disease. Imaging of the cord demonstrated normal alignment of the vertebral bodies. We performed 18-fluoro-2-deoxyglucose (FDG) whole-body positron emission tomography, which showed no detectable metabolically active lesions that could suggest malignancy in the rest of the scanned body. The MRI did not show the reason for rapid progression, and a diagnosis of MS was made based on radiological features (Fig. 2 ).

figure 2

Axial and sagittal view of brain MRI showing scattered foci of hyperintense T2/FLAIR signal abnormality involving the periventricular and subcortical white matter in both cerebral hemispheres. Some of these lesions appeared perpendicular to the lateral surface of the lateral ventricle and suggested a demyelinating process

Electrophysiological diagnosis

Due to the presence of both upper and lower motor signs in examination, a nerve conduction study (NCS) and electromyography (EMG) were done. The motor NCS revealed that the right median to abductor pollicis brevis was absent, the right ulnar to abductor digiti minimi showed a very small compound motor action potential of 0.4 mV, the right tibial to adductor hallucis was absent, and so was the right peroneal to extensor digitorum brevis. The sensory NCS results were normal .

In EMG, three segments were sampled. In the bulbar segment, the right tongue showed features of active denervation (+ positive sharp waves and + fibrillations). The cervical segment (right deltoid, extensor digitorum communis, and biceps) showed features of active denervation (+ positive sharp waves and + fibrillations). The lumbar segment (right tibialis anterior and vastus medialis) showed features of active denervation (+ positive sharp waves and + fibrillations). These findings are compatible with widespread motor neuron disease (Fig. 3 ).

figure 3

Nerve conduction study showing A very low compound motor action potential (CMAP) of right ulnar nerve responses, B absent CMAP of the left fibular nerve responses, and C , D normal sensory nerve action potential (SNAP) of upper and lower-limb sensory nerve stimulation sampled from the sural and median nerve. O: onset of the wave. P: peak of the wave. T: terminal part of the wave

The patient was diagnosed with MS and was managed based on the radiological features and clinical assessment. The rapid progression of the symptoms, involvement of bulbar dysfunction, and lack of response to acute therapy and immunotherapy made the diagnosis of MS less likely or suggested an association with another diagnosis. Clinical features and the results of the neurophysiological investigation met the El Escorial criteria for ALS. She was started on riluzole at 50 mg twice per day and was referred for multidisciplinary care.

The combination of MS and ALS is rare but can be explained by links between neurodegeneration, inflammation, and genetic susceptibility. In post-mortem pathological findings, demyelinating activity is observed, and degenerative processes of the anterior horn cells occur at multiple serial lumbosacral cord levels through an inflammatory cascade. This leads to the release of reactive oxygen species and nitric oxide, cell death, and apoptosis, which are observed concomitantly in ALS with MS [ 3 , 4 , 5 , 6 , 7 ]. In a case series study by Ismail et al., the co-occurrence of MS in a patient with ALS was explained as being driven in some way by a hexanucleotide repeat expansion of C9ORF72. The study highlighted that more than 1% of patients with ALS may have a history of MS [ 8 ]. Fiondella et al. reported one case of heterozygous mutation in FUS exon 15 [ 1 ].

So far, there have been 32 reported cases of the co-occurrence of ALS and MS in different populations, which have mainly occurred in Europe and North America. Our case is the 33rd to be reported and is the only case to our knowledge that has occurred in the Middle East and specifically in Saudi Arabia. We reviewed all related articles from 1986 to 2023. Most of the cases were females (25 out of 33), and 8 were males. The mean age of the onset of ALS is 52 years with a range of 34 to 72 years. The mean age of the onset of MS is 41 years. In some studies, no autopsies or genetic tests were performed, but clinical examinations, radiological findings, and neurophysiological observations were consistent with MS and ALS.

In the different cases, patients were diagnosed with MS initially and were later diagnosed with late-onset or rapid-onset ALS. Autopsy has shown a loss of myelinated axons and neuronal loss with gliosis of the motor neuron cells [ 8 ]. Only 5 patients have been reported to be positive for C9orf72 out of the 33 cases reviewed, but genetic tests were not done in all cases. HLA genotyping performed on genomic DNA has also been studied, and three cases showed positivity for HLA-B*18:01A according to Dattola et al. This antigen could play an important role in activating both neuroinflammation and neurodegenerative processes [ 9 ]. Table 1 shows the characteristics and diagnostic information of the 33 cases (Figs. 4 and 5 ).

figure 4

Illustration of the main characteristics of the 33 cases of MS with ALS from 1986 to 2023. There is a predominance of females (25 cases). The onset of MS occurs at an average age of 41 years, with late-onset ALS diagnosis occurring at the age of 52 years. C9orf72 was found in only 5 cases

figure 5

Worldwide distributions of patients with co-occurring MS/ALS diagnoses

The co-occurrence of ALS and MS is extremely rare, but it can be explained by a mix of pathogenesis involving neurodegeneration, inflammation, and genetic susceptibility. Careful evaluation is needed for patients with rapid progressive motor and bulbar symptoms who are initially diagnosed with MS as this presentation could be a red flag. Extensive evaluation might be needed for these patients. To gain more understanding of the co-occurrence, pathological testing, genetic testing, and HLA genotyping should be considered for diagnosis.

Availability of data and materials

All data generated or analysed during this study are included in this published article and its supplementary information files.

Data availability

No datasets were generated or analysed during the current study.

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Department of Adult Neurology, Prince Sultan Military Medical City, Riyadh, Saudi Arabia

Raseel Aljthalin, Rawan Albalawi, Atheer Alyahya, Rawabi Alhathlool & Moustafa Alhashemi

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Aljthalin, R., Albalawi, R., Alyahya, A. et al. Multiple sclerosis and amyotrophic lateral sclerosis: is there an association or a red flag? A case report and literature review. BMC Neurol 24 , 307 (2024). https://doi.org/10.1186/s12883-024-03821-x

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