- Biochemistry
Little Girl Lost: A Case Study on Defective Cellular Organelles
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Little Girl Lost
A Case Study on Defective Cellular Organelles
By Tracie Y. Hudson
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This case study introduces students to the structure and function of cellular organelles and seeks to show their importance by discussing diseases and disorders that can result when an organelle does not function as it should. The storyline follows a family whose joy at bringing home a new baby is soon altered by their child's sudden illness, which is eventually diagnosed as Leigh Disease. This disease occurs when defective mitochondria fail to produce energy needed by the cell, particularly affecting cells with high-energy needs like those in the brain, muscle, and gastrointestinal tract. The narrative also discusses some of the ways in which Leigh disease is inherited, treatment options, and the typical prognosis. The case was designed for an introductory non-majors biology course, but could also be used in other science or health related courses. Instructors also have the option of running the case in a "flipped classroom" in which students watch three recommended videos outside of class as a way of preparing for working on the case in class.
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Date Posted
- Define the term organelle .
- List the key organelles found in animal cells.
- Describe the functions of animal cell organelles.
- Map other disorders and syndromes to the appropriate defective organelles.
- Describe Leigh Syndrome as well as other disorders and syndromes linked to defective cellular organelles.
- Compare and contrast cellular structure and function to that of a factory.
- Create analogies to aid in understanding and remembering the function of cellular organelles.
Organelles; cellular structure; inheritance; plant cells; animal cells; failure to thrive; Leigh Disease; mitochondria; mitochondrial disease; autosomal recessive mutation
Subject Headings
EDUCATIONAL LEVEL
High school, Undergraduate lower division, General public & informal education
TOPICAL AREAS
TYPE/METHODS
Teaching Notes & Answer Key
Teaching notes.
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Teaching notes are intended to help teachers select and adopt a case. They typically include a summary of the case, teaching objectives, information about the intended audience, details about how the case may be taught, and a list of references and resources.
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Answer Keys are protected and access to them is limited to paid subscribed instructors. To become a paid subscriber, purchase a subscription here .
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Materials & Media
Supplemental materials.
- Through the Virtual Cell This video provides an overview of many cellular organelles and also discusses transcription and translation. Running time: 6:47 min. Produced by NDSU Virtual Cell Animations Project, 2009.
- Faces of Mitochondrial Disease—The Swinns Emily Swinn and her family discuss what life is like for Emily, who suffers from a mitochondrial disease. Running time: 2:58 min. Produced by the United Mitochondrial Disease Foundation. Uploaded to YouTube October 29, 2000.
- Cellular Respiration and the Mighty Mitochondria This video provides a general overview of mitochondria, ATP, and cellular respiration. Running time: 7:48 min. Produced by the Amoeba Sisters, 2014.
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ANSWER KEY for "Little Girl Lost: A Case Study on Defective Cellular Organelles" by Tracie Y. Hudson Department of Biology Malcolm X College, Chicago, Illinois. Case Questions Part I - Bringing Home Baby. What does the phrase "failure to thrive" mean?
Little Girl Lost: A Case Study on Defective Cellular Organelles "Little Girl Lost" by Tracie Y. Hudson Page Part II - The Diagnosis "Given the results of the metabolic screen, the multiple organ system involvement, and the telltale lesions in the brain, it appears that Nicole has Leigh Syndrome (LS)," reported the ER doctor.
3. The doctor named the syndromes and diseases listed belowabout cellular organelles, complete the table by matching the disease or syndrome with the. Using what you have learned affected organelle using the symptoms and the organelles' normal function as clues. DiseaseSymptomsOrganelle Normal Function Affected Organelle
Tracie Y. Hudson Department of Biology Malcolm X College, Chicago, Illinois. Little Girl Lost: A Case Study on Defective Cellular Organelles. Part I - Bringing Home Baby. After many years of trying to get pregnant again, Kenneth and Vicki Johnson were thrilled at the birth of their baby. Nicole.
ALD. Build up of fatty acids in the brain and spinal cord; lethargic, weak, dizzy; loss of limb control. Break down fatty acids and toxic cell products. Pompe. Build up of excess glycogen within muscle cells; extreme muscle weakness and a "fl oppy" appearance; breathing difi culties, trouble feeding.
View Answer Key for "Little Girl Lost" - Case Study Collection - National Center for Case Study Teaching from BIOLOGY 102 at Compton College. 9/14/2020 Answer Key for "Little Girl Lost" - Case ... defective_organelle_case_study-little_girl_lost.docx. Solutions Available. Wheeler High School, Marietta ... A Case Study on Defective Cellular ...
Movement of material in lungs and fallopian tube. "Little Girl Lost" by Tracie Y. Hudson Affected Organelle Page 6 NATIONAL CENTER FOR CASE STUDY TEACHING IN SCIENCE Part V—History Repeats Kenneth and Vicki left the hospital determined to make whatever time Nicole had left as happy and healthy as possible.
Case Study on Defective Mitochondria- Cellular Respiration Unit. You will want to read the cards before studying as it is basically word per word questions…
Abstract. This case study introduces students to the structure and function of cellular organelles and seeks to show their importance by discussing diseases and disorders that can result when an organelle does not function as it should. The storyline follows a family whose joy at bringing home a new baby is soon altered by their child's sudden ...
1.2 Ultrastructure of Cells. 28 terms. SuryAm504. Preview. Exam 2 Chapter 5. 43 terms. phall1232. Preview. Study with Quizlet and memorize flashcards containing terms like What does the phrase failure to thrive mean?, Reasons some newborn babies fail to thrive, Leigh syndrome and more.
Special Populations Exam II Part II. 142 terms. Julie_Kim67. Preview. Study with Quizlet and memorize flashcards containing terms like Failure to Thrive, First baby died at 12 mos old, Leigh Syndrome and more.
Workshop notes case study on defective cellular organelles tracie hudson department of biology malcolm college, chicago, illinois part bringing home ba after ... "But how could this one tiny defective organelle cause the range of problems that Nicole has," he. ... Mitochondria are key organelles that produce energy for the factory to run ...
organelle_defect_flip - Free download as PDF File (.pdf), Text File (.txt) or read online for free.
BIO125 Defective Organelle Case Study Handout Answer the following questions taken from the case study "Little Girl Lost: A Case Study on Defective Cellular Organelles" and save your file using the following format ([Last Name] Defective Organelle Case Study Handout.docx) and upload it to Canvas for grading.
Organelle Case Studies Learn with flashcards, games, and more — for free. ... Chapter 8 section 2 quiz answers, Chapter 8 section 1 & 2 test study cards. 40 terms. codeman128. Preview. IB Topic 1 - Cells. Teacher 51 terms. ... one of a class of lysosomal storage diseases in which one or more enzymes that are normally found in the lysosomes ...
NATIONAL CENTER FOR CASE STUDY TEACHING IN SCIENCE by Tracie Y. Hudson Department of Biology Malcolm X College, Chicago, Illinois Little Girl Lost: A Case Study on Defective Cellular Organelles Part I - Bringing Home Baby After many years of trying to get pregnant again, Kenneth and Vicki Johnson were thrilled at the birth of their baby Nicole. eir rst child had died mysteriously at 12 ...
Little Girl Lost assignment answers, McDermit, THHS little girl lost questions part bringing home ba questions the phrase to is the inability to grow or gain ... Given that the cells of an organism function as a factory, and each organelle contributes to a comprehensive working body, the failure of the mitochondria would result in the collapse ...
Answer Key for "Little Girl Lost" - Case Study Collection - National Center for Case Study Teaching ... View Defective Organelle Case Study Handout.pdf from BIO 125 at Ringgold High School. ... Below is the scatterplot, regression line, and corresponding statistics for price ( x ) -vs- number sold ( y ) data. Answer the following questions ...
Study with Quizlet and memorize flashcards containing terms like Nucleus, Nucleolus, Cytoplasm and more.
Rather, administrative closure temporarily pauses the case until a party files a motion to recalendar the case and the motion is granted. Once recalendared, the case is completed through an order of relief, removal, termination, or dismissal, as warranted by the circumstances of each case. See, e.g., Arevalo v.
View Defective Organelle Student Worksheet.docx from BIO 125 at Ringgold High School. BIO125 Defective Organelle Case Study Handout Name_ Answer the following questions taken from the case study AI Homework Help
Answer Key for "Little Girl Lost" - Case Study Collection - National Center for Case Study Teaching . ... View Organelle Case Study done.docx from BIOL 101 at Bowie State University. Name: Orga... Little Girl Lost_ A Case Study on Defective Cellular Organelles.docx. Ultimate Medical Academy, Tampa. ANATOMY 101. Bacteria.
Part 3 - Understanding the Cell Kenneth and Vicki were in a state of shock as they drove home. Te doctor had said that Nicole's disease was caused by a defective cellular organelle. However he hadn't explained what an organelle was or which one was defective. Kenneth decided to do some research. "I need to better understand the source of Nicole's illness ," Kenneth said with resolve.