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Infection and Immunity
Biology is a constant struggle between pathogens that seek to exploit the resources of their hosts, and host immune systems that seek to prevent this. Over 80 leading scientists in the Infection and Immunity Research Theme study multiple facets of infection and immunity, ranging from the functions of individual host or pathogen proteins, and of specific immune cells in the body, through to population-scale studies of infectious disease spread. This research contributes to some of the biggest questions we face in the 21 st century: Can we prevent the next pandemic before it occurs? Can malaria and tuberculosis be consigned to the history books? How can we harness the immune system to fight diseases like cancer? Research by Infection and Immunity Theme members will provide fundamental insights into immune system function and the biology of pathogens, underpinning the development of new therapies to improve human and animal health, and helping safeguard the crops on which we depend.
Current areas of focus include: Understanding the Immune System to Treat Disease; Changing Pathogens in a Changing World; The molecular interface between pathogens and hosts.
The ability to visualise host-pathogen interactions across multiple scales, from individual molecules to whole organisms, unlocks unprecedented opportunities for breakthroughs in our basic understanding of infectious disease biology. However, working with the live human or animal pathogens also brings unique challenges. By sharing experiences, skills and resources, researchers in Cambridge are redefining what is possible in infections disease imaging and illuminating novel biological processes that can be targeted for the development of next-generation therapies. Read more
Growing human populations, environmental shifts and increasing international movement are the recognisable features of our changing world, and are contributing factors to the emergence, resurgence, and redistribution of many infectious diseases. Cambridge researchers are working across disciplinary boundaries to understand how pathogens are responding to our changing world. Working collaboratively and in partnership with affected communities, we will deliver effective strategies to protect our planetary health and the global community across future generations. Read more
Recent Discoveries
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Highly antibiotic-resistant strain of MRSA that arose in pigs can jump to humans
A new study from the department of veterinary medicine has found that a highly antibiotic-resistant strain of the superbug mrsa – methicillin resistant staphylococcus aureus – has emerged in livestock in the last 50 years, probably due to widespread antibiotic use in pig farming..
The strain, called CC398, has become the dominant type of MRSA in European livestock in the past fifty years. It is also a growing cause of human MRSA infections. The study found that CC398 has maintained its antibiotic resistance over decades in pigs and other livestock. And it is capable of rapidly adapting to human hosts while maintaining this antibiotic resistance. The results highlight the potential threat that this strain of MRSA poses to public health. Read
Wider Impact
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Shaping WHO meningitis guidelines
Meningitis is a serious infection that causes swelling of the meninges, the membranes surrounding the brain and spinal cord..
Caroline Trotter was engaged by the World Health Organization (WHO) as a trusted advisor to help tackle the challenge of meningitis on the African continent. Epidemiological modelling of vaccine strategies using MenAfriVac® to control bacterial meningitis group A, widely found in sub-Saharan Africa, was undertaken at the University of Cambridge. Trotter’s contributions led to the successful introduction of the vaccine into routine immunisation schedules, supported by a ‘catch-up’ campaign. Read
Theme Leads
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Cinzia Cantacessi
Veterinary Medicine
Brian Ferguson
Jeanne Salje
Biochemistry and Pathology
Theme Members
James Ajioka
Alexandre Almeida
Katerina Artavanis-Tsakonas
Nicholas Bexfield
Barbara Blacklaws
Andrew Blagborough
Alexander Borodavka
Louise Boyle
Ian Brierley
Clare Bryant
Neil Bryant
Raymond Bujdoso
Harry Bulstrode
Mark Carrington
Mike Chapman
Jeongmin Choi
Betty Chung
Andrew Conlan
Andrew Conway Morris
Colin Crump
Nik Cunniffe
Lida Derevnina
John Doorbar
Ming-Qing Du
James Edgar
Sebastian Eves-van den Akker
Andrew Firth
Gillian Fraser
Camilla Godlee
Ian Goodfellow
Stephen Graham
Andrew Grant
Jake Harris
Richard Hayward
Jonathan Heeney
Florian Hollfelder
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Nick Holmes
Charlotte Houldcroft
Mark Howarth
Kate Hughes
Nerea Irigoyen
Randall Johnson
Adrian Kelly
Julia Kenyon
Vassilis Koronakis
Heike Laman
Adrian Liston
Valeria Lulla
Bidesh Mahata
Pietro Mastroeni
Ioanna Mela
Ian McCrone
Naomi McGovern
Catherine Merrick
Ashley Moffett
Richard Newton
Klaus Okkenhaug
Julian Parkhill
Uta Paszkowski
Taufiq Rahman
Olivier Restif
Rahul Roychoudhuri
Henrik Salje
Milka Sarris
Elena Scarpa
Wilhelm Schwaeble
Liza Selley
Andrew Sharkey
Jordan Skittrall
Stephen Smith
Derek Smith
Geoffrey Smith
Elizabeth Soilleux
Nancy Standart
James Thaventhiran
Laurence Tiley
Caroline Trotter
A.W. (Dan) Tucker
Ross Waller
Lucy Weinert
Martin Welch
Jeremy Wells
Tim Williams
Shona Wilson
Members of the School can find out more about the Research Themes on the School Information Hub .
Related initiatives.
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What impact will your next connection have?
Cambridge Global Impact
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From the Arctic to Zambia, explore the new interactive global map to learn how Cambridge and its partners make a positive impact around the world.
Postal Address: School of the Biological Sciences 17 Mill Lane Cambridge CB2 1RX Information provided by: [email protected]
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Infection Biology and Molecular Immunology
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The COVID-19 pandemic dramatically illustrated how understanding the biology of infectious agents and of the host immune system is fundamental to human health and prosperity. Our knowledge of infection and immunity is increasing at a rapid rate, opening opportunities for new therapies, new vaccines, and a better understanding of disease emergence that will help safeguard human health and food security in the 21st century. The Infection Biology & Molecular Immunology MPhil is specifically targeted at providing advanced training in the experimental skills and theoretical concepts that underpin modern infection biology and molecular immunology research.
Find out more and apply.
More information:.
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Application deadline: 24 April 2024
Funding application deadline: 4 January 2024
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Our Research
The immune system defends us against infections and cancer, but its excessive engagement can result in autoimmunity and allergy. The function of the immune system can also be suppressed in cancer and chronic infection, preventing immune-mediated clearance of disease. Our mission is to advance a fundamental understanding of the immune system in order to improve the diagnosis, prevention and treatment of individuals with infections, autoimmunity, allergy, and cancer.
The Division, led by Prof Klaus Okkenhaug, spans multiple research groups with interests in innate and adaptive immunity, cancer immunology, inflammation, and immunity at the foetal-maternal interface. Our research builds upon strengths in signal transduction, epigenetics and gene regulation, molecular biology and antigen processing and presentation. Research at the Division benefits from collaborations within the University of Cambridge and its affiliated institutions, Cambridge University Hospitals, and national and international collaborations with academic and industrial researchers.
Division Lead: Professor Klaus Okkenhaug
Our research groups
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The degree of Doctor of Philosophy (PhD) is the University's principal research degree for graduate students and is available in all faculties and departments.
A Cambridge PhD is intellectually demanding and you will need to have a high level of attainment and motivation to pursue this programme of advanced study and research.
In most faculties, a candidate is expected to have completed one year of postgraduate study, normally on a research preparation master's course, prior to starting a PhD.
Completion normally requires three or four years of full-time study, or at least five years of part-time study, including a probationary period.
Terms of research are normally consecutive and, for full-time students, require residency in Cambridge. Not all departments offer part-time research degrees.
Various routes to the PhD are possible and, if you are made an offer of admission, it will be made clear whether you are required to study for a master's degree or certificate in the first instance, or will be admitted directly to the probationary year for the PhD. You are registered for the PhD only after a satisfactory progress assessment at the end of the probationary year (five terms for part-time degrees). The assessment is designed also to focus your mind on the stages necessary for the completion of your research within the normal time limit and to address any structural problems that have arisen during the first year. Students must pass the first year assessment in order to continue their PhD study.
During your PhD, your effort will be focused on writing a dissertation. The word count of the dissertation is dependent on the department and the Student Registry or Educational Student Policy will be able to tell you the maximum word limit. This must represent a significant contribution to learning, for example through the discovery of new knowledge, the connection of previously unrelated facts, the development of a new theory, or the revision of older views, and must take account of previously published work on the subject. Some Cambridge dissertations go on to form the basis of significant publications.
Although you will spend long hours working independently, your department and College will both support you throughout your PhD. You are also able to attend regular seminars in your subject area and could be involved in teaching, perhaps giving seminars or supervising, or in the social life of your department and College.
PhD course search
Go to the Course Directory and filter courses using the relevant checkboxes.
Term Information
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Immunotherapy
Dr Lorena Boquete Vilarino
Dr Louise Boyle
Dr Maike de la Roche
Dr. Rachel Hewitt
Sabita Islam
Dr David Jayne
Marian Jones Evans
Dr Luca Pellegrinet
Dr. Andrea Manrique Rincón
Dr Juan Carlos Yam-Puc
Cambridge Immunology Network Coordinator
University of Cambridge Department of Medicine, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, Puddicombe Way, Cambridge, CB2 0AW
Contact: [email protected]
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IMAGES
VIDEO
COMMENTS
NIH Oxford Cambridge Scholars. PhD researchers are funded from a variety of sources (research councils, departments, charities etc) including: Wellcome Trust 4 Year PhD Programme in Infection & Immunity. More details, including course details, testimonials, timetables and contact details are on the dedicated website. NIH Oxford Cambridge ...
Infection and Immunity. Biology is a constant struggle between pathogens that seek to exploit the resources of their hosts, and host immune systems that seek to prevent this. Over 80 leading scientists in the Infection and Immunity Research Theme study multiple facets of infection and immunity, ranging from the functions of individual host or ...
The 2019 opening of The Cambridge Institute of Therapeutic Immunology and Infectious Disease (CITIID) provides a new and unique opportunity for postgraduate student training in immunity and infection - CITIID combines clinical and scientific expertise with state-of-the-art flow cytometry, proteomic, imaging and CL3 facilities.
The Infection Biology & Molecular Immunology MPhil is specifically targeted at providing advanced training in the experimental skills and theoretical concepts that underpin modern infection biology and molecular immunology research. Find out more and apply. More information: Infection Biology and Molecular Immunology Course Structure.
Our mission is to advance a fundamental understanding of the immune system in order to improve the diagnosis, prevention and treatment of individuals with infections, autoimmunity, allergy, and cancer. The Division, led by Prof Klaus Okkenhaug, spans multiple research groups with interests in innate and adaptive immunity, cancer immunology ...
Cambridge Immunology and Medicine Webinar Series. The Cambridge Immunology and Medicine Weekly Seminar Series has been running since 1998, highlighting local, national and international research in immunology and is very well received by researchers in both academia and industry. Join us online as we go virtual for some excellent presentations.
PhD researchers. Membership of Cambridge Immunology is free and open to researchers at the University of Cambridge and affiliated institutes who are actively engaged in research related to Immunology. Researchers at any stage of their career are welcome.
University of Cambridge Department of Zoology. Our research focus is to design and develop analytical, computational, and mathematical methods to understand the fundamental processes that govern the evolution of influenza and SARS-CoV-2 viruses. Read more. Supervisors: Prof D Smith, Prof H Baylis. Year round applications PhD Research Project ...
The Cambridge Immunology Network is a community for immunologists working in and around Cambridge. It builds on a rich tradition of immunological research in Cambridge, and brings together groups whose work ranges from discovery of the basic molecular mechanisms underpinning the immune response through to applications relevant to the clinic, to ...
The degree of Doctor of Philosophy (PhD) is the University's principal research degree for graduate students and is available in all faculties and departments. A Cambridge PhD is intellectually demanding and you will need to have a high level of attainment and motivation to pursue this programme of advanced study and research.
Nick HOLMES, University Senior Lecturer | Cited by 3,769 | of University of Cambridge, Cambridge (Cam) | Read 45 publications | Contact Nick HOLMES
An immunology PhD would give you the opportunity to research a specific area of the immune system in great detail. You'll likely be trying to understand how cells communicate, the role of certain signals, or how the immune system is altered in specific diseases. These projects are almost always laboratory-based.
Wellcome Trust Senior Research Fellow. Reader in Molecular Immunology. 01223 333705. [email protected].