author thesis define

• Literary Terms
• Definition & Examples
• When & How to Write a Thesis

I. What is a Thesis?

The thesis (pronounced thee -seez), also known as a thesis statement, is the sentence that introduces the main argument or point of view of a composition (formal essay, nonfiction piece, or narrative). It is the main claim that the author is making about that topic and serves to summarize and introduce that writing that will be discussed throughout the entire piece. For this reason, the thesis is typically found within the first introduction paragraph.

II. Examples of Theses

Here are a few examples of theses which may be found in the introductions of a variety of essays :

In “The Mending Wall,” Robert Frost uses imagery, metaphor, and dialogue to argue against the use of fences between neighbors.

In this example, the thesis introduces the main subject (Frost’s poem “The Mending Wall”), aspects of the subject which will be examined (imagery, metaphor, and dialogue) and the writer’s argument (fences should not be used).

While Facebook connects some, overall, the social networking site is negative in that it isolates users, causes jealousy, and becomes an addiction.

This thesis introduces an argumentative essay which argues against the use of Facebook due to three of its negative effects.

During the college application process, I discovered my willingness to work hard to achieve my dreams and just what those dreams were.

In this more personal example, the thesis statement introduces a narrative essay which will focus on personal development in realizing one’s goals and how to achieve them.

III. The Importance of Using a Thesis

Theses are absolutely necessary components in essays because they introduce what an essay will be about. Without a thesis, the essay lacks clear organization and direction. Theses allow writers to organize their ideas by clearly stating them, and they allow readers to be aware from the beginning of a composition’s subject, argument, and course. Thesis statements must precisely express an argument within the introductory paragraph of the piece in order to guide the reader from the very beginning.

IV. Examples of Theses in Literature

For examples of theses in literature, consider these thesis statements from essays about topics in literature:

In William Shakespeare’s “ Sonnet 46,” both physicality and emotion together form powerful romantic love.

This thesis statement clearly states the work and its author as well as the main argument: physicality and emotion create romantic love.

In The Scarlet Letter, Nathaniel Hawthorne symbolically shows Hester Prynne’s developing identity through the use of the letter A: she moves from adulteress to able community member to angel.

In this example, the work and author are introduced as well as the main argument and supporting points: Prynne’s identity is shown through the letter A in three ways: adulteress, able community member, and angel.

John Keats’ poem “To Autumn” utilizes rhythm, rhyme, and imagery to examine autumn’s simultaneous birth and decay.

This thesis statement introduces the poem and its author along with an argument about the nature of autumn. This argument will be supported by an examination of rhythm, rhyme, and imagery.

V. Examples of Theses in Pop Culture

Sometimes, pop culture attempts to make arguments similar to those of research papers and essays. Here are a few examples of theses in pop culture:

America’s food industry is making a killing and it’s making us sick, but you have the power to turn the tables.

The documentary Food Inc. examines this thesis with evidence throughout the film including video evidence, interviews with experts, and scientific research.

Orca whales should not be kept in captivity, as it is psychologically traumatizing and has caused them to kill their own trainers.

Blackfish uses footage, interviews, and history to argue for the thesis that orca whales should not be held in captivity.

VI. Related Terms

Just as a thesis is introduced in the beginning of a composition, the hypothesis is considered a starting point as well. Whereas a thesis introduces the main point of an essay, the hypothesis introduces a proposed explanation which is being investigated through scientific or mathematical research. Thesis statements present arguments based on evidence which is presented throughout the paper, whereas hypotheses are being tested by scientists and mathematicians who may disprove or prove them through experimentation. Here is an example of a hypothesis versus a thesis:

Hypothesis:

Students skip school more often as summer vacation approaches.

This hypothesis could be tested by examining attendance records and interviewing students. It may or may not be true.

Students skip school due to sickness, boredom with classes, and the urge to rebel.

This thesis presents an argument which will be examined and supported in the paper with detailed evidence and research.

Introduction

A paper’s introduction is its first paragraph which is used to introduce the paper’s main aim and points used to support that aim throughout the paper. The thesis statement is the most important part of the introduction which states all of this information in one concise statement. Typically, introduction paragraphs require a thesis statement which ties together the entire introduction and introduces the rest of the paper.

VII. Conclusion

Theses are necessary components of well-organized and convincing essays, nonfiction pieces, narratives , and documentaries. They allow writers to organize and support arguments to be developed throughout a composition, and they allow readers to understand from the beginning what the aim of the composition is.

List of Terms

• Alliteration
• Amplification
• Anachronism
• Anthropomorphism
• Antonomasia
• APA Citation
• Aposiopesis
• Autobiography
• Bildungsroman
• Characterization
• Circumlocution
• Cliffhanger
• Comic Relief
• Connotation
• Deus ex machina
• Deuteragonist
• Doppelganger
• Double Entendre
• Dramatic irony
• Equivocation
• Extended Metaphor
• Figures of Speech
• Flash-forward
• Foreshadowing
• Intertextuality
• Juxtaposition
• Literary Device
• Malapropism
• Onomatopoeia
• Parallelism
• Pathetic Fallacy
• Personification
• Point of View
• Polysyndeton
• Protagonist
• Red Herring
• Rhetorical Device
• Rhetorical Question
• Science Fiction
• Self-Fulfilling Prophecy
• Synesthesia
• Turning Point
• Understatement
• Urban Legend
• Verisimilitude
• Essay Guide
• Cite This Website

Literary Devices

Literary devices, terms, and elements, definition of thesis.

A thesis is a statement or central idea that a writer puts forward at the beginning of an argument, and will support throughout the following text. The thesis is a premise that the author believes to be true, and will give evidence for by way of facts or situations that reinforce this central idea. Thesis statements are most often found in academic writing, and have a subtler yet analogous role in fiction.

The word “thesis” comes from Greek, in which it means “something put forth.” The definition of thesis developed from this reference to an proposition for which the author wants to argue the validity.

Common Examples of Thesis

We generally do not use formal thesis examples in ordinary life. It is possible, however, to state a main idea and back this idea up with evidence. Someone could say, for example, “We’re destined to be together,” and give reasons why this is the case. The lyrics of the popular song “Ho Hey” by the Lumineers illustrates this concept:

1, 2, 3 I belong with you, you belong with me, you’re my sweetheart I belong with you, you belong with me, you’re my sweet (Ho!) So show me family (Hey!) All the blood that I would bleed (Ho!) I don’t know where I belong (Hey!) I don’t know where I went wrong (Ho!) But I can write a song (Hey!)

Bob Dylan’s song “The Hurricane” also puts forward a thesis statement—Rubin Carter “The Hurricane was innocent of a crime he was charged with—and supports it with evidence of the story:

Pistols shots ring out in the barroom night Enter Patty Valentine from the upper hall She sees the bartender in a pool of blood Cries out “My God they killed them all” Here comes the story of the Hurricane The man the authorities came to blame For something that he never done Put him in a prison cell but one time he could-a been The champion of the world.

There are also countless examples of theses in academia; everyone who attains a Ph.D. must first present a thesis paper, sometimes called a dissertation, that is the product of many years of research and investigation. Examples of thesis papers are often found in other undergraduate and graduate studies as well.

Significance of Thesis in Literature

While the thesis of a work of literature can be harder to extract from the body of the text than in academic writing, it can be just as important. Writers have a certain point of view from which they are writing, and may construct entire poems and novels to prove certain ideas true. While an academic writer can base his or her argument off of fact and data, the literary writer often uses situations and the emotions they provoke to help prove certain ideas. This process can take longer to develop than in academic thesis examples, and yet the result can often be stronger. When authors of poetry and prose appeal to emotion as well as logic (both pathos and logos), the reader is more likely to be convinced of a certain message, as well as remember the message for a longer period of time.

Examples of Thesis in Literature

JAQUES: All the world’s a stage, And all the men and women merely players; They have their exits and their entrances, And one man in his time plays many parts, His acts being seven ages.

( As You Like It by William Shakespeare)

This famous example of thesis from the character of Jaques is a beautiful metaphor for the similarities between life and the stage. It is often quoted because it seems to reflect a world-view that Shakespeare probably held; everything that happens in the world can be read as a type of performance with everyone just trying to play their part.

You never really understand a person until you consider things from his point of view . . . until you climb into his skin and walk around in it.

( To Kill a Mockingbird by Harper Lee)

The above excerpt from Harper Lee’s To Kill a Mockingbird is famous because it is an important central idea to the novel. Atticus Finch believes in empathy and understanding other people’s life stories and points of view. Therefore, he strongly believes that we must try to understand where other people are coming from. This one statement is a thesis that the rest of the book supports.

TOM: Yes, I have tricks in my pocket, I have things up my sleeve. But I am the opposite of a stage magician. He gives you illusion that has the appearance of truth. I give you truth in the pleasant disguise of illusion.

( The Glass Menagerie by Tennessee Williams) Thesis examples can often be found at the beginning of a work of poetry, prose, or drama, as is the case with Tennessee Williams’s The Glass Menagerie . The character of Tom narrates the play, and often breaks the fourth wall to address the audience directly. In this quote, which opens the play, Tom presents the idea that the drama that is about to unfold is entertaining yet tells the truth. Similar to Shakespeare, this could be understood as Tennessee William’s thesis about the power of drama.

And this I believe: that the free, exploring mind of the individual human is the most valuable thing in the world. And this I would fight for: the freedom of the mind to take any direction it wishes, undirected. And this I must fight against: any idea, religion, or government which limits or destroys the individual.

( East of Eden by John Steinbeck)

In his novel East of Eden , John Steinbeck often makes authorial interjections. These passages seem to highlight Steinbeck’s own views on different matters, rather than any particular character’s views. The short excerpt above is one of the strongest examples of a thesis statement in all of literature; Steinbeck firmly believe in free will, and vows to fight against anything that would limit free will. He presents more than one example of thesis in his novel, and creates characters and situations that support his beliefs.

so much depends upon a red wheel barrow glazed with rain water beside the white chickens.

(“The Red Wheelbarrow” by William Carlos Williams)

Poetry can have examples of thesis statements just as easily as prose or drama. William Carlos Williams’s poem “The Red Wheelbarrow” is famously enigmatic, while also being quite direct. He makes the straightforward argument that “so much depends” on a certain intangible object. In this case, “a red wheel / barrow.” Many readers and scholars have interpreted this short thesis statement in countless different ways. Thus, it is an interesting thesis example because Williams states it so unswervingly, yet does not support it with other evidence. Readers are left to interpret and prove this thesis example themselves.

Test Your Knowledge of Thesis

1. Which of the following statements is the best thesis definition? A. A minor claim to support the main proposition that author has put forth. B. A central idea which the author intends to support via evidence. C. A piece of evidence or a fact. [spoiler title=”Answer to Question #1″] Answer: B is the correct answer.[/spoiler]

2. What thesis could be extracted from the following quote from John Steinbeck’s East of Eden?

Monsters are variations from the accepted normal to a greater or a less degree. As a child may be born without an arm, so one may be born without kindness or the potential of conscience.

A. All people with physical deformities are monsters. B. All monsters are evil. C. Some people can be born without kindness, making them monstrous. [spoiler title=”Answer to Question #2″] Answer: C is the correct answer.[/spoiler]

3. What is the thesis in William Shakespeare’s “Sonnet 116”?

Let me not to the marriage of true minds Admit impediments. Love is not love Which alters when it alteration finds, Or bends with the remover to remove: O no; it is an ever-fixed mark, That looks on tempests, and is never shaken; It is the star to every wandering bark, Whose worth’s unknown, although his height be taken. Love’s not Time’s fool, though rosy lips and cheeks Within his bending sickle’s compass come; Love alters not with his brief hours and weeks, But bears it out even to the edge of doom. If this be error and upon me proved, I never writ, nor no man ever loved.

A. True love does not change when problems arise. B. Love is a game for fools. C. Only married people understand true love. [spoiler title=”Answer to Question #3″] Answer: A is the correct answer.[/spoiler]

Thesis Statements

What this handout is about.

This handout describes what a thesis statement is, how thesis statements work in your writing, and how you can craft or refine one for your draft.

Introduction

Writing in college often takes the form of persuasion—convincing others that you have an interesting, logical point of view on the subject you are studying. Persuasion is a skill you practice regularly in your daily life. You persuade your roommate to clean up, your parents to let you borrow the car, your friend to vote for your favorite candidate or policy. In college, course assignments often ask you to make a persuasive case in writing. You are asked to convince your reader of your point of view. This form of persuasion, often called academic argument, follows a predictable pattern in writing. After a brief introduction of your topic, you state your point of view on the topic directly and often in one sentence. This sentence is the thesis statement, and it serves as a summary of the argument you’ll make in the rest of your paper.

What is a thesis statement?

A thesis statement:

• tells the reader how you will interpret the significance of the subject matter under discussion.
• is a road map for the paper; in other words, it tells the reader what to expect from the rest of the paper.
• directly answers the question asked of you. A thesis is an interpretation of a question or subject, not the subject itself. The subject, or topic, of an essay might be World War II or Moby Dick; a thesis must then offer a way to understand the war or the novel.
• makes a claim that others might dispute.
• is usually a single sentence near the beginning of your paper (most often, at the end of the first paragraph) that presents your argument to the reader. The rest of the paper, the body of the essay, gathers and organizes evidence that will persuade the reader of the logic of your interpretation.

If your assignment asks you to take a position or develop a claim about a subject, you may need to convey that position or claim in a thesis statement near the beginning of your draft. The assignment may not explicitly state that you need a thesis statement because your instructor may assume you will include one. When in doubt, ask your instructor if the assignment requires a thesis statement. When an assignment asks you to analyze, to interpret, to compare and contrast, to demonstrate cause and effect, or to take a stand on an issue, it is likely that you are being asked to develop a thesis and to support it persuasively. (Check out our handout on understanding assignments for more information.)

How do I create a thesis?

A thesis is the result of a lengthy thinking process. Formulating a thesis is not the first thing you do after reading an essay assignment. Before you develop an argument on any topic, you have to collect and organize evidence, look for possible relationships between known facts (such as surprising contrasts or similarities), and think about the significance of these relationships. Once you do this thinking, you will probably have a “working thesis” that presents a basic or main idea and an argument that you think you can support with evidence. Both the argument and your thesis are likely to need adjustment along the way.

Writers use all kinds of techniques to stimulate their thinking and to help them clarify relationships or comprehend the broader significance of a topic and arrive at a thesis statement. For more ideas on how to get started, see our handout on brainstorming .

How do I know if my thesis is strong?

If there’s time, run it by your instructor or make an appointment at the Writing Center to get some feedback. Even if you do not have time to get advice elsewhere, you can do some thesis evaluation of your own. When reviewing your first draft and its working thesis, ask yourself the following :

• Do I answer the question? Re-reading the question prompt after constructing a working thesis can help you fix an argument that misses the focus of the question. If the prompt isn’t phrased as a question, try to rephrase it. For example, “Discuss the effect of X on Y” can be rephrased as “What is the effect of X on Y?”
• Have I taken a position that others might challenge or oppose? If your thesis simply states facts that no one would, or even could, disagree with, it’s possible that you are simply providing a summary, rather than making an argument.
• Is my thesis statement specific enough? Thesis statements that are too vague often do not have a strong argument. If your thesis contains words like “good” or “successful,” see if you could be more specific: why is something “good”; what specifically makes something “successful”?
• Does my thesis pass the “So what?” test? If a reader’s first response is likely to  be “So what?” then you need to clarify, to forge a relationship, or to connect to a larger issue.
• Does my essay support my thesis specifically and without wandering? If your thesis and the body of your essay do not seem to go together, one of them has to change. It’s okay to change your working thesis to reflect things you have figured out in the course of writing your paper. Remember, always reassess and revise your writing as necessary.
• Does my thesis pass the “how and why?” test? If a reader’s first response is “how?” or “why?” your thesis may be too open-ended and lack guidance for the reader. See what you can add to give the reader a better take on your position right from the beginning.

Suppose you are taking a course on contemporary communication, and the instructor hands out the following essay assignment: “Discuss the impact of social media on public awareness.” Looking back at your notes, you might start with this working thesis:

Social media impacts public awareness in both positive and negative ways.

You can use the questions above to help you revise this general statement into a stronger thesis.

• Do I answer the question? You can analyze this if you rephrase “discuss the impact” as “what is the impact?” This way, you can see that you’ve answered the question only very generally with the vague “positive and negative ways.”
• Have I taken a position that others might challenge or oppose? Not likely. Only people who maintain that social media has a solely positive or solely negative impact could disagree.
• Is my thesis statement specific enough? No. What are the positive effects? What are the negative effects?
• Does my thesis pass the “how and why?” test? No. Why are they positive? How are they positive? What are their causes? Why are they negative? How are they negative? What are their causes?
• Does my thesis pass the “So what?” test? No. Why should anyone care about the positive and/or negative impact of social media?

After thinking about your answers to these questions, you decide to focus on the one impact you feel strongly about and have strong evidence for:

Because not every voice on social media is reliable, people have become much more critical consumers of information, and thus, more informed voters.

This version is a much stronger thesis! It answers the question, takes a specific position that others can challenge, and it gives a sense of why it matters.

Let’s try another. Suppose your literature professor hands out the following assignment in a class on the American novel: Write an analysis of some aspect of Mark Twain’s novel Huckleberry Finn. “This will be easy,” you think. “I loved Huckleberry Finn!” You grab a pad of paper and write:

Mark Twain’s Huckleberry Finn is a great American novel.

You begin to analyze your thesis:

• Do I answer the question? No. The prompt asks you to analyze some aspect of the novel. Your working thesis is a statement of general appreciation for the entire novel.

Think about aspects of the novel that are important to its structure or meaning—for example, the role of storytelling, the contrasting scenes between the shore and the river, or the relationships between adults and children. Now you write:

In Huckleberry Finn, Mark Twain develops a contrast between life on the river and life on the shore.

• Do I answer the question? Yes!
• Have I taken a position that others might challenge or oppose? Not really. This contrast is well-known and accepted.
• Is my thesis statement specific enough? It’s getting there–you have highlighted an important aspect of the novel for investigation. However, it’s still not clear what your analysis will reveal.
• Does my thesis pass the “how and why?” test? Not yet. Compare scenes from the book and see what you discover. Free write, make lists, jot down Huck’s actions and reactions and anything else that seems interesting.
• Does my thesis pass the “So what?” test? What’s the point of this contrast? What does it signify?”

After examining the evidence and considering your own insights, you write:

Through its contrasting river and shore scenes, Twain’s Huckleberry Finn suggests that to find the true expression of American democratic ideals, one must leave “civilized” society and go back to nature.

This final thesis statement presents an interpretation of a literary work based on an analysis of its content. Of course, for the essay itself to be successful, you must now present evidence from the novel that will convince the reader of your interpretation.

Works consulted

We consulted these works while writing this handout. This is not a comprehensive list of resources on the handout’s topic, and we encourage you to do your own research to find additional publications. Please do not use this list as a model for the format of your own reference list, as it may not match the citation style you are using. For guidance on formatting citations, please see the UNC Libraries citation tutorial . We revise these tips periodically and welcome feedback.

Anson, Chris M., and Robert A. Schwegler. 2010. The Longman Handbook for Writers and Readers , 6th ed. New York: Longman.

Lunsford, Andrea A. 2015. The St. Martin’s Handbook , 8th ed. Boston: Bedford/St Martin’s.

Ramage, John D., John C. Bean, and June Johnson. 2018. The Allyn & Bacon Guide to Writing , 8th ed. New York: Pearson.

Ruszkiewicz, John J., Christy Friend, Daniel Seward, and Maxine Hairston. 2010. The Scott, Foresman Handbook for Writers , 9th ed. Boston: Pearson Education.

You may reproduce it for non-commercial use if you use the entire handout and attribute the source: The Writing Center, University of North Carolina at Chapel Hill

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What is a Thesis in Literature? Definition, Examples of Literary Thesis

Thesis is the major claim or point made by an author in a work of writing. A thesis statement is the sentence in a composition that introduces the main argument or main point of view. It introduces the main idea of the following writing.

What is a Thesis?

Thesis statements can be found in all types of writing and are used by the author to introduce what is the intended topic of focus. A thesis gives a work of writing direction and indicates to the reader what is about to be discussed, supported, or developed.

Since thesis statements help to give context to the following writing, they are found in the beginning of a composition— usually in the first paragraph.

For example, in an essay about a literary work, a thesis statement would look something like this:

• In Ovid’s Metamorphoses , stories of transformation are told in order to support Ovid’s personal belief that art and art alone allows humans to transcend suffering.

The Importance of a Thesis Statement

Without a thesis statement to guide it, an essay, narrative story, or any other kind of writing, may lack direction. Without a clearly defined thesis, readers can have trouble comprehending and following what the writer plans to explain and develop.

In an essay, a thesis statement will introduce the writer’s main point or argument so that the reader understands what is about to be discussed. A structure and source of direction is developed in a successful thesis statement when it is introduced in the first paragraph. The rest of the essay then follows what the thesis has clearly outlined.

In narrative, or story-telling writing, a narrative thesis also provides a jumping-off point for the story by giving the reader information which helps set context. Narrative theses can be apparent or implied, or hidden. In either case, thesis guides the story towards development and its overall purpose.

The Importance of Thesis in Literature

In literature, a thesis acts as an early source of information about what kind of story is about to be told. Authors can state the thesis outright in a literary work, or they can hide the thesis so that it blends in with the beginning of the story.

The main purpose of a thesis in any type of literature, whether narrative or essay/academic, is to concisely outline the writing that will follow. The function of this is to provide readers with a clear concept of what kinds of material they are about to read.

For example, in an argumentative essay, the thesis will clearly state the argument and how it will be supported. In a narrative thesis statement, some context will be given to the story. This can include hints about setting, characters, and tone or style.

How Theses are Used in Literature

The following examples show how thesis has been used in various ways in classic literary works:

In One Hundred Years of Solitude by Gabriel García Márquez , the thesis serves to frame the overall context for the story that is about to follow:

• Many years later, as he faced the firing squad, Colonel Aureliana Buendía was to remember that distant afternoon when his father took him to discover ice.

Anna Karenina by Leo Tolstoy does a similar thing by informing the reader that they are about to read a story about one unhappy family’s trials and tribulations:

• Happy families are all alike; every unhappy family is unhappy in its own way.

The wildly popular contemporary memoir, Wild by Cheryl Strayed uses thesis to provide a framework and also set the plot in motion:

• My solo three-month hike on the Pacific Crest Trail had many beginnings. There was the first, flip decision to do it, followed by the second, more serious decision to actually do it, and then the long third beginning, composed of weeks of shopping and packing and preparing to do it.

Recap: What is a Thesis in Literature?

Thesis is a tool used to provide context in the beginning of a work of writing that will help the reader to gain an idea of what is about to be argued, revealed, or developed. Thesis statements are necessary to providing structure and direction for the reader and good writing upholds the thesis statement throughout the entirety of the piece.

Developing a Thesis Statement

Many papers you write require developing a thesis statement. In this section you’ll learn what a thesis statement is and how to write one.

Keep in mind that not all papers require thesis statements . If in doubt, please consult your instructor for assistance.

What is a thesis statement?

A thesis statement . . .

• Makes an argumentative assertion about a topic; it states the conclusions that you have reached about your topic.
• Makes a promise to the reader about the scope, purpose, and direction of your paper.
• Is focused and specific enough to be “proven” within the boundaries of your paper.
• Is generally located near the end of the introduction ; sometimes, in a long paper, the thesis will be expressed in several sentences or in an entire paragraph.
• Identifies the relationships between the pieces of evidence that you are using to support your argument.

Not all papers require thesis statements! Ask your instructor if you’re in doubt whether you need one.

Identify a topic

Your topic is the subject about which you will write. Your assignment may suggest several ways of looking at a topic; or it may name a fairly general concept that you will explore or analyze in your paper.

Consider what your assignment asks you to do

Inform yourself about your topic, focus on one aspect of your topic, ask yourself whether your topic is worthy of your efforts, generate a topic from an assignment.

Below are some possible topics based on sample assignments.

Sample assignment 1

Analyze Spain’s neutrality in World War II.

Identified topic

Franco’s role in the diplomatic relationships between the Allies and the Axis

This topic avoids generalities such as “Spain” and “World War II,” addressing instead on Franco’s role (a specific aspect of “Spain”) and the diplomatic relations between the Allies and Axis (a specific aspect of World War II).

Sample assignment 2

Analyze one of Homer’s epic similes in the Iliad.

The relationship between the portrayal of warfare and the epic simile about Simoisius at 4.547-64.

This topic focuses on a single simile and relates it to a single aspect of the Iliad ( warfare being a major theme in that work).

Developing a Thesis Statement–Additional information

Your assignment may suggest several ways of looking at a topic, or it may name a fairly general concept that you will explore or analyze in your paper. You’ll want to read your assignment carefully, looking for key terms that you can use to focus your topic.

Sample assignment: Analyze Spain’s neutrality in World War II Key terms: analyze, Spain’s neutrality, World War II

After you’ve identified the key words in your topic, the next step is to read about them in several sources, or generate as much information as possible through an analysis of your topic. Obviously, the more material or knowledge you have, the more possibilities will be available for a strong argument. For the sample assignment above, you’ll want to look at books and articles on World War II in general, and Spain’s neutrality in particular.

As you consider your options, you must decide to focus on one aspect of your topic. This means that you cannot include everything you’ve learned about your topic, nor should you go off in several directions. If you end up covering too many different aspects of a topic, your paper will sprawl and be unconvincing in its argument, and it most likely will not fulfull the assignment requirements.

For the sample assignment above, both Spain’s neutrality and World War II are topics far too broad to explore in a paper. You may instead decide to focus on Franco’s role in the diplomatic relationships between the Allies and the Axis , which narrows down what aspects of Spain’s neutrality and World War II you want to discuss, as well as establishes a specific link between those two aspects.

Before you go too far, however, ask yourself whether your topic is worthy of your efforts. Try to avoid topics that already have too much written about them (i.e., “eating disorders and body image among adolescent women”) or that simply are not important (i.e. “why I like ice cream”). These topics may lead to a thesis that is either dry fact or a weird claim that cannot be supported. A good thesis falls somewhere between the two extremes. To arrive at this point, ask yourself what is new, interesting, contestable, or controversial about your topic.

As you work on your thesis, remember to keep the rest of your paper in mind at all times . Sometimes your thesis needs to evolve as you develop new insights, find new evidence, or take a different approach to your topic.

Derive a main point from topic

Once you have a topic, you will have to decide what the main point of your paper will be. This point, the “controlling idea,” becomes the core of your argument (thesis statement) and it is the unifying idea to which you will relate all your sub-theses. You can then turn this “controlling idea” into a purpose statement about what you intend to do in your paper.

Look for patterns in your evidence

Compose a purpose statement.

Consult the examples below for suggestions on how to look for patterns in your evidence and construct a purpose statement.

• Franco first tried to negotiate with the Axis
• Franco turned to the Allies when he couldn’t get some concessions that he wanted from the Axis

Possible conclusion:

Spain’s neutrality in WWII occurred for an entirely personal reason: Franco’s desire to preserve his own (and Spain’s) power.

Purpose statement

This paper will analyze Franco’s diplomacy during World War II to see how it contributed to Spain’s neutrality.

• The simile compares Simoisius to a tree, which is a peaceful, natural image.
• The tree in the simile is chopped down to make wheels for a chariot, which is an object used in warfare.

At first, the simile seems to take the reader away from the world of warfare, but we end up back in that world by the end.

This paper will analyze the way the simile about Simoisius at 4.547-64 moves in and out of the world of warfare.

Derive purpose statement from topic

To find out what your “controlling idea” is, you have to examine and evaluate your evidence . As you consider your evidence, you may notice patterns emerging, data repeated in more than one source, or facts that favor one view more than another. These patterns or data may then lead you to some conclusions about your topic and suggest that you can successfully argue for one idea better than another.

For instance, you might find out that Franco first tried to negotiate with the Axis, but when he couldn’t get some concessions that he wanted from them, he turned to the Allies. As you read more about Franco’s decisions, you may conclude that Spain’s neutrality in WWII occurred for an entirely personal reason: his desire to preserve his own (and Spain’s) power. Based on this conclusion, you can then write a trial thesis statement to help you decide what material belongs in your paper.

Sometimes you won’t be able to find a focus or identify your “spin” or specific argument immediately. Like some writers, you might begin with a purpose statement just to get yourself going. A purpose statement is one or more sentences that announce your topic and indicate the structure of the paper but do not state the conclusions you have drawn . Thus, you might begin with something like this:

• This paper will look at modern language to see if it reflects male dominance or female oppression.
• I plan to analyze anger and derision in offensive language to see if they represent a challenge of society’s authority.

At some point, you can turn a purpose statement into a thesis statement. As you think and write about your topic, you can restrict, clarify, and refine your argument, crafting your thesis statement to reflect your thinking.

As you work on your thesis, remember to keep the rest of your paper in mind at all times. Sometimes your thesis needs to evolve as you develop new insights, find new evidence, or take a different approach to your topic.

Compose a draft thesis statement

If you are writing a paper that will have an argumentative thesis and are having trouble getting started, the techniques in the table below may help you develop a temporary or “working” thesis statement.

Begin with a purpose statement that you will later turn into a thesis statement.

Assignment: Discuss the history of the Reform Party and explain its influence on the 1990 presidential and Congressional election.

Purpose Statement: This paper briefly sketches the history of the grassroots, conservative, Perot-led Reform Party and analyzes how it influenced the economic and social ideologies of the two mainstream parties.

Question-to-Assertion

If your assignment asks a specific question(s), turn the question(s) into an assertion and give reasons why it is true or reasons for your opinion.

Assignment : What do Aylmer and Rappaccini have to be proud of? Why aren’t they satisfied with these things? How does pride, as demonstrated in “The Birthmark” and “Rappaccini’s Daughter,” lead to unexpected problems?

Beginning thesis statement: Alymer and Rappaccinni are proud of their great knowledge; however, they are also very greedy and are driven to use their knowledge to alter some aspect of nature as a test of their ability. Evil results when they try to “play God.”

Write a sentence that summarizes the main idea of the essay you plan to write.

Main idea: The reason some toys succeed in the market is that they appeal to the consumers’ sense of the ridiculous and their basic desire to laugh at themselves.

Make a list of the ideas that you want to include; consider the ideas and try to group them.

• nature = peaceful
• war matériel = violent (competes with 1?)
• need for time and space to mourn the dead
• war is inescapable (competes with 3?)

Use a formula to arrive at a working thesis statement (you will revise this later).

• although most readers of _______ have argued that _______, closer examination shows that _______.
• _______ uses _______ and _____ to prove that ________.
• phenomenon x is a result of the combination of __________, __________, and _________.

What to keep in mind as you draft an initial thesis statement

Beginning statements obtained through the methods illustrated above can serve as a framework for planning or drafting your paper, but remember they’re not yet the specific, argumentative thesis you want for the final version of your paper. In fact, in its first stages, a thesis statement usually is ill-formed or rough and serves only as a planning tool.

As you write, you may discover evidence that does not fit your temporary or “working” thesis. Or you may reach deeper insights about your topic as you do more research, and you will find that your thesis statement has to be more complicated to match the evidence that you want to use.

You must be willing to reject or omit some evidence in order to keep your paper cohesive and your reader focused. Or you may have to revise your thesis to match the evidence and insights that you want to discuss. Read your draft carefully, noting the conclusions you have drawn and the major ideas which support or prove those conclusions. These will be the elements of your final thesis statement.

Sometimes you will not be able to identify these elements in your early drafts, but as you consider how your argument is developing and how your evidence supports your main idea, ask yourself, “ What is the main point that I want to prove/discuss? ” and “ How will I convince the reader that this is true? ” When you can answer these questions, then you can begin to refine the thesis statement.

Refine and polish the thesis statement

To get to your final thesis, you’ll need to refine your draft thesis so that it’s specific and arguable.

• Ask if your draft thesis addresses the assignment
• Question each part of your draft thesis
• Clarify vague phrases and assertions
• Investigate alternatives to your draft thesis

Consult the example below for suggestions on how to refine your draft thesis statement.

Sample Assignment

Choose an activity and define it as a symbol of American culture. Your essay should cause the reader to think critically about the society which produces and enjoys that activity.

• Ask The phenomenon of drive-in facilities is an interesting symbol of american culture, and these facilities demonstrate significant characteristics of our society.This statement does not fulfill the assignment because it does not require the reader to think critically about society.

Drive-ins are an interesting symbol of American culture because they represent Americans’ significant creativity and business ingenuity.

Among the types of drive-in facilities familiar during the twentieth century, drive-in movie theaters best represent American creativity, not merely because they were the forerunner of later drive-ins and drive-throughs, but because of their impact on our culture: they changed our relationship to the automobile, changed the way people experienced movies, and changed movie-going into a family activity.

While drive-in facilities such as those at fast-food establishments, banks, pharmacies, and dry cleaners symbolize America’s economic ingenuity, they also have affected our personal standards.

While drive-in facilities such as those at fast- food restaurants, banks, pharmacies, and dry cleaners symbolize (1) Americans’ business ingenuity, they also have contributed (2) to an increasing homogenization of our culture, (3) a willingness to depersonalize relationships with others, and (4) a tendency to sacrifice quality for convenience.

This statement is now specific and fulfills all parts of the assignment. This version, like any good thesis, is not self-evident; its points, 1-4, will have to be proven with evidence in the body of the paper. The numbers in this statement indicate the order in which the points will be presented. Depending on the length of the paper, there could be one paragraph for each numbered item or there could be blocks of paragraph for even pages for each one.

Complete the final thesis statement

The bottom line.

As you move through the process of crafting a thesis, you’ll need to remember four things:

• Context matters! Think about your course materials and lectures. Try to relate your thesis to the ideas your instructor is discussing.
• As you go through the process described in this section, always keep your assignment in mind . You will be more successful when your thesis (and paper) responds to the assignment than if it argues a semi-related idea.
• Your thesis statement should be precise, focused, and contestable ; it should predict the sub-theses or blocks of information that you will use to prove your argument.
• Make sure that you keep the rest of your paper in mind at all times. Change your thesis as your paper evolves, because you do not want your thesis to promise more than your paper actually delivers.

In the beginning, the thesis statement was a tool to help you sharpen your focus, limit material and establish the paper’s purpose. When your paper is finished, however, the thesis statement becomes a tool for your reader. It tells the reader what you have learned about your topic and what evidence led you to your conclusion. It keeps the reader on track–well able to understand and appreciate your argument.

Writing Process and Structure

This is an accordion element with a series of buttons that open and close related content panels.

Getting Started with Your Paper

Interpreting Writing Assignments from Your Courses

Generating Ideas for

Creating an Argument

Thesis vs. Purpose Statements

Architecture of Arguments

Working with Sources

Quoting and Paraphrasing Sources

Using Literary Quotations

Citing Sources in Your Paper

Drafting Your Paper

Generating Ideas for Your Paper

Introductions

Paragraphing

Developing Strategic Transitions

Conclusions

Revising Your Paper

Peer Reviews

Reverse Outlines

Revising an Argumentative Paper

Revision Strategies for Longer Projects

Finishing Your Paper

Twelve Common Errors: An Editing Checklist

How to Proofread your Paper

Writing Collaboratively

Collaborative and Group Writing

Thesis Definition

A thesis is a statement in a non- fiction or a fiction work that a writer intends to support and prove. One can find examples of thesis statement at the beginning of literary pieces. These thesis statements are of utmost importance, as they provide clear indicators as to which direction the writer will follow in their work.

A thesis statement is carefully crafted by a writer, and is marked by vigilant selection of words that will never miss its target. Generally, such a statement shows up in the first paragraph, or what is called an introduction . Despite writers’ efforts to prove their thesis statements, not all of these statements can be verified for their exactness. Nevertheless, they do develop an argument .

Importance of a Thesis Statement

In writing an essay , a thesis statement determines the worth of the essay by its capacity to stay focused on its thesis statement. For instance, if a writer fails to clearly mention or define a solid thesis statement in his or her essay, it will be difficult for readers to track the issue the writer plans to discuss and explain. Suppose a writer wants to write an essay on how to make a perfect fruit salad, the quality of his or her writing will exceedingly improve if he or she lets the readers know the subject matter at the start of the essay, for example:

“In this essay, I will tell you how to make the perfect fruit salad. Not only will it be tasty, but also healthy for your body.”

Narrative Thesis

In a narrative essay, or narrative section of a piece of literature, a thesis statement is called a “narrative thesis.” A narrative thesis can be an apparent one or a hidden or implied one. In both cases, such a statement is a powerful, propelling force behind an entire work, that guides it toward its ultimate purpose and the lesson it intends to instruct.

Narrative Thesis Examples

Below is a list of a few narrative thesis examples – opening lines that determine the entire course of the narratives.

Example #1: Pride and Prejudice (By Jane Austen)

“It is a truth universally acknowledged that a single man in possession of a good fortune, must be in want of a wife.”

Example #2: One Hundred Years of Solitude (By Gabriel García Márquez)

“Many years later, as he faced the firing squad, Colonel Aureliano Buendía was to remember that distant afternoon when his father took him to discover ice.”

Example #3: Lolita (By Vladimir Nabokov)

“Lolita, light of my life, fire of my loins.”

Example #4: Anna Karenina (By Leo Tolstoy)

“Happy families are all alike; every unhappy family is unhappy in its own way.”

Example #5: 1984 (By George Orwell)

“It was a bright cold day in April, and the clocks were striking thirteen.”

Example #6: A Tale of Two Cities (By Charles Dickens)

“It was the best of times, it was the worst of times, it was the age of wisdom, it was the age of foolishness, it was the epoch of belief, it was the epoch of incredulity, it was the season of Light, it was the season of Darkness , it was the spring of hope, it was the winter of despair.”

Example #7: The Catcher in the Rye (By J. D. Salinger)

“If you really want to hear about it, the first thing you’ll probably want to know is where I was born, and what my lousy childhood was like, and how my parents were occupied and all before they had me, and all that David Copperfield kind of crap, but I don’t feel like going into it, if you want to know the truth.”

Example #8: A Portrait of the Artist as a Young Man (By James Joyce)

“Once upon a time and a very good time it was there was a moocow coming down along the road and this moocow that was coming down along the road met a nicens little boy named baby tuckoo.”

Function of Thesis

The above arguments clearly reveal the function of a thesis statements or a narrative thesis as a driving force behind a literary composition. It guides the narrative toward its ultimate purpose, which is the moral lesson it aims to inculcate.

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Writing a Paper: Thesis Statements

Basics of thesis statements.

The thesis statement is the brief articulation of your paper's central argument and purpose. You might hear it referred to as simply a "thesis." Every scholarly paper should have a thesis statement, and strong thesis statements are concise, specific, and arguable. Concise means the thesis is short: perhaps one or two sentences for a shorter paper. Specific means the thesis deals with a narrow and focused topic, appropriate to the paper's length. Arguable means that a scholar in your field could disagree (or perhaps already has!).

Strong thesis statements address specific intellectual questions, have clear positions, and use a structure that reflects the overall structure of the paper. Read on to learn more about constructing a strong thesis statement.

Being Specific

This thesis statement has no specific argument:

Needs Improvement: In this essay, I will examine two scholarly articles to find similarities and differences.

This statement is concise, but it is neither specific nor arguable—a reader might wonder, "Which scholarly articles? What is the topic of this paper? What field is the author writing in?" Additionally, the purpose of the paper—to "examine…to find similarities and differences" is not of a scholarly level. Identifying similarities and differences is a good first step, but strong academic argument goes further, analyzing what those similarities and differences might mean or imply.

Better: In this essay, I will argue that Bowler's (2003) autocratic management style, when coupled with Smith's (2007) theory of social cognition, can reduce the expenses associated with employee turnover.

The new revision here is still concise, as well as specific and arguable.  We can see that it is specific because the writer is mentioning (a) concrete ideas and (b) exact authors.  We can also gather the field (business) and the topic (management and employee turnover). The statement is arguable because the student goes beyond merely comparing; he or she draws conclusions from that comparison ("can reduce the expenses associated with employee turnover").

Making a Unique Argument

This thesis draft repeats the language of the writing prompt without making a unique argument:

Needs Improvement: The purpose of this essay is to monitor, assess, and evaluate an educational program for its strengths and weaknesses. Then, I will provide suggestions for improvement.

You can see here that the student has simply stated the paper's assignment, without articulating specifically how he or she will address it. The student can correct this error simply by phrasing the thesis statement as a specific answer to the assignment prompt.

Better: Through a series of student interviews, I found that Kennedy High School's antibullying program was ineffective. In order to address issues of conflict between students, I argue that Kennedy High School should embrace policies outlined by the California Department of Education (2010).

Words like "ineffective" and "argue" show here that the student has clearly thought through the assignment and analyzed the material; he or she is putting forth a specific and debatable position. The concrete information ("student interviews," "antibullying") further prepares the reader for the body of the paper and demonstrates how the student has addressed the assignment prompt without just restating that language.

Creating a Debate

This thesis statement includes only obvious fact or plot summary instead of argument:

Needs Improvement: Leadership is an important quality in nurse educators.

A good strategy to determine if your thesis statement is too broad (and therefore, not arguable) is to ask yourself, "Would a scholar in my field disagree with this point?" Here, we can see easily that no scholar is likely to argue that leadership is an unimportant quality in nurse educators.  The student needs to come up with a more arguable claim, and probably a narrower one; remember that a short paper needs a more focused topic than a dissertation.

Better: Roderick's (2009) theory of participatory leadership  is particularly appropriate to nurse educators working within the emergency medicine field, where students benefit most from collegial and kinesthetic learning.

Here, the student has identified a particular type of leadership ("participatory leadership"), narrowing the topic, and has made an arguable claim (this type of leadership is "appropriate" to a specific type of nurse educator). Conceivably, a scholar in the nursing field might disagree with this approach. The student's paper can now proceed, providing specific pieces of evidence to support the arguable central claim.

Choosing the Right Words

This thesis statement uses large or scholarly-sounding words that have no real substance:

Needs Improvement: Scholars should work to seize metacognitive outcomes by harnessing discipline-based networks to empower collaborative infrastructures.

There are many words in this sentence that may be buzzwords in the student's field or key terms taken from other texts, but together they do not communicate a clear, specific meaning. Sometimes students think scholarly writing means constructing complex sentences using special language, but actually it's usually a stronger choice to write clear, simple sentences. When in doubt, remember that your ideas should be complex, not your sentence structure.

Better: Ecologists should work to educate the U.S. public on conservation methods by making use of local and national green organizations to create a widespread communication plan.

Notice in the revision that the field is now clear (ecology), and the language has been made much more field-specific ("conservation methods," "green organizations"), so the reader is able to see concretely the ideas the student is communicating.

Leaving Room for Discussion

This thesis statement is not capable of development or advancement in the paper:

Needs Improvement: There are always alternatives to illegal drug use.

This sample thesis statement makes a claim, but it is not a claim that will sustain extended discussion. This claim is the type of claim that might be appropriate for the conclusion of a paper, but in the beginning of the paper, the student is left with nowhere to go. What further points can be made? If there are "always alternatives" to the problem the student is identifying, then why bother developing a paper around that claim? Ideally, a thesis statement should be complex enough to explore over the length of the entire paper.

Better: The most effective treatment plan for methamphetamine addiction may be a combination of pharmacological and cognitive therapy, as argued by Baker (2008), Smith (2009), and Xavier (2011).

In the revised thesis, you can see the student make a specific, debatable claim that has the potential to generate several pages' worth of discussion. When drafting a thesis statement, think about the questions your thesis statement will generate: What follow-up inquiries might a reader have? In the first example, there are almost no additional questions implied, but the revised example allows for a good deal more exploration.

Thesis Mad Libs

If you are having trouble getting started, try using the models below to generate a rough model of a thesis statement! These models are intended for drafting purposes only and should not appear in your final work.

• In this essay, I argue ____, using ______ to assert _____.
• While scholars have often argued ______, I argue______, because_______.
• Through an analysis of ______, I argue ______, which is important because_______.

Words to Avoid and to Embrace

When drafting your thesis statement, avoid words like explore, investigate, learn, compile, summarize , and explain to describe the main purpose of your paper. These words imply a paper that summarizes or "reports," rather than synthesizing and analyzing.

Instead of the terms above, try words like argue, critique, question , and interrogate . These more analytical words may help you begin strongly, by articulating a specific, critical, scholarly position.

Read Kayla's blog post for tips on taking a stand in a well-crafted thesis statement.

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Didn't find what you need? Email us at [email protected] .

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Definition of thesis

Did you know.

In high school, college, or graduate school, students often have to write a thesis on a topic in their major field of study. In many fields, a final thesis is the biggest challenge involved in getting a master's degree, and the same is true for students studying for a Ph.D. (a Ph.D. thesis is often called a dissertation ). But a thesis may also be an idea; so in the course of the paper the student may put forth several theses (notice the plural form) and attempt to prove them.

Examples of thesis in a Sentence

These examples are programmatically compiled from various online sources to illustrate current usage of the word 'thesis.' Any opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback about these examples.

Word History

in sense 3, Middle English, lowering of the voice, from Late Latin & Greek; Late Latin, from Greek, downbeat, more important part of a foot, literally, act of laying down; in other senses, Latin, from Greek, literally, act of laying down, from tithenai to put, lay down — more at do

14th century, in the meaning defined at sense 3a(1)

Dictionary Entries Near thesis

the sins of the fathers are visited upon the children

thesis novel

Cite this Entry

“Thesis.” Merriam-Webster.com Dictionary , Merriam-Webster, https://www.merriam-webster.com/dictionary/thesis. Accessed 24 May. 2024.

Kids Definition

Kids definition of thesis, more from merriam-webster on thesis.

Nglish: Translation of thesis for Spanish Speakers

Britannica English: Translation of thesis for Arabic Speakers

Britannica.com: Encyclopedia article about thesis

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How to Talk to an Employee Who Isn’t Meeting Expectations

• Jenny Fernandez

It’s an opportunity to address the gap between the work they’re delivering and the company’s goals.

Approaching a conversation about improving an employee’s performance requires preparation, empathy, and a focus on collaboration. Even though hearing the truth about their current performance will be tough and potentially hurtful, it’s a teaching moment managers must embrace to help them become more resilient and adept at problem-solving and developing professional relationships. The author offers several strategies for treating difficult performance conversations not as fault-finding missions, but instead as opportunities to work collaboratively to define a shared commitment to growth and development.

As a leadership and team coach, I frequently encounter situations where managers feel ill-equipped to give their team members negative performance feedback. These conversations can be particularly challenging because the stakes are high for both sides. Unfavorable performance reviews and ratings come with tangible consequences for an employee’s compensation and career progression. Further, if the negative feedback is a surprise to them, it might prompt them to start looking for a new job.

• Jenny Fernandez , MBA, is an executive and team coach, Columbia and NYU faculty, and future of work and brand strategist. She works with senior leaders and their teams to become more collaborative, innovative, and resilient. Her work spans Fortune 500 companies, startups, and higher education. Jenny has been recognized by LinkedIn as a “Top Voice in Executive Coaching, Leadership Development, and Personal Branding” and was invited to join the prestigious Marshall Goldsmith’s 100 Coaches community. She is a Gen Z advocate. Connect with her on LinkedIn .

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• Published: 20 May 2024

A deep catalogue of protein-coding variation in 983,578 individuals

• Kathie Y. Sun   ORCID: orcid.org/0000-0003-1200-452X 1   na1 ,
• Xiaodong Bai 1   na1 ,
• Siying Chen 1 ,
• Suying Bao   ORCID: orcid.org/0000-0002-6220-0257 1 ,
• Chuanyi Zhang 1 ,
• Manav Kapoor   ORCID: orcid.org/0000-0001-6682-940X 1 ,
• Joshua Backman   ORCID: orcid.org/0000-0001-7262-0880 1 ,
• Tyler Joseph 1 ,
• Evan Maxwell 1 ,
• George Mitra 1 ,
• Alexander Gorovits 1 ,
• Adam Mansfield 1 ,
• Boris Boutkov 1 ,
• Sujit Gokhale 1 ,
• Lukas Habegger 1 ,
• Anthony Marcketta 1 ,
• Adam E. Locke   ORCID: orcid.org/0000-0001-6227-198X 1 ,
• Liron Ganel   ORCID: orcid.org/0000-0002-8762-622X 1 ,
• Alicia Hawes 1 ,
• Michael D. Kessler 1 ,
• Deepika Sharma 1 ,
• Jeffrey Staples 1 ,
• Jonas Bovijn 1 ,
• Sahar Gelfman 1 ,
• Alessandro Di Gioia 1 ,
• Veera M. Rajagopal   ORCID: orcid.org/0000-0002-5236-168X 1 ,
• Alexander Lopez 1 ,
• Jennifer Rico Varela 1 ,
• Jesus Alegre   ORCID: orcid.org/0000-0001-9390-3871 2 ,
• Jaime Berumen   ORCID: orcid.org/0000-0001-6707-3317 2 ,
• Roberto Tapia-Conyer   ORCID: orcid.org/0000-0003-3814-2904 2 ,
• Pablo Kuri-Morales   ORCID: orcid.org/0000-0002-0704-9507 2 , 3 ,
• Jason Torres   ORCID: orcid.org/0000-0002-7537-7035 4 ,
• Jonathan Emberson   ORCID: orcid.org/0000-0001-7792-9422 4 ,
• Rory Collins 4 ,
• Regeneron Genetics Center ,
• RGC-ME Cohort Partners ,
• Michael Cantor   ORCID: orcid.org/0000-0002-1074-1203 1 ,
• Timothy Thornton   ORCID: orcid.org/0000-0001-7071-2642 1 ,
• Hyun Min Kang 1 ,
• John D. Overton 1 ,
• Alan R. Shuldiner   ORCID: orcid.org/0000-0001-9921-4305 1 ,
• M. Laura Cremona 1 ,
• Mona Nafde 1 ,
• Aris Baras   ORCID: orcid.org/0000-0002-6830-3396 1 ,
• Goncalo Abecasis   ORCID: orcid.org/0000-0003-1509-1825 1 ,
• Jonathan Marchini   ORCID: orcid.org/0000-0003-0610-8322 1 ,
• Jeffrey G. Reid   ORCID: orcid.org/0000-0001-8645-4713 1 ,
• William Salerno   ORCID: orcid.org/0000-0003-2975-4108 1 &
• Suganthi Balasubramanian   ORCID: orcid.org/0000-0003-2243-5948 1  

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• Genetic variation
• Medical genetics
• Medical genomics

Rare coding variants that significantly impact function provide insights into the biology of a gene 1-3 . However, ascertaining their frequency requires large sample sizes 4-8 . Here, we present a catalogue of human protein-coding variation, derived from exome sequencing of 983,578 individuals across diverse populations. 23% of the Regeneron Genetics Center Million Exome data (RGC-ME) comes from non-European individuals of African, East Asian, Indigenous American, Middle Eastern, and South Asian ancestry. This catalogue includes over 10.4 million missense and 1.1 million predicted loss-of-function (pLOF) variants. We identify individuals with rare biallelic pLOF variants in 4,848 genes, 1,751 of which have not been previously reported. From precise quantitative estimates of selection against heterozygous loss-of-function, we identify 3,988 loss-of-function intolerant genes, including 86 that were previously assessed as tolerant and 1,153 lacking established disease annotation. We also define regions of missense depletion at high resolution. Notably, 1,482 genes have regions depleted of missense variants despite being tolerant to pLOF variants. Finally, we estimate that 3% of individuals have a clinically actionable genetic variant, and that 11,773 variants reported in ClinVar with unknown significance are likely to be deleterious cryptic splice sites. To facilitate variant interpretation and genetics-informed precision medicine, we make this important resource of coding variation from the RGC-ME accessible via a public variant allele frequency browser.

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These authors contributed equally: Kathie Y. Sun, Xiaodong Bai

Authors and Affiliations

Regeneron Genetics Center, Tarrytown, NY, USA

Kathie Y. Sun, Xiaodong Bai, Siying Chen, Suying Bao, Chuanyi Zhang, Manav Kapoor, Joshua Backman, Tyler Joseph, Evan Maxwell, George Mitra, Alexander Gorovits, Adam Mansfield, Boris Boutkov, Sujit Gokhale, Lukas Habegger, Anthony Marcketta, Adam E. Locke, Liron Ganel, Alicia Hawes, Michael D. Kessler, Deepika Sharma, Jeffrey Staples, Jonas Bovijn, Sahar Gelfman, Alessandro Di Gioia, Veera M. Rajagopal, Alexander Lopez, Jennifer Rico Varela, Michael Cantor, Timothy Thornton, Hyun Min Kang, John D. Overton, Alan R. Shuldiner, M. Laura Cremona, Mona Nafde, Aris Baras, Goncalo Abecasis, Jonathan Marchini, Jeffrey G. Reid, William Salerno & Suganthi Balasubramanian

Faculty of Medicine, National Autonomous University of Mexico (UNAM), Mexico City, Mexico

Jesus Alegre, Jaime Berumen, Roberto Tapia-Conyer & Pablo Kuri-Morales

Instituto Tecnológico y de Estudios Superiores de Monterrey, Monterrey, Mexico

Pablo Kuri-Morales

Clinical Trial Service Unit & Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK

Jason Torres, Jonathan Emberson & Rory Collins

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Regeneron Genetics Center

Rgc-me cohort partners, corresponding authors.

Correspondence to William Salerno or Suganthi Balasubramanian .

Supplementary information

Supplementary information.

This Supplementary information file contains the following. Description of Supplementary Tables 1-14. Supplementary Tables 1-6, and 11 are provided as separate data Excel tables. Supplementary Tables 7-10 and 12-14 are embedded within the Supplementary Information document. Supplementary Methods and descriptions of Supplementary Analyses. Supplementary Figures 1-7. Supplementary References.

Reporting Summary

Supplementary table 1.

This table includes: Sample subsets of RGC-ME used in different analyses; Full breakdown of sample counts in fine-scale ancestry groups used in Fig. 1 and for the browser; and Sample sizes and collaborator details for each dataset in RGC-ME. See main Supplementary Information PDF for full legend.

Supplementary Table 2

s het values for 16,710 genes and other annotations, including additional annotations, LOEUF scores from gnomAD, minor allele frequency, and coding sequence length. See main Supplementary Information PDF for full legend.

Supplementary Table 3

List of continuous segments of missense constrained regions found in 12,349 genes (canonical transcripts), based on the top 15-percentile threshold of MTR values. See main Supplementary Information PDF for full legend.

Supplementary Table 4

Jaccard index analysis between the MTR-constrained regions and features from UniProt (release 2022_05). See main Supplementary Information PDF for full legend.

Supplementary Table 5

List of genes with significant proportion of CDS in top 1, 5, 10, 15, and 20 percentile of exome wide MTR missense constraint scores based on one-sided binomial tests. See main Supplementary Information PDF for full legend.

Supplementary Table 6

List of 4,848 genes with rare (alternate allele frequency <1%) biallelic pLOF variants (homozygous alternate and compound heterozygous) reported for the entire RGC-ME dataset including related individuals. See main Supplementary Information PDF for full legend.

Supplementary Table 11

List of highly differentiated variants (F ST > 0.15).

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Sun, K.Y., Bai, X., Chen, S. et al. A deep catalogue of protein-coding variation in 983,578 individuals. Nature (2024). https://doi.org/10.1038/s41586-024-07556-0

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Received : 19 June 2023

Accepted : 10 May 2024

Published : 20 May 2024

DOI : https://doi.org/10.1038/s41586-024-07556-0

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