Stakeholders identify future directions for diabetes translation
The promising future of insulin therapy in diabetes mellitus
Management of type 2 diabetes: new and future developments in treatment
(PDF) Success of nutrition-therapy interventions in persons with type 2
AACE Releases 2023 Type 2 Diabetes Management Algorithm to Support
(PDF) Current Obstacles (With Solutions) in Type 2 Diabetes Management
COMMENTS
Emerging therapeutic options in the management of diabetes ...
Since type 2 diabetes has the long-term effect of increasing the risk of cardiovascular disorders, statins (HMG-CoA reductase inhibitors) are a cornerstone of therapy for lowering cardiovascular ...
A promising new pathway to treating type 2 diabetes
June 24, 2021 —Across the world, type 2 diabetes is on the rise. A research group has discovered a new gene that may hold the key to preventing and treating lifestyle related diseases such as ...
New Aspects of Diabetes Research and Therapeutic Development
I. Introduction. Diabetes mellitus, a metabolic disease defined by elevated fasting blood glucose levels due to insufficient insulin production, has reached epidemic proportions worldwide (World Health Organization, 2020).Type 1 and type 2 diabetes (T1D and T2D, respectively) make up the majority of diabetes cases with T1D characterized by autoimmune destruction of the insulin-producing ...
Recent Advances
Recent Advances. ADA-funded researchers use the money from their awards to conduct critical diabetes research. In time, they publish their findings in order to inform fellow scientists of their results, which ensures that others will build upon their work. Ultimately, this cycle drives advances to prevent diabetes and to help people burdened by it.
New research directions on disparities in obesity and type 2 diabetes
Promising research directions for obesity and type 2 diabetes. Study Designs. • Novel designs/methods for evaluating multi-level interventions including mixed methods research. • Study designs other than the traditional RCTs to allow for flexible recruitment approaches and account for dynamic, pragmatic issues.
Treatment of type 2 diabetes: challenges, hopes, and anticipated
Despite the successful development of new therapies for the treatment of type 2 diabetes, such as glucagon-like peptide-1 (GLP-1) receptor agonists and sodium-glucose cotransporter-2 inhibitors, the search for novel treatment options that can provide better glycaemic control and at reduce complications is a continuous effort. The present Review aims to present an overview of novel targets and ...
New Research Sheds Light on Cause of Type 2 Diabetes
St. Petersburg, Fla. - September 12, 2023 - Scientists at Johns Hopkins All Children's Hospital, along with an international team of researchers, are shedding new light on the causes of Type 2 diabetes. The new research, published in the journal Nature Communications, offers a potential strategy for developing new therapies that could restore dysfunctional pancreatic beta-cells or ...
Pharmacotherapy of type 2 diabetes: An update and future directions
Abstract. Type 2 diabetes (T2D) is a widely prevalent disease with substantial economic and social impact for which multiple conventional and novel pharmacotherapies are currently available; however, the landscape of T2D treatment is constantly changing as new therapies emerge and the understanding of currently available agents deepens.
The next steps in obesity and type 2 diabetes research
JW:Obesity is a disease and a risk factor for many other conditions. The COVID-19 pandemic has shown us that obesity is the greatest modifiable risk factor for poor outcomes; this is likely true ...
Type 2 diabetes
Abstract. Type 2 diabetes accounts for nearly 90% of the approximately 537 million cases of diabetes worldwide. The number affected is increasing rapidly with alarming trends in children and young adults (up to age 40 years). Early detection and proactive management are crucial for prevention and mitigation of microvascular and macrovascular ...
Management of Type 2 Diabetes: Current Insights and Future Directions
Dear Colleagues, In the Special Issue titled "Management of type 2 diabetes - Current insights and future directions", edited by Belančić A., Klobučar S. & Rahelić D., a discussion on current novelties and future directions in the (co)management of type 2 diabetes (e.g., digital solutions to improve medication adherence, gut microbiome modification, predictors for successful GLP-1RA ...
New Molecules in Type 2 Diabetes: Advancements, Challenges and Future
Moreover, future research directions on innovative therapeutic tools will be reported, which may help to advance future clinical management of T2D and cardiometabolic diseases towards personalized treatments and minimizing adverse effects. ... 8.1. β-Cells Senescence in Type 2 Diabetes. Cellular senescence is a process characterized by a cell ...
New Study Reveals Promising Findings to Treat Type 2 Diabetes
The findings hold promise for future therapeutics that will improve the lives of individuals with type 2 diabetes—a condition that affects more than half a billion people worldwide. Dr. Laura Alonso. "That's reassuring because there is a long-standing belief in the field that proliferation can lead to 'de-differentiation' and a loss ...
Current Advances in the Management of Diabetes Mellitus
Diabetes mellitus (DM) underscores a rising epidemic orchestrating critical socio-economic burden on countries globally. Different treatment options for the management of DM are evolving rapidly because the usual methods of treatment have not completely tackled the primary causes of the disease and are laden with critical adverse effects. Thus, this narrative review explores different ...
Advances & Emerging Opportunities in Diabetes Research: A Strategic
Diabetes Research Strategic Plan (Full Report) (PDF, 6.19 MB) Cover and Table of Contents (PDF, 782.42 KB) Summary and Future Research Directions (PDF, 523.79 KB) Introduction (PDF, 434.38 KB) Genetic Basis of Type 1 Diabetes, Type 2 Diabetes, Obesity, and Their Complications (PDF, 893.15 KB) Type 1 Diabetes and Autoimmunity (PDF, 518.21 KB)
PDF Advances and Emerging Opportunities in Diabetes Research: A Strategic
type 2 diabetes at the time she enrolled in the dPP, she says "i didn't have diabetes at that time and, t. hanks to the study, i still don't." ... Summary and Future reSearch directionS. Diabetes is a common, chronic, and costly disease that is threatening the health of generations of
Treatment of type 2 diabetes: future approaches
Introduction. Type 2 diabetes mellitus (T2DM) accounts for ~90% of the 425 million people with diagnosed diabetes worldwide, and is projected to increase to ~629 million by 2045. 1 All treatment guidelines emphasise the benefits of early, effective and sustained control of blood glucose in order to delay the onset and reduce the severity of ...
Type-2 diabetes: Current understanding and future perspectives
The pathogenesis of type-2 diabetes primarily initiates with inadequacy of pancreatic islet β-cells to respond to chronic fuel surfeit and hence causing glycemic load, insulin resistance, and obesity. Urban Indian life is threatened with unhealthy high calorie diet and sedentary habits, and thus impairing the metabolic status of "thin-fat ...
Shift Work as a Risk Factor for Future Type 2 Diabetes: Evidence
New Findings on Shift Work and Diabetes Risk. In this issue of PLoS Medicine, An Pan et al. contribute substantially to this field of research by examining the association between rotating shift work (≥3 nights/month plus days and evenings) and T2D among 177,000 female nurses aged 25-67 at baseline followed up for up to two decades (the Nurses' Health Study) .
PDF Advances and Emerging Opportunities in Diabetes Research
Summary and Future reSearch directionS 3 introduction 25 areaS oF imPortant reSearch oPPortunity Genetic Basis of type 1 diabetes, type 2 diabetes, obesity, and their complications 45 type 1 diabetes and autoimmunity 6 the Beta cell 95 type 2 diabetes as a multi-dimensional disease 11 obesity 14
Type 2 diabetes can be prevented by diet and exercise even in
A new study shows that a healthy diet and regular exercise reduce the risk of type 2 diabetes even in individuals with a high genetic risk. In other words, everyone benefits from lifestyle changes ...
Diabetes treatment in 2025: can scientific advances keep pace with
Type 1 (T1DM) and type 2 diabetes mellitus (T2DM) are both characterized by abnormally high levels of glucose in the bloodstream and until the 1930s, when 'insulin-sensitive' and 'insulin-insensitive' diabetes were differentiated, all patients with diabetes were thought to have a shortage of insulin production [Saltiel, 2000].Since then the pathophysiology of the two diseases has been ...
Probiotics intervention for type 2 diabetes mellitus therapy: a review
Abstract. Type 2 diabetes mellitus (T2DM) is one of the metabolic diseases with the highest morbidity rates in the world. Probiotics have positive health impacts on human health and a considerable amount of research has demonstrated their beneficial effects in treating T2DM.
Ageing well with diabetes: the role of technology
There is a paucity of data on the effect of glucose variability on physical and cognitive function and frailty. Among people with type 2 diabetes, high glucose variability has been associated with cognitive impairment [].In the Taiwan diabetes study, visit-to-visit variations in fasting plasma glucose levels and HbA 1c have been associated with Alzheimer's disease [].
Shift work as a risk factor for future type 2 diabetes: evidence
Mika Kivimaki and colleagues discuss new research that shows an association between shift work and the risk of developing type 2 diabetes among nurses. ... Shift work as a risk factor for future type 2 diabetes: evidence, mechanisms, implications, and future research directions PLoS Med. 2011 Dec;8(12):e1001138. doi: 10.1371/journal.pmed ...
New directions for diabetes prevention and management in behavioral
Behavioral medicine scientists and practitioners are poised to address these and other proposed future research directions to advance diabetes prevention and management. Keywords: Diabetes, Research, Behavior, Public health, ... 2015) highlights the extent of the crisis of prediabetes and type 2 diabetes and is a harbinger of future burden ...
Early findings from the NHS Type 2 Diabetes Path to Remission Programme
Findings from the NHS T2DR programme show that remission of type 2 diabetes is possible outside of research settings, through at-scale service delivery. However, the rate of remission achieved is lower and the ascertainment of data is more limited with implementation in the real world than in randomised controlled trial settings.
Study Finds Why Type 2 Diabetes Increases Risk Of ...
Type 2 diabetes has long been associated with various health complications, but recent research highlights a significant concern for older women: an increased risk of fractures.
IMAGES
COMMENTS
Since type 2 diabetes has the long-term effect of increasing the risk of cardiovascular disorders, statins (HMG-CoA reductase inhibitors) are a cornerstone of therapy for lowering cardiovascular ...
June 24, 2021 —Across the world, type 2 diabetes is on the rise. A research group has discovered a new gene that may hold the key to preventing and treating lifestyle related diseases such as ...
I. Introduction. Diabetes mellitus, a metabolic disease defined by elevated fasting blood glucose levels due to insufficient insulin production, has reached epidemic proportions worldwide (World Health Organization, 2020).Type 1 and type 2 diabetes (T1D and T2D, respectively) make up the majority of diabetes cases with T1D characterized by autoimmune destruction of the insulin-producing ...
Recent Advances. ADA-funded researchers use the money from their awards to conduct critical diabetes research. In time, they publish their findings in order to inform fellow scientists of their results, which ensures that others will build upon their work. Ultimately, this cycle drives advances to prevent diabetes and to help people burdened by it.
Promising research directions for obesity and type 2 diabetes. Study Designs. • Novel designs/methods for evaluating multi-level interventions including mixed methods research. • Study designs other than the traditional RCTs to allow for flexible recruitment approaches and account for dynamic, pragmatic issues.
Despite the successful development of new therapies for the treatment of type 2 diabetes, such as glucagon-like peptide-1 (GLP-1) receptor agonists and sodium-glucose cotransporter-2 inhibitors, the search for novel treatment options that can provide better glycaemic control and at reduce complications is a continuous effort. The present Review aims to present an overview of novel targets and ...
St. Petersburg, Fla. - September 12, 2023 - Scientists at Johns Hopkins All Children's Hospital, along with an international team of researchers, are shedding new light on the causes of Type 2 diabetes. The new research, published in the journal Nature Communications, offers a potential strategy for developing new therapies that could restore dysfunctional pancreatic beta-cells or ...
Abstract. Type 2 diabetes (T2D) is a widely prevalent disease with substantial economic and social impact for which multiple conventional and novel pharmacotherapies are currently available; however, the landscape of T2D treatment is constantly changing as new therapies emerge and the understanding of currently available agents deepens.
JW:Obesity is a disease and a risk factor for many other conditions. The COVID-19 pandemic has shown us that obesity is the greatest modifiable risk factor for poor outcomes; this is likely true ...
Abstract. Type 2 diabetes accounts for nearly 90% of the approximately 537 million cases of diabetes worldwide. The number affected is increasing rapidly with alarming trends in children and young adults (up to age 40 years). Early detection and proactive management are crucial for prevention and mitigation of microvascular and macrovascular ...
Dear Colleagues, In the Special Issue titled "Management of type 2 diabetes - Current insights and future directions", edited by Belančić A., Klobučar S. & Rahelić D., a discussion on current novelties and future directions in the (co)management of type 2 diabetes (e.g., digital solutions to improve medication adherence, gut microbiome modification, predictors for successful GLP-1RA ...
Moreover, future research directions on innovative therapeutic tools will be reported, which may help to advance future clinical management of T2D and cardiometabolic diseases towards personalized treatments and minimizing adverse effects. ... 8.1. β-Cells Senescence in Type 2 Diabetes. Cellular senescence is a process characterized by a cell ...
The findings hold promise for future therapeutics that will improve the lives of individuals with type 2 diabetes—a condition that affects more than half a billion people worldwide. Dr. Laura Alonso. "That's reassuring because there is a long-standing belief in the field that proliferation can lead to 'de-differentiation' and a loss ...
Diabetes mellitus (DM) underscores a rising epidemic orchestrating critical socio-economic burden on countries globally. Different treatment options for the management of DM are evolving rapidly because the usual methods of treatment have not completely tackled the primary causes of the disease and are laden with critical adverse effects. Thus, this narrative review explores different ...
Diabetes Research Strategic Plan (Full Report) (PDF, 6.19 MB) Cover and Table of Contents (PDF, 782.42 KB) Summary and Future Research Directions (PDF, 523.79 KB) Introduction (PDF, 434.38 KB) Genetic Basis of Type 1 Diabetes, Type 2 Diabetes, Obesity, and Their Complications (PDF, 893.15 KB) Type 1 Diabetes and Autoimmunity (PDF, 518.21 KB)
type 2 diabetes at the time she enrolled in the dPP, she says "i didn't have diabetes at that time and, t. hanks to the study, i still don't." ... Summary and Future reSearch directionS. Diabetes is a common, chronic, and costly disease that is threatening the health of generations of
Introduction. Type 2 diabetes mellitus (T2DM) accounts for ~90% of the 425 million people with diagnosed diabetes worldwide, and is projected to increase to ~629 million by 2045. 1 All treatment guidelines emphasise the benefits of early, effective and sustained control of blood glucose in order to delay the onset and reduce the severity of ...
The pathogenesis of type-2 diabetes primarily initiates with inadequacy of pancreatic islet β-cells to respond to chronic fuel surfeit and hence causing glycemic load, insulin resistance, and obesity. Urban Indian life is threatened with unhealthy high calorie diet and sedentary habits, and thus impairing the metabolic status of "thin-fat ...
New Findings on Shift Work and Diabetes Risk. In this issue of PLoS Medicine, An Pan et al. contribute substantially to this field of research by examining the association between rotating shift work (≥3 nights/month plus days and evenings) and T2D among 177,000 female nurses aged 25-67 at baseline followed up for up to two decades (the Nurses' Health Study) .
Summary and Future reSearch directionS 3 introduction 25 areaS oF imPortant reSearch oPPortunity Genetic Basis of type 1 diabetes, type 2 diabetes, obesity, and their complications 45 type 1 diabetes and autoimmunity 6 the Beta cell 95 type 2 diabetes as a multi-dimensional disease 11 obesity 14
A new study shows that a healthy diet and regular exercise reduce the risk of type 2 diabetes even in individuals with a high genetic risk. In other words, everyone benefits from lifestyle changes ...
Type 1 (T1DM) and type 2 diabetes mellitus (T2DM) are both characterized by abnormally high levels of glucose in the bloodstream and until the 1930s, when 'insulin-sensitive' and 'insulin-insensitive' diabetes were differentiated, all patients with diabetes were thought to have a shortage of insulin production [Saltiel, 2000].Since then the pathophysiology of the two diseases has been ...
Abstract. Type 2 diabetes mellitus (T2DM) is one of the metabolic diseases with the highest morbidity rates in the world. Probiotics have positive health impacts on human health and a considerable amount of research has demonstrated their beneficial effects in treating T2DM.
There is a paucity of data on the effect of glucose variability on physical and cognitive function and frailty. Among people with type 2 diabetes, high glucose variability has been associated with cognitive impairment [].In the Taiwan diabetes study, visit-to-visit variations in fasting plasma glucose levels and HbA 1c have been associated with Alzheimer's disease [].
Mika Kivimaki and colleagues discuss new research that shows an association between shift work and the risk of developing type 2 diabetes among nurses. ... Shift work as a risk factor for future type 2 diabetes: evidence, mechanisms, implications, and future research directions PLoS Med. 2011 Dec;8(12):e1001138. doi: 10.1371/journal.pmed ...
Behavioral medicine scientists and practitioners are poised to address these and other proposed future research directions to advance diabetes prevention and management. Keywords: Diabetes, Research, Behavior, Public health, ... 2015) highlights the extent of the crisis of prediabetes and type 2 diabetes and is a harbinger of future burden ...
Findings from the NHS T2DR programme show that remission of type 2 diabetes is possible outside of research settings, through at-scale service delivery. However, the rate of remission achieved is lower and the ascertainment of data is more limited with implementation in the real world than in randomised controlled trial settings.
Type 2 diabetes has long been associated with various health complications, but recent research highlights a significant concern for older women: an increased risk of fractures.