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Published May 13, 2024
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Geophysical Research Letters is a gold open access journal that publishes high-impact, innovative and timely communications-length articles on major advances spanning all of the major geoscience disciplines.
The paper, “ Causes of Higher Climate Sensitivity in CMIP6 Models ,” was co-written with Mark Zelinka, a research scientist for Lawrence Livermore National Laboratory at the University of Washington. The paper discusses the ability to predict how much the earth warms in response to changes in greenhouse gas using Earth system models (ESMs).
“I was really pleased to see this paper selected by the Geophysical Research Letters editorial board,” says McCoy, who works in UW’s Department of Atmospheric Science. “At the time when Mark Zelinka reached out to me to collaborate, it was clear that he had identified a big shift in how our models were representing future climate and that it was important to disseminate it to the community.”
Other contributors to the paper were Timothy Myers, who works in the Physical Sciences Laboratory at the National Oceanic and Atmospheric Administration; Paulo Ceppi, a senior lecturer of climate science at Imperial College London; and Stephen Po-Chedley, a research scientist; Peter Caldwell, Climate Modeling Group leader and staff scientist; Stephen Klein, an atmospheric research scientist; and Karl Taylor, director of the Program for Climate Model Diagnosis and Intercomparison, all of Lawrence Livermore National Laboratory.
“When I saw the initial results that cloud feedback had gotten more amplifying in the latest models, I immediately reached out to Daniel for his help in interpreting them since his previous work had greatly influenced my thinking,” Zelinka says. “He provided useful calculations to strengthen our case that changes in the cloud liquid content were a key part of the story in leading to a new class of highly sensitive models.”
The group found that the temperature response to an abrupt quadrupling of atmospheric CO 2 has increased substantially in the latest generation of global climate models relative to previous generations. This is primarily because cloud water content and coverage decrease more strongly with global warming, causing enhanced planetary absorption of sunlight -- amplifying feedback that ultimately results in more warming. Differences in the physical representation of clouds in ESMs drive this enhanced sensitivity relative to the previous generation of models.
“It was really exciting to be part of this study. What Mark and my co-authors showed in this paper is that an important source of ESM uncertainty on a time scale that matters to the near future are these difficult-to-treat, small-scale processes, such as clouds, convection, aerosol and precipitation,” McCoy says. “It allows us to identify and target specific processes that have a lot of leverage on our predictions of future climate for observations and for continued model development and evaluation.”
Since its publication in 2020, the paper has exceeded 1,000 citations, placing it in the top 1 percent of geoscience articles.
UW will host a US Climate Variability and Predictability workshop, titled “ Micro2Macro: Origins of Climate Change Uncertainty ,” Oct. 28-30. The workshop will address issues related to McCoy’s representation of microscale processes in global ESMs.
McCoy is director of the Perturbed Physics Ensemble Regression Optimization Center for ESM Evaluation and Development ( PROCEED ), a collaboration among the UW Department of Atmospheric Science; the UW School of Computing; the University of Hawaii-Manoa; Pacific Northwest National Laboratory; and Lawrence Livermore National Laboratory. PROCEED seeks to leverage UW’s unique access to the National Center for Atmospheric Research-Wyoming Supercomputing Center to reduce uncertainty related to subgrid phenomena in ESMs.
For more information about McCoy, go to www.uwyo.edu/atsc/directory/faculty/mccoy .
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Volume 52, Issue 8, 8 May 2024
Critical steps in the assembly process of the bacterial 50s ribosomal subunit.
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The diversity of splicing modifiers acting on A -1 bulged 5′-splice sites reveals rules for rational drug design
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Discovering DNA shape motifs with multiple DNA shape features: generalization, methods, and validation
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Chromatin damage generated by DNA intercalators leads to degradation of RNA Polymerase II
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Differential expression of paralog RNA binding proteins establishes a dynamic splicing program required for normal cerebral cortex development
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Activation of zinc uptake regulator by zinc binding to three regulatory sites
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Set2 regulates Ccp1 and Swc2 to ensure centromeric stability by retargeting CENP-A
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Leveraging chromatin state transitions for the identification of regulatory networks orchestrating heart regeneration
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Lineage-determining transcription factor-driven promoters regulate cell type-specific macrophage gene expression
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Zebrafish Mbd5 binds to RNA m 5 C and regulates histone deubiquitylation and gene expression in development metabolism and behavior
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Phylogeny-linked occurrence of ribosome stalling on the mRNAs of Arabidopsis unfolded protein response factor bZIP60 orthologs in divergent plant species
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Novel insights into the role of translesion synthesis polymerase in DNA incorporation and bypass of 5-fluorouracil in colorectal cancer
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DNA-PK controls Apollo’s access to leading-end telomeres
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Physical interaction with Spo11 mediates the localisation of Mre11 to chromatin in meiosis and promotes its nuclease activity
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The origin recognition complex requires chromatin tethering by a hypervariable intrinsically disordered region that is functionally conserved from sponge to man
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Pathogenic CANVAS (AAGGG) n repeats stall DNA replication due to the formation of alternative DNA structures
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COSA-1 mediated pro-crossover complex formation promotes meiotic crossing over in C. elegans
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Mutation rate heterogeneity at the sub-gene scale due to local DNA hypomethylation
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Discovery of a polymorphic gene fusion via bottom-up chimeric RNA prediction
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BRD2 promotes antibody class switch recombination by facilitating DNA repair in collaboration with NIPBL
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A phage nucleus-associated RNA-binding protein is required for jumbo phage infection
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Bridging DNA contacts allow Dps from E. coli to condense DNA
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The effect of pseudoknot base pairing on cotranscriptional structural switching of the fluoride riboswitch
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Identifying human pre-mRNA cleavage and polyadenylation factors by genome-wide CRISPR screens using a dual fluorescence readthrough reporter
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Determinants of CRISPR Cas12a nuclease activation by DNA and RNA targets
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Molecular basis of A. thaliana KEOPS complex in biosynthesizing tRNA t 6 A
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Biochemical characterization of the meiosis-essential yet evolutionarily divergent topoisomerase VIB-like protein MTOPVIB from Arabidopsis thaliana
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RNA polymerase SI3 domain modulates global transcriptional pausing and pause-site fluctuations
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Temperature-sensitive splicing defects in Arabidopsis mitochondria caused by mutations in the ROOT PRIMORDIUM DEFECTIVE 1 gene
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All exons are not created equal—exon vulnerability determines the effect of exonic mutations on splicing
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RIP-seq reveals RNAs that interact with RNA polymerase and primary sigma factors in bacteria
![research journal articles featured image](https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/nar/52/8/10.1093_nar_gkae081/1/s_gkae081figgra1.jpeg?Expires=1718932033&Signature=OcjZ6~4SE6r6cbqhdFUtxptSsVxWJQcC9mJrvuSFgzws4eiNVgeMQokNBqXzEC7kkEgujsMZUUaVCk4t~NZ92P42m~wp2qkGwizqfonlKBPFUN2gcUIXrLLLg75m0dUKRK7HIMmYWxRhJGNTIrLg4iEKo9HFLz2K1uj00WwHQR99jQlKXsgHx02rSlnOr~jBpgONgvrhdb0dcJiN7wCsU32h5uV4kr8kDQP~~q9emyuNF8-Lnsj4u0wiXabU9H5cHF1Gf1TCWl2BCuqFAa1ijDGJKP3lrTQrlM42nLZNtpneBFQH6~JAF70HJ1pi9lwiCnWptZbfwOz5j3jGV~-hiw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Ribosomal collision is not a prerequisite for ZNF598-mediated ribosome ubiquitination and disassembly of ribosomal complexes by ASCC
![research journal articles featured image](https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/nar/52/8/10.1093_nar_gkae087/1/s_gkae087figgra1.jpeg?Expires=1718932033&Signature=39ekRAxuamgAcAj-4kBR~l4mb1ISfxQuPQNyr5mpTndQOFMX4nhvQs6fQpFeaZivyWjjX1zAPC1-TTrWdpzC68PBajzmBkZ3QLZRsNJ5VYsNgcIsU-0Rul4wOwuf5gYLNXlFHPg98Z8EwxLUBa1mz80KReTgAeryh5IN5yJwFX-Ab0eHbznLCqM0nRUN2wwPTb6GulV2CbMcBNbRQh6wTCTNy6NNJJESwTztFnI5piE4OXTxKBrqS3SdvsdPWNw3X3-5F7Boqct~jD3O1UjzsPZxe0-eM-LgJneSntSVXR3c9qDwU~xGrXjCophQRsMtSDfkXZocOtl4bvX45gvOUQ__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Landscape of RNA pseudouridylation in archaeon Sulfolobus islandicus
![research journal articles featured image](https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/nar/52/8/10.1093_nar_gkae096/1/s_gkae096figgra1.jpeg?Expires=1718932033&Signature=GWMJOM8gUibfPgq5nQBr7u2ciPPRAlxqxRpewvUZXDJGDrfDTSZZEh6jz45KYbJJhD8Yev5Dik62qHH1sbE~j9j9guGY3o-0chPcA6ToW-z24s2~saa3ClBwBBlnAOJTeXtTxhypw5UtPNb~2Mc74egqaQ4VX92D4113amSHifA8o3NtJTZdrsvjg7DsvzTRDhvQRzgTBv873I58dbGR0LLLCVAvyEFodSuYJAb6xBlVR9aIDlv6vfafE9YjbbWdjiS2Ub7CikdXkwbNc55FqsADCxPQJki0nybCQwVywV5MpUcPM7WRL8IWOF9Jc3Q~PPV2wR3xhMksQayM-WNumA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
The crystal structure of bacteriophage λ RexA provides novel insights into the DNA binding properties of Rex-like phage exclusion proteins
![research journal articles featured image](https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/nar/52/8/10.1093_nar_gkae212/1/s_gkae212figgra1.jpeg?Expires=1718932033&Signature=ScTy1HEWB90jvjbTStv-E1Elgf~EHH99GL5YEipj~NYZb~xcHN2nbHNZSqkAX0uv~ihoCZocQO22ECQuuuY0VTTibNAEPrAcOPRIaI3oNavtzgU09ufdSRfPemhDlKP3jZZyLoCxnv15F2BZcUHf8flKJraeL0NrcfpTkzLJs-hMaXbD606bImyKtSwxEtpsr5REPvwo79S9-2Q~w3lck1WiMbX4tUJx0HC0mf7s8l-NSQ9gckzLFk9QpmKkk2mHlc44CY5TKVKDuSwM8n5pFRmqMSX1dZajIYmG8GbINuYiMVTedpsJUga2WhPWkqRpSQ10ZCB2k3ZYYL8F915WIg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Unearthing a novel function of SRSF1 in binding and unfolding of RNA G-quadruplexes
![research journal articles featured image](https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/nar/52/8/10.1093_nar_gkae213/1/s_gkae213figgra1.jpeg?Expires=1718932033&Signature=v0qgRC2rci1ttUnC3Q6metfp6t15RLXzilUkEu~qkSPYJvRdk3bn2Dv3LVWzkoYYY~hg7osh1-ebK8gvL~1ZkVSvGg1wUIWGUBNwWPhAPFeHeLZzpMwOao8NAZDrXzmagRVhmrMXVtjBjLyuqwZgTfBG~0vPdpjKt-sliKEtVsEztOAH3zouKJ5jExbtiV3~nPG50TiEofjfJo0TMT7jhnPl-eA6DWWxJ-Ged447AmEh1V-rQtPzV3ng2sm~z8Vm~aAfj2ohK4jn55GEbo3ztTWas~aVbUW8Zm6qSdf5vAriFhBQtnUIsr7YAQRD3xp93nFdnaLFOvlfAlM-SRdZJw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Resolving the intricate binding of neomycin B to multiple binding motifs of a neomycin-sensing riboswitch aptamer by native top-down mass spectrometry and NMR spectroscopy
![research journal articles featured image](https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/nar/52/8/10.1093_nar_gkae224/1/s_gkae224figgra1.jpeg?Expires=1718932033&Signature=uUYLBcOdW7KgCltjWEAh3S6616atfvm8doGiyd7GrecLOMoou7D399jBrB3owkB8V~o1M5T399EmYJ0Vu9VKFweGfkfC4ZxNXCiCTXOYwrEcVK7M15OcoYlEDt78C9BfUcrYaUx6wVRcLZ4VqzWXb5B1ZPzAfVmA6aD5ZXaA7sZYMGrp8Vnw-qEF8SvlHtVT239Qa3YG87a4IX0rCcP4CmzHK0DvSQOjovpvZHa4PgtRYPLIGSA1nVgxFst2M0k~FNhQWTYZhsqObft~Cz~FI0D1mtevYBByNvDlJad0Z2OcnvGoQ0SjziWpAlTR1ANsBdRe1yHy5pPwBZgHtr1tEw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Protein G-quadruplex interactions and their effects on phase transitions and protein aggregation
![research journal articles featured image](https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/nar/52/8/10.1093_nar_gkae229/1/s_gkae229figgra1.jpeg?Expires=1718932033&Signature=hta33bGwTNnEiKMQJ6Exz-HU0jSKmUqdpgxA6dP~BBBYxBwHitFKHSe58PDzp1BaCFuIIYx5yn~2iwDZ8vLonw3znr-tpOjXFEJBE2lJn~KtONgLrzoqXIUiUwKSszrOh3b-Ke1VW7asVr8nznBUe7GdfsVm1CYZx1R8dzYzYywmAsLq3CaDLlm1eNQ1jIM0ZJgHQLnH05HfNTqJS9WnKDDFzgugij1~jE1qefkgZmFfHRWThWOifYv2ei8gB7pG46ahByzj8~tdmy~apbszwYNX8yUFcAqn0wy7jU6Z8RumO~iSN5o04SCgmfoufxgIlvMWb6ZSnSYuzUncgi4pYQ__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Structure-functional characterization of Lactococcus AbiA phage defense system
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Multiplexed in - situ mutagenesis driven by a dCas12a-based dual-function base editor
![research journal articles featured image](https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/nar/52/8/10.1093_nar_gkae228/1/s_gkae228figgra1.jpeg?Expires=1718932033&Signature=bB~O1CKYC~NYLN0QxXBdU263NgkVfC2JJ~~B8xLzBUztNBo9tGGmEQtqYRngpQfBcSdjKo~sTfnw3-uRXJNE2ffcNDCQ-E5kKRKq7eZTz4yR3D3YKdWpFCErJiDfKYk3MvHQCpJIVf2kmzsgeBWl6qQ7UK5T1-giONIfofSzXx--9uzKlUvN4zlMq8FXmG9gwon-ySjD~BfTK4lvrxCmFdVMCgB3oqwpi5b8qwGdziTTBx1TFVo3q9vwkzoi~aly3Y52z-GzhvgmvI5ani2PggnoJUivokoH7Mit3JodU21q5Cn0JEG1dZwCAQprZ23UtwJGWIGlxmmq~8sxqFIk-A__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Correction to ‘Non-CpG methylation by DNMT3B facilitates REST binding and gene silencing in developing mouse hearts’
Correction to ‘somamutdb: a database of somatic mutations in normal human tissues’, correction to ‘pot-3 preferentially binds the terminal dna-repeat on the telomeric g-overhang’, live-cell imaging of human apurinic/apyrimidinic endonuclease 1 in the nucleus and nucleolus using a chaperone@dna probe.
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txtools: an R package facilitating analysis of RNA modifications, structures, and interactions
![research journal articles featured image](https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/nar/52/8/10.1093_nar_gkae203/1/s_gkae203figgra1.jpeg?Expires=1718932033&Signature=Um0AEr2NHQYa3hEMIHmjyzIHmXqXYfnp1PD379F1DHc1apzm4VQwq6sFV5g9bBXaFos8Q55pJpxZHZ3FE9q7uxKqEIogJLdtaY3R9~WtrGGUA8JIboRbCWaVTRf3vwLtzXeM4F7X7OOJRxbOld8KMT~vBrauCLHJ-CIZJOyb9kXOwQdpwEwisiuGo2P49BeigdN5SND2LA45f9naiq8zWquOiecyE6cLOnSThuCeIzwlClYj8SkXysfEfyQQMlb-QysGsX0vdUxw35iEd6SU4qZu-1Wn7ResaBErBwi8LonL3-WMYr6WLyXBBtRY8pg-UlceahS1rpow~p4AbdG70A__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
ORBIT for E. coli : kilobase-scale oligonucleotide recombineering at high throughput and high efficiency
![research journal articles featured image](https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/nar/52/8/10.1093_nar_gkae227/1/s_gkae227figgra1.jpeg?Expires=1718932033&Signature=0JOzdB36KMcVA9ZL7uQqRYhKVDTqX9IX~6nl3gxdzRrkcm-Xoth7IzET9st0Yz1w-Tg5ZpSOw8H6ciWUqS0gXtNR2v5wQpRH2Py5Uqx7HUM56O8UIQyu~tCNCxeg3c-9~TJGxZwiGGE495iC2u~0TgYapHaP6DsOC~3rTadh0D6lizmU28FSOfbuMaEbF~JGQUug1CCU-k5~tioTLdiVe1zQhQZD9KD0GPXLDHPyKULwI9wcNBUaqnX5nPIhEYg8X6NAAcdWLFdyl47SymSQymM95kOtVHs2DDqxgPtH9zGG9Nm7bxaHiqV6OKWBMuO9kj9AMJ3D-BN08eL~2DhYzw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
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Research articles
Imprinting of serum neutralizing antibodies by wuhan-1 mrna vaccines.
- Chieh-Yu Liang
- Saravanan Raju
- Michael S. Diamond
![research journal articles research journal articles](https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41586-024-07423-y/MediaObjects/41586_2024_7423_Fig1_HTML.png)
Evolution of a novel adrenal cell type that promotes parental care
The adrenal gland of the oldfield mouse ( Peromyscus polionotus ) has a recently evolved cell type that promotes monogamous-typical parenting behaviour and is not present in closely related species.
- Natalie Niepoth
- Jennifer R. Merritt
- Andres Bendesky
![research journal articles research journal articles](https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41586-024-07390-4/MediaObjects/41586_2024_7390_Fig1_HTML.png)
Suppressed thermal transport in silicon nanoribbons by inhomogeneous strain
We report on a method for inducing uncontaminated and precise inhomogeneous strain in nanoscale silicon ribbons and its use for determining physical effects in these strained materials, in particular, an increase in the range and control of thermal conductivity.
- Shengying Yue
![research journal articles research journal articles](https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41586-024-07447-4/MediaObjects/41586_2024_7447_Fig1_HTML.png)
The rise of baobab trees in Madagascar
We carried out genomic and ecological analyses of all eight extant baobab species, providing insights into their evolutionary history and recommendations for conservation efforts.
- Jun-Nan Wan
- Sheng-Wei Wang
- Qing-Feng Wang
![research journal articles research journal articles](https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41586-024-07268-5/MediaObjects/41586_2024_7268_Fig1_HTML.png)
Arresting failure propagation in buildings through collapse isolation
A design approach arrests collapse propagation in buildings after major initial failures by ensuring that specific elements fail before the failure of the most important components for global stability.
- Nirvan Makoond
- Andri Setiawan
- Jose M. Adam
![research journal articles research journal articles](https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41586-024-07398-w/MediaObjects/41586_2024_7398_Fig1_HTML.png)
Dispersion-assisted high-dimensional photodetector
By combining spatial and frequency dispersive thin-film interfaces with deep residual learning, a miniature photodetector allowing the acquisition of high-dimensional information on light in a single-shot fashion is described.
- Yandong Fan
- Weian Huang
![research journal articles research journal articles](https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41586-024-07419-8/MediaObjects/41586_2024_7419_Fig1_HTML.png)
GLP-1-directed NMDA receptor antagonism for obesity treatment
Unimolecular integration of NMDA receptor antagonism with GLP-1 receptor agonism effectively reverses obesity, hyperglycaemia and dyslipidaemia in rodent models of metabolic disease.
- Jonas Petersen
- Mette Q. Ludwig
- Christoffer Clemmensen
![research journal articles research journal articles](https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41586-024-07400-5/MediaObjects/41586_2024_7400_Fig1_HTML.png)
Photocatalytic doping of organic semiconductors
A previously undescribed photocatalytic approach enables the effective p-type and n-type doping of organic semiconductors at room temperature using only widely available weak dopants such as oxygen and triethylamine.
- Wenlong Jin
- Chi-Yuan Yang
- Simone Fabiano
![research journal articles research journal articles](https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41586-024-07424-x/MediaObjects/41586_2024_7424_Fig1_HTML.png)
The temperature sensor TWA1 is required for thermotolerance in Arabidopsis
TWA1 is a temperature-sensing transcriptional co-regulator that is needed for basal and acquired thermotolerance in Arabidopsis thaliana.
- Erwin Grill
![research journal articles research journal articles](https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41586-024-07349-5/MediaObjects/41586_2024_7349_Fig1_HTML.png)
Temporal multiplexing of perception and memory codes in IT cortex
We examined how familiar faces are encoded in inferotemporal, perirhinal and temporal pole face patches, and found that relative response magnitude to familiar versus unfamiliar faces was not a stable indicator of familiarity in any patch.
- Marcus K. Benna
- Doris Y. Tsao
![research journal articles research journal articles](https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41586-024-07431-y/MediaObjects/41586_2024_7431_Fig1_HTML.png)
Superconducting diode effect and interference patterns in kagome CsV 3 Sb 5
We observe the superconducting diode effect and interference patterns in CsV 3 Sb 5 , implying a time-reversal symmetry-breaking superconducting order in kagome superconductors.
- Zhiming Pan
![research journal articles research journal articles](https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41586-024-07436-7/MediaObjects/41586_2024_7436_Fig1_HTML.png)
Physiological temperature drives TRPM4 ligand recognition and gating
A temperature-dependent Ca 2+ -binding site in the intracellular domain of TRPM4 is essential for TRPM4 function in physiological contexts.
- Sung Jin Park
![research journal articles research journal articles](https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41586-024-07252-z/MediaObjects/41586_2024_7252_Fig1_HTML.png)
Entanglement of nanophotonic quantum memory nodes in a telecom network
Entanglement of two nanophotonic quantum network nodes is demonstrated through 40 km spools of low-loss fibre and a 35-km long fibre loop deployed in the Boston area urban environment.
- C. M. Knaut
- A. Suleymanzade
- M. D. Lukin
![research journal articles research journal articles](https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41586-024-07443-8/MediaObjects/41586_2024_7443_Fig1_HTML.png)
Engineered CD47 protects T cells for enhanced antitumour immunity
Combination of TCR or CAR T cells expressing the engineered CD47 variant 47 E with anti-CD47 antibody therapy results in synergistic antitumour efficacy due to T cell resistance to clearance by macrophages, while maintaining macrophage recruitment into the tumour microenvironment.
- Sean A. Yamada-Hunter
- Johanna Theruvath
- Crystal L. Mackall
![research journal articles research journal articles](https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41586-024-07422-z/MediaObjects/41586_2024_7422_Fig1_HTML.png)
Wavefunction matching for solving quantum many-body problems
An approach called wavefunction matching transforms particle interactions so that their wavefunctions match those of easily computable interactions, to allow for calculations of quantum many-body systems that would otherwise be difficult or impossible.
- Serdar Elhatisari
- Lukas Bovermann
- Gianluca Stellin
![research journal articles research journal articles](https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41586-024-07366-4/MediaObjects/41586_2024_7366_Fig1_HTML.png)
One-third of Southern Ocean productivity is supported by dust deposition
Nitrate observations over 11 years from autonomous biogeochemical ocean profiling combined with a Southern Hemisphere dust simulation find that iron supplied by dust supports about 30% of Southern Ocean productivity.
- Zanna Chase
- Sonya L. Fiddes
![research journal articles research journal articles](https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41586-024-07399-9/MediaObjects/41586_2024_7399_Fig1_HTML.png)
A renewably sourced, circular photopolymer resin for additive manufacturing
A photopolymer platform derived from renewable lipoates can be 3D-printed into high-resolution parts, which possess properties comparable to some commercial acrylic resins, and then recycled to produce a re-printable resin.
- Thiago O. Machado
- Connor J. Stubbs
- Andrew P. Dove
![research journal articles research journal articles](https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41586-024-07425-w/MediaObjects/41586_2024_7425_Fig1_HTML.png)
Volatile working memory representations crystallize with practice
Delay- and choice-related activities that are essential for working-memory performance drift during learning and stabilize only after several days of expert performance.
- Arash Bellafard
- Ghazal Namvar
- Peyman Golshani
![research journal articles research journal articles](https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41586-024-07418-9/MediaObjects/41586_2024_7418_Fig1_HTML.png)
Release of a ubiquitin brake activates OsCERK1-triggered immunity in rice
The ubiquitin E3 ligase OsCIE1 acts as a brake to inhibit OsCERK1 during homeostasis; this brake is released after chitin stimulation.
![research journal articles research journal articles](https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41586-024-07437-6/MediaObjects/41586_2024_7437_Fig1_HTML.png)
Dimerization and antidepressant recognition at noradrenaline transporter
Cryo-electron microscopy structures of the noradrenaline transporter in the apo state, bound to noradrenaline and bound to various antidepressants shed light on the substrate transport, molecular recognition and dimeric architecture of this protein.
- Yu-Ling Yin
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Spring 2024 Baseball Research Journal
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- Rickwood Field Adds to Its Legacy as the Major Leagues Return to Alabama John Shorey and Kevin Warneke
- Jimmie Foxx: Baseball’s ‘Forgotten’ Super Slugger Thomas Ferraro
- Mary Dobkin: Baltimore’s Grande Dame of Baseball David Krell
- Major and Minor League Occupancy at Cleveland’s League Park, 1914–15 Alan Cohen
- The Ill-Fated Dodgers and Indians World Baseball Tour of 1952 Matthew Jacob
- ‘Death to Flying Things’: The Life and Times of a Spurious Nickname Richard Hershberger
- Shining Light on the Smiling Stan Hack Mirror: A Bill Veeck Gamesmanship Ploy—Was It Real or Mythical? Herm Krabbenhoft
- Teenage Umpires of the Nineteenth Century Larry DeFillipo
- The International Association of 1877–80 Woody Eckard
- The Union Association War of 1884 Richard Hershberger
- An Infield Hit Model From the 2023 MLB Season: ‘Hit ‘Em Where They Ain’t’ Donald Slavik
- Plummeting Batting Averages Are Due to Far More Than Infield Shifting, Part One: Fielding and Batting Strategy Charlie Pavitt
- Going Beyond the Baseball Adage ‘One Game at a Time’: A Geek’s Peek at Streaks Ed Denta
- Jews and Baseball: History and Demographics (Part One) Peter Dreier
- Henry Chadwick Award: Larry Gerlach Steve Gietschier
- Henry Chadwick Award: Leslie Heaphy Roberta J. Newman
- Henry Chadwick Award: Sarah Langs Karl Ravech
- Editor’s Note: Spring 2024 Baseball Research Journal Cecilia M. Tan
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3.3 million articles on ScienceDirect are open access. Articles published open access are peer-reviewed and made freely available for everyone to read, download and reuse in line with the user license displayed on the article. ScienceDirect is the world's leading source for scientific, technical, and medical research.
Read the latest Research articles from Nature. A completely genetically encoded boronic-acid-containing designer enzyme was created and characterized using X-ray crystallography, high-resolution ...
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Deep learning segmentation of non-perfusion area from color fundus images and AI-generated fluorescein angiography. Kanato Masayoshi. Yusaku Katada. Toshihide Kurihara. Article Open Access 11 May ...
We develop a method for providing high-quality, holographic, three-dimensional augmented-reality images in a small form factor suitable for incorporation in eyeglass-scale wearables, using high ...
PubMed Central ® (PMC) is a free full-text archive of biomedical and life sciences journal literature at the U.S. National Institutes of Health's National Library of Medicine (NIH/NLM) ... Discover a digital archive of scholarly articles, spanning centuries of scientific research. User Guide Learn how to find and read articles of interest to ...
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Rigorously reported, peer reviewed and immediately available without restrictions, promoting the widest readership and impact possible. We encourage you to consider the scope of each journal before submission, as journals are editorially independent and specialized in their publication criteria and breadth of content. PLOS Biology PLOS Climate
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Journal of Church and State. Printing and Misprinting: A Companion to Mistakes and In-House Corrections in Renaissance Europe (1450–1650). Edited by Geri Della Rocca de Candal, Anthony Grafton, and Paolo Sachet. French Studies. The priority of intentional action: From developmental to conceptual priority. The Philosophical Quarterly.
While many books and articles guide various qualitative research methods and analyses, there is currently no concise resource that explains and differentiates among the most common qualitative approaches. We believe novice qualitative researchers, students planning the design of a qualitative study or taking an introductory qualitative research course, and faculty teaching such courses can ...
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1: Journal Article Reporting Standards for Qualitative Research in Psychology. This American Psychologist open-access article lays out—for the first time—journal article reporting standards for qualitative research in psychology (Levitt, H.M., et al., Vol. 73, No. 1). The voluntary guidelines are designed to help authors communicate their work clearly, accurately and transparently.
A nasal chemosensation–dependent critical window for somatosensory development. by. Linbi Cai. Ali Özgür Argunşah. Angeliki Damilou. Theofanis Karayannis. Science Vol. 384, NO. 6696 09 May 2024 : 652-660. Research Article.
Editor’s Choice articles are based on recommendations by the scientific editors of MDPI journals from around the world. Editors select a small number of articles recently published in the journal that they believe will be particularly interesting to readers, or important in the respective research area.
In celebration of the 50th anniversary of the American Geophysical Union’s journal Geophysical Research Letters, a paper co-written by University of Wyoming Assistant Professor Daniel McCoy was selected by the editor-in-chief as the “Editor’s Choice Paper.”. Geophysical Research Letters is a gold open access journal that publishes high ...
Cover: In E. coli Dps is an essential protein that boosts survival during times of stress by protecting DNA. In this issue, Shahu et al. explore how Dps first binds to DNA. The authors demonstrate that Dps-DNA complexes nucleate rapidly at sites containing plectonemic supercoils. For more information see article by Shahu, S. et al., pages 4456–4465 in this issue.
Recently, the research integrity community have been using artificial intelligence (AI) tools, such as Papermill Alarm, Proofig, FigCheck, ImaCheck, and ImageTwin, to identify manipulated images and papers produced by paper mills or AI ChatBots (Else, 2022; Oza, 2023; Sanderson, 2024; STM Integrity Hub, n.d).Now, journals and publishers are beginning to take advantage of these tools (Conroy ...
Research reveals how to phrase questions to get the best responses. But that can lead to some unusual requests. Some researchers even ask the chatbots themselves for tips on how to talk to them ...
The Guide for Authors and link to submit your manuscript is available on the Journal’s homepage at: Guide for authors - European Journal of Operational Research - ISSN 0377-2217 | ScienceDirect.com by Elsevier. Inquiries, including questions about appropriate topics, may be sent electronically to GE (Sergio Vergalli) at Email: sergio.vergalli ...
Physics and Chemistry: Preliminary Report on the Masses of 12 C and 14 N. T. ASADA. T. OKUDA. S. YOSHIMOTO. Research Article 13 May 1939.
Read the latest Research articles from Nature. A completely genetically encoded boronic-acid-containing designer enzyme was created and characterized using X-ray crystallography, high-resolution ...
Spring 2024 Baseball Research Journal. Rickwood Field Adds to Its Legacy as the Major Leagues Return to Alabama. John Shorey and Kevin Warneke. Jimmie Foxx: Baseball’s ‘Forgotten’ Super Slugger. Thomas Ferraro. Mary Dobkin: Baltimore’s Grande Dame of Baseball. David Krell. Major and Minor League Occupancy at Cleveland’s League Park ...