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How to Write and Publish a Research Paper for a Peer-Reviewed Journal

• Open access
• Published: 30 April 2020
• Volume 36 , pages 909–913, ( 2021 )

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• Clara Busse   ORCID: orcid.org/0000-0002-0178-1000 1 &
• Ella August   ORCID: orcid.org/0000-0001-5151-1036 1 , 2  

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Communicating research findings is an essential step in the research process. Often, peer-reviewed journals are the forum for such communication, yet many researchers are never taught how to write a publishable scientific paper. In this article, we explain the basic structure of a scientific paper and describe the information that should be included in each section. We also identify common pitfalls for each section and recommend strategies to avoid them. Further, we give advice about target journal selection and authorship. In the online resource 1 , we provide an example of a high-quality scientific paper, with annotations identifying the elements we describe in this article.

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Introduction

Writing a scientific paper is an important component of the research process, yet researchers often receive little formal training in scientific writing. This is especially true in low-resource settings. In this article, we explain why choosing a target journal is important, give advice about authorship, provide a basic structure for writing each section of a scientific paper, and describe common pitfalls and recommendations for each section. In the online resource 1 , we also include an annotated journal article that identifies the key elements and writing approaches that we detail here. Before you begin your research, make sure you have ethical clearance from all relevant ethical review boards.

Select a Target Journal Early in the Writing Process

We recommend that you select a “target journal” early in the writing process; a “target journal” is the journal to which you plan to submit your paper. Each journal has a set of core readers and you should tailor your writing to this readership. For example, if you plan to submit a manuscript about vaping during pregnancy to a pregnancy-focused journal, you will need to explain what vaping is because readers of this journal may not have a background in this topic. However, if you were to submit that same article to a tobacco journal, you would not need to provide as much background information about vaping.

Information about a journal’s core readership can be found on its website, usually in a section called “About this journal” or something similar. For example, the Journal of Cancer Education presents such information on the “Aims and Scope” page of its website, which can be found here: https://www.springer.com/journal/13187/aims-and-scope .

Peer reviewer guidelines from your target journal are an additional resource that can help you tailor your writing to the journal and provide additional advice about crafting an effective article [ 1 ]. These are not always available, but it is worth a quick web search to find out.

Identify Author Roles Early in the Process

Early in the writing process, identify authors, determine the order of authors, and discuss the responsibilities of each author. Standard author responsibilities have been identified by The International Committee of Medical Journal Editors (ICMJE) [ 2 ]. To set clear expectations about each team member’s responsibilities and prevent errors in communication, we also suggest outlining more detailed roles, such as who will draft each section of the manuscript, write the abstract, submit the paper electronically, serve as corresponding author, and write the cover letter. It is best to formalize this agreement in writing after discussing it, circulating the document to the author team for approval. We suggest creating a title page on which all authors are listed in the agreed-upon order. It may be necessary to adjust authorship roles and order during the development of the paper. If a new author order is agreed upon, be sure to update the title page in the manuscript draft.

In the case where multiple papers will result from a single study, authors should discuss who will author each paper. Additionally, authors should agree on a deadline for each paper and the lead author should take responsibility for producing an initial draft by this deadline.

Structure of the Introduction Section

The introduction section should be approximately three to five paragraphs in length. Look at examples from your target journal to decide the appropriate length. This section should include the elements shown in Fig.  1 . Begin with a general context, narrowing to the specific focus of the paper. Include five main elements: why your research is important, what is already known about the topic, the “gap” or what is not yet known about the topic, why it is important to learn the new information that your research adds, and the specific research aim(s) that your paper addresses. Your research aim should address the gap you identified. Be sure to add enough background information to enable readers to understand your study. Table 1 provides common introduction section pitfalls and recommendations for addressing them.

The main elements of the introduction section of an original research article. Often, the elements overlap

Methods Section

The purpose of the methods section is twofold: to explain how the study was done in enough detail to enable its replication and to provide enough contextual detail to enable readers to understand and interpret the results. In general, the essential elements of a methods section are the following: a description of the setting and participants, the study design and timing, the recruitment and sampling, the data collection process, the dataset, the dependent and independent variables, the covariates, the analytic approach for each research objective, and the ethical approval. The hallmark of an exemplary methods section is the justification of why each method was used. Table 2 provides common methods section pitfalls and recommendations for addressing them.

Results Section

The focus of the results section should be associations, or lack thereof, rather than statistical tests. Two considerations should guide your writing here. First, the results should present answers to each part of the research aim. Second, return to the methods section to ensure that the analysis and variables for each result have been explained.

Begin the results section by describing the number of participants in the final sample and details such as the number who were approached to participate, the proportion who were eligible and who enrolled, and the number of participants who dropped out. The next part of the results should describe the participant characteristics. After that, you may organize your results by the aim or by putting the most exciting results first. Do not forget to report your non-significant associations. These are still findings.

Tables and figures capture the reader’s attention and efficiently communicate your main findings [ 3 ]. Each table and figure should have a clear message and should complement, rather than repeat, the text. Tables and figures should communicate all salient details necessary for a reader to understand the findings without consulting the text. Include information on comparisons and tests, as well as information about the sample and timing of the study in the title, legend, or in a footnote. Note that figures are often more visually interesting than tables, so if it is feasible to make a figure, make a figure. To avoid confusing the reader, either avoid abbreviations in tables and figures, or define them in a footnote. Note that there should not be citations in the results section and you should not interpret results here. Table 3 provides common results section pitfalls and recommendations for addressing them.

Discussion Section

Opposite the introduction section, the discussion should take the form of a right-side-up triangle beginning with interpretation of your results and moving to general implications (Fig.  2 ). This section typically begins with a restatement of the main findings, which can usually be accomplished with a few carefully-crafted sentences.

Major elements of the discussion section of an original research article. Often, the elements overlap

Next, interpret the meaning or explain the significance of your results, lifting the reader’s gaze from the study’s specific findings to more general applications. Then, compare these study findings with other research. Are these findings in agreement or disagreement with those from other studies? Does this study impart additional nuance to well-accepted theories? Situate your findings within the broader context of scientific literature, then explain the pathways or mechanisms that might give rise to, or explain, the results.

Journals vary in their approach to strengths and limitations sections: some are embedded paragraphs within the discussion section, while some mandate separate section headings. Keep in mind that every study has strengths and limitations. Candidly reporting yours helps readers to correctly interpret your research findings.

The next element of the discussion is a summary of the potential impacts and applications of the research. Should these results be used to optimally design an intervention? Does the work have implications for clinical protocols or public policy? These considerations will help the reader to further grasp the possible impacts of the presented work.

Finally, the discussion should conclude with specific suggestions for future work. Here, you have an opportunity to illuminate specific gaps in the literature that compel further study. Avoid the phrase “future research is necessary” because the recommendation is too general to be helpful to readers. Instead, provide substantive and specific recommendations for future studies. Table 4 provides common discussion section pitfalls and recommendations for addressing them.

Follow the Journal’s Author Guidelines

After you select a target journal, identify the journal’s author guidelines to guide the formatting of your manuscript and references. Author guidelines will often (but not always) include instructions for titles, cover letters, and other components of a manuscript submission. Read the guidelines carefully. If you do not follow the guidelines, your article will be sent back to you.

Finally, do not submit your paper to more than one journal at a time. Even if this is not explicitly stated in the author guidelines of your target journal, it is considered inappropriate and unprofessional.

Your title should invite readers to continue reading beyond the first page [ 4 , 5 ]. It should be informative and interesting. Consider describing the independent and dependent variables, the population and setting, the study design, the timing, and even the main result in your title. Because the focus of the paper can change as you write and revise, we recommend you wait until you have finished writing your paper before composing the title.

Be sure that the title is useful for potential readers searching for your topic. The keywords you select should complement those in your title to maximize the likelihood that a researcher will find your paper through a database search. Avoid using abbreviations in your title unless they are very well known, such as SNP, because it is more likely that someone will use a complete word rather than an abbreviation as a search term to help readers find your paper.

After you have written a complete draft, use the checklist (Fig. 3 ) below to guide your revisions and editing. Additional resources are available on writing the abstract and citing references [ 5 ]. When you feel that your work is ready, ask a trusted colleague or two to read the work and provide informal feedback. The box below provides a checklist that summarizes the key points offered in this article.

Checklist for manuscript quality

Data Availability

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International Committee of Medical Journal Editors. Defining the role of authors and contributors: who is an author? http://www.icmje.org/recommendations/browse/roles-and-responsibilities/defining-the-role-of-authosrs-and-contributors.html . Accessed 15 January, 2020

Vetto JT (2014) Short and sweet: a short course on concise medical writing. J Cancer Educ 29(1):194–195

Brett M, Kording K (2017) Ten simple rules for structuring papers. PLoS ComputBiol. https://doi.org/10.1371/journal.pcbi.1005619

Lang TA (2017) Writing a better research article. J Public Health Emerg. https://doi.org/10.21037/jphe.2017.11.06

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Acknowledgments

Ella August is grateful to the Sustainable Sciences Institute for mentoring her in training researchers on writing and publishing their research.

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Clara Busse & Ella August

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Busse, C., August, E. How to Write and Publish a Research Paper for a Peer-Reviewed Journal. J Canc Educ 36 , 909–913 (2021). https://doi.org/10.1007/s13187-020-01751-z

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The Macroeconomic Impact of Climate Change: Global vs. Local Temperature

This paper estimates that the macroeconomic damages from climate change are six times larger than previously thought. We exploit natural variability in global temperature and rely on time-series variation. A 1°C increase in global temperature leads to a 12% decline in world GDP. Global temperature shocks correlate much more strongly with extreme climatic events than the country-level temperature shocks commonly used in the panel literature, explaining why our estimate is substantially larger. We use our reduced-form evidence to estimate structural damage functions in a standard neoclassical growth model. Our results imply a Social Cost of Carbon of $1,056 per ton of carbon dioxide. A business-as-usual warming scenario leads to a present value welfare loss of 31%. Both are multiple orders of magnitude above previous estimates and imply that unilateral decarbonization policy is cost-effective for large countries such as the United States.

Adrien Bilal gratefully acknowledges support from the Chae Family Economics Research Fund at Harvard University. The views expressed herein are those of the authors and do not necessarily reflect the views of the National Bureau of Economic Research.

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A modern way to teach and practice manual therapy

Affiliations.

• 1 School of Health Sciences, Queens Medical Centre, University of Nottingham, Nottingham, NG7 2HA, UK.
• 2 Allied Health Research Unit, University of Central Lancashire, Preston, PR1 2HE, UK. [email protected].
• 3 Centre of Precision Rehabilitation for Spinal Pain, School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
• 4 Nottingham CityCare Partnership, Bennerley Rd, Nottingham, NG6 8WR, UK.
• 5 School of Medicine, University of Nottingham, Queens Medical Centre, Nottingham, NG7 2HA, UK.
• 6 Department of Orthopaedics, West Herts Hospitals Trust, Watford, WD18 0HB, UK.
• 7 School of Physiotherapy, Manchester Metropolitan University, Manchester, M15 6GX, UK.
• 8 Department of Orthopaedics, Duke University, 200 Morris Street, Durham, NC, 27701, USA.
• 9 School of Sport and Health Sciences, University of Brighton, Darley Rd, Eastbourne, BN20 7UR, UK.
• 10 Clinical Neuroscience, Trafford Building, Brighton and Sussex Medical School, University of Sussex, Brighton, BN1 9PX, UK.
• 11 University College of Osteopathy, 275 Borough High St, London, SE1 1JE, UK.
• 12 Department of Clinical Sciences, Obstetrics and Gynecology, Umeå University, S-90187, Umeå, Sweden.
• 13 The School of Soft Tissue Therapy, Exmouth, Devon, EX8 1DQ, UK.
• 14 Department of health, LUNEX, Differdange, 4671, Luxembourg.
• 15 Luxembourg Health & Sport Sciences Research Institute A.s.b.l., 50, Avenue du Parc des Sports, Differdange, 4671, Luxembourg.
• 16 Department of Occupation and Health, School of Organization and Development, HAN University of Applied Sciences, Nijmegen, the Netherlands.
• PMID: 38773515
• PMCID: PMC11110311
• DOI: 10.1186/s12998-024-00537-0

Background: Musculoskeletal conditions are the leading contributor to global disability and health burden. Manual therapy (MT) interventions are commonly recommended in clinical guidelines and used in the management of musculoskeletal conditions. Traditional systems of manual therapy (TMT), including physiotherapy, osteopathy, chiropractic, and soft tissue therapy have been built on principles such as clinician-centred assessment, patho-anatomical reasoning, and technique specificity. These historical principles are not supported by current evidence. However, data from clinical trials support the clinical and cost effectiveness of manual therapy as an intervention for musculoskeletal conditions, when used as part of a package of care.

Purpose: The purpose of this paper is to propose a modern evidence-guided framework for the teaching and practice of MT which avoids reference to and reliance on the outdated principles of TMT. This framework is based on three fundamental humanistic dimensions common in all aspects of healthcare: safety, comfort, and efficiency. These practical elements are contextualised by positive communication, a collaborative context, and person-centred care. The framework facilitates best-practice, reasoning, and communication and is exemplified here with two case studies.

Methods: A literature review stimulated by a new method of teaching manual therapy, reflecting contemporary evidence, being trialled at a United Kingdom education institute. A group of experienced, internationally-based academics, clinicians, and researchers from across the spectrum of manual therapy was convened. Perspectives were elicited through reviews of contemporary literature and discussions in an iterative process. Public presentations were made to multidisciplinary groups and feedback was incorporated. Consensus was achieved through repeated discussion of relevant elements.

Conclusions: Manual therapy interventions should include both passive and active, person-empowering interventions such as exercise, education, and lifestyle adaptations. These should be delivered in a contextualised healing environment with a well-developed person-practitioner therapeutic alliance. Teaching manual therapy should follow this model.

Keywords: Chiropractic; Evidence-based healthcare; Manual Therapy; Osteopathy; Person-centred healthcare; Physiotherapy; Soft-tissue therapy.

© 2024. The Author(s).

Publication types

• Musculoskeletal Diseases / therapy
• Musculoskeletal Manipulations* / education
• Musculoskeletal Manipulations* / methods

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• Published: 14 May 2024

2023 summer warmth unparalleled over the past 2,000 years

• Jan Esper   ORCID: orcid.org/0000-0003-3919-014X 1 , 2 ,
• Max Torbenson   ORCID: orcid.org/0000-0003-2720-2238 1 &
• Ulf Büntgen 2 , 3 , 4  

Nature ( 2024 ) Cite this article

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• Climate change
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Including an exceptionally warm Northern Hemisphere (NH) summer 1 ,2 , 2023 has been reported as the hottest year on record 3-5 . Contextualizing recent anthropogenic warming against past natural variability is nontrivial, however, because the sparse 19 th century meteorological records tend to be too warm 6 . Here, we combine observed and reconstructed June-August (JJA) surface air temperatures to show that 2023 was the warmest NH extra-tropical summer over the past 2000 years exceeding the 95% confidence range of natural climate variability by more than half a degree Celsius. Comparison of the 2023 JJA warming against the coldest reconstructed summer in 536 CE reveals a maximum range of pre-Anthropocene-to-2023 temperatures of 3.93°C. Although 2023 is consistent with a greenhouse gases-induced warming trend 7 that is amplified by an unfolding El Niño event 8 , this extreme emphasizes the urgency to implement international agreements for carbon emission reduction.

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Department of Geography, Johannes Gutenberg University, Mainz, Germany

Jan Esper & Max Torbenson

Global Change Research Institute of the Czech Academy of Sciences, Brno, Czech Republic

Jan Esper & Ulf Büntgen

Department of Geography, University of Cambridge, Cambridge, United Kingdom

Ulf Büntgen

Department of Geography, Masaryk University, Brno, Czech Republic

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Esper, J., Torbenson, M. & Büntgen, U. 2023 summer warmth unparalleled over the past 2,000 years. Nature (2024). https://doi.org/10.1038/s41586-024-07512-y

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Published : 14 May 2024

DOI : https://doi.org/10.1038/s41586-024-07512-y

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Study explains why the brain can robustly recognize images, even without color

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Even though the human visual system has sophisticated machinery for processing color, the brain has no problem recognizing objects in black-and-white images. A new study from MIT offers a possible explanation for how the brain comes to be so adept at identifying both color and color-degraded images.

Using experimental data and computational modeling, the researchers found evidence suggesting the roots of this ability may lie in development. Early in life, when newborns receive strongly limited color information, the brain is forced to learn to distinguish objects based on their luminance, or intensity of light they emit, rather than their color. Later in life, when the retina and cortex are better equipped to process colors, the brain incorporates color information as well but also maintains its previously acquired ability to recognize images without critical reliance on color cues.

The findings are consistent with previous work showing that initially degraded visual and auditory input can actually be beneficial to the early development of perceptual systems.

“This general idea, that there is something important about the initial limitations that we have in our perceptual system, transcends color vision and visual acuity. Some of the work that our lab has done in the context of audition also suggests that there’s something important about placing limits on the richness of information that the neonatal system is initially exposed to,” says Pawan Sinha, a professor of brain and cognitive sciences at MIT and the senior author of the study.

The findings also help to explain why children who are born blind but have their vision restored later in life, through the removal of congenital cataracts, have much more difficulty identifying objects presented in black and white. Those children, who receive rich color input as soon as their sight is restored, may develop an overreliance on color that makes them much less resilient to changes or removal of color information.

MIT postdocs Marin Vogelsang and Lukas Vogelsang, and Project Prakash research scientist Priti Gupta, are the lead authors of the study, which appears today in Science . Sidney Diamond, a retired neurologist who is now an MIT research affiliate, and additional members of the Project Prakash team are also authors of the paper.

Seeing in black and white

The researchers’ exploration of how early experience with color affects later object recognition grew out of a simple observation from a study of children who had their sight restored after being born with congenital cataracts. In 2005, Sinha launched Project Prakash (the Sanskrit word for “light”), an effort in India to identify and treat children with reversible forms of vision loss.

Many of those children suffer from blindness due to dense bilateral cataracts. This condition often goes untreated in India, which has the world’s largest population of blind children, estimated between 200,000 and 700,000.

Children who receive treatment through Project Prakash may also participate in studies of their visual development, many of which have helped scientists learn more about how the brain's organization changes following restoration of sight, how the brain estimates brightness, and other phenomena related to vision.

In this study, Sinha and his colleagues gave children a simple test of object recognition, presenting both color and black-and-white images. For children born with normal sight, converting color images to grayscale had no effect at all on their ability to recognize the depicted object. However, when children who underwent cataract removal were presented with black-and-white images, their performance dropped significantly.

This led the researchers to hypothesize that the nature of visual inputs children are exposed to early in life may play a crucial role in shaping resilience to color changes and the ability to identify objects presented in black-and-white images. In normally sighted newborns, retinal cone cells are not well-developed at birth, resulting in babies having poor visual acuity and poor color vision. Over the first years of life, their vision improves markedly as the cone system develops.

Because the immature visual system receives significantly reduced color information, the researchers hypothesized that during this time, the baby brain is forced to gain proficiency at recognizing images with reduced color cues. Additionally, they proposed, children who are born with cataracts and have them removed later may learn to rely too much on color cues when identifying objects, because, as they experimentally demonstrated in the paper, with mature retinas, they commence their post-operative journeys with good color vision.

To rigorously test that hypothesis, the researchers used a standard convolutional neural network, AlexNet, as a computational model of vision. They trained the network to recognize objects, giving it different types of input during training. As part of one training regimen, they initially showed the model grayscale images only, then introduced color images later on. This roughly mimics the developmental progression of chromatic enrichment as babies’ eyesight matures over the first years of life.

Another training regimen comprised only color images. This approximates the experience of the Project Prakash children, because they can process full color information as soon as their cataracts are removed.

The researchers found that the developmentally inspired model could accurately recognize objects in either type of image and was also resilient to other color manipulations. However, the Prakash-proxy model trained only on color images did not show good generalization to grayscale or hue-manipulated images.

“What happens is that this Prakash-like model is very good with colored images, but it’s very poor with anything else. When not starting out with initially color-degraded training, these models just don’t generalize, perhaps because of their over-reliance on specific color cues,” Lukas Vogelsang says.

The robust generalization of the developmentally inspired model is not merely a consequence of it having been trained on both color and grayscale images; the temporal ordering of these images makes a big difference. Another object-recognition model that was trained on color images first, followed by grayscale images, did not do as well at identifying black-and-white objects.

“It’s not just the steps of the developmental choreography that are important, but also the order in which they are played out,” Sinha says.

The advantages of limited sensory input

By analyzing the internal organization of the models, the researchers found that those that begin with grayscale inputs learn to rely on luminance to identify objects. Once they begin receiving color input, they don’t change their approach very much, since they’ve already learned a strategy that works well. Models that began with color images did shift their approach once grayscale images were introduced, but could not shift enough to make them as accurate as the models that were given grayscale images first.

A similar phenomenon may occur in the human brain, which has more plasticity early in life, and can easily learn to identify objects based on their luminance alone. Early in life, the paucity of color information may in fact be beneficial to the developing brain, as it learns to identify objects based on sparse information.

“As a newborn, the normally sighted child is deprived, in a certain sense, of color vision. And that turns out to be an advantage,” Diamond says.

Researchers in Sinha’s lab have observed that limitations in early sensory input can also benefit other aspects of vision, as well as the auditory system. In 2022, they used computational models to show that early exposure to only low-frequency sounds, similar to those that babies hear in the womb, improves performance on auditory tasks that require analyzing sounds over a longer period of time, such as recognizing emotions. They now plan to explore whether this phenomenon extends to other aspects of development, such as language acquisition.

The research was funded by the National Eye Institute of NIH and the Intelligence Advanced Research Projects Activity.

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