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Little Girl Lost
A Case Study on Defective Cellular Organelles
By Tracie Y. Hudson
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This case study introduces students to the structure and function of cellular organelles and seeks to show their importance by discussing diseases and disorders that can result when an organelle does not function as it should. The storyline follows a family whose joy at bringing home a new baby is soon altered by their child's sudden illness, which is eventually diagnosed as Leigh Disease. This disease occurs when defective mitochondria fail to produce energy needed by the cell, particularly affecting cells with high-energy needs like those in the brain, muscle, and gastrointestinal tract. The narrative also discusses some of the ways in which Leigh disease is inherited, treatment options, and the typical prognosis. The case was designed for an introductory non-majors biology course, but could also be used in other science or health related courses. Instructors also have the option of running the case in a "flipped classroom" in which students watch three recommended videos outside of class as a way of preparing for working on the case in class.
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Date Posted
- Define the term organelle .
- List the key organelles found in animal cells.
- Describe the functions of animal cell organelles.
- Map other disorders and syndromes to the appropriate defective organelles.
- Describe Leigh Syndrome as well as other disorders and syndromes linked to defective cellular organelles.
- Compare and contrast cellular structure and function to that of a factory.
- Create analogies to aid in understanding and remembering the function of cellular organelles.
Organelles; cellular structure; inheritance; plant cells; animal cells; failure to thrive; Leigh Disease; mitochondria; mitochondrial disease; autosomal recessive mutation
Subject Headings
EDUCATIONAL LEVEL
High school, Undergraduate lower division, General public & informal education
TOPICAL AREAS
TYPE/METHODS
Teaching Notes & Answer Key
Teaching notes.
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Teaching notes are intended to help teachers select and adopt a case. They typically include a summary of the case, teaching objectives, information about the intended audience, details about how the case may be taught, and a list of references and resources.
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Answer Keys are protected and access to them is limited to paid subscribed instructors. To become a paid subscriber, purchase a subscription here .
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Materials & Media
Supplemental materials.
- Through the Virtual Cell This video provides an overview of many cellular organelles and also discusses transcription and translation. Running time: 6:47 min. Produced by NDSU Virtual Cell Animations Project, 2009.
- Faces of Mitochondrial Disease—The Swinns Emily Swinn and her family discuss what life is like for Emily, who suffers from a mitochondrial disease. Running time: 2:58 min. Produced by the United Mitochondrial Disease Foundation. Uploaded to YouTube October 29, 2000.
- Cellular Respiration and the Mighty Mitochondria This video provides a general overview of mitochondria, ATP, and cellular respiration. Running time: 7:48 min. Produced by the Amoeba Sisters, 2014.
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Abstract. This case study introduces students to the structure and function of cellular organelles and seeks to show their importance by discussing diseases and disorders that can result when an organelle does not function as it should. The storyline follows a family whose joy at bringing home a new baby is soon altered by their child's sudden ...
Little Girl Lost: A Case Study Defective Cellular Organelles. After many years of trying to get pregnant again, Kenneth and Vicki Johnson were thrilled at the birth of their baby Nicole. T eir frst child had died mysteriously at 12 months of age, and it had taken fve years for Vicki to become pregnant again.
"Little Girl Lost: A Case Study on Defective Cellular ... Using what you have learned about cellular organelles, complete the table by matching the disease or syndrome with the affected organelle using the symptoms and the organelles normal functions as clues.
Little Girl Lost: A Case Study on Defective Cellular Organelles. NATIONAL CENTER FOR CASE STUDY TEACHING IN SCIENCE "Little Girl Lost" by Tracie Y. Hudson Page 2 Part II - The Diagnosis "Given the results of the metabolic screen, the multiple organ system involvement, and the telltale lesions in the brain, ...
Little Girl Lost: A Case Study on Defective Cellular Organelles "Little Girl Lost" by Tracie Y. Hudson Page Part II - The Diagnosis "Given the results of the metabolic screen, the multiple organ system involvement, and the telltale lesions in the brain, it appears that Nicole has Leigh Syndrome (LS)," reported the ER doctor.
Describe what is Leigh syndrome. severe neurological disorder that usually becomes apparent in the first year of life. This condition is characterized by progressive loss of mental and movement abilities (psychomotor regression) and typically results in death within two to three years, usually due to respiratory failure. Cause of Leigh Syndrome.
Case Study on Defective Mitochondria- Cellular Respiration Unit. You will want to read the cards before studying as it is basically word per word questions…
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organelle_defect_flip - Free download as PDF File (.pdf), Text File (.txt) or read online for free.
Special Populations Exam II Part II. 142 terms. Julie_Kim67. Preview. Study with Quizlet and memorize flashcards containing terms like Failure to Thrive, First baby died at 12 mos old, Leigh Syndrome and more.
Little Girl Lost A Case Study on Defective Cellular Organelles. Course. General Biology 101 (BI101) 18 Documents. Students shared 18 documents in this course. ... The mutation described above affects a protein commonly found in cellular organelles involved in energy production. What organelle would this most likely be? A protein commonly found ...
NATIONAL CENTER FOR CASE STUDY TEACHING IN SCIENCE Little Girl Lost: A Case Study on Defective Cellular Organelles by Tracie Y. Hudson Department of Biology Malcolm X College, Chicago, Illinois Part I - Bringing Home Baby After many years of trying to get pregnant again, Kenneth and Vicki Johnson were thrilled at the birth of their baby Nicole.
NATIONAL CENTER FOR CASE STUDY TEACHING IN SCIENCE by Tracie Y. Hudson Department of Biology Malcolm X College, Chicago, Illinois Little Girl Lost: A Case Study on Defective Cellular Organelles Part I - Bringing Home Baby After many years of trying to get pregnant again, Kenneth and Vicki Johnson were thrilled at the birth of their baby Nicole. . Teir frst child had died mysteriously at 12 ...
Little girl lost: study on defective cellular organelles case study. What does the phrase failure to thrive mean? Click the card to flip 👆. When children are not gaining weight at a rate they are supposed to. Click the card to flip 👆.
Little Girl Lost: A Case Study on Defective Cellular Organelles. NATIONAL CENTER FOR CASE STUDY TEACHING IN SCIENCE "Little Girl Lost" by Tracie Y. Hudson Page 2 Part II - The Diagnosis "Given the results of the metabolic screen, the multiple organ system involvement, and the telltale lesions in the brain, ...
View Answer Key for "Little Girl Lost" - Case Study Collection - National Center for Case Study Teaching from BIOLOGY 102 at Compton College. 9/14/2020 Answer Key for "Little Girl Lost" - Case ... Little Girl Lost_ A Case Study on Defective Cellular Organelles.pdf. Solutions Available. Buckhorn High School. SCIENCE 101. APUS BIOL133 Exam 4 ...
Little Gil Lost: A Case Study on Defective Cellular Organelles N\~ L Part |-Bringing Home Baby After many years of trying to get pregnant again, Kenneth and Vicki Johnson were thrilled at the birth of their baby Nicole. Their first child had died mysteriously at 12 months of age, and it had taken five years for Vicki to become pregnant again ...
"Little Girl Lost: A Case Study on Defective Cellular Organelles" what triggered Nicole's sudden deterioration Your solution's ready to go! Enhanced with AI, our expert help has broken down your problem into an easy-to-learn solution you can count on.
Little Girl Lost: A Case Study on Defective Cellular Organelles Part I - Bringing Home Baby. After many years of trying to get pregnant again, Kenneth and Vicki Johnson were thrilled at the birth of their baby Nicole. Teir frst child had died mysteriously at 12 months of age, and it had taken fve years for Vicki to become pregnant again.
Study with Quizlet and memorize flashcards containing terms like Nucleus, Nucleolus, Cytoplasm and more.
LITTLE GIRL LOST QUESTIONS. PART 1- Bringing Home Baby Questions. The phrase "failure to thrive" is the inability to grow or gain weight as a newborn. Some reasons why newborn babies fail to thrive are an unhealthy environment or genetic defects. She developed a severe respiratory infection that brought about her deterioration.
Biology- Case Study: Little Girl Lost. What organelle does Leigh Syndrome affect? Click the card to flip 👆. mitochondria. Click the card to flip 👆. 1 / 39.
Little Girl Lost: A Case Study on Defective Cellular Organelles Part I - Bringing Home Baby 1. What does the phrase "failure to thrive" mean? ANSWER: Failure to develop and grow normally as an infant 2. What are some reasons why newborn babies "fail to thrive"? ANSWER: milk allergy, cystic fibrosis, or acid reflux disease 3. What was ...