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Understanding the World and Shaping Its Future

Through bold thinking, rigorous scholarship, and cross-cutting collaborations, Yale research pushes the boundaries of scientific and technological knowledge to benefit people and our planet.

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From A(nalytical and stable isotopes) to Z(ebrafish phenotyping), research at Yale combines serious inquiry, deep expertise, and state-of-the-art technology.

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Yale’s research cores enable scientists across campus to interact, collaborate, and develop new applications that advance the university’s scientific mission.

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At a series of autumn Cores Fairs, visitors learn how core facilities can help with their research. Mass spectrometry and nuclear magnetic resonance (NMR) spectroscopy are among the offerings at West Campus Analytical Core.  

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Eric Paulson, PhD, tunes the probe under a nuclear magnetic resonance (NMR) spectrometer, one of twelve at the Chemical and Biophysical Instrumentation Center (CBIC). The Center also houses instruments for mass spectrometry and X-rays.

Micrograph image of a Meissner corpuscle, a sensory organ

A Meissner corpuscle is a group of cells that acts as a touch detector. Its 3D structure was revealed for the first time using enhanced focused ion-beam scanning electron microscopy (FIB-SEM). Image credit: Yury Nikolaev, PhD, a postdoctoral fellow in the Slav Bagriantsev lab .

Microscopic image of liver cancer cells escaping a tumor spheroid in a fibrotic environment.

Liver cancer cells escape a tumor spheroid in a fibrotic environment. This Art in Research contest -winning image was collected by Xiangyu Gong, a postdoctoral associate in the Michael Mak biomedical engineering lab , with a Leica SP8 Confocal microscope.

Research cores make science easier, more fruitful, and more efficient.

“You’d be hard-pressed to find a high-profile experimental research paper from Yale that hasn’t been touched by a core."

Related Research Cores

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Characterizing and elucidating structures

“The WCAC provides our research community here at Yale access to high-level instrumentation, helping to forward discovery.”
  • West Campus Analytical Core

A more collaborative approach

"One of the most enjoyable aspects of what we do is collaborate with the grad students and faculty to solve the problems they’re up against. It’s not just cranking out the data."

Cutting-edge electron microscopy

“Potentially, this research will inform the development of tactile sensors for next generation of prosthetics.”
  • FIB-SEM Collaboration Core (F-SCC)

New cancer insights

"Compared to cell culture in a petri dish, the three-dimensional models provide new insights into understanding cancer and enable more accurate cancer drug screening. Yale core facilities make it possible for us to unveil novel cellular behaviors in the midst of disease progression."
  • Confocal Microscopy at CCMI

By the numbers

Yale takes a data-intensive approach to science and technology research, harnessing today's volume, speed, and availability of data to transform knowledge production.

Research Infrastructure

  • 70+ core science facilities
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Empowering Support

in sci/tech R&D expenditures in FY22

HERD Report, 2022

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‘Full steam ahead’: Yale research as engine of innovation

In a Q&A, Michael C. Crair, Yale’s vice provost for research, discusses Yale's ongoing research enterprise and the role of federal funding for basic research.

Roberts Innovation Fund to support inventions in AI, quantum, water

The awards provide $1 million in accelerator funding to support 10 new inventions led by faculty from Yale’s School of Engineering & Applied Science.

Opinion: Connecticut must seize quantum technology opportunity and the job crea…

As QuantumCT works to position Connecticut as a quantum tech leader, we urge Congress to fully fund the CHIPS and Science Act—and we invite Connecticut residents, lawmakers, businesses, and organizations to join in the work.

World’s most powerful 3D super-resolution microscope arrives at Yale’s West Ca…

Yale researchers will soon watch individual molecules move through living cells, thanks to the arrival of an Abberior MINFLUX instrument, the world’s most powerful 3D super-resolution fluorescence microscope.

Announcements

Salaries for research scientists & postdocs in fas, seas, yse; 2024-2025.

New 12-month salary minima are effective July 1, 2024.

Yale Center for Geospatial Solutions has its first executive director

Jennifer Marlon will begin her appointment on July 1, 2024.

Tech Tank to open at West Campus

Celebrate the new facility's grand opening May 9th with tours, robotics demonstrations, and more.

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Centers & institutes.

Yale is home to a number of renowned research centers, laboratories, and institutes that are pushing the boundaries of knowledge on topics ranging from autism to globalization.

Discover all the ways Yale scholars are advancing the fields of humanities, arts, social sciences, medicine, science, and engineering.

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Located in West Haven, CT, Yale’s West Campus is home to a number of interdisciplinary scientific research institutes.

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Award helps yale scientist pursue novel research into natural mechanisms.

Alison Sweeney

Alison Sweeney (Photo by Dan Renzetti)

In her research, Yale’s Alison Sweeney has crafted innovative studies that have revealed novel mechanisms in the natural world that could aid in the design of future technology. For instance, she has discovered the blueprints for possible new advances in the self-assembling proteins in squid eyes and iridescence in giant clams.

A new, five-year, $1.25 million award will help her continue this groundbreaking work.

The award is part of the Gordon and Betty Moore Foundation’s Experimental Physics Investigators Initiative , which provides flexible funding for scientists to pursue imaginative research ideas and advance scientific understanding of the natural world. This year, the initiative’s third, 20 researchers won the award.

“ Throughout my career, I’ve had the most scientific success pursuing somewhat orthogonal, seemingly divergent ideas that can often be hard to fund through traditional mechanisms,” said Sweeney, an associate professor of physics and of evolutionary biology and ecology in the Faculty of Arts and Sciences. “The ideas are surprising, and therefore require a lot of careful and creative communication to break through a review process, and it doesn’t always work.”

Sweeney will use the award funding to study proteins in squid eyes. Some scientists believe these proteins have “stealthy hyperuniformity” properties that allow squid to “self-assemble” a highly sophisticated optical system for seeing underwater.

Earlier this year, Sweeney’s lab also published new research revealing the science at the heart of iridescent giant clams’ efficiency at solar energy conversion: an intricate combination of geometry, movement, and light-scattering characteristics.

Sweeney joined the Yale faculty in 2019; she began her faculty career at the University of Pennsylvania in 2012.

One of the aims of the Experimental Physics Investigators Initiative is to support scientists who may lack flexible research funding to explore their most creative research ideas. The initiative also pays special attention to research groups that develop and reinforce practices to promote inclusion and equitable access to education and career development within the experimental physics community.

“ The Moore Foundation’s vote of confidence and the opportunity they have provided will be the difference between my group continuing to pursue creative, surprising work over the next five years, versus shifting to less surprising, more established ideas,” Sweeney said. “It is a big psychological boost that the things I think are important and interesting at the interface of the disciplines of physics and evolution also matter to the larger scientific community.”

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Yale School of the Environment’s summer interns learn in the field

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Philosophy and Black Studies pioneer returns to Yale

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At Yale, local students explore science, technology, and the natural world

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Power lift: Helping community leaders tackle energy justice challenges

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Yale’s Department of Neurology has been at the forefront of cutting-edge clinical care and scientific discovery since it began in 1952. It was Yale scientists who discovered the genes that cause Multiple Sclerosis. Yale housed one of the first epilepsy monitoring units in the country, and one of the first stroke centers at its partner, the Veterans Affairs (VA) Center in West Haven.

Today, our team of experienced doctors are committed to understanding and treating the entire spectrum of nervous system diseases. Expert physicians specialize in brain and nerve health for both children and adults.

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Multiple sclerosis (ms).

Multiple sclerosis (MS) is a disease that causes damage to the central nervous system that can ultimately lead to paralysis. Learn about symptoms and treatment.

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Alzheimer's disease is a type of dementia, causing confusion and memory loss severe enough to interfere with everyday life.

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Multiple sclerosis (MS) presents with a variety of symptoms, and advanced imaging is one of the best ways doctors can verify a patient's diagnosis. Learn more about this procedure.

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Amyotrophic lateral sclerosis (ALS), also called “motor neuron disease“ or “Lou Gehrig's disease,“ is a condition characterized by the degeneration and death of nerve cells in the brain that control voluntary muscles. The degeneration and death of these nerve cells, known as motor neurons, results in muscle weakness and muscle wasting that worsen over time.

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Wildfires: what you need to know to stay safe

This summer, wildfires have become a common occurrence on the West Coast, with fires burning in Oregon, California, and Colorado . In March, Texas experienced the largest and most destructive wildfire in state history. The Smokehouse Creek Fire burned more than one million acres of land, killing two people and more than 7,000 cattle, according to news reports. And in Greece, wildfires came close to consuming towns and villages.

In addition to deadly flames, harmful smoke from wildfires also is a threat to human lives and health. Wildfire smoke contains a mixture of fine particle pollutants that have been shown to lead to adverse health effects .

A study by researchers at the Yale School of Public Health (YSPH) confirms that harmful smoke from wildfires is capable of traveling great distances and can impact the health of people hundreds of miles away.

When smoke from a Canadian wildfire descended on New York City in 2023, Kai Chen , associate professor of epidemiology (Environmental Health Sciences), noted that the wildfire smoke “had such a high concentration of particles that it turned the sky orange, which tells you how polluted the air is during a smoke wave.”

Extreme heat could enhance the health effects of wildfire smoke, Chen added. “With a warming climate, the health burden of exposure to extreme heat and wildfire smoke is expected to increase,” said Chen, who is also co-faculty director of the Yale Center on Climate Change and Health.

Wildfire smoke and pollutants

Wildfire risk in the United States is highest in the West and Midwest, but regions in the South and Northeast can be at heightened risk . In 2023, more than 2.6 million acres were burned across the country from 55,571 fires , including the wildfire on the Hawaiian island of Maui. The Lahaina fire was the deadliest U.S. fire in more than 100 years .

Wildfires are often human-caused , from campfires, equipment, cigarettes, and arson. Lightning strikes can also spark flames. Climate change has been identified as a contributor to an increase in conditions that fuel wildfires, including increased temperatures and drought.

While wildfire flames can damage land and property, and be deadly for humans and wildlife, wildfire smoke is also a concern. Protecting yourself from wildfire smoke is an important step in avoiding the health effects of wildfires, as the particulates can be incredibly small, allowing them to travel to deep parts of the lungs .

The Air Quality Index (AQI) provides information about the status of air pollution. Check the AQI of your current location now at AirNow.gov .

“When it comes to wildfire preparedness, the time to act is now, said Joanne McGovern , a YSPH lecturer and affiliated faculty at the Yale Center on Climate Change and Health. “Stay informed by monitoring local news, weather, and emergency alerts for wildfire updates and evacuation orders. Create a fire break by clearing brush, dead wood, and leaves around your home. Develop an emergency plan.”

Health Effects

Exposure to wildfire smoke can lead to :

  • Breathing difficulties
  • Diminished lung function
  • Exacerbated asthma and lung conditions
  • Heart failure
  • Heart attack
  • Aggravation of kidney disease
  • Cognitive decline and dementia
  • Premature death

Who should be particularly careful when exposed to wildfire smoke?

  • People with certain health conditions (i.e. asthma, COPD, heart disease, diabetes and chronic kidney disease)
  • Pregnant people
  • Older adults and people with disabilities may face challenges when evacuating from wildfires. Having a preparedness plan ahead of time is important.

Health Safety Tips

When wildfire smoke is present in your area:

  • Stay indoors when possible with windows and doors closed . If you need to go outside, wear a NIOSH approved respirator .
  • Use a filtered HVAC system or portable air filter .
  • Check the air quality in your area .
  • Monitor your health symptoms .
  • Pay attention to alert systems and monitor fires on AirNow.gov’s Fire and Smoke Map .
  • Check on your friends and family!

YSPH Research

  • Several YSPH students and faculty co-authored a paper that identified “a non-linear association between 12-month moving average concentration of smoke PM2.5 and monthly non-accidental mortality rate.” The paper is awaiting peer review.
  • In a research letter published in JAMA, YSPH researchers and a colleague discussed the relationship between wildfire smoke and asthma-related emergency department visits.The research letter was authored by Kai Chen , associate professor of epidemiology (Environmental Health Sciences), Yiqun Ma , pre-doctoral fellow, Climate Change and Health, Michelle Bell , Mary E. Pinchot Professor at the Yale School of the Environment, and Wan Yang , assistant professor of epidemiology at Columbia Mailman School of Public Health. Elizabeth Ziying Lin , a postdoctoral associate in the Pollitt Lab, wrote about the research in an article for the YSPH News .
  • Kai Chen recently wrote about heatwaves and wildfire smoke in the Spring 2024 Focus publication, A Climate Change Handbook .

For more information on wildfire smoke and your health, check out resources provided by the CDC .

  • Climate Change

Featured in this article

  • Kai Chen, PhD Associate Professor of Epidemiology (Environmental Health Sciences); Co-Faculty Director, Yale Center on Climate Change and Health; Affiliated Faculty, Yale Institute for Global Health
  • LTC (RET) Joanne E. McGovern Program Manager 4; Lecturer in Medical and Public Health Disaster Planning and Operations, Department of Environmental Health Sciences; Senior Progam Coordinator for the Paramedic Referrals for Increased Independence and Decreased Disability in the Elderly (PRIDE)
  • Yiqun Ma Pre-doctoral Fellow, Climate Change and Health
  • Michelle L. Bell, PhD Mary E. Pinchot Professor at the School of the Environment and Professor of Environmental Health; Affiliated Faculty, Yale Institute for Global Health
  • Elizabeth Ziying Lin, MPH, BS (Hon), PhD Postdoctoral Associate

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Yale Child Study Center Welcomes International Visitors

In early December 2012, the Child Study Center hosted a group of esteemed visitors from Moscow State University of Psychology and Education (MSUPE): Drs. Elena Zadorina, the Deputy Provost of the University; Tatiana Stroganova, Director of the MEG-Center at MSUPE; Igor Savchenko, the Director of the MSUPE Center for Psychological, Medical and Social Support for Children and Adolescents; Natalia Gorbachevskaya, Director of the MSUPE Center of Neurobiological Diagnostics of Hereditary Mental Disorders in Children and Adolescents; Alexander Sorokin, a researcher at the Center of Neurobiological Diagnostics of Hereditary Mental Disorders in Children and Adolescents; and Sofya Belova, the Director of MSUPE's Laboratory for Giftedness Assessment.

Their objectives were to meet with colleagues at the Child Study Center to learn about the Center's autism research and its clinical work with autistic children, particularly with respect to the organization and methodologies of the Center's approaches to identification and support. They also came to "synchronize watches" with the Center, to compare the progress and approaches of the US and Russia in the field of autism. Drs. Zadorina and Belova also met with collaborators at the Child Study Center on the Aurora Project, which is based in the laboratory of Dr. Elena Grigorenko. Aurora is the development of a new assessment for gifted identification. Translated and adapted for the Russian context, it was administered to a representative Moscow sample as part of a standardization exercise under the direction of Dr. Belova. Their goals were to share their experiences administering Aurora in Moscow, consult on the subsequent data analyses, and plan future collaborative efforts.

This group was graciously received by many of the Center's experts in autism, who gave their time and expertise in the form of tours, lectures, and arranged visits to care and living facilities in the greater New Haven area. Comprehensively, topics covered communication, assessment, interventions, new methods of diagnosis (such as eye-tracking), advanced studies of brain development, and treatment. Activities included clinical observations at the Toddler Developmental Disabilities Clinic and the Developmental Disabilities, and visits to schools (Benhaven and Chapel Haven). For Aurora, Dr. Belova was able to meet with members of the Aurora Project Team several times to discuss data scoring, organization and processing, current research questions the US team is addressing with their own data, and future collaborations. As Dr. Belova commented, “I believe that cross-cultural research on different forms of intelligence and creativity is an inspiring domain for both educational practice and fundamental science.”

These visitors have since expressed deep appreciation Dr. Fred Volkmar’s, "hospitality, openness, and willingness for collaboration." They declared that their goals had been successfully met, their questions thoroughly answered, and were grateful for the warm welcome they received by everyone at the Center. They also enjoyed visits to the Yale Art Gallery ("brilliant!"), the Beinecke and Sterling Libraries, and a local middle school's winter music concert. Dinner at Mory's, where they were regaled by the Whiffenpoofs ("unforgettable"), was also a highlight. By the end of their visit, our Russian visitors were much encouraged that the Russian and American centers might cooperatively conduct fundamental research and practice evidence-based approaches in the field of autism spectrum disorders. They look forward to formulating concrete proposals to colleagues at the Child Study Center in the very near future.

Many thanks to Leah Booth, Cara Cordeaux, Karen Helene, Lori Klein, Kathy Koenig, Catalina Morgues, Elizabeth Schoen Simmons, Cheri Stahl, Michael Storz, Rachael Tillman, and Drs. Baptiste Barbot, Kasia Chawarska, Michele Goyette-Ewing, Abha Gupta, Elena Grigorenko, Sascha Hein, Ellen Hoffman, Sergey Kornilov, Paul Lombroso, Jamie McPartland, Natalia Rakhlin, Brian Reichow, Fred Shic, Steve Stemler, Denis Sukhodolsky, Flora Vaccarino, Brent Vander Wyk and Fred Volkmar for their contributions to the success of this international exchange.

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