how to write a scientific research article

Scientific Writing: Structuring a scientific article

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• Structuring a scientific article
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How to Structure a Scientific Article

Many scientific articles include the following elements:

I. Abstract: The abstract should briefly summarize the contents of your article. Be sure to include a quick overview of the focus, results and conclusion of your study.

II. Introduction:  The introduction should include any relevant background information and articulate the idea that is being investigated. Why is this study unique? If others have performed research on the topic, include a literature review. 

III. Methods and Materials:  The methods and materials section should provide information on how the study was conducted and what materials were included. Other researchers should be able to reproduce your study based on the information found in this section. 

IV. Results:  The results sections includes the data produced by your study. It should reflect an unbiased account of the study's findings. 

V.  Discussion and Conclusion:  The discussion section provides information on what researches felt was significant and analyzes the data. You may also want to provide final thoughts and ideas for further research in the conclusion section. 

For more information, see How to Read a Scientific Paper.  

Scientific Article Infographic

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Welcome to the PLOS Writing Center

Your source for scientific writing & publishing essentials.

A collection of free, practical guides and hands-on resources for authors looking to improve their scientific publishing skillset.

ARTICLE-WRITING ESSENTIALS

Your title is the first thing anyone who reads your article is going to see, and for many it will be where they stop reading. Learn how to write a title that helps readers find your article, draws your audience in and sets the stage for your research!

The abstract is your chance to let your readers know what they can expect from your article. Learn how to write a clear, and concise abstract that will keep your audience reading.

A clear methods section impacts editorial evaluation and readers’ understanding, and is also the backbone of transparency and replicability. Learn what to include in your methods section, and how much detail is appropriate.

In many fields, a statistical analysis forms the heart of both the methods and results sections of a manuscript. Learn how to report statistical analyses, and what other context is important for publication success and future reproducibility.

The discussion section contains the results and outcomes of a study. An effective discussion informs readers what can be learned from your experiment and provides context for the results.

Ensuring your manuscript is well-written makes it easier for editors, reviewers and readers to understand your work. Avoiding language errors can help accelerate review and minimize delays in the publication of your research.

The PLOS Writing Toolbox

Delivered to your inbox every two weeks, the Writing Toolbox features practical advice and tools you can use to prepare a research manuscript for submission success and build your scientific writing skillset. 

Discover how to navigate the peer review and publishing process, beyond writing your article.

The path to publication can be unsettling when you’re unsure what’s happening with your paper. Learn about staple journal workflows to see the detailed steps required for ensuring a rigorous and ethical publication.

Reputable journals screen for ethics at submission—and inability to pass ethics checks is one of the most common reasons for rejection. Unfortunately, once a study has begun, it’s often too late to secure the requisite ethical reviews and clearances. Learn how to prepare for publication success by ensuring your study meets all ethical requirements before work begins.

From preregistration, to preprints, to publication—learn how and when to share your study.

How you store your data matters. Even after you publish your article, your data needs to be accessible and useable for the long term so that other researchers can continue building on your work. Good data management practices make your data discoverable and easy to use, promote a strong foundation for reproducibility and increase your likelihood of citations.

You’ve just spent months completing your study, writing up the results and submitting to your top-choice journal. Now the feedback is in and it’s time to revise. Set out a clear plan for your response to keep yourself on-track and ensure edits don’t fall through the cracks.

There’s a lot to consider when deciding where to submit your work. Learn how to choose a journal that will help your study reach its audience, while reflecting your values as a researcher.

Are you actively preparing a submission for a PLOS journal? Select the relevant journal below for more detailed guidelines. 

How to Write an Article  

Share the lessons of the Writing Center in a live, interactive training.

Access tried-and-tested training modules, complete with slides and talking points, workshop activities, and more.

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• CAREER FEATURE
• 28 February 2018
• Correction 16 March 2018

How to write a first-class paper

• Virginia Gewin 0

Virginia Gewin is a freelance writer in Portland, Oregon.

You can also search for this author in PubMed   Google Scholar

Manuscripts may have a rigidly defined structure, but there’s still room to tell a compelling story — one that clearly communicates the science and is a pleasure to read. Scientist-authors and editors debate the importance and meaning of creativity and offer tips on how to write a top paper.

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doi: https://doi.org/10.1038/d41586-018-02404-4

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Structuring your article correctly

Anthony Newman

About this module

One of the key goals when writing a journal article is to communicate the findings clearly. In order to help researchers achieve that objective, scientific papers share a common structure (with slight variations per journal). Clear communication isn’t the only reason these article elements are so important; for example, the title, abstract, and keywords all help to ensure the article is found, indexed, and advertised to potential readers.

In this interactive module, we walk early career researchers through each of the building blocks. We help you understand the type of content each element should contain. We also share tips on how you can maximize their potential, such as key points to consider when writing your article title.

You will come away with the detailed knowledge you need to write an effective scientific article, increasing your chances of publication success.

About the presenter

Senior Publisher, Life Sciences, Elsevier

Anthony Newman is a Senior Publisher with Elsevier and is based in Amsterdam. Each year he presents numerous Author Workshops and other similar trainings worldwide. He is currently responsible for fifteen biochemistry and laboratory medicine journals, he joined Elsevier over thirty years ago and has been Publisher for more than twenty of those years. Before then he was the marketing communications manager for the biochemistry journals of Elsevier.  By training he is a polymer chemist and was active in the surface coating industry before leaving London and moving to Amsterdam in 1987 to join Elsevier.

Writing a Scientific Paper: From Clutter to Clarity

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How to write a good scientific review article

Affiliation.

• 1 The FEBS Journal Editorial Office, Cambridge, UK.
• PMID: 35792782
• DOI: 10.1111/febs.16565

Literature reviews are valuable resources for the scientific community. With research accelerating at an unprecedented speed in recent years and more and more original papers being published, review articles have become increasingly important as a means to keep up to date with developments in a particular area of research. A good review article provides readers with an in-depth understanding of a field and highlights key gaps and challenges to address with future research. Writing a review article also helps to expand the writer's knowledge of their specialist area and to develop their analytical and communication skills, amongst other benefits. Thus, the importance of building review-writing into a scientific career cannot be overstated. In this instalment of The FEBS Journal's Words of Advice series, I provide detailed guidance on planning and writing an informative and engaging literature review.

© 2022 Federation of European Biochemical Societies.

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StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-.

StatPearls [Internet].

How to write and publish a scientific manuscript.

Martin R. Huecker ; Jacob Shreffler .

Affiliations

Last Update: October 31, 2022 .

• Definition/Introduction

A clinician should continuously strive to increase knowledge by reviewing and critiquing papers, thoughtfully considering how to integrate new data into practice. This is the essence of evidence-based medicine (EBM). [1]  When new clinical queries arise, one should seek answers in the published literature. The ability to read a scientific or medical manuscript remains vitally important throughout the career of a clinician.

When gaps exist in the literature, clinicians should consider conducting their own research into these questions. Though typically performed by academic doctors or physician-scientists, medical research is open to all clinicians in both informal and formal methods. Anyone who treats patients can collect data on outcomes to assess the quality of care delivered (quality improvement is research). [2]  Though beyond the scope of this chapter, instruction for clinicians on how to conduct research and contribute to medical science is provided by many resources. [3] [4] [5]

Additionally, a clinician who integrates a new practice can study effects on patient outcomes, retro- or prospectively. Continuous practice improvement need not be shared with the larger population of treating providers, but dissemination to the entire scientific community allows widespread adoption, criticism, or further testing for replication of findings.

• Issues of Concern

Clinicians who seek to conduct retrospective chart reviews, prospective studies, or even randomized, controlled clinical trials should access the many resources to ensure quality methodology. [5] Once you have followed the appropriate steps to conduct a study (Table 1), you should complete the process by writing a manuscript to describe your findings and share it with other clinicians and researchers. Other resources detail the steps in undertaking writing a review article, but this StatPearls chapter will focus on Writing a Scientific Manuscript for original research. See also the StatPearls chapter for the different types of research manuscripts. [6]

• Clinical Significance

Steps to Conducting Research

• Develop a research question
• Perform a literature search
• Identify a gap in the literature
• Design a study protocol (including personnel)
• Submit to an institutional review board for approval
• Collect, responsibly store, and then analyze data
• Write a manuscript to interpret and describe your research.

After conducting a quality investigation or a study, one should put together an abstract and manuscript to share results. Researchers can write an abstract in a short amount of time, though the abstract will evolve as the full manuscript moves to completion. Many published and presented abstracts do not reach full manuscript publication. [7] [8]  Although journals and conferences do often publish abstracts, studies with important results should be published in full manuscript form to ensure dissemination and allow attempts at replication. [9]

IRB protocols, study design, and data collection and aggregation require a team effort. Those involved in the research should discuss who will contribute to the full manuscript (i.e., qualify as an author) and thus the planned order of authorship to reduce complications at the time of manuscript submission. The author, who devotes the most effort to the paper, is typically the first and corresponding author. In contrast, the last author is often the most senior member of the team, often the principal investigator of the study. All individuals listed as authors should contribute to the manuscript and overall project in some fashion. [10]

The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) checklist is perhaps the most valuable tool in the process of preparing your manuscript for submission [11] . 

Original research manuscripts have the following sections (in chronologic order): [11]

Title and Abstract

Introduction (Background and Objectives)

Methods (Design, Setting, Participants, Variables, Statistics)

Results (Participants, Descriptives, Outcomes, Subgroups)

Tables and Figures     

Discussion (Key findings, Limitations, Interpretations)

Conflict of Interest (COI), Author affiliations, Acknowledgments, Funding

Individuals involved in the IRB submission (prior to data collection) can write the introduction and methods of the manuscript before and during the process of data collection and analysis. This head start on writing makes the full manuscript composition task less formidable. The content of the introduction and methods should be well known to the study group prior to data collection and analysis. The introduction should be organized into a “problem/gap/hook” order: what problem does this study address, the precise gap in the literature, and the objectives of this study (in addressing the gap). [12]  The methods should provide enough detail such that readers who would like to replicate the study could do so.

Once data is collected and analyzed, authors can write an abstract to organize major themes of the research, understanding that the abstract will undergo edits once the manuscript is complete. Similarly, the title can change with revisions, as authors determine the most salient trends in the data. Most readers will only read the title +/- abstract. Thus these are the most important sections of the paper. The title should be concise and should directly describe the results of the trial– this correlates with more citations. The abstract must convey the crucial findings of the paper, ideally divided into sections for easier reading (unless the desired journal does not allow this). [13]

With the larger picture in mind, authors should create tables and figures that visually convey the themes of the data analysis. Working with statisticians or data experts, authors should devote a great deal of time to this component of the manuscript. Some general concepts: [14]

• Only include tables/figures that you believe are necessary.
• Make sure tables/figures are of high quality, simple, clear, with concise captions.
• Do not repeat language in results that appear in tables/figures, i.e., the tables/figures should stand alone.
• Consider how the figure will look in grayscale (in case the journal if not in color)

As with the abstract and title, the tables and figures will likely undergo further edits prior to the completion of the manuscript. The abstract and tables/figures should intuitively evolve together to convey the ‘story’ of the research project.

At this point, refer back to the introduction and methods composed during data collection. Make revisions as necessary to reflect the overall narrative of the project. Ensure you have adhered to the originally determined objectives or hypotheses. 

Next, focus on the results and discussion. The results should contain only objective data with no interpretation of significance. Describe salient results than do not already receive explanations within the figures and tables. The discussion section begins with a lead paragraph highlighting the most important findings from the study. Then the discussion interprets the current results in light of prior published literature. Ensure citation of keystone papers on this topic, including new papers that have been published since embarking on the current project. Frame your results, describing how this study adds to the literature. The discussion section usually includes study limitations. Attempt to anticipate criticisms of the methodology, the results, the organization of the manuscript itself, and the (ability to draw) conclusions. A stronger limitations section preempts journal reviewer feedback, potentially simplifying the revision/resubmission process.

The conclusion section should be concise, conveying the main take-home points from your study. You can make recommendations for current clinical practice and for future research endeavors. Finally, consider using citation management software such as Endnote or Mendeley. Though initially cumbersome, these software platforms drastically improve revision efforts and allow for easy reference reformatting.  All authors should review the manuscript multiple times, potentially sharing with other uninvolved colleagues for objective feedback. Consider who should receive acknowledgment for supporting the project and prepare to disclose conflicts of interest and funding.

Although authors should have an initial idea of which journal to submit to, once the manuscript is near completion, this decision will be more straightforward. Journal rankings are beyond the scope of this StatPearls chapter. Still, generally, one should devise a list of the journals within a specialty in order of highest to lowest impact factor (some sites categorize into tiers). High-quality prospective research and clinical trials have a higher likelihood of acceptance into the more prestigious journals within a specialty or to the high-quality general science or medicine journals. Although many journals have an option for open access publication, and numerous legitimate, open access journals now exist, beware of ‘predatory journals’ that charge a fee to publish and may not be indexed in Pubmed or other databases. [12]

Journals have diverse guidelines for formatting and submission, and the manuscript submission process can be tedious. Prior to submission, review Bordage’s paper on reasons for manuscript rejection. [15]  Most journals require a title page and cover letter, the latter of which represents an opportunity to lobby for your paper’s importance. When (not if) you experience manuscript rejections, take reviewer comments and recommendations seriously. Use this valuable feedback for resubmission to the original journal (when invited) or for subsequent submission to other journals. When submitting a requested revision, compose a point by point response to the reviewers and attach a new manuscript with tracked changes. Attempt to resubmit manuscripts as promptly as possible, keeping your work in the hands of journals (allowing you to work on other research). [14]

• Nursing, Allied Health, and Interprofessional Team Interventions

The above logistic steps will differ for review articles, case reports, editorials, and other types of submissions. [16]  However, the organization, precise methods, and adherence to journal guidelines remain important. See work by Provenzale on principles to increase the likelihood of acceptance for original and revised manuscripts. After submission, revision, resubmission, and proofing, you may experience the fulfillment of an official publication. Academics should promote their scientific work, enhancing the dissemination of research to the wider scientific community. [17] [18] [17] [19]

• Review Questions
• Access free multiple choice questions on this topic.
• Comment on this article.

Disclosure: Martin Huecker declares no relevant financial relationships with ineligible companies.

Disclosure: Jacob Shreffler declares no relevant financial relationships with ineligible companies.

This book is distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) ( http://creativecommons.org/licenses/by-nc-nd/4.0/ ), which permits others to distribute the work, provided that the article is not altered or used commercially. You are not required to obtain permission to distribute this article, provided that you credit the author and journal.

• Cite this Page Huecker MR, Shreffler J. How To Write And Publish A Scientific Manuscript. [Updated 2022 Oct 31]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-.

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