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• v.106(4); 2018 Oct

A systematic approach to searching: an efficient and complete method to develop literature searches

Associated data.

Creating search strategies for systematic reviews, finding the best balance between sensitivity and specificity, and translating search strategies between databases is challenging. Several methods describe standards for systematic search strategies, but a consistent approach for creating an exhaustive search strategy has not yet been fully described in enough detail to be fully replicable. The authors have established a method that describes step by step the process of developing a systematic search strategy as needed in the systematic review. This method describes how single-line search strategies can be prepared in a text document by typing search syntax (such as field codes, parentheses, and Boolean operators) before copying and pasting search terms (keywords and free-text synonyms) that are found in the thesaurus. To help ensure term completeness, we developed a novel optimization technique that is mainly based on comparing the results retrieved by thesaurus terms with those retrieved by the free-text search words to identify potentially relevant candidate search terms. Macros in Microsoft Word have been developed to convert syntaxes between databases and interfaces almost automatically. This method helps information specialists in developing librarian-mediated searches for systematic reviews as well as medical and health care practitioners who are searching for evidence to answer clinical questions. The described method can be used to create complex and comprehensive search strategies for different databases and interfaces, such as those that are needed when searching for relevant references for systematic reviews, and will assist both information specialists and practitioners when they are searching the biomedical literature.

INTRODUCTION

Librarians and information specialists are often involved in the process of preparing and completing systematic reviews (SRs), where one of their main tasks is to identify relevant references to include in the review [ 1 ]. Although several recommendations for the process of searching have been published [ 2 – 6 ], none describe the development of a systematic search strategy from start to finish.

Traditional methods of SR search strategy development and execution are highly time consuming, reportedly requiring up to 100 hours or more [ 7 , 8 ]. The authors wanted to develop systematic and exhaustive search strategies more efficiently, while preserving the high sensitivity that SR search strategies necessitate. In this article, we describe the method developed at Erasmus University Medical Center (MC) and demonstrate its use through an example search. The efficiency of the search method and outcome of 73 searches that have resulted in published reviews are described in a separate article [ 9 ].

As we aimed to describe the creation of systematic searches in full detail, the method starts at a basic level with the analysis of the research question and the creation of search terms. Readers who are new to SR searching are advised to follow all steps described. More experienced searchers can consider the basic steps to be existing knowledge that will already be part of their normal workflow, although step 4 probably differs from general practice. Experienced searchers will gain the most from reading about the novelties in the method as described in steps 10–13 and comparing the examples given in the supplementary appendix to their own practice.

CREATING A SYSTEMATIC SEARCH STRATEGY

Our methodology for planning and creating a multi-database search strategy consists of the following steps:

• Determine a clear and focused question
• Describe the articles that can answer the question
• Decide which key concepts address the different elements of the question
• Decide which elements should be used for the best results
• Choose an appropriate database and interface to start with
• Document the search process in a text document
• Identify appropriate index terms in the thesaurus of the first database
• Identify synonyms in the thesaurus
• Add variations in search terms
• Use database-appropriate syntax, with parentheses, Boolean operators, and field codes
• Optimize the search
• Evaluate the initial results
• Check for errors
• Translate to other databases
• Test and reiterate

Each step in the process is reflected by an example search described in the supplementary appendix .

1. Determine a clear and focused question

A systematic search can best be applied to a well-defined and precise research or clinical question. Questions that are too broad or too vague cannot be answered easily in a systematic way and will generally result in an overwhelming number of search results. On the other hand, a question that is too specific will result into too few or even zero search results. Various papers describe this process in more detail [ 10 – 12 ].

2. Describe the articles that can answer the question

Although not all clinical or research questions can be answered in the literature, the next step is to presume that the answer can indeed be found in published studies. A good starting point for a search is hypothesizing what the research that can answer the question would look like. These hypothetical (when possible, combined with known) articles can be used as guidance for constructing the search strategy.

3. Decide which key concepts address the different elements of the question

Key concepts are the topics or components that the desired articles should address, such as diseases or conditions, actions, substances, settings, domains (e.g., therapy, diagnosis, etiology), or study types. Key concepts from the research question can be grouped to create elements in the search strategy.

Elements in a search strategy do not necessarily follow the patient, intervention, comparison, outcome (PICO) structure or any other related structure. Using the PICO or another similar framework as guidance can be helpful to consider, especially in the inclusion and exclusion review stage of the SR, but this is not necessary for good search strategy development [ 13 – 15 ]. Sometimes concepts from different parts of the PICO structure can be grouped together into one search element, such as when the desired outcome is frequently described in a certain study type.

4. Decide which elements should be used for the best results

Not all elements of a research question should necessarily be used in the search strategy. Some elements are less important than others or may unnecessarily complicate or restrict a search strategy. Adding an element to a search strategy increases the chance of missing relevant references. Therefore, the number of elements in a search strategy should remain as low as possible to optimize recall.

Using the schema in Figure 1 , elements can be ordered by their specificity and importance to determine the best search approach. Whether an element is more specific or more general can be measured objectively by the number of hits retrieved in a database when searching for a key term representing that element. Depending on the research question, certain elements are more important than others. If articles (hypothetically or known) exist that can answer the question but lack a certain element in their titles, abstracts, or keywords, that element is unimportant to the question. An element can also be unimportant because of expected bias or an overlap with another element.

Schema for determining the optimal order of elements

Bias in elements

The choice of elements in a search strategy can introduce bias through use of overly specific terminology or terms often associated with positive outcomes. For the question “does prolonged breastfeeding improve intelligence outcomes in children?,” searching specifically for the element of duration will introduce bias, as articles that find a positive effect of prolonged breastfeeding will be much more likely to mention time factors in their titles or abstracts.

Overlapping elements

Elements in a question sometimes overlap in their meaning. Sometimes certain therapies are interventions for one specific disease. The Lichtenstein technique, for example, is a repair method for inguinal hernias. There is no need to include an element of “inguinal hernias” to a search for the effectiveness of the Lichtenstein therapy. Likewise, sometimes certain diseases are only found in certain populations. Adding such an overlapping element could lead to missing relevant references.

The elements to use in a search strategy can be found in the plot of elements in Figure 1 , by following the top row from left to right. For this method, we recommend starting with the most important and specific elements. Then, continue with more general and important elements until the number of results is acceptable for screening. Determining how many results are acceptable for screening is often a matter of negotiation with the SR team.

5. Choose an appropriate database and interface to start with

Important factors for choosing databases to use are the coverage and the presence of a thesaurus. For medically oriented searches, the coverage and recall of Embase, which includes the MEDLINE database, are superior to those of MEDLINE [ 16 ]. Each of these two databases has its own thesaurus with its own unique definitions and structure. Because of the complexity of the Embase thesaurus, Emtree, which contains much more specific thesaurus terms than the MEDLINE Medical Subject Headings (MeSH) thesaurus, translation from Emtree to MeSH is easier than the other way around. Therefore, we recommend starting in Embase.

MEDLINE and Embase are available through many different vendors and interfaces. The choice of an interface and primary database is often determined by the searcher’s accessibility. For our method, an interface that allows searching with proximity operators is desirable, and full functionality of the thesaurus, including explosion of narrower terms, is crucial. We recommend developing a personal workflow that always starts with one specific database and interface.

6. Document the search process in a text document

We advise designing and creating the complete search strategies in a log document, instead of directly in the database itself, to register the steps taken and to make searches accountable and reproducible. The developed search strategies can be copied and pasted into the desired databases from the log document. This way, the searcher is in control of the whole process. Any change to the search strategy should be done in the log document, assuring that the search strategy in the log is always the most recent.

7. Identify appropriate index terms in the thesaurus of the first database

Searches should start by identifying appropriate thesaurus terms for the desired elements. The thesaurus of the database is searched for matching index terms for each key concept. We advise restricting the initial terms to the most important and most relevant terms. Later in the process, more general terms can be added in the optimization process, in which the effect on the number of hits, and thus the desirability of adding these terms, can be evaluated more easily.

Several factors can complicate the identification of thesaurus terms. Sometimes, one thesaurus term is found that exactly describes a specific element. In contrast, especially in more general elements, multiple thesaurus terms can be found to describe one element. If no relevant thesaurus terms have been found for an element, free-text terms can be used, and possible thesaurus terms found in the resulting references can be added later (step 11).

Sometimes, no distinct thesaurus term is available for a specific key concept that describes the concept in enough detail. In Emtree, one thesaurus term often combines two or more elements. The easiest solution for combining these terms for a sensitive search is to use such a thesaurus term in all elements where it is relevant. Examples are given in the supplementary appendix .

8. Identify synonyms in the thesaurus

Most thesauri offer a list of synonyms on their term details page (named Synonyms in Emtree and Entry Terms in MeSH). To create a sensitive search strategy for SRs, these terms need to be searched as free-text keywords in the title and abstract fields, in addition to searching their associated thesaurus terms.

The Emtree thesaurus contains more synonyms (300,000) than MeSH does (220,000) [ 17 ]. The difference in number of terms is even higher considering that many synonyms in MeSH are permuted terms (i.e., inversions of phrases using commas).

Thesaurus terms are ordered in a tree structure. When searching for a more general thesaurus term, the more specific (narrower) terms in the branches below that term will also be searched (this is frequently referred to as “exploding” a thesaurus term). However, to perform a sensitive search, all relevant variations of the narrower terms must be searched as free-text keywords in the title or abstract, in addition to relying on the exploded thesaurus term. Thus, all articles that describe a certain narrower topic in their titles and abstracts will already be retrieved before MeSH terms are added.

9. Add variations in search terms (e.g., truncation, spelling differences, abbreviations, opposites)

Truncation allows a searcher to search for words beginning with the same word stem. A search for therap* will, thus, retrieve therapy, therapies, therapeutic, and all other words starting with “therap.” Do not truncate a word stem that is too short. Also, limitations of interfaces should be taken into account, especially in PubMed, where the number of search term variations that can be found by truncation is limited to 600.

Databases contain references to articles using both standard British and American English spellings. Both need to be searched as free-text terms in the title and abstract. Alternatively, many interfaces offer a certain code to replace zero or one characters, allowing a search for “pediatric” or “paediatric” as “p?ediatric.” Table 1 provides a detailed description of the syntax for different interfaces.

Field codes in five most used interfaces for biomedical literature searching

Searching for abbreviations can identify extra, relevant references and retrieve more irrelevant ones. The search can be more focused by combining the abbreviation with an important word that is relevant to its meaning or by using the Boolean “NOT” to exclude frequently observed, clearly irrelevant results. We advise that searchers do not exclude all possible irrelevant meanings, as it is very time consuming to identify all the variations, it will result in unnecessarily complicated search strategies, and it may lead to erroneously narrowing the search and, thereby, reduce recall.

Searching partial abbreviations can be useful for retrieving relevant references. For example, it is very likely that an article would mention osteoarthritis (OA) early in the abstract, replacing all further occurrences of osteoarthritis with OA . Therefore, it may not contain the phrase “hip osteoarthritis” but only “hip oa.”

It is also important to search for the opposites of search terms to avoid bias. When searching for “disease recurrence,” articles about “disease free” may be relevant as well. When the desired outcome is survival , articles about mortality may be relevant.

10. Use database-appropriate syntax, with parentheses, Boolean operators, and field codes

Different interfaces require different syntaxes, the special set of rules and symbols unique to each database that define how a correctly constructed search operates. Common syntax components include the use of parentheses and Boolean operators such as “AND,” “OR,” and “NOT,” which are available in all major interfaces. An overview of different syntaxes for four major interfaces for bibliographic medical databases (PubMed, Ovid, EBSCOhost, Embase.com, and ProQuest) is shown in Table 1 .

Creating the appropriate syntax for each database, in combination with the selected terms as described in steps 7–9, can be challenging. Following the method outlined below simplifies the process:

• Create single-line queries in a text document (not combining multiple record sets), which allows immediate checking of the relevance of retrieved references and efficient optimization.
• Type the syntax (Boolean operators, parentheses, and field codes) before adding terms, which reduces the chance that errors are made in the syntax, especially in the number of parentheses.
• Use predefined proximity structures including parentheses, such as (() ADJ3 ()) in Ovid, that can be reused in the query when necessary.
• Use thesaurus terms separately from free-text terms of each element. Start an element with all thesaurus terms (using “OR”) and follow with the free-text terms. This allows the unique optimization methods as described in step 11.
• When adding terms to an existing search strategy, pay close attention to the position of the cursor. Make sure to place it appropriately either in the thesaurus terms section, in the title/abstract section, or as an addition (broadening) to an existing proximity search.

The supplementary appendix explains the method of building a query in more detail, step by step for different interfaces: PubMed, Ovid, EBSCOhost, Embase.com, and ProQuest. This method results in a basic search strategy designed to retrieve some relevant references upon which a more thorough search strategy can be built with optimization such as described in step 11.

11. Optimize the search

The most important question when performing a systematic search is whether all (or most) potentially relevant articles have been retrieved by the search strategy. This is also the most difficult question to answer, since it is unknown which and how many articles are relevant. It is, therefore, wise first to broaden the initial search strategy, making the search more sensitive, and then check if new relevant articles are found by comparing the set results (i.e., search for Strategy #2 NOT Strategy #1 to see the unique results).

A search strategy should be tested for completeness. Therefore, it is necessary to identify extra, possibly relevant search terms and add them to the test search in an OR relationship with the already used search terms. A good place to start, and a well-known strategy, is scanning the top retrieved articles when sorted by relevance, looking for additional relevant synonyms that could be added to the search strategy.

We have developed a unique optimization method that has not been described before in the literature. This method often adds valuable extra terms to our search strategy and, therefore, extra, relevant references to our search results. Extra synonyms can be found in articles that have been assigned a certain set of thesaurus terms but that lack synonyms in the title and/or abstract that are already present in the current search strategy. Searching for thesaurus terms NOT free-text terms will help identify missed free-text terms in the title or abstract. Searching for free-text terms NOT thesaurus terms will help identify missed thesaurus terms. If this is done repeatedly for each element, leaving the rest of the query unchanged, this method will help add numerous relevant terms to the query. These steps are explained in detail for five different search platforms in the supplementary appendix .

12. Evaluate the initial results

The results should now contain relevant references. If the interface allows relevance ranking, use that in the evaluation. If you know some relevant references that should be included in the research, search for those references specifically; for example, combine a specific (first) author name with a page number and the publication year. Check whether those references are retrieved by the search. If the known relevant references are not retrieved by the search, adapt the search so that they are. If it is unclear which element should be adapted to retrieve a certain article, combine that article with each element separately.

Different outcomes are desired for different types of research questions. For instance, in the case of clinical question answering, the researcher will not be satisfied with many references that contain a lot of irrelevant references. A clinical search should be rather specific and is allowed to miss a relevant reference. In the case of an SR, the researchers do not want to miss any relevant reference and are willing to handle many irrelevant references to do so. The search for references to include in an SR should be very sensitive: no included reference should be missed. A search that is too specific or too sensitive for the intended goal can be adapted to become more sensitive or specific. Steps to increase sensitivity or specificity of a search strategy can be found in the supplementary appendix .

13. Check for errors

Errors might not be easily detected. Sometimes clues can be found in the number of results, either when the number of results is much higher or lower than expected or when many retrieved references are not relevant. However, the number expected is often unknown, and very sensitive search strategies will always retrieve many irrelevant articles. Each query should, therefore, be checked for errors.

One of the most frequently occurring errors is missing the Boolean operator “OR.” When no “OR” is added between two search terms, many interfaces automatically add an “AND,” which unintentionally reduces the number of results and likely misses relevant references. One good strategy to identify missing “OR”s is to go to the web page containing the full search strategy, as translated by the database, and using Ctrl-F search for “AND.” Check whether the occurrences of the “AND” operator are deliberate.

Ideally, search strategies should be checked by other information specialists [ 18 ]. The Peer Review of Electronic Search Strategies (PRESS) checklist offers good guidance for this process [ 4 ]. Apart from the syntax (especially Boolean operators and field codes) of the search strategy, it is wise to have the search terms checked by the clinician or researcher familiar with the topic. At Erasmus MC, researchers and clinicians are involved during the complete process of structuring and optimizing the search strategy. Each word is added after the combined decision of the searcher and the researcher, with the possibility of directly comparing results with and without the new term.

14. Translate to other databases

To retrieve as many relevant references as possible, one has to search multiple databases. Translation of complex and exhaustive queries between different databases can be very time consuming and cumbersome. The single-line search strategy approach detailed above allows quick translations using the find and replace method in Microsoft Word (<Ctrl-H>).

At Erasmus MC, macros based on the find-and-replace method in Microsoft Word have been developed for easy and fast translation between the most used databases for biomedical and health sciences questions. The schema that is followed for the translation between databases is shown in Figure 2 . Most databases simply follow the structure set by the Embase.com search strategy. The translation from Emtree terms to MeSH terms for MEDLINE in Ovid often identifies new terms that need to be added to the Embase.com search strategy before the translation to other databases.

Schematic representation of translation between databases used at Erasmus University Medical Center

Dotted lines represent databases that are used in less than 80% of the searches.

Using five different macros, a thoroughly optimized query in Embase.com can be relatively quickly translated into eight major databases. Basic search strategies will be created to use in many, mostly smaller, databases, because such niche databases often do not have extensive thesauri or advanced syntax options. Also, there is not much need to use extensive syntax because the number of hits and, therefore, the amount of noise in these databases is generally low. In MEDLINE (Ovid), PsycINFO (Ovid), and CINAHL (EBSCOhost), the thesaurus terms must be adapted manually, as each database has its own custom thesaurus. These macros and instructions for their installation, use, and adaptation are available at bit.ly/databasemacros.

15. Test and reiterate

Ideally, exhaustive search strategies should retrieve all references that are covered in a specific database. For SR search strategies, checking searches for their recall is advised. This can be done after included references have been determined by the authors of the systematic review. If additional papers have been identified through other non-database methods (i.e., checking references in included studies), results that were not identified by the database searches should be examined. If these results were available in the databases but not located by the search strategy, the search strategy should be adapted to try to retrieve these results, as they may contain terms that were omitted in the original search strategies. This may enable the identification of additional relevant results.

A methodology for creating exhaustive search strategies has been created that describes all steps of the search process, starting with a question and resulting in thorough search strategies in multiple databases. Many of the steps described are not new, but together, they form a strong method creating high-quality, robust searches in a relatively short time frame.

Our methodology is intended to create thoroughness for literature searches. The optimization method, as described in step 11, will identify missed synonyms or thesaurus terms, unlike any other method that largely depends on predetermined keywords and synonyms. Using this method results in a much quicker search process, compared to traditional methods, especially because of the easier translation between databases and interfaces (step 13). The method is not a guarantee for speed, since speed depends on many factors, including experience. However, by following the steps and using the tools as described above, searchers can gain confidence first and increase speed through practice.

What is new?

This method encourages searchers to start their search development process using empty syntax first and later adding the thesaurus terms and free-text synonyms. We feel this helps the searcher to focus on the search terms, instead of on the structure of the search query. The optimization method in which new terms are found in the already retrieved articles is used in some other institutes as well but has to our knowledge not been described in the literature. The macros to translate search strategies between interfaces are unique in this method.

What is different compared to common practice?

Traditionally, librarians and information specialists have focused on creating complex, multi-line (also called line-by-line) search strategies, consisting of multiple record sets, and this method is frequently advised in the literature and handbooks [ 2 , 19 – 21 ]. Our method, instead, uses single-line searches, which is critical to its success. Single-line search strategies can be easily adapted by adding or dropping a term without having to recode numbers of record sets, which would be necessary in multi-line searches. They can easily be saved in a text document and repeated by copying and pasting for search updates. Single-line search strategies also allow easy translation to other syntaxes using find-and-replace technology to update field codes and other syntax elements or using macros (step 13).

When constructing a search strategy, the searcher might experience that certain parentheses in the syntax are unnecessary, such as parentheses around all search terms in the title/abstract portion, if there is only one such term, there are double parentheses in the proximity statement, or one of the word groups exists for only one word. One might be tempted to omit those parentheses for ease of reading and management. However, during the optimization process, the searcher is likely to find extra synonyms that might consist of one word. To add those terms to the first query (with reduced parentheses) requires adding extra parentheses (meticulously placing and counting them), whereas, in the latter search, it only requires proper placement of those terms.

Many search methods highly depend on the PICO framework. Research states that often PICO or PICOS is not suitable for every question [ 22 , 23 ]. There are other acronyms than PICO—such as sample, phenomenon of interest, design, evaluation, research type (SPIDER) [ 24 ]—but each is just a variant. In our method, the most important and specific elements of a question are being analyzed for building the best search strategy.

Though it is generally recommended that searchers search both MEDLINE and Embase, most use MEDLINE as the starting point. It is considered the gold standard for biomedical searching, partially due to historical reasons, since it was the first of its kind, and more so now that it is freely available via the PubMed interface. Our method can be used with any database as a starting point, but we use Embase instead of MEDLINE or another database for a number of reasons. First, Embase provides both unique content and the complete content of MEDLINE. Therefore, searching Embase will be, by definition, more complete than searching MEDLINE only. Second, the number of terms in Emtree (the Embase thesaurus) is three times as high as that of MeSH (the MEDLINE thesaurus). It is easier to find MeSH terms after all relevant Emtree terms have been identified than to start with MeSH and translate to Emtree.

At Erasmus MC, the researchers sit next to the information specialist during most of the search strategy design process. This way, the researchers can deliver immediate feedback on the relevance of proposed search terms and retrieved references. The search team then combines knowledge about databases with knowledge about the research topic, which is an important condition to create the highest quality searches.

Limitations of the method

One disadvantage of single-line searches compared to multi-line search strategies is that errors are harder to recognize. However, with the methods for optimization as described (step 11), errors are recognized easily because missed synonyms and spelling errors will be identified during the process. Also problematic is that more parentheses are needed, making it more difficult for the searcher and others to assess the logic of the search strategy. However, as parentheses and field codes are typed before the search terms are added (step 10), errors in parentheses can be prevented.

Our methodology works best if used in an interface that allows proximity searching. It is recommended that searchers with access to an interface with proximity searching capabilities select one of those as the initial database to develop and optimize the search strategy. Because the PubMed interface does not allow proximity searches, phrases or Boolean “AND” combinations are required. Phrase searching complicates the process and is more specific, with the higher risk of missing relevant articles, and using Boolean “AND” combinations increases sensitivity but at an often high loss of specificity. Due to some searchers’ lack of access to expensive databases or interfaces, the freely available PubMed interface may be necessary to use, though it should never be the sole database used for an SR [ 2 , 16 , 25 ]. A limitation of our method is that it works best with subscription-based and licensed resources.

Another limitation is the customization of the macros to a specific institution’s resources. The macros for the translation between different database interfaces only work between the interfaces as described. To mitigate this, we recommend using the find-and-replace functionality of text editors like Microsoft Word to ease the translation of syntaxes between other databases. Depending on one’s institutional resources, custom macros can be developed using similar methods.

Results of the method

Whether this method results in exhaustive searches where no important article is missed is difficult to determine, because the number of relevant articles is unknown for any topic. A comparison of several parameters of 73 published reviews that were based on a search developed with this method to 258 reviews that acknowledged information specialists from other Dutch academic hospitals shows that the performance of the searches following our method is comparable to those performed in other institutes but that the time needed to develop the search strategies was much shorter than the time reported for the other reviews [ 9 ].

CONCLUSIONS

With the described method, searchers can gain confidence in their search strategies by finding many relevant words and creating exhaustive search strategies quickly. The approach can be used when performing SR searches or for other purposes such as answering clinical questions, with different expectations of the search’s precision and recall. This method, with practice, provides a stepwise approach that facilitates the search strategy development process from question clarification to final iteration and beyond.

SUPPLEMENTAL FILE

Acknowledgments.

We highly appreciate the work that was done by our former colleague Louis Volkers, who in his twenty years as an information specialist in Erasmus MC laid the basis for our method. We thank Professor Oscar Franco for reviewing earlier drafts of this article.

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What (exactly) is a research topic.

A research topic is the subject of a research project or study – for example, a dissertation or thesis. A research topic typically takes the form of a problem to be solved, or a question to be answered.

A good research topic should be specific enough to allow for focused research and analysis. For example, if you are interested in studying the effects of climate change on agriculture, your research topic could focus on how rising temperatures have impacted crop yields in certain regions over time.

To learn more about the basics of developing a research topic, consider our free research topic ideation webinar.

What constitutes a good research topic?

A strong research topic comprises three important qualities : originality, value and feasibility.

• Originality – a good topic explores an original area or takes a novel angle on an existing area of study.
• Value – a strong research topic provides value and makes a contribution, either academically or practically.
• Feasibility – a good research topic needs to be practical and manageable, given the resource constraints you face.

To learn more about what makes for a high-quality research topic, check out this post .

What's the difference between a research topic and research problem?

A research topic and a research problem are two distinct concepts that are often confused. A research topic is a broader label that indicates the focus of the study , while a research problem is an issue or gap in knowledge within the broader field that needs to be addressed.

To illustrate this distinction, consider a student who has chosen “teenage pregnancy in the United Kingdom” as their research topic. This research topic could encompass any number of issues related to teenage pregnancy such as causes, prevention strategies, health outcomes for mothers and babies, etc.

Within this broad category (the research topic) lies potential areas of inquiry that can be explored further – these become the research problems . For example:

• What factors contribute to higher rates of teenage pregnancy in certain communities?
• How do different types of parenting styles affect teen pregnancy rates?
• What interventions have been successful in reducing teenage pregnancies?

Simply put, a key difference between a research topic and a research problem is scope ; the research topic provides an umbrella under which multiple questions can be asked, while the research problem focuses on one specific question or set of questions within that larger context.

How can I find potential research topics for my project?

There are many steps involved in the process of finding and choosing a high-quality research topic for a dissertation or thesis. We cover these steps in detail in this video (also accessible below).

How can I find quality sources for my research topic?

Finding quality sources is an essential step in the topic ideation process. To do this, you should start by researching scholarly journals, books, and other academic publications related to your topic. These sources can provide reliable information on a wide range of topics. Additionally, they may contain data or statistics that can help support your argument or conclusions.

Identifying Relevant Sources

When searching for relevant sources, it’s important to look beyond just published material; try using online databases such as Google Scholar or JSTOR to find articles from reputable journals that have been peer-reviewed by experts in the field.

You can also use search engines like Google or Bing to locate websites with useful information about your topic. However, be sure to evaluate any website before citing it as a source—look for evidence of authorship (such as an “About Us” page) and make sure the content is up-to-date and accurate before relying on it.

Evaluating Sources

Once you’ve identified potential sources for your research project, take some time to evaluate them thoroughly before deciding which ones will best serve your purpose. Consider factors such as author credibility (are they an expert in their field?), publication date (is the source current?), objectivity (does the author present both sides of an issue?) and relevance (how closely does this source relate to my specific topic?).

By researching the current literature on your topic, you can identify potential sources that will help to provide quality information. Once you’ve identified these sources, it’s time to look for a gap in the research and determine what new knowledge could be gained from further study.

How can I find a good research gap?

Finding a strong gap in the literature is an essential step when looking for potential research topics. We explain what research gaps are and how to find them in this post.

How should I evaluate potential research topics/ideas?

When evaluating potential research topics, it is important to consider the factors that make for a strong topic (we discussed these earlier). Specifically:

• Originality
• Feasibility

So, when you have a list of potential topics or ideas, assess each of them in terms of these three criteria. A good topic should take a unique angle, provide value (either to academia or practitioners), and be practical enough for you to pull off, given your limited resources.

Finally, you should also assess whether this project could lead to potential career opportunities such as internships or job offers down the line. Make sure that you are researching something that is relevant enough so that it can benefit your professional development in some way. Additionally, consider how each research topic aligns with your career goals and interests; researching something that you are passionate about can help keep motivation high throughout the process.

How can I assess the feasibility of a research topic?

When evaluating the feasibility and practicality of a research topic, it is important to consider several factors.

First, you should assess whether or not the research topic is within your area of competence. Of course, when you start out, you are not expected to be the world’s leading expert, but do should at least have some foundational knowledge.

Time commitment

When considering a research topic, you should think about how much time will be required for completion. Depending on your field of study, some topics may require more time than others due to their complexity or scope.

Additionally, if you plan on collaborating with other researchers or institutions in order to complete your project, additional considerations must be taken into account such as coordinating schedules and ensuring that all parties involved have adequate resources available.

Resources needed

It’s also critically important to consider what type of resources are necessary in order to conduct the research successfully. This includes physical materials such as lab equipment and chemicals but can also include intangible items like access to certain databases or software programs which may be necessary depending on the nature of your work. Additionally, if there are costs associated with obtaining these materials then this must also be factored into your evaluation process.

Potential risks

It’s important to consider the inherent potential risks for each potential research topic. These can include ethical risks (challenges getting ethical approval), data risks (not being able to access the data you’ll need), technical risks relating to the equipment you’ll use and funding risks (not securing the necessary financial back to undertake the research).

If you’re looking for more information about how to find, evaluate and select research topics for your dissertation or thesis, check out our free webinar here . Alternatively, if you’d like 1:1 help with the topic ideation process, consider our private coaching services .

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This post was based on one of our popular Research Bootcamps . If you're working on a research project, you'll definitely want to check this out ...

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Sat / act prep online guides and tips, 113 great research paper topics.

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One of the hardest parts of writing a research paper can be just finding a good topic to write about. Fortunately we've done the hard work for you and have compiled a list of 113 interesting research paper topics. They've been organized into ten categories and cover a wide range of subjects so you can easily find the best topic for you.

In addition to the list of good research topics, we've included advice on what makes a good research paper topic and how you can use your topic to start writing a great paper.

What Makes a Good Research Paper Topic?

Not all research paper topics are created equal, and you want to make sure you choose a great topic before you start writing. Below are the three most important factors to consider to make sure you choose the best research paper topics.

#1: It's Something You're Interested In

A paper is always easier to write if you're interested in the topic, and you'll be more motivated to do in-depth research and write a paper that really covers the entire subject. Even if a certain research paper topic is getting a lot of buzz right now or other people seem interested in writing about it, don't feel tempted to make it your topic unless you genuinely have some sort of interest in it as well.

#2: There's Enough Information to Write a Paper

Even if you come up with the absolute best research paper topic and you're so excited to write about it, you won't be able to produce a good paper if there isn't enough research about the topic. This can happen for very specific or specialized topics, as well as topics that are too new to have enough research done on them at the moment. Easy research paper topics will always be topics with enough information to write a full-length paper.

Trying to write a research paper on a topic that doesn't have much research on it is incredibly hard, so before you decide on a topic, do a bit of preliminary searching and make sure you'll have all the information you need to write your paper.

#3: It Fits Your Teacher's Guidelines

Don't get so carried away looking at lists of research paper topics that you forget any requirements or restrictions your teacher may have put on research topic ideas. If you're writing a research paper on a health-related topic, deciding to write about the impact of rap on the music scene probably won't be allowed, but there may be some sort of leeway. For example, if you're really interested in current events but your teacher wants you to write a research paper on a history topic, you may be able to choose a topic that fits both categories, like exploring the relationship between the US and North Korea. No matter what, always get your research paper topic approved by your teacher first before you begin writing.

113 Good Research Paper Topics

Below are 113 good research topics to help you get you started on your paper. We've organized them into ten categories to make it easier to find the type of research paper topics you're looking for.

Arts/Culture

• Discuss the main differences in art from the Italian Renaissance and the Northern Renaissance .
• Analyze the impact a famous artist had on the world.
• How is sexism portrayed in different types of media (music, film, video games, etc.)? Has the amount/type of sexism changed over the years?
• How has the music of slaves brought over from Africa shaped modern American music?
• How has rap music evolved in the past decade?
• How has the portrayal of minorities in the media changed?

Current Events

• What have been the impacts of China's one child policy?
• How have the goals of feminists changed over the decades?
• How has the Trump presidency changed international relations?
• Analyze the history of the relationship between the United States and North Korea.
• What factors contributed to the current decline in the rate of unemployment?
• What have been the impacts of states which have increased their minimum wage?
• How do US immigration laws compare to immigration laws of other countries?
• How have the US's immigration laws changed in the past few years/decades?
• How has the Black Lives Matter movement affected discussions and view about racism in the US?
• What impact has the Affordable Care Act had on healthcare in the US?
• What factors contributed to the UK deciding to leave the EU (Brexit)?
• What factors contributed to China becoming an economic power?
• Discuss the history of Bitcoin or other cryptocurrencies  (some of which tokenize the S&P 500 Index on the blockchain) .
• Do students in schools that eliminate grades do better in college and their careers?
• Do students from wealthier backgrounds score higher on standardized tests?
• Do students who receive free meals at school get higher grades compared to when they weren't receiving a free meal?
• Do students who attend charter schools score higher on standardized tests than students in public schools?
• Do students learn better in same-sex classrooms?
• How does giving each student access to an iPad or laptop affect their studies?
• What are the benefits and drawbacks of the Montessori Method ?
• Do children who attend preschool do better in school later on?
• What was the impact of the No Child Left Behind act?
• How does the US education system compare to education systems in other countries?
• What impact does mandatory physical education classes have on students' health?
• Which methods are most effective at reducing bullying in schools?
• Do homeschoolers who attend college do as well as students who attended traditional schools?
• Does offering tenure increase or decrease quality of teaching?
• How does college debt affect future life choices of students?
• Should graduate students be able to form unions?

• What are different ways to lower gun-related deaths in the US?
• How and why have divorce rates changed over time?
• Is affirmative action still necessary in education and/or the workplace?
• Should physician-assisted suicide be legal?
• How has stem cell research impacted the medical field?
• How can human trafficking be reduced in the United States/world?
• Should people be able to donate organs in exchange for money?
• Which types of juvenile punishment have proven most effective at preventing future crimes?
• Has the increase in US airport security made passengers safer?
• Analyze the immigration policies of certain countries and how they are similar and different from one another.
• Several states have legalized recreational marijuana. What positive and negative impacts have they experienced as a result?
• Do tariffs increase the number of domestic jobs?
• Which prison reforms have proven most effective?
• Should governments be able to censor certain information on the internet?
• Which methods/programs have been most effective at reducing teen pregnancy?
• What are the benefits and drawbacks of the Keto diet?
• How effective are different exercise regimes for losing weight and maintaining weight loss?
• How do the healthcare plans of various countries differ from each other?
• What are the most effective ways to treat depression ?
• What are the pros and cons of genetically modified foods?
• Which methods are most effective for improving memory?
• What can be done to lower healthcare costs in the US?
• What factors contributed to the current opioid crisis?
• Analyze the history and impact of the HIV/AIDS epidemic .
• Are low-carbohydrate or low-fat diets more effective for weight loss?
• How much exercise should the average adult be getting each week?
• Which methods are most effective to get parents to vaccinate their children?
• What are the pros and cons of clean needle programs?
• How does stress affect the body?
• Discuss the history of the conflict between Israel and the Palestinians.
• What were the causes and effects of the Salem Witch Trials?
• Who was responsible for the Iran-Contra situation?
• How has New Orleans and the government's response to natural disasters changed since Hurricane Katrina?
• What events led to the fall of the Roman Empire?
• What were the impacts of British rule in India ?
• Was the atomic bombing of Hiroshima and Nagasaki necessary?
• What were the successes and failures of the women's suffrage movement in the United States?
• What were the causes of the Civil War?
• How did Abraham Lincoln's assassination impact the country and reconstruction after the Civil War?
• Which factors contributed to the colonies winning the American Revolution?
• What caused Hitler's rise to power?
• Discuss how a specific invention impacted history.
• What led to Cleopatra's fall as ruler of Egypt?
• How has Japan changed and evolved over the centuries?
• What were the causes of the Rwandan genocide ?

• Why did Martin Luther decide to split with the Catholic Church?
• Analyze the history and impact of a well-known cult (Jonestown, Manson family, etc.)
• How did the sexual abuse scandal impact how people view the Catholic Church?
• How has the Catholic church's power changed over the past decades/centuries?
• What are the causes behind the rise in atheism/ agnosticism in the United States?
• What were the influences in Siddhartha's life resulted in him becoming the Buddha?
• How has media portrayal of Islam/Muslims changed since September 11th?

Science/Environment

• How has the earth's climate changed in the past few decades?
• How has the use and elimination of DDT affected bird populations in the US?
• Analyze how the number and severity of natural disasters have increased in the past few decades.
• Analyze deforestation rates in a certain area or globally over a period of time.
• How have past oil spills changed regulations and cleanup methods?
• How has the Flint water crisis changed water regulation safety?
• What are the pros and cons of fracking?
• What impact has the Paris Climate Agreement had so far?
• What have NASA's biggest successes and failures been?
• How can we improve access to clean water around the world?
• Does ecotourism actually have a positive impact on the environment?
• Should the US rely on nuclear energy more?
• What can be done to save amphibian species currently at risk of extinction?
• What impact has climate change had on coral reefs?
• How are black holes created?
• Are teens who spend more time on social media more likely to suffer anxiety and/or depression?
• How will the loss of net neutrality affect internet users?
• Analyze the history and progress of self-driving vehicles.
• How has the use of drones changed surveillance and warfare methods?
• Has social media made people more or less connected?
• What progress has currently been made with artificial intelligence ?
• Do smartphones increase or decrease workplace productivity?
• What are the most effective ways to use technology in the classroom?
• How is Google search affecting our intelligence?
• When is the best age for a child to begin owning a smartphone?
• Has frequent texting reduced teen literacy rates?

How to Write a Great Research Paper

Even great research paper topics won't give you a great research paper if you don't hone your topic before and during the writing process. Follow these three tips to turn good research paper topics into great papers.

#1: Figure Out Your Thesis Early

Before you start writing a single word of your paper, you first need to know what your thesis will be. Your thesis is a statement that explains what you intend to prove/show in your paper. Every sentence in your research paper will relate back to your thesis, so you don't want to start writing without it!

As some examples, if you're writing a research paper on if students learn better in same-sex classrooms, your thesis might be "Research has shown that elementary-age students in same-sex classrooms score higher on standardized tests and report feeling more comfortable in the classroom."

If you're writing a paper on the causes of the Civil War, your thesis might be "While the dispute between the North and South over slavery is the most well-known cause of the Civil War, other key causes include differences in the economies of the North and South, states' rights, and territorial expansion."

#2: Back Every Statement Up With Research

Remember, this is a research paper you're writing, so you'll need to use lots of research to make your points. Every statement you give must be backed up with research, properly cited the way your teacher requested. You're allowed to include opinions of your own, but they must also be supported by the research you give.

#3: Do Your Research Before You Begin Writing

You don't want to start writing your research paper and then learn that there isn't enough research to back up the points you're making, or, even worse, that the research contradicts the points you're trying to make!

Get most of your research on your good research topics done before you begin writing. Then use the research you've collected to create a rough outline of what your paper will cover and the key points you're going to make. This will help keep your paper clear and organized, and it'll ensure you have enough research to produce a strong paper.

What's Next?

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Thinking about becoming a nurse practitioner? Nurse practitioners have one of the fastest growing careers in the country, and we have all the information you need to know about what to expect from nurse practitioner school .

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These recommendations are based solely on our knowledge and experience. If you purchase an item through one of our links, PrepScholar may receive a commission.

Christine graduated from Michigan State University with degrees in Environmental Biology and Geography and received her Master's from Duke University. In high school she scored in the 99th percentile on the SAT and was named a National Merit Finalist. She has taught English and biology in several countries.

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Using ideas from game theory to improve the reliability of language models

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Imagine you and a friend are playing a game where your goal is to communicate secret messages to each other using only cryptic sentences. Your friend's job is to guess the secret message behind your sentences. Sometimes, you give clues directly, and other times, your friend has to guess the message by asking yes-or-no questions about the clues you've given. The challenge is that both of you want to make sure you're understanding each other correctly and agreeing on the secret message.

MIT Computer Science and Artificial Intelligence Laboratory (CSAIL) researchers have created a similar "game" to help improve how AI understands and generates text. It is known as a “consensus game” and it involves two parts of an AI system — one part tries to generate sentences (like giving clues), and the other part tries to understand and evaluate those sentences (like guessing the secret message).

The researchers discovered that by treating this interaction as a game, where both parts of the AI work together under specific rules to agree on the right message, they could significantly improve the AI's ability to give correct and coherent answers to questions. They tested this new game-like approach on a variety of tasks, such as reading comprehension, solving math problems, and carrying on conversations, and found that it helped the AI perform better across the board.

Traditionally, large language models answer one of two ways: generating answers directly from the model (generative querying) or using the model to score a set of predefined answers (discriminative querying), which can lead to differing and sometimes incompatible results. With the generative approach, "Who is the president of the United States?" might yield a straightforward answer like "Joe Biden." However, a discriminative query could incorrectly dispute this fact when evaluating the same answer, such as "Barack Obama."

So, how do we reconcile mutually incompatible scoring procedures to achieve coherent, efficient predictions? 

"Imagine a new way to help language models understand and generate text, like a game. We've developed a training-free, game-theoretic method that treats the whole process as a complex game of clues and signals, where a generator tries to send the right message to a discriminator using natural language. Instead of chess pieces, they're using words and sentences," says Athul Jacob, an MIT PhD student in electrical engineering and computer science and CSAIL affiliate. "Our way to navigate this game is finding the 'approximate equilibria,' leading to a new decoding algorithm called 'equilibrium ranking.' It's a pretty exciting demonstration of how bringing game-theoretic strategies into the mix can tackle some big challenges in making language models more reliable and consistent."

When tested across many tasks, like reading comprehension, commonsense reasoning, math problem-solving, and dialogue, the team's algorithm consistently improved how well these models performed. Using the ER algorithm with the LLaMA-7B model even outshone the results from much larger models. "Given that they are already competitive, that people have been working on it for a while, but the level of improvements we saw being able to outperform a model that's 10 times the size was a pleasant surprise," says Jacob. 

"Diplomacy," a strategic board game set in pre-World War I Europe, where players negotiate alliances, betray friends, and conquer territories without the use of dice — relying purely on skill, strategy, and interpersonal manipulation — recently had a second coming. In November 2022, computer scientists, including Jacob, developed “Cicero,” an AI agent that achieves human-level capabilities in the mixed-motive seven-player game, which requires the same aforementioned skills, but with natural language. The math behind this partially inspired the Consensus Game. 

While the history of AI agents long predates when OpenAI's software entered the chat in November 2022, it's well documented that they can still cosplay as your well-meaning, yet pathological friend. 

The consensus game system reaches equilibrium as an agreement, ensuring accuracy and fidelity to the model's original insights. To achieve this, the method iteratively adjusts the interactions between the generative and discriminative components until they reach a consensus on an answer that accurately reflects reality and aligns with their initial beliefs. This approach effectively bridges the gap between the two querying methods. 

In practice, implementing the consensus game approach to language model querying, especially for question-answering tasks, does involve significant computational challenges. For example, when using datasets like MMLU, which have thousands of questions and multiple-choice answers, the model must apply the mechanism to each query. Then, it must reach a consensus between the generative and discriminative components for every question and its possible answers. 

The system did struggle with a grade school right of passage: math word problems. It couldn't generate wrong answers, which is a critical component of understanding the process of coming up with the right one. 

“The last few years have seen really impressive progress in both strategic decision-making and language generation from AI systems, but we’re just starting to figure out how to put the two together. Equilibrium ranking is a first step in this direction, but I think there’s a lot we’ll be able to do to scale this up to more complex problems,” says Jacob.   

An avenue of future work involves enhancing the base model by integrating the outputs of the current method. This is particularly promising since it can yield more factual and consistent answers across various tasks, including factuality and open-ended generation. The potential for such a method to significantly improve the base model's performance is high, which could result in more reliable and factual outputs from ChatGPT and similar language models that people use daily. 

"Even though modern language models, such as ChatGPT and Gemini, have led to solving various tasks through chat interfaces, the statistical decoding process that generates a response from such models has remained unchanged for decades," says Google Research Scientist Ahmad Beirami, who was not involved in the work. "The proposal by the MIT researchers is an innovative game-theoretic framework for decoding from language models through solving the equilibrium of a consensus game. The significant performance gains reported in the research paper are promising, opening the door to a potential paradigm shift in language model decoding that may fuel a flurry of new applications."

Jacob wrote the paper with MIT-IBM Watson Lab researcher Yikang Shen and MIT Department of Electrical Engineering and Computer Science assistant professors Gabriele Farina and Jacob Andreas, who is also a CSAIL member. They presented their work at the International Conference on Learning Representations (ICLR) earlier this month, where it was highlighted as a "spotlight paper." The research also received a “best paper award” at the NeurIPS R0-FoMo Workshop in December 2023.

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MIT researchers have developed a new procedure that uses game theory to improve the accuracy and consistency of large language models (LLMs), reports Steve Nadis for Quanta Magazine . “The new work, which uses games to improve AI, stands in contrast to past approaches, which measured an AI program’s success via its mastery of games,” explains Nadis. 

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Research: What Companies Don’t Know About How Workers Use AI

• Jeremie Brecheisen

Three Gallup studies shed light on when and why AI is being used at work — and how employees and customers really feel about it.

Leaders who are exploring how AI might fit into their business operations must not only navigate a vast and ever-changing landscape of tools, but they must also facilitate a significant cultural shift within their organizations. But research shows that leaders do not fully understand their employees’ use of, and readiness for, AI. In addition, a significant number of Americans do not trust business’ use of AI. This article offers three recommendations for leaders to find the right balance of control and trust around AI, including measuring how their employees currently use AI, cultivating trust by empowering managers, and adopting a purpose-led AI strategy that is driven by the company’s purpose instead of a rules-heavy strategy that is driven by fear.

If you’re a leader who wants to shift your workforce toward using AI, you need to do more than manage the implementation of new technologies. You need to initiate a profound cultural shift. At the heart of this cultural shift is trust. Whether the use case for AI is brief and experimental or sweeping and significant, a level of trust must exist between leaders and employees for the initiative to have any hope of success.

• Jeremie Brecheisen is a partner and managing director of The Gallup CHRO Roundtable.

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Resultados científicos revolucionarios en la estación espacial de 2023

Station science 101 | research in microgravity: higher, faster, longer.

Melissa L. Gaskill

Microgravity, a unique orbit, crewed laboratory, twenty years and counting, adding subjects adds time.

The International Space Station provides unique features that enable innovative research, including microgravity, exposure to space, a unique orbit, and hands-on operation by crew members.

The space station provides consistent, long-term access to microgravity. Eliminating the effects of Earth’s gravity on experiments is a game-changer across many disciplines, including research on living things and physical and chemical processes. For example, without gravity hot air does not rise, so flames become spherical and behave differently. Removing the forces of surface tension and capillary movement allows scientists to examine fluid behavior more closely.

The speed, pattern, and altitude of the space station’s orbit provide unique advantages. Traveling at 17,500 miles per hour, it circles the planet every 90 minutes, passing over a majority of Earth’s landmass and population centers in daylight and darkness. Its 250-mile-high altitude is low enough for detailed observation of features, atmospheric phenomena, and natural disasters from different angles and with varying lighting conditions. At the same time, the station is high enough to study how space radiation affects material durability and how organisms adapt and examine phenomena such as neutron stars and blackholes. The spacecraft also places observing instruments outside Earth’s atmosphere and magnetic field, which can interfere with observations from the ground.

Other satellites in orbit contain scientific experiments and conduct Earth observations, but the space station also has crew members aboard to manage and maintain scientific activities. Human operators can respond to and assess events in real time, swap out experiment samples, troubleshoot, and observe results first-hand. Crew members also pack experiment samples and send them back to the ground for detailed analysis.

Thanks to the space station’s longevity, experiments can continue for months or even years. Scientists can design follow-up studies based on previous results, and every expedition offers the chance to expand the number of subjects for human research.

One area of long-term human research is on changes in vision, first observed when astronauts began spending months at a time in space. Scientists wondered whether fluids shifting from the lower to the upper body in microgravity caused increased pressure inside the head that changed eye shape. The Fluid Shifts investigation began in 2015 and continued to measure the extent of fluid shifts in multiple astronauts through 2020. 1

Whether the original study is long or short, it can take years for research to go from the lab into practical applications. Many steps are involved, some of them lengthy. First, researchers must come up with a question and a possible answer, or hypothesis. For example, Fluid Shifts questioned what was causing vision changes and a possible answer was increased fluid pressure in the head. Scientists must then design an experiment to test the hypothesis, determining what data to collect and how to do so.

Getting research onto the space station in the first place takes time, too. NASA reviews proposals for scientific merit and relevance to the agency’s goals. Selected investigations are assigned to a mission, typically months in the future. NASA works with investigators to meet their science requirements, obtain approvals, schedule crew training, develop flight procedures, launch hardware and supplies, and collect any preflight data needed. Once the study launches, in-flight data collection begins. When scientists complete their data collection, they need time to analyze the data and determine what it means. This may take a year or more.

Scientists then write a paper about the results – which can take many months – and submit it to a scientific journal. Journals send the paper to other experts in the same field, a process known as peer review. According to one analysis, this review takes an average of 100 days. 2 The editors may request additional analysis and revisions based on this review before publishing.

Aspects of research on the space station can add more time to the process. Generally, the more test subjects, the better – from 100 to 1,000 subjects for statistically significant results for clinical research. But the space station typically only houses about six people at a time.

Lighting Effects shows how the need for more subjects adds time to a study. This investigation examined whether adjusting the intensity and color of lighting inside the station could help improve crew circadian rhythms, sleep, and cognitive performance. To collect data from enough crew members, the study ran from 2016 until 2020.

Other lengthy studies about how humans adapt to life in space include research on loss of heart muscle and a suite of long-term studies on nutrition, including producing fresh food in space.

For physical science studies, investigators can send batches of samples to the space station and collect data more quickly, but results can create a need for additional research. Burning and Suppression of Solids ( BASS ) examined the characteristics of a wide variety of fuel samples from 2011 to 2013, and BASS-II continued that work through 2017. The Saffire series of fire safety demonstrations began in 2016 and wrapped up in 2024. Researchers have answered many burning (pun intended) questions, but still have much to learn about preventing, detecting, and extinguishing fires in space.

The timeline for scientific results can run long, especially in microgravity. But those results can be well worth the wait.

Melissa Gaskill International Space Station Research Communications Team Johnson Space Center

Search this database of scientific experiments to learn more about those mentioned above.

1 Macias BR, Liu JHK, Grande-Gutierrez N, Hargens AR. Intraocular and intracranial pressures during head-down tilt with lower body negative pressure. Aerosp Med Hum Perform. 2015; 86(1):3–7.  https://www.ingentaconnect.com/content/asma/amhp/2015/00000086/00000001/art00004;jsessionid=31bonpcj2e8tj.x-ic-live-01

2 Powell K. Does it take too long to publish research? Nature 530, pages148–151 (2016). https://www.nature.com/articles/530148a

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• Americans’ Changing Relationship With Local News

As news consumption habits become more digital, U.S. adults continue to see value in local outlets

Table of contents.

• 1. Attention to local news
• 2. Local news topics
• Americans’ changing local news providers
• How people feel about their local news media’s performance
• Most Americans think local journalists are in touch with their communities
• Interactions with local journalists
• 5. Americans’ views on the financial health of local news
• Acknowledgments
• The American Trends Panel survey methodology

The Pew-Knight Initiative supports new research on how Americans absorb civic information, form beliefs and identities, and engage in their communities.

Pew Research Center is a nonpartisan fact tank that informs the public about the issues, attitudes and trends shaping the world. Knight Foundation is a social investor committed to supporting informed and engaged communities. Learn more >

Pew Research Center conducted this study to better understand the local news habits and attitudes of U.S. adults. It is a follow-up to a similar study conducted in 2018 .

The survey of 5,146 U.S. adults was conducted from Jan. 22 to 28, 2024. Everyone who completed the survey is a member of the Center’s American Trends Panel (ATP), an online survey panel that is recruited through national, random sampling of residential addresses. This way nearly all U.S. adults have a chance of selection. The survey is weighted to be representative of the U.S. adult population by gender, race, ethnicity, partisan affiliation, education and other categories.  Read more about the ATP’s methodology .

Refer to the topline for the questions used for this survey , along with responses, and to the methodology for more details.

This is a Pew Research Center report from the Pew-Knight Initiative, a research program funded jointly by The Pew Charitable Trusts and the John S. and James L. Knight Foundation. Find related reports online at https://www.pewresearch.org/pew-knight/ .

The local news landscape in America is going through profound changes as both news consumers and producers continue to adapt to a more digital news environment. We recently asked U.S. adults about the ways they access local news, as well as their attitudes toward local journalism, finding that:

• A growing share of Americans prefer to get local news online, while fewer are getting news on TV or in print. And newspapers are no longer primarily consumed as a print product – the majority of readers of local daily newspapers now access them digitally.
• The share of U.S. adults who say they are paying close attention to local news has dropped since our last major survey of attitudes toward local news in 2018, mirroring declining attention to national news.
• Americans still see value in local news and local journalists. A large majority say local news outlets are at least somewhat important to the well-being of their local community. Most people also say local journalists are in touch with their communities and that their local news media perform well at several aspects of their jobs, such as reporting the news accurately.
• At the same time, a relatively small share of Americans (15%) say they have paid for local news in the last year. And many seem unaware of the major financial challenges facing local news: A 63% majority (albeit a smaller majority than in 2018) say they think their local news outlets are doing very or somewhat well financially.
• Majorities of both major parties say local media in their area are doing their jobs well. While Republicans and GOP-leaning independents are slightly less positive than Democrats and Democratic leaners in their opinions of local media, views of local news don’t have the same stark political divides that exist within Americans’ opinions about national media .
• Most Americans say local journalists should remain neutral on issues in their community, but a substantial minority say local journalists should take a more active role. About three-in-ten say local journalists should advocate for change in their communities, a view that’s especially common among Democrats and younger adults.

These are some of the key findings from a new Pew Research Center survey of about 5,000 U.S. adults conducted in January 2024. This is the first in a series of Pew Research Center reports on local news from the Pew-Knight Initiative, a research program funded jointly by The Pew Charitable Trusts and the John S. and James L. Knight Foundation.

Americans largely hold positive views of local news organizations

At a time when many local news outlets are struggling and Americans’ trust in the news media has waned, the vast majority of U.S. adults (85%) say local news outlets are at least somewhat important to the well-being of their local community. This includes 44% who say local journalism is extremely or very important to their community

About seven-in-ten U.S. adults (69%) say that local journalists in their area are mostly in touch with their community, up from 63% who said this in 2018. And most Americans also say their local news organizations are doing well at four key roles:

• Reporting news accurately (71%)
• Covering the most important stories (68%)
• Being transparent (63%)
• Keeping an eye on local political leaders (61%).

These are relatively positive views compared with how Americans see news organizations more broadly. For instance, a 2022 Pew Research Center survey found that fewer than half of U.S. adults say that news organizations in general do a very or somewhat good job of covering the most important stories, reporting the news accurately and serving as a watchdog over elected leaders.

What’s more, views toward local news are not as politically polarized as Americans’ opinions about the news media overall. While Republicans and GOP-leaning independents are not quite as positive as Democrats and Democratic leaners in some of their assessments of local journalists, most Republicans still say the local media in their area are doing their jobs well.

For example, roughly three-quarters of Democrats (78%) say their local media do well at reporting news accurately, compared with about two-thirds of Republicans (66%).

By comparison, the 2022 survey found that 51% of Democrats and just 17% of Republicans say that news organizations in general do a very or somewhat good job of reporting the news accurately.

Jump to more information on views toward local news organizations.

Fewer Americans are closely following local news – and other types of news

Despite these positive views toward local news organizations, there are signs that Americans are engaging less with local journalism than they used to.

The share of Americans who say they follow local news very closely has fallen by 15 percentage points since 2016 (from 37% to 22%). Most U.S. adults still say they follow local news at least somewhat closely (66%), but this figure also has dropped in recent years.

This trend is not unique to local news – Americans’ attention to national and international news also has declined.

The local news landscape is becoming more digital

The ways in which Americans access local news are changing, reflecting an increasingly digital landscape – and matching patterns in overall news consumption habits .

Preferred pathways to local news

• Fewer people now say they prefer to get local news through a television set (32%, down from 41% who said the same in 2018).
• Americans are now more likely to say they prefer to get local news online, either through news websites (26%) or social media (23%). Both of these numbers have increased in recent years.
• Smaller shares prefer getting their local news from a print newspaper or on the radio (9% each).

Specific sources for local news

The types of sources (e.g., outlets or organizations) Americans are turning to are changing as well:

• While local television stations are still the most common source of local news beyond friends, family and neighbors, the share who often or sometimes get news there has declined from 70% to 64% in recent years.
• Online forums, such as Facebook groups or the Nextdoor app, have become a more common destination for local news: 52% of U.S. adults say they at least sometimes get local news from these types of forums, up 14 percentage points from 2018. This is on par with the percentage who get local news at least sometimes from local radio stations.
• Meanwhile, a third of Americans say they at least sometimes get local news from a daily newspaper, regardless of whether it is accessed via print, online or through a social media website – down 10 points from 2018. The share of Americans who get local news from newspapers is now roughly on par with the share who get local news from local government agencies (35%) or local newsletters or Listservs (31%).

Not only are fewer Americans getting local news from newspapers, but local daily newspapers are now more likely to be accessed online than in print.

• 31% of those who get news from daily newspapers do so via print, while far more (66%) do so digitally, whether through websites, apps, emails or social media posts that include content from the paper.
• In 2018, just over half of those who got news from local daily newspapers (54%) did so from print, and 43% did so via a website, app, email or social media site.

There is a similar move toward digital access for local TV stations, though local TV news is still mostly consumed through a TV set.

• In 2024, 62% of those getting news from local TV stations do so through a television, compared with 37% who do so through one of the digital pathways.
• An even bigger majority of local TV news consumers (76%) got that news through a TV set in 2018.

Jump to more information on how people access local news.

The financial state of local news

The turmoil for the local news industry in recent years has come with major financial challenges. Circulation and advertising revenue for newspapers have seen sharp declines in the last decade, according to our analysis of industry data , and other researchers have documented that thousands of newspapers have stopped publishing in the last two decades. There also is evidence of audience decline for local TV news stations, although advertising revenue on local TV has been more stable.

When asked about the financial state of the news outlets in their community, a majority of Americans (63%) say they think their local news outlets are doing very or somewhat well, with a third saying that they’re not doing too well or not doing well at all. This is a slightly more pessimistic view than in 2018, when 71% said their local outlets were doing well, though it is still a relatively positive assessment of the financial state of the industry.

Just 15% of Americans say they have paid or given money to any local news source in the past year – a number that has not changed much since 2018. The survey also asked Americans who did not pay for news in the past year the main reason why not. The most common explanation is that people don’t pay because they can find plenty of free local news, although young adults are more inclined to say they just aren’t interested enough in local news to pay for it.

Jump to more information on how people view the financial state of local news.

Other key findings in this report

Americans get local news about a wide variety of topics. Two-thirds or more of U.S. adults at least sometimes get news about local weather, crime, government and politics, and traffic and transportation, while smaller shares (but still at least half) say they get local news about arts and culture, the economy, schools, and sports.

Relatively few Americans are highly satisfied with the coverage they see of many topics. The survey also asked respondents who at least sometimes get each type of local news how satisfied they are with the news they get. With the exception of weather, fewer than half say they are extremely or very satisfied with the quality of the news they get about each topic. For example, about a quarter of those who consume news about their local economy (26%) say they are extremely or very satisfied with this news. Read more about different local news topics in Chapter 2.

When asked whether local journalists should remain neutral on community issues or advocate for change in the community, a majority of Americans (69%) say journalists should remain neutral, reflecting more traditional journalistic norms. However, 29% say that local journalists should be advocating for change in their communities. Younger adults are the most likely to favor advocacy by journalists: 39% of those ages 18 to 29 say that local journalists should push for change, as do 34% of those 30 to 49. Read more about Americans’ views of the role of local journalists in Chapter 4.

Americans who feel a strong sense of connection to their community are more likely to engage with local news, say that local news outlets are important to the community, and rate local media more highly overall. For example, 66% of those who say they are very attached to their community say local news outlets are extremely or very important to the well-being of their local community, compared with 46% of those who are somewhat attached and 31% of those who are not very or not at all attached to their community.

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Collection  29 March 2022

2021 Top 25 Health Sciences Articles

We are pleased to share with you the 25 most downloaded  Nature Communications  articles* in health sciences published in 2021. (Please note we have a separate collection on the Top 25 COVID-19 papers .) Featuring authors from around the world, these papers highlight valuable research from an international community.

Browse all Top 25 subject area collections  here .

*Data obtained from SN Insights (based on Digital Science's Dimensions) and normalised to account for articles published later in the year.

Research highlights

Association of sleep duration in middle and old age with incidence of dementia

Sleep dysregulation has been linked to dementia, but it is unknown whether sleep duration earlier in life is associated with dementia risk. Here, the authors show higher dementia risk associated with short sleep duration (six hours or less) in a longitudinal study of middle and older age adults.

• Séverine Sabia
• Aurore Fayosse
• Archana Singh-Manoux

Longitudinal analysis of blood markers reveals progressive loss of resilience and predicts human lifespan limit

Aging is associated with an increased risk of chronic diseases and functional decline. Here, the authors investigate the fluctuations of physiological indices along aging trajectories and observed a characteristic decrease in the organism state recovery rate.

• Timothy V. Pyrkov
• Konstantin Avchaciov
• Peter O. Fedichev

Restoration of energy homeostasis by SIRT6 extends healthy lifespan

Aging is associated with increased frailty and disrupted energy homeostasis. Here, the authors show that SIRT6 overexpression extends the lifespan of male and female mice and demonstrate that SIRT6 optimizes energy homeostasis in old age, which delays frailty and preserves healthy aging.

• A. Roichman
• S. Elhanati
• H. Y. Cohen

Triptonide is a reversible non-hormonal male contraceptive agent in mice and non-human primates

No male contraceptive pills are currently available. Here, the authors use triptonide, a compound derived from a Chinese plant, to deform sperm so that they cannot move properly, thereby causing reversible infertility in male mice and monkeys.

• Zongliang Chang
• Weibing Qin

Fasting alters the gut microbiome reducing blood pressure and body weight in metabolic syndrome patients

Nutritional modification including fasting has been shown to reduce cardiometabolic risk linked to western diet. Here the authors show implementation of fasting resulted in alterations to the intestinal microbiota, and circulating immune cells, improving blood pressure and body weight in patients with metabolic syndrome.

• András Maifeld
• Hendrik Bartolomaeus
• Sofia K. Forslund

Transneuronal delivery of hyper-interleukin-6 enables functional recovery after severe spinal cord injury in mice

The CNS has limited ability to regenerate following injury, Here, the authors show that a single injection of AAV-hyper-interleukin-6 in the sensory motor cortex results in corticospinal and raphe spinal tracts regeneration in the injured spinal cord as well as functional recovery in mice.

• Marco Leibinger
• Charlotte Zeitler
• Dietmar Fischer

Spatially resolved transcriptomics reveals the architecture of the tumor-microenvironment interface

During tumor progression, cancer cells contact different neighboring cell types, but it is unclear how these interactions affect cancer cell behavior. Here, the authors use spatially resolved transcriptomics and single-cell RNA-seq to study the role of cilia at the tumormicroenvironment interface.

• Miranda V. Hunter
• Reuben Moncada
• Richard M. White

Adjuvant oncolytic virotherapy for personalized anti-cancer vaccination

Viruses expressing tumour antigens can prime and boost anti-tumour immunity but the efficiency of this approach depends on the capacity of the virus to infect the host. Here, the authors show that vaccination with oncolytic viruses co-administered with tumour antigenic peptides is as efficient as antigen-engineered oncolytic viruses.

• K. Geoffroy
• M.-C. Bourgeois-Daigneault

Detection and characterization of lung cancer using cell-free DNA fragmentomes

DNA from tumour cells can be detected in the blood of cancer patients. Here, the authors show that cell free DNA fragmentation patterns can identify lung cancer patients and when this information is further interrogated it can be used to predict lung cancer histological subtype.

• Dimitrios Mathios
• Jakob Sidenius Johansen
• Victor E. Velculescu

A randomized controlled trial of pharmacist-led therapeutic carbohydrate and energy restriction in type 2 diabetes

Community pharmacists are accessible healthcare providers with expertise in medication management. Here the authors show that a low-carbohydrate, low-energy diet implemented by community pharmacists reduced diabetes medication use and improved glucose control in people with type 2 diabetes.

• Cody Durrer
• Sean McKelvey
• Jonathan P. Little

A metabolome atlas of the aging mouse brain

Metabolites play an important role in physiology, yet the complexity of the metabolome and its interaction with disease and aging is poorly understood. Here the authors present a comprehensive atlas of the mouse brain metabolome and how it changes during aging.

• Oliver Fiehn

Investigating immune and non-immune cell interactions in head and neck tumors by single-cell RNA sequencing

The tumor microenvironment (TME) has an important role in Head and Neck Squamous Cell Carcinoma (HNSCC) progression. Here, using single-cell RNA sequencing and multiplexed imaging, the authors report the cellular complexity of the TME in patients with HNSCC, exploring inflammatory status, stromal heterogeneity and immune checkpoint receptor-ligand interactions.

• Cornelius H. L. Kürten
• Aditi Kulkarni
• Robert L. Ferris

Single-cell profiling of tumor heterogeneity and the microenvironment in advanced non-small cell lung cancer

Comprehensive profiles of tumour and microenvironment are critical to understand heterogeneity in non-small cell lung cancer (NSCLC). Here, the authors profile 42 late-stage NSCLC patients with single-cell RNA-seq, revealing immune landscapes that are associated with cancer subtype or heterogeneity.

• Fengying Wu
• Caicun Zhou

Biomimetic nanoparticles deliver mRNAs encoding costimulatory receptors and enhance T cell mediated cancer immunotherapy

Antibodies targeting OX40 or CD137, two T cell costimulatory receptors, have been shown to improve antitumor immunity. Here the authors design a phospholipid-derived nanoparticle to deliver OX40 or CD137 mRNA to T cells in vivo, improving efficacy of anti-OX40 and anti-CD137 antibody therapy in preclinical tumor models.

• Xinfu Zhang
• Yizhou Dong

Sexual dimorphism in glucose metabolism is shaped by androgen-driven gut microbiome

Male sex is a risk factor for impaired glucose metabolism and type 2 diabetes. Here the authors identify that androgen modulates the gut microbiome, which drives insulin resistance and contributes to sexual dimorphism in glucose metabolism in mice.

• Weiqing Wang

Blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies

Associations between of omega-3 fatty acids and mortality are not clear. Here the authors report that, based on a pooled analysis of 17 prospective cohort studies, higher blood omega-3 fatty acid levels correlate with lower risk of all-cause mortality.

• William S. Harris
• Nathan L. Tintle
• The Fatty Acids and Outcomes Research Consortium (FORCE)

Multi-omics analysis identifies therapeutic vulnerabilities in triple-negative breast cancer subtypes

Triple negative breast cancer can be divided into additional subtypes. Here, using omics analyses, the authors show that in the mesenchymal subtype expression of MHC-1 is repressed and that this can be restored by using drugs that target subunits of the epigenetic modifier PRC2.

• Brian D. Lehmann
• Antonio Colaprico
• X. Steven Chen

Daily caloric restriction limits tumor growth more effectively than caloric cycling regardless of dietary composition

Caloric restriction (CR) has been shown as an effective intervention to reduce tumorigenesis, but alternative less stringent dietary interventions have also been considered. Here, the authors show that in a murine model of breast cancer CR has a larger effect on preventing tumorigenesis and metastasis compared to periodic caloric cycling.

• Laura C. D. Pomatto-Watson
• Monica Bodogai
• Rafael de Cabo

Neoadjuvant immunotherapy with nivolumab and ipilimumab induces major pathological responses in patients with head and neck squamous cell carcinoma

Immune checkpoint blockade has become standard care for patients with recurrent metastatic head and neck squamous cell carcinoma (HNSCC). Here the authors present the results of a non-randomized phase Ib/IIa trial, reporting safety and efficacy of neoadjuvant nivolumab monotherapy and nivolumab plus ipilimumab prior to standard-of-care surgery in patients with HNSCC. .

• Joris L. Vos
• Joris B. W. Elbers
• Charlotte L. Zuur

9p21 loss confers a cold tumor immune microenvironment and primary resistance to immune checkpoint therapy

The molecular mechanisms of resistance to immune checkpoint therapy remain elusive. Here, the authors perform immunogenomic analysis of TCGA data and data from clinical trials for antiPD-1/PD-L1 therapy and highlight the association of 9p21 loss with a cold tumor microenvironment and resistance to therapy.

• Guangchun Han
• Guoliang Yang
• Linghua Wang

Gut bacteria identified in colorectal cancer patients promote tumourigenesis via butyrate secretion

Several bacteria in the gut microbiota have been associated with colorectal cancer (CRC) but it is not completely clear whether they have a role in tumourigenesis. Here, the authors show enrichment of 12 bacterial taxa in two cohorts of CRC patients and that two Porphyromonas species accelerate CRC onset through butyrate secretion.

• Shintaro Okumura
• Yusuke Konishi

Elevated circulating follistatin associates with an increased risk of type 2 diabetes

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New research initiative tackles pressing global development issues

By alison fromme cornell sc johnson college of business.

Fundamental challenges in food insecurity, poverty, agriculture, health, education and markets form the focus of Collaboration for International Development Economics Research (CIDER) , a new initiative launched by the Office of the Provost, the SC Johnson College of Business, the College of Agriculture and Life Sciences, the College of Arts and Sciences and the Cornell Jeb E. Brooks School of Policy.

“CIDER builds on a long history of Cornell research and engagement in the economies of nations, particularly developing and emerging economies challenged by global economic forces,” said Provost Michael I. Kotlikoff. “This initiative expands the interdisciplinary focus of these efforts, bringing economists, social scientists, policy experts and agricultural experts together to pursue solutions to some of our most difficult global challenges.”

Hosted by the SC Johnson College, CIDER unites 24 faculty across campus and the world, along with students, staff, researchers and external partners, to create and share knowledge. CIDER’s activities will encompass research, workshops, seminars, internships, career mentoring and continuing-education coursework.

“We’re delighted to embark on this new collaborative effort in development economics,” said Andrew Karolyi, the Charles Field Knight Dean of the Cornell SC Johnson College of Business. “CIDER taps into existing expertise and a grand legacy of intellectual leadership at Cornell going back decades. I can’t wait to see the tangible impact CIDER makes on campus and around the world.”

CIDER’s inaugural faculty director is Chris Barrett , the Stephen B. and Janice G. Ashley Professor of Applied Economics and Management in the Charles H. Dyson School of Applied Economics and Management and professor in the Brooks School.

“We expect CIDER will further reinforce Cornell's already formidable reputation in this space,” Barrett said. The university’s impact in development economics was established over many decades and reinforced when standard measures of poverty and food insecurity were developed here in the 1980s. Now, CIDER provides a forum to collaborate on large-scale projects, advance policy-relevant research and train early career scholars and practitioners.

Through a workshop hosted by CIDER on May 10, the center is already encouraging new collaborations in East African dryland drought research, risk management and policy.

The World Bank, the African Development Bank, private organizations and multiple East African national governments are currently investing nearly $1 billion in the region to address drought, Barrett said.

“The efficacy and the impact of these massive investments can be directly influenced by research findings,” he said. “Indeed, research by Cornell and partners going back to the late 2000s underpins the initiative. We’re now working to produce timely policy-relevant, clearly communicated and rigorous research that can inform that effort.”

Among other presentations at the workshop, Karlijn Morsink , Utrecht University economist and CIDER-affiliated adjunct associate professor at the Dyson School, discussed her work leading the evaluation of World Bank programs in the region and share opportunities for Cornell faculty and student involvement.

“This workshop and the collaborations it represents offer just one example,” Barrett said. “We look to scale this type of effort across a range of different domains.”

CIDER will also support early career mentoring through two formal programs. Structural Transformation of Agriculture and Rural Spaces (STARS) , an existing Cornell program, previously paired early career researchers who earned degrees in Africa with mentors at Cornell and affiliated institutions. Now under CIDER’s umbrella, STARS is open to scholars across all low- and lower-middle-income countries.

Additionally, a predoctoral program for scholars who have not yet earned advanced degrees will provide one to three years of research experience and professional development training with core faculty. One predoctoral fellow already began work in January, and three more arrive this summer.

Building professional networks, increasing research capacity, disseminating best practices in the field and shaping early career researchers for the next generation are at the heart of CIDER’s mission, Barrett said. “This is a really exciting venture.”

Alison Fromme is a writer for the Cornell SC Johnson College of Business.

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