research proposal for biotechnology

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Research Proposal Topics In Biotechnology

Biotechnology is a fascinating subject that blends biology and technology and provides a huge chance to develop new ideas. However, before pursuing a career in this field, a person needs to complete a number of studies and have a thorough knowledge of the matter. When we begin our career must we conduct study to discover some innovative innovations that could benefit people around the world. Biotechnology is one of a variety of sciences of life, including pharmacy. Students who are pursuing graduation, post-graduation or PhD must complete the research work and compose their thesis to earn the satisfaction in their education. When choosing a subject for biotechnology-related research it is important to choose one that is likely to inspire us. Based on our passion and personal preferences, the subject to study may differ.

What is Biotechnology?

In its most basic sense, biotechnology is the science of biology that enables technology Biotechnology harnesses the power of the biomolecular and cellular processes to create products and technologies that enhance our lives and the wellbeing of the planet. Biotechnology has been utilizing microorganisms' biological processes for over six thousand years to create useful food items like cheese and bread as well as to keep dairy products in good condition.

Modern biotechnology has created breakthrough products and technology to treat rare and debilitating illnesses help reduce our footprint on the environment and feed hungry people, consume less energy and use less and provide safer, more clean and productive industrial production processes.

Introduction

Biotechnology is credited with groundbreaking advancements in technological development and development of products to create sustainable and cleaner world. This is in large part due to biotechnology that we've made progress toward the creation of more efficient industrial manufacturing bases. Additionally, it assists in the creation of greener energy, feeding more hungry people and not leaving a large environmental footprint, and helping humanity fight rare and fatal diseases.

Our writing services for assignments within the field of biotechnology covers all kinds of subjects that are designed to test and validate the skills of students prior to awarding their certificates. We assist students to successfully complete their course in all kinds of biotechnology-related courses. This includes biological sciences for medical use (red) and eco-biotechnology (green) marine biotechnology (blue) and industrial biotechnology (white).

What do we hope to gain from all these Initiatives?

Our primary goal in preparing this list of the top 100 biotechnology assignment subjects is to aid students in deciding on effective time management techniques. We've witnessed a large amount of cases where when looking for online help with assignments with the topic, examining sources of information, and citing the correct order of reference students find themselves stuck at various points. In the majority of cases, students have difficulty even to get through their dilemma of choosing a topic. This is why we contribute in our effort to help make the process easier for students in biotech quickly and efficiently. Our students are able to save time and energy in order to help them make use of the time they are given to write the assignment with the most appropriate topics.

Let's look at some of the newest areas of biotechnology research and the related areas.

Renewable Energy Technology Management Promoting Village
Molasses is a molasses-based ingredient that can be used to produce and the treatment of its effluent
Different ways to evapotranspirate
Scattering Parameters of Circulator Bio-Technology
Renewable Energy Technology Management Promoting Village.

Structural Biology of Infectious Diseases

A variety of studies are being conducted into the techniques used by pathogens in order to infect humans and other species and for designing strategies for countering the disease. The main areas that are available to study by biotech researchers include:

inlA from Listeria monocytogenes when combined with E-cadherin from humans.
InlC in Listeria monocytogenes that are multipart with human Tuba.
Phospholipase PatA of Legionella pnemophila.
The inactivation process of mammalian TLR2 by inhibiting antibody.
There are many proteins that come originate from Mycobacterium tuberculosis.

Plant Biotechnology

Another significant area for research in biotechnology for plants is to study the genetic causes of the plant's responses to scarcity and salinity, which have a significant impact on yields of the crop and food.

Recognition and classification of genes that influence the responses of plants to drought and salinity.
A component of small-signing molecules in plants' responses to salinity and drought.
Genetic enhancement of plant sensitivity salinity and drought.

Pharmacogenetics

It's also a significant area for conducting research in biotechnology. One of the most important reasons for doing so could be the identification of various genetic factors that cause differences in drug effectiveness and susceptibility for adverse reactions. Some of the subjects which can be studied are,

Pharmacogenomics of Drug Transporters
Pharmacogenomics of Metformin's response to type II mellitus
The pharmacogenomics behind anti-hypertensive medicines
The Pharmacogenomics of anti-cancer drugs

Forensic DNA

A further area of research in biotechnology research is the study of the genetic diversity of humans for its applications in criminal justice. Some of the topics that could be studied include,

Y-chromosome Forensic Kit, Development of commercial prototype.
Genetic testing of Indels in African populations.
The Y-chromosome genotyping process is used for African populations.
Study of paternal and maternal ancestry of mixed communities in South Africa.
The study of the local diversity in genetics using highly mutating Y-STRs and Indels.
South African Innocence Project: The study of DNA extracted from historical crime scene.
Nanotechnology is a new technology that can be applied to DNA genotyping.
Nanotechnology methods to isolate DNA.

Food Biotechnology

It is possible to conduct research in order to create innovative methods and processes in the fields of food processing and water. The most fascinating topics include:

A molecular-based technology that allows for the rapid identification and detection of foodborne pathogens in intricate food chains.
The effects of conventional and modern processing techniques on the bacteria that are associated with Aspalathus lineriasis.
DNA-based identification of species of animals that are present in meat products that are sold raw.
The phage assay and PCR are used to detect and limit the spread of foodborne pathogens.
Retention and elimination of pathogenic, heat-resistant and other microorganisms that are treated by UV-C.
Analysis of an F1 generation of the cross Bon Rouge x Packham's Triumph by Simple Sequence Repeat (SSR/microsatellite).
The identification of heavy metal tolerant and sensitive genotypes
Identification of genes that are involved in tolerance to heavy metals
The isolation of novel growth-promoting bacteria that can help crops cope with heavy metal stress . Identification of proteins that signal lipids to increase the tolerance of plants to stress from heavy metals

This topic includes high-resolution protein expression profiling for the investigation of proteome profiles. The following are a few of the most fascinating topics:

The identification and profile of stress-responsive proteins that respond to abiotic stress in Arabidopsis Thalian and Sorghum bicolor.
Analyzing sugar biosynthesis-related proteins in Sorghum bicolor, and study of their roles in drought stress tolerance
Evaluation of the viability and long-term sustainability of Sweet Sorghum for bioethanol (and other by-products) production in South Africa
In the direction of developing an environmentally sustainable, low-tech hypoallergenic latex Agroprocessing System designed specifically especially for South African small-holder farmers.

Bioinformatics

This is an additional aspect of biotechnology research. The current trend is to discover new methods to combat cancer. Bioinformatics may help identify proteins and genes as well as their role in the fight against cancer. Check out some of the areas that are suitable to study.

Prediction of anticancer peptides with HIMMER and the the support vector machine.
The identification and verification of innovative therapeutic antimicrobial peptides for Human Immunodeficiency Virus In the lab and molecular method.
The identification of biomarkers that are associated with cancer of the ovary using an molecular and in-silico method.
Biomarkers identified in breast cancer, as possible therapeutic and diagnostic agents with a combination of molecular and in-silico approaches.
The identification of MiRNA's as biomarkers for screening of cancerous prostates in the early stages an in-silico and molecular method
Identification of putatively identified the genes present in breast cancer tissues as biomarkers for early detection of lobular and ductal breast cancers.
Examining the significance of Retinoblastoma Binding Protein 6 (RBBP6) in the regulation of the cancer-related protein Y-Box Binding Protein 1 (YB-1).
Examining the role played by Retinoblastoma Binding Protein 6 (RBBP6) in the regulation of the cancer suppressor p53 through Mouse Double Minute 2 (MDM2).
Structural analysis of the anti-oxidant properties of the 1-Cys peroxiredoxin Prx2 found in the plant that resurrects itself Xerophyta viscosa.

Nanotechnology

This is a fascinating aspect of biotechnology, which can be used to identify effective tools to address the most serious health issues.

Evaluation of cancer-specific peptides to determine their applications for the detection of cancer.
The development of a quantum dot-based detection systems for breast cancer.
The creation of targeted Nano-constructs for in vivo imaging as well as the treatment of tumors.
Novel quinone compounds are being tested as anti-cancer medicines.
Embedelin is delivered to malignant cells in a specific manner.
The anti-cancer activities of Tulbaghia Violacea extracts were studied biochemically .
Novel organic compounds are screened for their anti-cancer potential.
To treat HIV, nanotechnology-based therapeutic techniques are being developed.

Frequently asked questions

What are some biotechnology research proposal topics .

Some of biotechnology topics are:

What are the research areas in biotechnology ?

What is best topic for research in biotechnology , what are some examples of biotechnology , what is the scope of biotechnology , what is master in biotechnology , is biotechnology a high paying job , is biotechnology hard to study , is biotechnology a good career , which agecy is best for biotechnology assignment help , can a biotechnologist become a doctor , is biotechnology better than microbiology , is b tech biotechnology a good course .

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10 Helpful Steps for Writing a Graduate Research Proposal

The road to obtain a graduate degree is unquestionably long. But we have ten incredibly helpful steps for writing your graduate research proposal. When you finally reach your destination, it will all be worthwhile.

As a graduate student, when you start your journey, you must write, present and defend a graduate research proposal in front of a committee of professors, also known as a graduate advisory committee.

A research proposal is usually short, with only fewer than ten pages, but it has to cover the proposed research in detail. After the committee approves it, you should follow the research plan explained in the research proposal to complete your research project.

Figure 1. The typical timeline in graduate school.

Why is it important to write a research proposal?

There are eight major reasons for graduate students to write a research proposal in graduate school:

It's required by the graduate school before performing research.
Students become more familiar with the research project
They develop research skills and academic writing skills.
Students develop literature review skills.
Students learn how to identify the research problem, objective, research questions and hypothesis.
They learn to explore different methods to collect and analyze data, and to select the most appropriate methods for solving research problems.
They learn to design research experiments based on logical and chronological steps.
The process nurtures critical thinking and logical reasoning skills.

What to include in a research proposal

The common elements to include in a good research proposal are:

Title : The title of a research proposal should be clear and brief.
Introduction : This part contains the background information of the proposed study leading to the research problem.
Statement of purpose : This element should include the research objectives.
Literature review : It should include an overview of findings from the previous studies, the gaps in the previous studies and the findings from a preliminary study.
Research questions and hypothesis : This includes the research questions and hypothesis.
Methodology : This element contains a full description of the research procedures, possible problems and alternatives strategies.
The significance and impact of the study : This part shows how the proposed research will contribute to the field of study.

The 10 steps to writing an incredible research proposal

Below are ten steps for writing a research proposal:

1.Choose a research topic and develop a working title

Having a strong interest in your research topic will certainly help you to keep going when the journey becomes more challenging. The research topic is the subject of your research, which is a part of a broader field of study.

When you pick a research topic, find a topic that is not too narrow nor too broad. You can limit your topic, for example, by focusing on a certain treatment, population group, species, geographical area, period, methodology, or other specific factors.

After selecting a research topic, develop a working title to help you focus on your topic. As you write the proposal, you can keep changing the working title to formulate the perfect title.

2.Perform a literature review

The next step is to conduct a literature review. This step is important because when you write out the background information and knowledge gaps in your topic area, it will help you become more familiar with your research topic.

In addition, performing a literature review will direct you to a research problem . A research problem is a specific area of concern serving as the focus of your proposed research.

When performing a literature review, a graduate student can also discover some ideas for designing their research plan.

To help you conduct a literature review, answer the following questions below:

What have others done so far to solve the research problem?

Some helpful steps to answer this question:

Understand the experimental designs from previous studies to help you design your own research experiments.
Learn about appropriate sample sizes, data collection, and statistical analyses from previous studies.
Investigate and make a list the reagents and equipment you’ll possibly need for your research.
Learn the research questions, the findings, the impact and the significance of previous studies.
Find out about any ethical concerns.

What additional studies are still needed to solve the research problem?

Pay attention to the strength and limitation part of the discussion section of scientific articles. From this part, make notes about the limitations of previous studies to give you an idea about a potential research problem.
Read the suggestions for future research part of scientific articles. That can serve as a call to action for you to solve those unanswered questions from previous studies.

3.Write an introduction

The introduction of your research proposal builds a framework for the research. This framework is the structure that supports your study and contains the background information. Its function is similar to the role of a foundation in supporting a building—if it is weak, a building will fall apart. Likewise, if your research lacks a strong background as a framework, it’s hard for others to see why it matters.

Writing your introduction can feel a little overwhelming. Where do you begin? How do you know you’re not missing anything?

You might want to read over our article:

How to Write an Effective Introduction Section of a Scientific Article

While the article is more specific to the introduction section of a formal research paper, there are some parts and tips you might find helpful.

4. Write research objectives or aims

In the next step, include research objectives or aims in the research proposal. A research objective is a goal you want to achieve in your research project ( Al-Riyami, 2008 ). Your research objectives must have a strong connection with your research problem.

When developing research objectives, identify all variables associated with the research problem. A variable in the research is a characteristic that you manipulate or observe in your experiment.

There are different types of variables, including an independent variable and dependent variable (Al-Riyami, 2008). An independent variable is a variable you can change in your experiment, whereas a dependent variable is a variable you observe in response to the independent variable. After identifying the variables, connect them to the research objective.

An example of a research objective: to determine the effect of different doses of a novel antibiotic X on the growth rate of some resistant bacterial strains . In this example, the independent variable is the treatment (the different doses of antibiotic X), and the dependent variable is the growth rate of some bacterial strains.

5.State a research question

The next step is to identify a research question. A research question is the key question you want to answer in your proposed study ( Farrugia et al ., 2010 ). A research project can contain several research questions.

Keep in mind that your research question must meet the criteria of a good research question, including specific, feasible, interesting, novel, ethical, and relevant (Farrugia et al ., 2010).

In term of feasibility, use current methods and technology to answer the question during your limited time in the graduate school.

An example of a research question : What doses of the antibiotic X are effective to inhibit the growth of some resistant bacterial strains?

6.Formulate a research hypothesis

After developing the research objectives and question, the next step is to formulate a research hypothesis. A research hypothesis is a statement of a possible research outcome.

Some criteria of a good hypothesis ( Prasad et al., 2010 ; Al-Riyami, 2008):

Logical, precise, and clear
Testable with research experiments
Makes a prediction about the relationship between variables

An example of a research hypothesis: The new antibiotic X will significantly prevent the growth of some resistant bacterial strains.

7.Explain research methods

The methodology section containing proposed experimental procedures is required for a research proposal. This section has the detailed plan to solve the research problem. It also reflects the research questions and hypothesis.

After reviewing the credibility and validity of your research methods, your advisory committee will make a decision about the fate of your proposed study. Therefore, when writing the methodology section, keep in mind that others should be able to follow each step in the research design to perform the same experiment.

In this section, you should include these following key points:

Experimental design : This is the research strategy you choose to solve your problem.
Samples : It contains the description about the samples for each group of treatment in the proposed study.
Sample size : This information is important to make sure your sample size is sufficient.
Materials : It contains the reagents and chemicals needed in the proposed study.
Equipment : This has the list of equipment needed for the proposed study.
Protocols of data collection : It contains the procedures needed before collecting your data.
Ethical issues and consent forms : You may need to include these if your proposed studies will need human participants.
Data analysis : This part should include the steps to analyze the data.
Gantt chart : This chart contains tasks in each research project with the timeline for each task.

8.Include potential problems and alternative strategies

When performing your study, you may encounter potential problems. Therefore, include some of the possible problems that may occur during your study and the potential solution for them. By doing so, you can use your backup plan to solve each potential problem when the problems actually occurs.

9.Conduct and include a preliminary study

Perform and include the findings from a preliminary study in your research proposal. A preliminary study is a small-scale pilot study, conducted to test the experimental design ahead of time and increase the likelihood of success. By including the findings from a preliminary study, your advisory committee can visualize and assess the feasibility of your large-scale study.

10.State the potential impact and significance

In the last paragraph of your research proposal, include the potential impact and significance of your proposed study.

The potential impact of your study means the changes that your proposed research would make. These changes can be positive or negative, immediate or long-term, and direct or indirect.

Whereas, the potential significance of your study means the contribution that your proposed research would make. For example, you can explain its contribution to the knowledge in your field of study.

After putting it all together, evaluate the entire proposal to make sure it is strong and well written.

Al-Riyami, A. (2008). How to prepare a Research Proposal. Oman Medical Journal, 23(2), 66–69. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC32824...

Benedetti, A. (n.d.). Research Guides: Advanced Research Methods: Writing a Research Proposal. Guides.library.ucla.edu. Retrieved March 17, 2021, from https://guides.library.ucla.edu/c.php?g=180334&p=1289236.

Crawford, L. (2020). LITERATURE-BASED DEFINITIONS OF CONCEPTUAL FRAMEWORKS. https://us.sagepub.com/sites/default/files/upm-assets/105274_book_item_105274.pdf.

Farrugia, P., Petrisor, B. A., Farrokhyar, F., & Bhandari, M. (2010). Practical tips for surgical research: Research questions, hypotheses and objectives. Canadian Journal of Surgery. Journal Canadien de Chirurgie, 53(4), 278–281. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC29120...

How to choose a research area. (2016, April 8). ASCB. https://www.ascb.org/careers/choose-research-area/

How to Select a Research Topic | University of Michigan-Flint. (2019). Umflint.edu; UM-Flint. https://www.umflint.edu/library/how-select-research-topic.

How To Write a Proposal | Science & Quantitative Reasoning. (n.d.). Science.yalecollege.yale.edu. Retrieved March 17, 2021, from https://science.yalecollege.yale.edu/fellowships/how-write-proposal.

Jacobs, R. L. (2013). Developing a dissertation research problem: A guide for doctoral students in human resource development and adult education. New Horizons in Adult Education and Human Resource Development, 25(3), 103–117. https://doi.org/10.1002/nha3.20034.

Kivunja, C. (2018). Distinguishing between Theory, Theoretical Framework, and Conceptual Framework: A Systematic Review of Lessons from the Field. International Journal of Higher Education, 7(6), 44. https://doi.org/10.5430/ijhe.v7n6p44.

LibGuides: Writing a Research Proposal: Parts of a Proposal. (2017). Illinois.edu. https://guides.library.illinois.edu/c.php?g=504643&p=3454882.

LibGuides: Research Process: Finding a Research Topic. (2019). Libguides.com. https://ncu.libguides.com/researchprocess/researchtopic.

LibGuides: Research Process: Literature Gap and Future Research. (2012). Libguides.com. https://ncu.libguides.com/researchprocess/literaturegap.

Pajares, F. (n.d.). THE ELEMENTS OF A PROPOSAL. https://www.uky.edu/~eushe2/Pajares/ElementsOfaProposal.pdf.

Prasad, S., Rao, A., & Rehani, E. (2001). DEVELOPING HYPOTHESES & RESEARCH QUESTIONS DEVELOPING HYPOTHESIS AND RESEARCH QUESTIONS. https://www.public.asu.edu/~kroel/www500/hypothesi...

Shardlow, M., Batista-Navarro, R., Thompson, P., Nawaz, R., McNaught, J., & Ananiadou, S. (2018). Identification of research hypotheses and new knowledge from scientific literature. BMC Medical Informatics and Decision Making, 18(1). https://doi.org/10.1186/s12911-018-0639-1

Steps in Developing a Research Proposal. Open.lib.umn.edu; University of Minnesota Libraries Publishing edition, 2015. This edition adapted from a work originally produced in 2010 by a publisher who has requested that it not receive attribution. https://open.lib.umn.edu/writingforsuccess/chapter...

Vining, S. (2019, July 22). Dissertation Proposal | Genetics and Genomics. https://genetics.mcb.uconn.edu/dissertation-propos...

Writing a Research Plan. (2017, December 11). Science | AAAS. https://www.sciencemag.org/careers

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How to Write a Research Proposal | Examples & Templates

How to Write a Research Proposal | Examples & Templates

Published on October 12, 2022 by Shona McCombes and Tegan George. Revised on November 21, 2023.

A research proposal describes what you will investigate, why it’s important, and how you will conduct your research.

The format of a research proposal varies between fields, but most proposals will contain at least these elements:

Introduction

Literature review.

Research design

Reference list

While the sections may vary, the overall objective is always the same. A research proposal serves as a blueprint and guide for your research plan, helping you get organized and feel confident in the path forward you choose to take.

Research proposal purpose, research proposal examples, research design and methods, contribution to knowledge, research schedule, other interesting articles, frequently asked questions about research proposals.

Academics often have to write research proposals to get funding for their projects. As a student, you might have to write a research proposal as part of a grad school application , or prior to starting your thesis or dissertation .

In addition to helping you figure out what your research can look like, a proposal can also serve to demonstrate why your project is worth pursuing to a funder, educational institution, or supervisor.

Research proposal aims
	Show your reader why your project is interesting, original, and important.
	Demonstrate your comfort and familiarity with your field. Show that you understand the current state of research on your topic.
	Make a case for your . Demonstrate that you have carefully thought about the data, tools, and procedures necessary to conduct your research.
	Confirm that your project is feasible within the timeline of your program or funding deadline.

Research proposal length

The length of a research proposal can vary quite a bit. A bachelor’s or master’s thesis proposal can be just a few pages, while proposals for PhD dissertations or research funding are usually much longer and more detailed. Your supervisor can help you determine the best length for your work.

One trick to get started is to think of your proposal’s structure as a shorter version of your thesis or dissertation , only without the results , conclusion and discussion sections.

Download our research proposal template

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Writing a research proposal can be quite challenging, but a good starting point could be to look at some examples. We’ve included a few for you below.

Example research proposal #1: “A Conceptual Framework for Scheduling Constraint Management”
Example research proposal #2: “Medical Students as Mediators of Change in Tobacco Use”

Like your dissertation or thesis, the proposal will usually have a title page that includes:

The proposed title of your project
Your supervisor’s name
Your institution and department

The first part of your proposal is the initial pitch for your project. Make sure it succinctly explains what you want to do and why.

Your introduction should:

Introduce your topic
Give necessary background and context
Outline your problem statement and research questions

To guide your introduction , include information about:

Who could have an interest in the topic (e.g., scientists, policymakers)
How much is already known about the topic
What is missing from this current knowledge
What new insights your research will contribute
Why you believe this research is worth doing

Receive feedback on language, structure, and formatting

Professional editors proofread and edit your paper by focusing on:

Academic style
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See an example

As you get started, it’s important to demonstrate that you’re familiar with the most important research on your topic. A strong literature review shows your reader that your project has a solid foundation in existing knowledge or theory. It also shows that you’re not simply repeating what other people have already done or said, but rather using existing research as a jumping-off point for your own.

In this section, share exactly how your project will contribute to ongoing conversations in the field by:

Comparing and contrasting the main theories, methods, and debates
Examining the strengths and weaknesses of different approaches
Explaining how will you build on, challenge, or synthesize prior scholarship

Following the literature review, restate your main objectives . This brings the focus back to your own project. Next, your research design or methodology section will describe your overall approach, and the practical steps you will take to answer your research questions.

Building a research proposal methodology
	? or ? , , or research design?
	, )? ?
	, , , )?
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To finish your proposal on a strong note, explore the potential implications of your research for your field. Emphasize again what you aim to contribute and why it matters.

For example, your results might have implications for:

Improving best practices
Informing policymaking decisions
Strengthening a theory or model
Challenging popular or scientific beliefs
Creating a basis for future research

Last but not least, your research proposal must include correct citations for every source you have used, compiled in a reference list . To create citations quickly and easily, you can use our free APA citation generator .

Some institutions or funders require a detailed timeline of the project, asking you to forecast what you will do at each stage and how long it may take. While not always required, be sure to check the requirements of your project.

Here’s an example schedule to help you get started. You can also download a template at the button below.

Download our research schedule template

Example research schedule
Research phase	Objectives	Deadline
1. Background research and literature review		20th January
2. Research design planning	and data analysis methods	13th February
3. Data collection and preparation	with selected participants and code interviews	24th March
4. Data analysis	of interview transcripts	22nd April
5. Writing		17th June
6. Revision	final work	28th July

If you are applying for research funding, chances are you will have to include a detailed budget. This shows your estimates of how much each part of your project will cost.

Make sure to check what type of costs the funding body will agree to cover. For each item, include:

Cost : exactly how much money do you need?
Justification : why is this cost necessary to complete the research?
Source : how did you calculate the amount?

To determine your budget, think about:

Travel costs : do you need to go somewhere to collect your data? How will you get there, and how much time will you need? What will you do there (e.g., interviews, archival research)?
Materials : do you need access to any tools or technologies?
Help : do you need to hire any research assistants for the project? What will they do, and how much will you pay them?

If you want to know more about the research process , methodology , research bias , or statistics , make sure to check out some of our other articles with explanations and examples.

Methodology

Sampling methods
Simple random sampling
Stratified sampling
Cluster sampling
Likert scales
Reproducibility

Statistics

Null hypothesis
Statistical power
Probability distribution
Effect size
Poisson distribution

Research bias

Optimism bias
Cognitive bias
Implicit bias
Hawthorne effect
Anchoring bias
Explicit bias

Once you’ve decided on your research objectives , you need to explain them in your paper, at the end of your problem statement .

Keep your research objectives clear and concise, and use appropriate verbs to accurately convey the work that you will carry out for each one.

I will compare …

A research aim is a broad statement indicating the general purpose of your research project. It should appear in your introduction at the end of your problem statement , before your research objectives.

Research objectives are more specific than your research aim. They indicate the specific ways you’ll address the overarching aim.

A PhD, which is short for philosophiae doctor (doctor of philosophy in Latin), is the highest university degree that can be obtained. In a PhD, students spend 3–5 years writing a dissertation , which aims to make a significant, original contribution to current knowledge.

A PhD is intended to prepare students for a career as a researcher, whether that be in academia, the public sector, or the private sector.

A master’s is a 1- or 2-year graduate degree that can prepare you for a variety of careers.

All master’s involve graduate-level coursework. Some are research-intensive and intend to prepare students for further study in a PhD; these usually require their students to write a master’s thesis . Others focus on professional training for a specific career.

Critical thinking refers to the ability to evaluate information and to be aware of biases or assumptions, including your own.

Like information literacy , it involves evaluating arguments, identifying and solving problems in an objective and systematic way, and clearly communicating your ideas.

The best way to remember the difference between a research plan and a research proposal is that they have fundamentally different audiences. A research plan helps you, the researcher, organize your thoughts. On the other hand, a dissertation proposal or research proposal aims to convince others (e.g., a supervisor, a funding body, or a dissertation committee) that your research topic is relevant and worthy of being conducted.

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Research Methodology in Bioscience and Biotechnology

Research Mindset • Best Practices • Integrity • Publications • Societal Impact

© 2023
Kian Mau Goh 0

Faculty of Science, Universiti Teknologi Malaysia, Johor, Malaysia

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Provides an overview of good research practices and mindsets

Shortens the learning curve for beginners in science writing and presentation

Underline the importance of research integrity and ethics despite the KPI pressure

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Table of contents (8 chapters)

Front matter, science and philosophy.

Kian Mau Goh

Student’s Proposal, Dissertation, or Thesis

Research integrity and publication ethics, good research practices, publication 101, improving writing and presentation skills, lessons learned from nature’s reports, success can be learned, back matter.

Research methodology
Journal publication
Research proposal
Thesis writing
Good research practice
Research integrity

About this book

This monograph offers a comprehensive guide to good research practices and mindsets, covering a wide range of topics across 8 chapters. Readers will find numerous themes and strategies that can help them develop their research skills and achieve their objectives, from effective proposal writing to stress management and upskilling. This book explains the purpose, process, tips, and mistakes of writing proposals, theses, articles, and reviews in clear and straightforward language, allowing readers to develop good research plans. By applying the advice and insights offered in this book, students and researchers can improve the quality of their work, cultivate research integrity, and develop good publication plans, write well, and reduce rejection rates. Research outputs will be more likely to be of high quality if students and researchers are encouraged to cultivate these pieces of advice. The focus of the book is not solely on the outcomes of research. Rather, it also delves into mindset, habits, adaptability, time management, stress management, recent tools for upskilling, planning, and execution. Throughout the book, the author seeks to instill a growth mindset in the readers, encouraging them to develop positive research habits and behaviors. KPIs, particularly publications, shall not be used as a reason to erode research integrity and ethnicity; therefore, plagiarism, self-citation, falsifying data, exaggerating findings, authorship in publications, the use of AI tools, CRediT, and COPE are discussed. This book contains interviews with high-profile researchers, top management at institutions, policy advisers, etc., whose opinions and advice the readers will find valuable. Overall, this all-in-one guide is an essential resource for postgraduate students, post-doctoral fellows, and academics who are struggling to find a survival strategy in the rapidly changing research environment. The book assists readers in developing right mindset, planning their research and publications, and in achieving their predetermined objectives.

Authors and Affiliations

About the author.

Kian Mau Goh obtained his Bachelor's degree in Chemical-Bioprocess Engineering from the esteemed engineering faculty in Universiti Teknologi Malaysia (UTM) in 2002. After graduation, he gained invaluable experience as a research scientist at A*STAR/National University of Singapore for two years before returning to UTM to complete his PhD in Protein Engineering in 2007. His team focuses on extremophiles, primarily thermophiles and halophiles, and his research interests include protein engineering, enzymology, metataxonomics, and metagenomics, as well as microbial comparative genomics and transcriptomics.

Bibliographic Information

Book Title : Research Methodology in Bioscience and Biotechnology

Book Subtitle : Research Mindset • Best Practices • Integrity • Publications • Societal Impact

Authors : Kian Mau Goh

DOI : https://doi.org/10.1007/978-981-99-2812-5

Publisher : Springer Singapore

eBook Packages : Biomedical and Life Sciences , Biomedical and Life Sciences (R0)

Copyright Information : The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2023

Hardcover ISBN : 978-981-99-2811-8 Published: 29 July 2023

Softcover ISBN : 978-981-99-2814-9 Due: 12 August 2024

eBook ISBN : 978-981-99-2812-5 Published: 28 July 2023

Edition Number : 1

Number of Pages : XXIII, 241

Number of Illustrations : 1 b/w illustrations

Topics : Plant Sciences , Biological Techniques , Biotechnology

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Prof. Christopher Burge
Prof. David Sabatini
Dr. Marilee Ogren-Balkema
Dr. Alice Rushforth

Departments

As taught in.

Biotechnology
Molecular Biology

Learning Resource Types

Experimental molecular biology: biotechnology ii, scientific comm..

This course includes significant instruction in scientific communications. During the term, Dr. Marilee Ogren-Balkema presents ten lectures on a range of reading, presentation and writing topics.

Background reading

Gopen, George D., and Judith A. Swan. “ The Science of Scientific Writing .” The American Scientist 78 (1990): 550-558.

Lectures on Scientific Communications

1: Basic Scientific Communication ( PDF )

2: How to Review the Literature ( PDF )

3: How To Write a Research Proposal ( PDF )

4: Preparing Effective Oral Presentations ( PDF )

5: How to Write a Mini Literature Review ( PDF )

6: How to Write a Research Paper I: Illustrations ( PDF - 1.2 MB )

7: How to Write a Research Paper II: Results Section ( PDF )

8: How to Write a Research Paper III: Methods Section ( PDF )

9: How to Write a Research Paper IV: Introduction and Discussion ( PDF )

10: How to Write a Research Paper V: Title and Abstract ( PDF )

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200+ Biotechnology Research Topics: Let’s Shape the Future

In the dynamic landscape of scientific exploration, biotechnology stands at the forefront, revolutionizing the way we approach healthcare, agriculture, and environmental sustainability. This interdisciplinary field encompasses a vast array of research topics that hold the potential to reshape our world.

In this blog post, we will delve into the realm of biotechnology research topics, understanding their significance and exploring the diverse avenues that researchers are actively investigating.

Overview of Biotechnology Research

Table of Contents

Biotechnology, at its core, involves the application of biological systems, organisms, or derivatives to develop technologies and products for the benefit of humanity.

The scope of biotechnology research is broad, covering areas such as genetic engineering, biomedical engineering, environmental biotechnology, and industrial biotechnology. Its interdisciplinary nature makes it a melting pot of ideas and innovations, pushing the boundaries of what is possible.

Unlock your academic potential with expert . Our experienced professionals are here to guide you, ensuring top-notch quality and timely submissions. Don’t let academic stress hold you back – excel with confidence!

How to Select The Best Biotechnology Research Topics?

Identify Your Interests

Start by reflecting on your own interests within the broad field of biotechnology. What aspects of biotechnology excite you the most? Identifying your passion will make the research process more engaging.

Stay Informed About Current Trends

Keep up with the latest developments and trends in biotechnology. Subscribe to scientific journals, attend conferences, and follow reputable websites to stay informed about cutting-edge research. This will help you identify gaps in knowledge or areas where advancements are needed.

Consider Societal Impact

Evaluate the potential societal impact of your chosen research topic. How does it contribute to solving real-world problems? Biotechnology has applications in healthcare, agriculture, environmental conservation, and more. Choose a topic that aligns with the broader goal of improving quality of life or addressing global challenges.

Assess Feasibility and Resources

Evaluate the feasibility of your research topic. Consider the availability of resources, including laboratory equipment, funding, and expertise. A well-defined and achievable research plan will increase the likelihood of successful outcomes.

Explore Innovation Opportunities

Look for opportunities to contribute to innovation within the field. Consider topics that push the boundaries of current knowledge, introduce novel methodologies, or explore interdisciplinary approaches. Innovation often leads to groundbreaking discoveries.

Consult with Mentors and Peers

Seek guidance from mentors, professors, or colleagues who have expertise in biotechnology. Discuss your research interests with them and gather insights. They can provide valuable advice on the feasibility and significance of your chosen topic.

Balance Specificity and Breadth

Strike a balance between biotechnology research topics that are specific enough to address a particular aspect of biotechnology and broad enough to allow for meaningful research. A topic that is too narrow may limit your research scope, while one that is too broad may lack focus.

Consider Ethical Implications

Be mindful of the ethical implications of your research. Biotechnology, especially areas like genetic engineering, can raise ethical concerns. Ensure that your chosen topic aligns with ethical standards and consider how your research may impact society.

Evaluate Industry Relevance

Consider the relevance of your research topic to the biotechnology industry. Industry-relevant research has the potential for practical applications and may attract funding and collaboration opportunities.

Stay Flexible and Open-Minded

Be open to refining or adjusting your research topic as you delve deeper into the literature and gather more information. Flexibility is key to adapting to new insights and developments in the field.

200+ Biotechnology Research Topics: Category-Wise

Genetic engineering.

CRISPR-Cas9: Recent Advances and Applications
Gene Editing for Therapeutic Purposes: Opportunities and Challenges
Precision Medicine and Personalized Genomic Therapies
Genome Sequencing Technologies: Current State and Future Prospects
Synthetic Biology: Engineering New Life Forms
Genetic Modification of Crops for Improved Yield and Resistance
Ethical Considerations in Human Genetic Engineering
Gene Therapy for Neurological Disorders
Epigenetics: Understanding the Role of Gene Regulation
CRISPR in Agriculture: Enhancing Crop Traits

Biomedical Engineering

Tissue Engineering: Creating Organs in the Lab
3D Printing in Biomedical Applications
Advances in Drug Delivery Systems
Nanotechnology in Medicine: Theranostic Approaches
Bioinformatics and Computational Biology in Biomedicine
Wearable Biomedical Devices for Health Monitoring
Stem Cell Research and Regenerative Medicine
Precision Oncology: Tailoring Cancer Treatments
Biomaterials for Biomedical Applications
Biomechanics in Biomedical Engineering

Environmental Biotechnology

Bioremediation of Polluted Environments
Waste-to-Energy Technologies: Turning Trash into Power
Sustainable Agriculture Practices Using Biotechnology
Bioaugmentation in Wastewater Treatment
Microbial Fuel Cells: Harnessing Microorganisms for Energy
Biotechnology in Conservation Biology
Phytoremediation: Plants as Environmental Cleanup Agents
Aquaponics: Integration of Aquaculture and Hydroponics
Biodiversity Monitoring Using DNA Barcoding
Algal Biofuels: A Sustainable Energy Source

Industrial Biotechnology

Enzyme Engineering for Industrial Applications
Bioprocessing and Bio-manufacturing Innovations
Industrial Applications of Microbial Biotechnology
Bio-based Materials: Eco-friendly Alternatives
Synthetic Biology for Industrial Processes
Metabolic Engineering for Chemical Production
Industrial Fermentation: Optimization and Scale-up
Biocatalysis in Pharmaceutical Industry
Advanced Bioprocess Monitoring and Control
Green Chemistry: Sustainable Practices in Industry

Emerging Trends in Biotechnology

CRISPR-Based Diagnostics: A New Era in Disease Detection
Neurobiotechnology: Advancements in Brain-Computer Interfaces
Advances in Nanotechnology for Healthcare
Computational Biology: Modeling Biological Systems
Organoids: Miniature Organs for Drug Testing
Genome Editing in Non-Human Organisms
Biotechnology and the Internet of Things (IoT)
Exosome-based Therapeutics: Potential Applications
Biohybrid Systems: Integrating Living and Artificial Components
Metagenomics: Exploring Microbial Communities

Ethical and Social Implications

Ethical Considerations in CRISPR-Based Gene Editing
Privacy Concerns in Personal Genomic Data Sharing
Biotechnology and Social Equity: Bridging the Gap
Dual-Use Dilemmas in Biotechnological Research
Informed Consent in Genetic Testing and Research
Accessibility of Biotechnological Therapies: Global Perspectives
Human Enhancement Technologies: Ethical Perspectives
Biotechnology and Cultural Perspectives on Genetic Modification
Social Impact Assessment of Biotechnological Interventions
Intellectual Property Rights in Biotechnology

Computational Biology and Bioinformatics

Machine Learning in Biomedical Data Analysis
Network Biology: Understanding Biological Systems
Structural Bioinformatics: Predicting Protein Structures
Data Mining in Genomics and Proteomics
Systems Biology Approaches in Biotechnology
Comparative Genomics: Evolutionary Insights
Bioinformatics Tools for Drug Discovery
Cloud Computing in Biomedical Research
Artificial Intelligence in Diagnostics and Treatment
Computational Approaches to Vaccine Design

Health and Medicine

Vaccines and Immunotherapy: Advancements in Disease Prevention
CRISPR-Based Therapies for Genetic Disorders
Infectious Disease Diagnostics Using Biotechnology
Telemedicine and Biotechnology Integration
Biotechnology in Rare Disease Research
Gut Microbiome and Human Health
Precision Nutrition: Personalized Diets Using Biotechnology
Biotechnology Approaches to Combat Antibiotic Resistance
Point-of-Care Diagnostics for Global Health
Biotechnology in Aging Research and Longevity

Agricultural Biotechnology

CRISPR and Gene Editing in Crop Improvement
Precision Agriculture: Integrating Technology for Crop Management
Biotechnology Solutions for Food Security
RNA Interference in Pest Control
Vertical Farming and Biotechnology
Plant-Microbe Interactions for Sustainable Agriculture
Biofortification: Enhancing Nutritional Content in Crops
Smart Farming Technologies and Biotechnology
Precision Livestock Farming Using Biotechnological Tools
Drought-Tolerant Crops: Biotechnological Approaches

Biotechnology and Education

Integrating Biotechnology into STEM Education
Virtual Labs in Biotechnology Teaching
Biotechnology Outreach Programs for Schools
Online Courses in Biotechnology: Accessibility and Quality
Hands-on Biotechnology Experiments for Students
Bioethics Education in Biotechnology Programs
Role of Internships in Biotechnology Education
Collaborative Learning in Biotechnology Classrooms
Biotechnology Education for Non-Science Majors
Addressing Gender Disparities in Biotechnology Education

Funding and Policy

Government Funding Initiatives for Biotechnology Research
Private Sector Investment in Biotechnology Ventures
Impact of Intellectual Property Policies on Biotechnology
Ethical Guidelines for Biotechnological Research
Public-Private Partnerships in Biotechnology
Regulatory Frameworks for Gene Editing Technologies
Biotechnology and Global Health Policy
Biotechnology Diplomacy: International Collaboration
Funding Challenges in Biotechnology Startups
Role of Nonprofit Organizations in Biotechnological Research

Biotechnology and the Environment

Biotechnology for Air Pollution Control
Microbial Sensors for Environmental Monitoring
Remote Sensing in Environmental Biotechnology
Climate Change Mitigation Using Biotechnology
Circular Economy and Biotechnological Innovations
Marine Biotechnology for Ocean Conservation
Bio-inspired Design for Environmental Solutions
Ecological Restoration Using Biotechnological Approaches
Impact of Biotechnology on Biodiversity
Biotechnology and Sustainable Urban Development

Biosecurity and Biosafety

Biosecurity Measures in Biotechnology Laboratories
Dual-Use Research and Ethical Considerations
Global Collaboration for Biosafety in Biotechnology
Security Risks in Gene Editing Technologies
Surveillance Technologies in Biotechnological Research
Biosecurity Education for Biotechnology Professionals
Risk Assessment in Biotechnology Research
Bioethics in Biodefense Research
Biotechnology and National Security
Public Awareness and Biosecurity in Biotechnology

Industry Applications

Biotechnology in the Pharmaceutical Industry
Bioprocessing Innovations for Drug Production
Industrial Enzymes and Their Applications
Biotechnology in Food and Beverage Production
Applications of Synthetic Biology in Industry
Biotechnology in Textile Manufacturing
Cosmetic and Personal Care Biotechnology
Biotechnological Approaches in Renewable Energy
Advanced Materials Production Using Biotechnology
Biotechnology in the Automotive Industry

Miscellaneous Topics

DNA Barcoding in Species Identification
Bioart: The Intersection of Biology and Art
Biotechnology in Forensic Science
Using Biotechnology to Preserve Cultural Heritage
Biohacking: DIY Biology and Citizen Science
Microbiome Engineering for Human Health
Environmental DNA (eDNA) for Biodiversity Monitoring
Biotechnology and Astrobiology: Searching for Life Beyond Earth
Biotechnology and Sports Science
Biotechnology and the Future of Space Exploration

Challenges and Ethical Considerations in Biotechnology Research

As biotechnology continues to advance, it brings forth a set of challenges and ethical considerations. Biosecurity concerns, especially in the context of gene editing technologies, raise questions about the responsible use of powerful tools like CRISPR.

Ethical implications of genetic manipulation, such as the creation of designer babies, demand careful consideration and international collaboration to establish guidelines and regulations.

Moreover, the environmental and social impact of biotechnological interventions must be thoroughly assessed to ensure responsible and sustainable practices.

Funding and Resources for Biotechnology Research

The pursuit of biotechnology research topics requires substantial funding and resources. Government grants and funding agencies play a pivotal role in supporting research initiatives.

Simultaneously, the private sector, including biotechnology companies and venture capitalists, invest in promising projects. Collaboration and partnerships between academia, industry, and nonprofit organizations further amplify the impact of biotechnological research.

Future Prospects of Biotechnology Research

As we look to the future, the integration of biotechnology with other scientific disciplines holds immense potential. Collaborations with fields like artificial intelligence, materials science, and robotics may lead to unprecedented breakthroughs.

The development of innovative technologies and their application to global health and sustainability challenges will likely shape the future of biotechnology.

In conclusion, biotechnology research is a dynamic and transformative force with the potential to revolutionize multiple facets of our lives. The exploration of diverse biotechnology research topics, from genetic engineering to emerging trends like synthetic biology and nanobiotechnology, highlights the breadth of possibilities within this field.

However, researchers must navigate challenges and ethical considerations to ensure that biotechnological advancements are used responsibly for the betterment of society.

With continued funding, collaboration, and a commitment to ethical practices, the future of biotechnology research holds exciting promise, propelling us towards a more sustainable and technologically advanced world.

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Biotechnology Research Paper Topics

This collection of biotechnology research paper topics provides the list of 10 potential topics for research papers and overviews the history of biotechnology.

Academic Writing, Editing, Proofreading, And Problem Solving Services

Get 10% off with 24start discount code, 1. animal breeding: genetic methods.

Modern animal breeding relies on scientific methods to control production of domesticated animals, both livestock and pets, which exhibit desired physical and behavioral traits. Genetic technology aids animal breeders to attain nutritional, medical, recreational, and fashion standards demanded by consumers for animal products including meat, milk, eggs, leather, wool, and pharmaceuticals. Animals are also genetically designed to meet labor and sporting requirements for speed and endurance, conformation and beauty ideals to win show competitions, and intelligence levels to perform obediently at tasks such as herding, hunting, and tracking. By the late twentieth century, genetics and mathematical models were appropriated to identify the potential of immature animals. DNA markers indicate how young animals will mature, saving breeders money by not investing in animals lacking genetic promise. Scientists also successfully transplanted sperm-producing stem cells with the goal of restoring fertility to barren breeding animals. At the National Animal Disease Center in Ames, Iowa, researchers created a gene-based test, which uses a cloned gene of the organism that causes Johne’s disease in cattle in order to detect that disease to avert epidemics. Researchers also began mapping the dog genome and developing molecular techniques to evaluate canine chromosomes in the Quantitative Trait Loci (QTL). Bioinformatics incorporates computers to analyze genetic material. Some tests were developed to diagnose many of several hundred genetic canine diseases including hip dysplasia and progressive retinal atrophy (PRA). A few breed organizations modified standards to discourage breeding of genetically flawed animals and promote heterozygosity.

2. Antibacterial Chemotherapy

In the early years of the twentieth century, the search for agents that would be effective against internal infections proceeded along two main routes. The first was a search for naturally occurring substances that were effective against microorganisms (antibiosis). The second was a search for chemicals that would have the same effect (chemotherapy). Despite the success of penicillin in the 1940s, the major early advances in the treatment of infection occurred not through antibiosis but through chemotherapy. The principle behind chemotherapy was that there was a relationship between chemical structure and pharmacological action. The founder of this concept was Paul Erhlich (1854–1915). An early success came in 1905 when atoxyl (an organic arsenic compound) was shown to destroy trypanosomes, the microbes that caused sleeping sickness. Unfortunately, atoxyl also damaged the optic nerve. Subsequently, Erhlich and his co-workers synthesized and tested hundreds of related arsenic compounds. Ehrlich was a co-recipient (with Ilya Ilyich Mechnikov) of the Nobel Prize in medicine in 1908 for his work on immunity. Success in discovering a range of effective antibacterial drugs had three important consequences: it brought a range of important diseases under control for the first time; it provided a tremendous stimulus to research workers and opened up new avenues of research; and in the resulting commercial optimism, it led to heavy postwar investment in the pharmaceutical industry. The therapeutic revolution had begun.

3. Artificial Insemination and in Vitro Fertilization

Artificial insemination (AI) involves the extraction and collection of semen together with techniques for depositing semen in the uterus in order to achieve successful fertilization and pregnancy. Throughout the twentieth century, the approach has offered animal breeders the advantage of being able to utilize the best available breeding stock and at the correct time within the female reproductive cycle, but without the limitations of having the animals in the same location. AI has been applied most intensively within the dairy and beef cattle industries and to a lesser extent horse breeding and numerous other domesticated species.

Many of the techniques involved in artificial insemination would lay the foundation for in vitro fertilization (IVF) in the latter half of the twentieth century. IVF refers to the group of technologies that allow fertilization to take place outside the body involving the retrieval of ova or eggs from the female and sperm from the male, which are then combined in artificial, or ‘‘test tube,’’ conditions leading to fertilization. The fertilized eggs then continue to develop for several days ‘‘in culture’’ until being transferred to the female recipient to continue developing within the uterus.

4. Biopolymers

Biopolymers are natural polymers, long-chained molecules (macromolecules) consisting mostly of a repeated composition of building blocks or monomers that are formed and utilized by living organisms. Each group of biopolymers is composed of different building blocks, for example chains of sugar molecules form starch (a polysaccharide), chains of amino acids form proteins and peptides, and chains of nucleic acid form DNA and RNA (polynucleotides). Biopolymers can form gels, fibers, coatings, and films depending on the specific polymer, and serve a variety of critical functions for cells and organisms. Proteins including collagens, keratins, silks, tubulins, and actin usually form structural composites or scaffolding, or protective materials in biological systems (e.g., spider silk). Polysaccharides function in molecular recognition at cell membrane surfaces, form capsular barrier layers around cells, act as emulsifiers and adhesives, and serve as skeletal or architectural materials in plants. In many cases these polymers occur in combination with proteins to form novel composite structures such as invertebrate exoskeletons or microbial cell walls, or with lignin in the case of plant cell walls.

The use of the word ‘‘cloning’’ is fraught with confusion and inconsistency, and it is important at the outset of this discussion to offer definitional clarification. For instance, in the 1997 article by Ian Wilmut and colleagues announcing the birth of the first cloned adult vertebrate (a ewe, Dolly the sheep) from somatic cell nuclear transfer, the word clone or cloning was never used, and yet the announcement raised considerable disquiet about the prospect of cloned human beings. In a desire to avoid potentially negative forms of language, many prefer to substitute ‘‘cell expansion techniques’’ or ‘‘therapeutic cloning’’ for cloning. Cloning has been known for centuries as a horticultural propagation method: for example, plants multiplied by grafting, budding, or cuttings do not differ genetically from the original plant. The term clone entered more common usage as a result of a speech in 1963 by J.B.S. Haldane based on his paper, ‘‘Biological possibilities for the human species of the next ten-thousand years.’’ Notwithstanding these notes of caution, we can refer to a number of processes as cloning. At the close of the twentieth century, such techniques had not yet progressed to the ability to bring a cloned human to full development; however, the ability to clone cells from an adult human has potential to treat diseases. International policymaking in the late 1990s sought to distinguish between the different end uses for somatic cell nuclear transfer resulting in the widespread adoption of the distinction between ‘‘reproductive’’ and ‘‘therapeutic’’ cloning. The function of the distinction has been to permit the use (in some countries) of the technique to generate potentially beneficial therapeutic applications from embryonic stem cell technology whilst prohibiting its use in human reproduction. In therapeutic applications, nuclear transfer from a patient’s cells into an enucleated ovum is used to create genetically identical embryos that would be grown in vitro but not be allowed to continue developing to become a human being. The resulting cloned embryos could be used as a source from which to produce stem cells that can then be induced to specialize into the specific type of tissue required by the patient (such as skin for burns victims, brain neuron cells for Parkinson’s disease sufferers, or pancreatic cells for diabetics). The rationale is that because the original nuclear material is derived from a patient’s adult tissue, the risks of rejection of such cells by the immune system are reduced.

6. Gene Therapy

In 1971, Australian Nobel laureate Sir F. MacFarlane Burnet thought that gene therapy (introducing genes into body tissue, usually to treat an inherited genetic disorder) looked more and more like a case of the emperor’s new clothes. Ethical issues aside, he believed that practical considerations forestalled possibilities for any beneficial gene strategy, then or probably ever. Bluntly, he wrote: ‘‘little further advance can be expected from laboratory science in the handling of ‘intrinsic’ types of disability and disease.’’ Joshua Lederberg and Edward Tatum, 1958 Nobel laureates, theorized in the 1960s that genes might be altered or replaced using viral vectors to treat human diseases. Stanfield Rogers, working from the Oak Ridge National Laboratory in 1970, had tried but failed to cure argininemia (a genetic disorder of the urea cycle that causes neurological damage in the form of mental retardation, seizures, and eventually death) in two German girls using Swope papilloma virus. Martin Cline at the University of California in Los Angeles, made the second failed attempt a decade later. He tried to correct the bone marrow cells of two beta-thalassemia patients, one in Israel and the other in Italy. What Cline’s failure revealed, however, was that many researchers who condemned his trial as unethical were by then working toward similar goals and targeting different diseases with various delivery methods. While Burnet’s pessimism finally proved to be wrong, progress in gene therapy was much slower than antibiotic or anticancer chemotherapy developments over the same period of time. While gene therapy had limited success, it nevertheless remained an active area for research, particularly because the Human Genome Project, begun in 1990, had resulted in a ‘‘rough draft’’ of all human genes by 2001, and was completed in 2003. Gene mapping created the means for analyzing the expression patterns of hundreds of genes involved in biological pathways and for identifying single nucleotide polymorphisms (SNPs) that have diagnostic and therapeutic potential for treating specific diseases in individuals. In the future, gene therapies may prove effective at protecting patients from adverse drug reactions or changing the biochemical nature of a person’s disease. They may also target blood vessel formation in order to prevent heart disease or blindness due to macular degeneration or diabetic retinopathy. One of the oldest ideas for use of gene therapy is to produce anticancer vaccines. One method involves inserting a granulocyte-macrophage colony-stimulating factor gene into prostate tumor cells removed in surgery. The cells then are irradiated to prevent any further cancer and injected back into the same patient to initiate an immune response against any remaining metastases. Whether or not such developments become a major treatment modality, no one now believes, as MacFarland Burnet did in 1970, that gene therapy science has reached an end in its potential to advance health.

7. Genetic Engineering

The term ‘‘genetic engineering’’ describes molecular biology techniques that allow geneticists to analyze and manipulate deoxyribonucleic acid (DNA). At the close of the twentieth century, genetic engineering promised to revolutionize many industries, including microbial biotechnology, agriculture, and medicine. It also sparked controversy over potential health and ecological hazards due to the unprecedented ability to bypass traditional biological reproduction.

For centuries, if not millennia, techniques have been employed to alter the genetic characteristics of animals and plants to enhance specifically desired traits. In a great many cases, breeds with which we are most familiar bear little resemblance to the wild varieties from which they are derived. Canine breeds, for instance, have been selectively tailored to changing esthetic tastes over many years, altering their appearance, behavior and temperament. Many of the species used in farming reflect long-term alterations to enhance meat, milk, and fleece yields. Likewise, in the case of agricultural varieties, hybridization and selective breeding have resulted in crops that are adapted to specific production conditions and regional demands. Genetic engineering differs from these traditional methods of plant and animal breeding in some very important respects. First, genes from one organism can be extracted and recombined with those of another (using recombinant DNA, or rDNA, technology) without either organism having to be of the same species. Second, removing the requirement for species reproductive compatibility, new genetic combinations can be produced in a much more highly accelerated way than before. Since the development of the first rDNA organism by Stanley Cohen and Herbert Boyer in 1973, a number of techniques have been found to produce highly novel products derived from transgenic plants and animals.

At the same time, there has been an ongoing and ferocious political debate over the environmental and health risks to humans of genetically altered species. The rise of genetic engineering may be characterized by developments during the last three decades of the twentieth century.

8. Genetic Screening and Testing

The menu of genetic screening and testing technologies now available in most developed countries increased rapidly in the closing years of the twentieth century. These technologies emerged within the context of rapidly changing social and legal contexts with regard to the medicalization of pregnancy and birth and the legalization of abortion. The earliest genetic screening tests detected inborn errors of metabolism and sex-linked disorders. Technological innovations in genomic mapping and DNA sequencing, together with an explosion in research on the genetic basis of disease which culminated in the Human Genome Project (HGP), led to a range of genetic screening and testing for diseases traditionally recognized as genetic in origin and for susceptibility to more common diseases such as certain types of familial cancer, cardiac conditions, and neurological disorders among others. Tests were also useful for forensic, or nonmedical, purposes. Genetic screening techniques are now available in conjunction with in vitro fertilization and other types of reproductive technologies, allowing the screening of fertilized embryos for certain genetic mutations before selection for implantation. At present selection is purely on disease grounds and selection for other traits (e.g., for eye or hair color, intelligence, height) cannot yet be done, though there are concerns for eugenics and ‘‘designer babies.’’ Screening is available for an increasing number of metabolic diseases through tandem mass spectrometry, which uses less blood per test, allows testing for many conditions simultaneously, and has a very low false-positive rate as compared to conventional Guthrie testing. Finally, genetic technologies are being used in the judicial domain for determination of paternity, often associated with child support claims, and for forensic purposes in cases where DNA material is available for testing.

9. Plant Breeding: Genetic Methods

The cultivation of plants is the world’s oldest biotechnology. We have continually tried to produce improved varieties while increasing yield, features to aid cultivation and harvesting, disease, and pest resistance, or crop qualities such as longer postharvest storage life and improved taste or nutritional value. Early changes resulted from random crosspollination, rudimentary grafting, or spontaneous genetic change. For centuries, man kept the seed from the plants with improved characteristics to plant the following season’s crop. The pioneering work of Gregor Mendel and his development of the basic laws of heredity showed for other first time that some of the processes of heredity could be altered by experimental means. The genetic analysis of bacterial (prokaryote) genes and techniques for analysis of the higher (eukaryotic) organisms such as plants developed in parallel streams, but the rediscovery of Mendel’s work in 1900 fueled a burst of activity on understanding the role of genes in inheritance. The knowledge that genes are linked along the chromosome thereby allowed mapping of genes (transduction analysis, conjugation analysis, and transformation analysis). The power of genetics to produce a desirable plant was established, and it was appreciated that controlled breeding (test crosses and back crosses) and careful analysis of the progeny could distinguish traits that were dominant or recessive, and establish pure breeding lines. Traditional horticultural techniques of artificial self-pollination and cross-pollination were also used to produce hybrids. In the 1930s the Russian Nikolai Vavilov recognized the value of genetic diversity in domesticated crop plants and their wild relatives to crop improvement, and collected seeds from the wild to study total genetic diversity and use these in breeding programs. The impact of scientific crop breeding was established by the ‘‘Green revolution’’ of the 1960s, when new wheat varieties with higher yields were developed by careful crop breeding. ‘‘Mutation breeding’’— inducing mutations by exposing seeds to x-rays or chemicals such as sodium azide, accelerated after World War II. It was also discovered that plant cells and tissues grown in tissue culture would mutate rapidly. In the 1970s, haploid breeding, which involves producing plants from two identical sets of chromosomes, was extensively used to create new cultivars. In the twenty-first century, haploid breeding could speed up plant breeding by shortening the breeding cycle.

10. Tissue Culturing

The technique of tissue or cell culture, which relates to the growth of tissue or cells within a laboratory setting, underlies a phenomenal proportion of biomedical research. Though it has roots in the late nineteenth century, when numerous scientists tried to grow samples in alien environments, cell culture is credited as truly beginning with the first concrete evidence of successful growth in vitro, demonstrated by Johns Hopkins University embryologist Ross Harrison in 1907. Harrison took sections of spinal cord from a frog embryo, placed them on a glass cover slip and bathed the tissue in a nutrient media. The results of the experiment were startling—for the first time scientists visualized actual nerve growth as it would happen in a living organism—and many other scientists across the U.S. and Europe took up culture techniques. Rather unwittingly, for he was merely trying to settle a professional dispute regarding the origin of nerve fibers, Harrison fashioned a research tool that has since been designated by many as the greatest advance in medical science since the invention of the microscope.

From the 1980s, cell culture has once again been brought to the forefront of cancer research in the isolation and identification of numerous cancer causing oncogenes. In addition, cell culturing continues to play a crucial role in fields such as cytology, embryology, radiology, and molecular genetics. In the future, its relevance to direct clinical treatment might be further increased by the growth in culture of stem cells and tissue replacement therapies that can be tailored for a particular individual. Indeed, as cell culture approaches its centenary, it appears that its importance to scientific, medical, and commercial research the world over will only increase in the twenty-first century.

History of Biotechnology

Biotechnology grew out of the technology of fermentation, which was called zymotechnology. This was different from the ancient craft of brewing because of its thought-out relationships to science. These were most famously conceptualized by the Prussian chemist Georg Ernst Stahl (1659–1734) in his 1697 treatise Zymotechnia Fundamentalis, in which he introduced the term zymotechnology. Carl Balling, long-serving professor in Prague, the world center of brewing, drew on the work of Stahl when he published his Bericht uber die Fortschritte der zymotechnische Wissenschaften und Gewerbe (Account of the Progress of the Zymotechnic Sciences and Arts) in the mid-nineteenth century. He used the idea of zymotechnics to compete with his German contemporary Justus Liebig for whom chemistry was the underpinning of all processes.

By the end of the nineteenth century, there were attempts to develop a new scientific study of fermentation. It was an aspect of the ‘‘second’’ Industrial Revolution during the period from 1870 to 1914. The emergence of the chemical industry is widely taken as emblematic of the formal research and development taking place at the time. The development of microbiological industries is another example. For the first time, Louis Pasteur’s germ theory made it possible to provide convincing explanations of brewing and other fermentation processes.

Pasteur had published on brewing in the wake of France’s humiliation in the Franco–Prussian war (1870–1871) to assert his country’s superiority in an industry traditionally associated with Germany. Yet the science and technology of fermentation had a wide range of applications including the manufacture of foods (cheese, yogurt, wine, vinegar, and tea), of commodities (tobacco and leather), and of chemicals (lactic acid, citric acid, and the enzyme takaminase). The concept of zymotechnology associated principally with the brewing of beer began to appear too limited to its principal exponents. At the time, Denmark was the world leader in creating high-value agricultural produce. Cooperative farms pioneered intensive pig fattening as well as the mass production of bacon, butter, and beer. It was here that the systems of science and technology were integrated and reintegrated, conceptualized and reconceptualized.

The Dane Emil Christian Hansen discovered that infection from wild yeasts was responsible for numerous failed brews. His contemporary Alfred Jørgensen, a Copenhagen consultant closely associated with the Tuborg brewery, published a widely used textbook on zymotechnology. Microorganisms and Fermentation first appeared in Danish 1889 and would be translated, reedited, and reissued for the next 60 years.

The scarcity of resources on both sides during World War I brought together science and technology, further development of zymotechnology, and formulation of the concept of biotechnology. Impending and then actual war accelerated the use of fermentation technologies to make strategic materials. In Britain a variant of a process to ferment starch to make butadiene for synthetic rubber production was adapted to make acetone needed in the manufacture of explosives. The process was technically important as the first industrial sterile fermentation and was strategically important for munitions supplies. The developer, chemist Chaim Weizmann, later became well known as the first president of Israel in 1949.

In Germany scarce oil-based lubricants were replaced by glycerol made by fermentation. Animal feed was derived from yeast grown with the aid of the new synthetic ammonia in another wartime development that inspired the coining of the word biotechnology. Hungary was the agricultural base of the Austro–Hungarian empire and aspired to Danish levels of efficiency. The economist Karl Ereky (1878–1952) planned to go further and build the largest industrial pig-processing factory. He envisioned a site that would fatten 50,000 swine at a time while railroad cars of sugar beet arrived and fat, hides, and meat departed. In this forerunner of the Soviet collective farm, peasants (in any case now falling prey to the temptations of urban society) would be completely superseded by the industrialization of the biological process in large factory-like animal processing units. Ereky went further in his ruminations over the meaning of his innovation. He suggested that it presaged an industrial revolution that would follow the transformation of chemical technology. In his book entitled Biotechnologie, he linked specific technical injunctions to wide-ranging philosophy. Ereky was neither isolated nor obscure. He had been trained in the mainstream of reflection on the meaning of the applied sciences in Hungary, which would be remarkably productive across the sciences. After World War I, Ereky served as Hungary’s minister of food in the short-lived right wing regime that succeeded the fall of the communist government of Bela Kun.

Nonetheless it was not through Ereky’s direct action that his ideas seem to have spread. Rather, his book was reviewed by the influential Paul Lindner, head of botany at the Institut fu¨ r Ga¨ rungsgewerbe in Berlin, who suggested that microorganisms could also be seen as biotechnological machines. This concept was already found in the production of yeast and in Weizmann’s work with strategic materials, which was widely publicized at that very time. It was with this meaning that the word ‘‘Biotechnologie’’ entered German dictionaries in the 1920s.

Biotechnology represented more than the manipulation of existing organisms. From the beginning it was concerned with their improvement as well, and this meant the enhancement of all living creatures. Most dramatically this would include humanity itself; more mundanely it would include plants and animals of agricultural importance. The enhancement of people was called eugenics by the Victorian polymath and cousin of Charles Darwin, Francis Galton. Two strains of eugenics emerged: negative eugenics associated with weeding out the weak and positive eugenics associated with enhancing strength. In the early twentieth century, many eugenics proponents believed that the weak could be made strong. People had after all progressed beyond their biological limits by means of technology.

Jean-Jacques Virey, a follower of the French naturalist Jean-Baptiste de Monet de Lamarck, had coined the term ‘‘biotechnie’’ in 1828 to describe man’s ability to make technology do the work of biology, but it was not till a century later that the term entered widespread use. The Scottish biologist and town planner Patrick Geddes made biotechnics popular in the English-speaking world. Geddes, too, sought to link life and technology. Before World War I he had characterized the technological evolution of mankind as a move from the paleotechnic era of coal and iron to the neotechnic era of chemicals, electricity, and steel. After the war, he detected a new era based on biology—the biotechnic era. Through his friend, writer Lewis Mumford, Geddes would have great influence. Mumford’s book Technics and Civilization, itself a founding volume of the modern historiography of technology, promoted his vision of the Geddesian evolution.

A younger generation of English experimental biologists with a special interest in genetics, including J. B. S. Haldane, Julian Huxley, and Lancelot Hogben, also promoted a concept of biotechnology in the period between the world wars. Because they wrote popular works, they were among Britain’s best-known scientists. Haldane wrote about biological invention in his far-seeing work Daedalus. Huxley looked forward to a blend of social and eugenics-based biological engineering. Hogben, following Geddes, was more interested in engineering plants through breeding. He tied the progressivism of biology to the advance of socialism.

The improvement of the human race, genetic manipulation of bacteria, and the development of fermentation technology were brought together by the development of penicillin during World War II. This drug was successfully extracted from the juice exuded by a strain of the Penicillium fungus. Although discovered by accident and then developed further for purely scientific reasons, the scarce and unstable ‘‘antibiotic’’ called penicillin was transformed during World War II into a powerful and widely used drug. Large networks of academic and government laboratories and pharmaceutical manufacturers in Britain and the U.S. were coordinated by agencies of the two governments. An unanticipated combination of genetics, biochemistry, chemistry, and chemical engineering skills had been required. When the natural mold was bombarded with high-frequency radiation, far more productive mutants were produced, and subsequently all the medicine was made using the product of these man-made cells. By the 1950s penicillin was cheap to produce and globally available.

The new technology of cultivating and processing large quantities of microorganisms led to calls for a new scientific discipline. Biochemical engineering was one term, and applied microbiology another. The Swedish biologist, Carl-Goran Heden, possibly influenced by German precedents, favored the term ‘‘Biotechnologi’’ and persuaded his friend Elmer Gaden to relabel his new journal Biotechnology and Biochemical Engineering. From 1962 major international conferences were held under the banner of the Global Impact of Applied Microbiology. During the 1960s food based on single-cell protein grown in fermenters on oil or glucose seemed, to visionary engineers and microbiologists and to major companies, to offer an immediate solution to world hunger. Tropical countries rich in biomass that could be used as raw material for fermentation were also the world’s poorest. Alcohol could be manufactured by fermenting such starch or sugar rich crops as sugar cane and corn. Brazil introduced a national program of replacing oil-based petrol with alcohol in the 1970s.

It was not, however, just the developing countries that hoped to benefit. The Soviet Union developed fermentation-based protein as a major source of animal feed through the 1980s. In the U.S. it seemed that oil from surplus corn would solve the problem of low farm prices aggravated by the country’s boycott of the USSR in1979, and the term ‘‘gasohol‘‘ came into currency. Above all, the decline of established industries made the discovery of a new wealth maker an urgent priority for Western governments. Policy makers in both Germany and Japan during the 1970s were driven by a sense of the inadequacy of the last generation of technologies. These were apparently maturing, and the succession was far from clear. Even if electronics or space travel offered routes to the bright industrial future, these fields seemed to be dominated by the U.S. Seeing incipient crisis, the Green, or environmental, movement promoted a technology that would depend on renewable resources and on low-energy processes that would produce biodegradable products, recycle waste, and address problems of the health and nutrition of the world.

In 1973 the German government, seeking a new and ‘‘greener’’ industrial policy, commissioned a report entitled Biotechnologie that identified ways in which biological processing was key to modern developments in technology. Even though the report was published at the time that recombinant DNA (deoxyribonucleic acid) was becoming possible, it did not refer to this new technique and instead focused on the use and combination of existing technologies to make novel products.

Nonetheless the hitherto esoteric science of molecular biology was making considerable progress, although its practice in the early 1970s was rather distant from the world of industrial production. The phrase ‘‘genetic engineering’’ entered common parlance in the 1960s to describe human genetic modification. Medicine, however, put a premium on the use of proteins that were difficult to extract from people: insulin for diabetics and interferon for cancer sufferers. During the early 1970s what had been science fiction became fact as the use of DNA synthesis, restriction enzymes, and plasmids were integrated. In 1973 Stanley Cohen and Herbert Boyer successfully transferred a section of DNA from one E. coli bacterium to another. A few prophets such as Joshua Lederberg and Walter Gilbert argued that the new biological techniques of recombinant DNA might be ideal for making synthetic versions of expensive proteins such as insulin and interferon through their expression in bacterial cells. Small companies, such as Cetus and Genentech in California and Biogen in Cambridge, Massachusetts, were established to develop the techniques. In many cases discoveries made by small ‘‘boutique’’ companies were developed for the market by large, more established, pharmaceutical organizations.

Many governments were impressed by these advances in molecular genetics, which seemed to make biotechnology a potential counterpart to information technology in a third industrial revolution. These inspired hopes of industrial production of proteins identical to those produced in the human body that could be used to treat genetic diseases. There was also hope that industrially useful materials such as alcohol, plastics (biopolymers), or ready-colored fibers might be made in plants, and thus the attractions of a potentially new agricultural era might be as great as the implications for medicine. At a time of concern over low agricultural prices, such hopes were doubly welcome. Indeed, the agricultural benefits sometimes overshadowed the medical implications.

The mechanism for the transfer of enthusiasm from engineering fermenters to engineering genes was the New York Stock Exchange. At the end of the 1970s, new tax laws encouraged already adventurous U.S. investors to put money into small companies whose stock value might grow faster than their profits. The brokerage firm E. F. Hutton saw the potential for the new molecular biology companies such as Biogen and Cetus. Stock market interest in companies promising to make new biological entities was spurred by the 1980 decision of the U.S. Supreme Court to permit the patenting of a new organism. The patent was awarded to the Exxon researcher Ananda Chakrabarty for an organism that metabolized hydrocarbon waste. This event signaled the commercial potential of biotechnology to business and governments around the world. By the early 1980s there were widespread hopes that the protein interferon, made with some novel organism, would provide a cure for cancer. The development of monoclonal antibody technology that grew out of the work of Georges J. F. Kohler and Cesar Milstein in Cambridge (co-recipients with Niels K. Jerne of the Nobel Prize in medicine in 1986) seemed to offer new prospects for precise attacks on particular cells.

The fear of excessive regulatory controls encouraged business and scientific leaders to express optimistic projections about the potential of biotechnology. The early days of biotechnology were fired by hopes of medical products and high-value pharmaceuticals. Human insulin and interferon were early products, and a second generation included the anti-blood clotting agent tPA and the antianemia drug erythropoietin. Biotechnology was also used to help identify potential new drugs that might be made chemically, or synthetically.

At the same time agricultural products were also being developed. Three early products that each raised substantial problems were bacteria which inhibited the formation of frost on the leaves of strawberry plants (ice-minus bacteria), genetically modified plants including tomatoes and rapeseed, and the hormone bovine somatrotropin (BST) produced in genetically modified bacteria and administered to cattle in the U.S. to increase milk yields. By 1999 half the soy beans and one third of the corn grown in the U.S. were modified. Although the global spread of such products would arouse the best known concern at the end of the century, the use of the ice-minus bacteria— the first authorized release of a genetically engineered organism into the environment—had previously raised anxiety in the U.S. in the 1980s.

In 1997 Dolly the sheep was cloned from an adult mother in the Roslin agricultural research institute outside Edinburgh, Scotland. This work was inspired by the need to find a way of reproducing sheep engineered to express human proteins in their milk. However, the public interest was not so much in the cloning of sheep that had just been achieved as in the cloning of people, which had not. As in the Middle Ages when deformed creatures had been seen as monsters and portents of natural disasters, Dolly was similarly seen as monster and as a portent of human cloning.

The name Frankenstein, recalled from the story written by Mary Shelley at the beginning of the nineteenth century and from the movies of the 1930s, was once again familiar at the end of the twentieth century. Shelley had written in the shadow of Stahl’s theories. The continued appeal of this book embodies the continuity of the fears of artificial life and the anxiety over hubris. To this has been linked a more mundane suspicion of the blending of commerce and the exploitation of life. Discussion of biotechnology at the end of the twentieth century was therefore colored by questions of whose assurances of good intent and reassurance of safety could be trusted.

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Summary

In preparation to undertake any new research project, it is wise to prepare one's ground. The most obvious preparation is to ask: what is already known about this area or topic? Less obvious preparations include consideration of the material resources that will be consumed in the course of the research, the cost of these resources and the time available to carry out the proposed research.

Course description

From around the start of the second semester, the class will initiate the process of carrying out the research work that will ultimately lead to the MSc Research Dissertation. Students will work with previous research to do a presentation and this will lead to beginning to work on the material they will examine during the research dissertation.

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On completion of this course, the student will be able to:

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Graduate Attributes and Skills	Better self-organisation, a stronger capacity to think before acting, a greater critical capacity.
Keywords	BiotechReProApp

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Course organiser	Dr Andrew Free (0131 6)50 5338 [email protected]	Course secretary	Ms Andrea Nichol (0131 6)50 8643 [email protected]

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Web enabled Project Management Information system, Department of Biotechnology, Ministry of Science & Technology, Government Of India

Competitive Research Grant Project Proposals under below mentioned R&D programs of the Department of Biotechnology (DBT) can be submitted by the Indian researchers round the year without waiting for specific call for proposals. Department also encourages submission of scientific lead based Innovative Translation Research and Demonstration Projects in all these areas in collaboration with all relevant stakeholders. Proposals in all these areas can be online submitted round the year in DBT Electronic Project Management System (eProMIS). Details of these programs can be seen at: https://dbtindia.gov.in Respective Program Officers can also be contacted for further details. Contact details of all program officers is given in DBT website.

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To provide user friendly system for online submission of proposal and various other documents related to ongoing projects.
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The Department of Biotechnology (DBT) recently initiated new program in the "Emerging Frontiers in Biotechnology". This program will have two verticals namely Biomedical Sciences and Biological Sciences.

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NSF enhances research security with new TRUST proposal assessment process

The U.S. National Science Foundation has announced a new risk mitigation process, the Trusted Research Using Safeguards and Transparency (TRUST) framework, which will guide the agency in assessing grant proposals for potential national security risks. The revised procedures will help safeguard U.S. taxpayer investments in research and innovation while strengthening international collaboration.

Developed by the NSF Office of the Chief of Research Security Strategy and Policy (OCRSSP), the TRUST framework includes three branches. The first focuses on assessing active personnel appointments and positions, while the second focuses on identifying instances of noncompliance with disclosure and other requirements. The third branch — the inclusion of potential foreseeable national security considerations — represents a significant new effort for NSF. The framework is designed to avoid curtailing beneficial research activities due to institutions or individuals in the community being overly cautious, protect the agency's core values of fairness and due process and maintain open lines of communication with the research community.

"This framework represents a major step in pivoting from a compliance culture to a research security culture," said CRSSP Rebecca Keiser. "But we cannot continue to lead the world in science and innovation if we are fixated on achieving zero risk related to research security. We must be bold and invest in science here at home while continuing to encourage principled, mutually beneficial international collaboration. NSF will work collaboratively with the research community, industry, individual researchers and our partners in the U.S. government to identify, understand and address the potential risks so researchers can continue to do their work."

The development of the framework was guided by requirements in the "CHIPS and Science Act of 2022" and the Fiscal Year 2023 Appropriations Report. The "CHIPS and Science Act of 2022" directs NSF to identify research areas that may involve access to "controlled unclassified or classified information" and "exercise due diligence in granting access." The FY 2023 Appropriations Report directs NSF to collaborate with the Secretary of Defense and the Director of National Intelligence to compile and maintain a list of all NSF-funded open-source research capabilities that are known or suspected to have an impact on foreign military operations.

NSF also commissioned a report by JASON, an independent scientific advisory group that provides consulting services to the U.S. government on matters of defense, science and technology. The key findings of the Safeguarding the Research Enterprise report included an assertion that "openness and transparency in fundamental research promote scientific discovery, which improves national security" and recommended specific steps NSF could take to identify sensitive areas of research and processes NSF might use to enhance security in those areas of concern.

The TRUST process will be rolled out in three phases. Beginning in FY 2025, the process will be piloted on quantum-related proposals. The pilot will collect data and assess key metrics, monitor the impact on NSF directorates and build and evaluate NSF's ability to review the potential national security applications of NSF-funded technology. In the second phase, lessons learned from the pilot phase will be implemented and the process will be expanded to include other key "CHIPS and Science Act of 2022"technology areas. In phase 3, NSF will scale up the review process to include all key technology areas and/or the priorities of the NSF Technology, Innovation and Partnerships Directorate's priorities.

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Research proposal for PhD application biotechnology: Background
Example of research proposal biotechnology
(PDF) Biotechnology research and integration with industry
Research Proposal
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Research proposal for PhD application biotechnology: Background

COMMENTS

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A well-formatted research proposal in the field of biotechnology will be written according to the required guidelines forms the mainstay for the research, and hence proposal writing is an essential step in the process of conducting research. The main objective in preparing a research proposal is to obtain approval from several committees such ...
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July 24, 2020. Preparing a concrete research proposal is an integral step ofthe PhD application process in Biotechnology. A well-structured research proposal highlights the significance of the study, defines the research problem, outlines the methodologies, and discusses the implications of the possible outcomes.The process of preparing a ...
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NMT) proposes a multidisciplinary Ph.D. program in Biotechnology to begin in August 2016. The aim of this novel program is to prepare students at the highest level for careers in research, development, and practical applications of the tools of biotechnology, e.g., biomolecular,
Research proposal for PhD application biotechnology: Background ...
Preparing a concrete research proposal is an integral step of the PhD application process in Biotechnology. A well-structured research proposal highlights the significance of the study, defines ...
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Conclusion A research proposal in biotechnology should communicate the researcherâ€™s knowledge on the project, methods and explain the need for the study. We provide a ...
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The Biotech Research Technique is changing. How research is being done is changing, as also how scientists are conducting it. Affected by both B2C eCommerce and growing independence in remote and cloud-dependent working, most of the biotechnology labs are going through some digital transformations. This implies more software, automation, and AI ...
Biotechnology Research Paper Topics
Biotechnology Research Paper Topics. This collection of biotechnology research paper topics provides the list of 10 potential topics for research papers and overviews the history of biotechnology. The term biotechnology came into popular use around 1980 and was understood to mean the industrial use of microorganisms to make goods and services ...
Course Catalogue
On completion of this course, the student will be able to: Use high-level research skills, practical industrial experience, experience in literature and data evaluation experiment planning and design. Demonstrate practical experimentation, data analysis, data recording, data interpretation skills. Create a consultative report.
Funding Opportunities for Engineering Research in Biotechnology
Dear Colleague: With this Dear Colleague Letter, the U.S. National Science Foundation (NSF) Directorate for Engineering (ENG) encourages the submission of research and education proposals related to Biotechnology as an Emerging Industry.. The U.S. is a world leader in biotechnology, a field that comprises the data, tools, research infrastructure, workforce capacity, and innovations that enable ...
(PDF) Biotechnology
and growing collection of techniques, grounded in molecular and cell biology, for. analyzing and manipulating the molecular building blocks of life. The term also. designates products, such as ...
eProMIS
Competitive Research Grant Project Proposals under below mentioned R&D programs of the Department of Biotechnology (DBT) can be submitted by the Indian researchers round the year without waiting for specific call for proposals.
Call For Proposals
Call For Proposals. Title. Currently content not available. Department of Biotechnology, an attached office of the Ministry of Science and Technology, Government of India, Biotechnology is a frontline area of science with immense potential for the benefit of the human kind.
NSF enhances research security with new TRUST proposal assessment
NSF enhances research security with new TRUST proposal assessment process June 5, 2024 The U.S. National Science Foundation has announced a new risk mitigation process, the Trusted Research Using Safeguards and Transparency (TRUST) framework, which will guide the agency in assessing grant proposals for potential national security risks.
Dear Colleague Letter: Catalyzing human-centered solutions through
The target date for full planning proposal submissions is by 5 p.m. submitting organization's local time on July 1, 2024. and planning proposals will only be accepted if accompanied by the email authorization to submit obtained in response to the research concept outline. Planning proposals submitted without written authorization from an NSF ...
Structure for writing a scientific research proposal in biotechnology
A well-formatted research proposal in the field of biotechnology will be written according to the required guidelines forms the mainstay for the research, and hence proposal writing is an essential step in the process of conducting research. The main objective in preparing a research proposal is to obtain approval from several committees such ...
An Update on Sunscreen Requirements: The Deemed Final Order and the
Today, there are two more: FDA is posting the deemed final order for over-the-counter (OTC) sunscreens and is issuing a proposed order for sunscreens. Theresa M. Michele, M.D. In this CDER ...
Job ID:24022408
The SMid-Cap Biotechnology Equity Research team covers companies spanning three main disease areas of oncology, central nervous system disorders, and rare diseases. The lead analyst is top three ranked in the Institutional Investor vote for the smid biotech category. In 2021 the team worked on several priced IPOs and add ons and is currently ...

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Why is it important to write a research proposal?

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The 10 steps to writing an incredible research proposal

1.Choose a research topic and develop a working title

2.Perform a literature review

What have others done so far to solve the research problem?

What additional studies are still needed to solve the research problem?

3.Write an introduction

4. Write research objectives or aims

5.State a research question

6.Formulate a research hypothesis

7.Explain research methods

8.Include potential problems and alternative strategies

9.Conduct and include a preliminary study

10.State the potential impact and significance

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Shona McCombes

Research Methodology in Bioscience and Biotechnology

Faculty of Science, Universiti Teknologi Malaysia, Johor, Malaysia

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200+ Biotechnology Research Topics: Let’s Shape the Future

Overview of Biotechnology Research

How to Select The Best Biotechnology Research Topics?

200+ Biotechnology Research Topics: Category-Wise

Biomedical Engineering

Environmental Biotechnology

Industrial Biotechnology

Emerging Trends in Biotechnology

Ethical and Social Implications