d. formulating a hypothesis

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Rookie F1 driver Colapinto laughs off Messi comparisons as excitement rises in Argentina

Williams driver Franco Colapinto of Argentina arrives at the Monza racetrack, in Monza, Italy, Thursday, Aug.29, 2024. The Formula one race will be held on Sunday. (AP Photo/Luca Bruno)

Williams driver Franco Colapinto of Argentina talks with reporters at the Monza racetrack, in Monza, Italy, Thursday, Aug.29, 2024. The Formula one race will be held on Sunday. (AP Photo/Luca Bruno)

FILE - Williams driver Franco Colapinto of Argentina steers his car at the Silverstone racetrack in Silverstone, England, July 5, 2024. (AP Photo/Luca Bruno, File)

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MONZA, Italy (AP) — Rookie driver Franco Colapinto laughed off comparisons to Lionel Messi as he prepares to become the first Argentine to race in Formula One for 23 years.

Colapinto has been drafted by Williams to replace the axed Logan Sargeant for the rest of the season, starting this week at the Italian Grand Prix.

The 21-year-old Colapinto, who is sixth in the F2 standings, becomes the first driver from Argentina to race in F1 since Gaston Mazzacane in 2001 — and excitement back in his home country has reached fever pitch, with some even likening him to soccer great Messi.

“It’s very difficult to feel as Lionel Messi, I don’t know how it is to feel that,” a bemused Colapinto said at Monza on Thursday.

“But sometimes I see that they compare me and I’m like, you guys are crazy, like Messi is God, it’s like you cannot, how are you comparing me?”

Colapinto was preparing to race in F2 this weekend at Monza and found out only on Monday that he would instead be making the step up.

He has driven only one practice session for Williams, at the British GP last month using Sargeant’s car. But he said the hours he has put in in the simulator and conversations with the engineers will help him with the steep learning curve.

“It’s an opportunity that I’ve always been ready for, that I’ve been waiting for for so long, since I was a young kid I was always dreaming of this coming true and happening,” Colapinto said. “I’m extremely grateful for this opportunity.

“It came very late of course but I’m always ready, I wasn’t expecting it to be honest. And I cannot explain how happy I am to be here with Williams, they have been very supportive and the opportunity that they have given me is insane.”

There is also little pressure on Colapinto.

Whatever happens in the remaining nine races, he knows he will not be in the seat next year, with Carlos Sainz Jr. moving from Ferrari to Williams to partner Alex Albon for 2025.

“My main focus is myself. Trying to do the best job I can … and trying to learn as quick as possible,” Colapinto said.

“I am going step by step, race by race, corner by corner. I have no idea about next year. It’s an amazing news to have. I can’t be more than grateful for this chance to be doing it here.”

Sargeant left F1 with one point in 36 race starts since he joined Williams at the start of the 2023 season. His best finish was 11th this season, a year in which Williams gave him clear performance goals to keep his seat through the end of the season.

Sargeant crashed heavily in practice at last week’s Dutch GP and finished 16th in the race.

AP auto racing: https://apnews.com/hub/auto-racing

Chemical Society Reviews

Proteolysis-targeting drug delivery system (prodds): integrating targeted protein degradation concepts into formulation design.

* Corresponding authors

a Pharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin-Madison, Madison, WI 53705, USA E-mail: [email protected]

b Carbone Cancer Center, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA

c Wisconsin Center for NanoBioSystems, School of Pharmacy, University of Wisconsin-Madison, Madison, WI 53705, USA

Targeted protein degradation (TPD) has emerged as a revolutionary paradigm in drug discovery and development, offering a promising avenue to tackle challenging therapeutic targets. Unlike traditional drug discovery approaches that focus on inhibiting protein function, TPD aims to eliminate proteins of interest (POIs) using modular chimeric structures. This is achieved through the utilization of proteolysis-targeting chimeras (PROTACs), which redirect POIs to E3 ubiquitin ligases, rendering them for degradation by the cellular ubiquitin–proteasome system (UPS). Additionally, other TPD technologies such as lysosome-targeting chimeras (LYTACs) and autophagy-based protein degraders facilitate the transportation of proteins to  endo-lysosomal or autophagy-lysosomal pathways for degradation, respectively. Despite significant growth in preclinical TPD research, many chimeras fail to progress beyond this stage in the drug development. Various factors contribute to the limited success of TPD agents, including a significant hurdle of inadequate delivery to the target site. Integrating TPD into delivery platforms could surmount the challenges of in vivo applications of TPD strategies by reshaping their pharmacokinetics and pharmacodynamic profiles. These proteolysis-targeting drug delivery systems (ProDDSs) exhibit superior delivery performance, enhanced targetability, and reduced off-tissue side effects. In this review, we will survey the latest progress in TPD-inspired drug delivery systems, highlight the importance of introducing delivery ideas or technologies to the development of protein degraders, outline design principles of protein degrader-inspired delivery systems, discuss the current challenges, and provide an outlook on future opportunities in this field.

• This article is part of the themed collection: 2024 Emerging Investigators

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FDA Approves and Authorizes Updated mRNA COVID-19 Vaccines to Better Protect Against Currently Circulating Variants

FDA News Release

Today, the U.S. Food and Drug Administration approved and granted emergency use authorization (EUA) for updated mRNA COVID-19 vaccines (2024-2025 formula) to include a monovalent (single) component that corresponds to the Omicron variant KP.2 strain of SARS-CoV-2. The mRNA COVID-19 vaccines have been updated with this formula to more closely target currently circulating variants and provide better protection against serious consequences of COVID-19, including hospitalization and death. Today’s actions relate to updated mRNA COVID-19 vaccines manufactured by ModernaTX Inc. and Pfizer Inc.

In early June, the FDA advised manufacturers of licensed and authorized COVID-19 vaccines that the COVID-19 vaccines (2024-2025 formula) should be monovalent JN.1 vaccines. Based on the further evolution of SARS-CoV-2 and a rise in cases of COVID-19, the agency subsequently determined and advised manufacturers that the preferred JN.1-lineage for the COVID-19 vaccines (2024-2025 formula) is the KP.2 strain, if feasible.

“Vaccination continues to be the cornerstone of COVID-19 prevention,” said Peter Marks, M.D., Ph.D., director of the FDA’s Center for Biologics Evaluation and Research. “These updated vaccines meet the agency’s rigorous, scientific standards for safety, effectiveness, and manufacturing quality. Given waning immunity of the population from previous exposure to the virus and from prior vaccination, we strongly encourage those who are eligible to consider receiving an updated COVID-19 vaccine to provide better protection against currently circulating variants.”

The updated mRNA COVID-19 vaccines include Comirnaty and Spikevax, both of which are approved for individuals 12 years of age and older, and the Moderna COVID-19 Vaccine and Pfizer-BioNTech COVID-19 Vaccine, both of which are authorized for emergency use for individuals 6 months through 11 years of age.

What You Need to Know

• Unvaccinated individuals 6 months through 4 years of age are eligible to receive three doses of the updated, authorized Pfizer-BioNTech COVID-19 Vaccine or two doses of the updated, authorized Moderna COVID-19 Vaccine.
• Individuals 6 months through 4 years of age who have previously been vaccinated against COVID-19 are eligible to receive one or two doses of the updated, authorized Moderna or Pfizer-BioNTech COVID-19 vaccines (timing and number of doses to administer depends on the previous COVID-19 vaccine received).
• Individuals 5 years through 11 years of age regardless of previous vaccination are eligible to receive a single dose of the updated, authorized Moderna or Pfizer-BioNTech COVID-19 vaccines; if previously vaccinated, the dose is administered at least 2 months after the last dose of any COVID-19 vaccine.
• Individuals 12 years of age and older are eligible to receive a single dose of the updated, approved Comirnaty or the updated, approved Spikevax; if previously vaccinated, the dose is administered at least 2 months since the last dose of any COVID-19 vaccine.
• Additional doses are authorized for certain immunocompromised individuals ages 6 months through 11 years of age as described in the Moderna COVID-19 Vaccine and Pfizer-BioNTech COVID-19 Vaccine fact sheets.

Individuals who receive an updated mRNA COVID-19 vaccine may experience similar side effects as those reported by individuals who previously received mRNA COVID-19 vaccines and as described in the respective prescribing information or fact sheets. The updated vaccines are expected to provide protection against COVID-19 caused by the currently circulating variants. Barring the emergence of a markedly more infectious variant of SARS-CoV-2, the FDA anticipates that the composition of COVID-19 vaccines will need to be assessed annually, as occurs for seasonal influenza vaccines.

For today’s approvals and authorizations of the mRNA COVID-19 vaccines, the FDA assessed manufacturing and nonclinical data to support the change to include the 2024-2025 formula in the mRNA COVID-19 vaccines. The updated mRNA vaccines are manufactured using a similar process as previous formulas of these vaccines. The mRNA COVID-19 vaccines have been administered to hundreds of millions of people in the U.S., and the benefits of these vaccines continue to outweigh their risks.

On an ongoing basis, the FDA will review any additional COVID-19 vaccine applications submitted to the agency and take appropriate regulatory action.

The approval of Comirnaty (COVID-19 Vaccine, mRNA) (2024-2025 Formula) was granted to BioNTech Manufacturing GmbH. The EUA amendment for the Pfizer-BioNTech COVID-19 Vaccine (2024-2025 Formula) was issued to Pfizer Inc.

The approval of Spikevax (COVID-19 Vaccine, mRNA) (2024-2025 Formula) was granted to ModernaTX Inc. and the EUA amendment for the Moderna COVID-19 Vaccine (2024-2025 Formula) was issued to ModernaTX Inc.

Related Information

• Comirnaty (COVID-19 Vaccine, mRNA) (2024-2025 Formula)
• Spikevax (COVID-19 Vaccine, mRNA) (2024-2025 Formula)
• Moderna COVID-19 Vaccine (2024-2025 Formula)
• Pfizer-BioNTech COVID-19 Vaccine (2024-2025 Formula)
• FDA Resources for the Fall Respiratory Illness Season
• Updated COVID-19 Vaccines for Use in the United States Beginning in Fall 2024
• June 5, 2024, Meeting of the Vaccines and Related Biological Products Advisory Committee

The FDA, an agency within the U.S. Department of Health and Human Services, protects the public health by assuring the safety, effectiveness, and security of human and veterinary drugs, vaccines and other biological products for human use, and medical devices. The agency also is responsible for the safety and security of our nation’s food supply, cosmetics, dietary supplements, radiation-emitting electronic products, and for regulating tobacco products.

Definition of a Hypothesis

What it is and how it's used in sociology

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A hypothesis is a prediction of what will be found at the outcome of a research project and is typically focused on the relationship between two different variables studied in the research. It is usually based on both theoretical expectations about how things work and already existing scientific evidence.

Within social science, a hypothesis can take two forms. It can predict that there is no relationship between two variables, in which case it is a null hypothesis . Or, it can predict the existence of a relationship between variables, which is known as an alternative hypothesis.

In either case, the variable that is thought to either affect or not affect the outcome is known as the independent variable, and the variable that is thought to either be affected or not is the dependent variable.

Researchers seek to determine whether or not their hypothesis, or hypotheses if they have more than one, will prove true. Sometimes they do, and sometimes they do not. Either way, the research is considered successful if one can conclude whether or not a hypothesis is true. 

Null Hypothesis

A researcher has a null hypothesis when she or he believes, based on theory and existing scientific evidence, that there will not be a relationship between two variables. For example, when examining what factors influence a person's highest level of education within the U.S., a researcher might expect that place of birth, number of siblings, and religion would not have an impact on the level of education. This would mean the researcher has stated three null hypotheses.

Alternative Hypothesis

Taking the same example, a researcher might expect that the economic class and educational attainment of one's parents, and the race of the person in question are likely to have an effect on one's educational attainment. Existing evidence and social theories that recognize the connections between wealth and cultural resources , and how race affects access to rights and resources in the U.S. , would suggest that both economic class and educational attainment of the one's parents would have a positive effect on educational attainment. In this case, economic class and educational attainment of one's parents are independent variables, and one's educational attainment is the dependent variable—it is hypothesized to be dependent on the other two.

Conversely, an informed researcher would expect that being a race other than white in the U.S. is likely to have a negative impact on a person's educational attainment. This would be characterized as a negative relationship, wherein being a person of color has a negative effect on one's educational attainment. In reality, this hypothesis proves true, with the exception of Asian Americans , who go to college at a higher rate than whites do. However, Blacks and Hispanics and Latinos are far less likely than whites and Asian Americans to go to college.

Formulating a Hypothesis

Formulating a hypothesis can take place at the very beginning of a research project , or after a bit of research has already been done. Sometimes a researcher knows right from the start which variables she is interested in studying, and she may already have a hunch about their relationships. Other times, a researcher may have an interest in ​a particular topic, trend, or phenomenon, but he may not know enough about it to identify variables or formulate a hypothesis.

Whenever a hypothesis is formulated, the most important thing is to be precise about what one's variables are, what the nature of the relationship between them might be, and how one can go about conducting a study of them.

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How to Write a Great Hypothesis

Hypothesis Definition, Format, Examples, and Tips

Verywell / Alex Dos Diaz

• The Scientific Method

Hypothesis Format

Falsifiability of a hypothesis.

• Operationalization

Hypothesis Types

Hypotheses examples.

• Collecting Data

A hypothesis is a tentative statement about the relationship between two or more variables. It is a specific, testable prediction about what you expect to happen in a study. It is a preliminary answer to your question that helps guide the research process.

Consider a study designed to examine the relationship between sleep deprivation and test performance. The hypothesis might be: "This study is designed to assess the hypothesis that sleep-deprived people will perform worse on a test than individuals who are not sleep-deprived."

At a Glance

A hypothesis is crucial to scientific research because it offers a clear direction for what the researchers are looking to find. This allows them to design experiments to test their predictions and add to our scientific knowledge about the world. This article explores how a hypothesis is used in psychology research, how to write a good hypothesis, and the different types of hypotheses you might use.

The Hypothesis in the Scientific Method

In the scientific method , whether it involves research in psychology, biology, or some other area, a hypothesis represents what the researchers think will happen in an experiment. The scientific method involves the following steps:

• Forming a question
• Performing background research
• Creating a hypothesis
• Designing an experiment
• Collecting data
• Analyzing the results
• Drawing conclusions
• Communicating the results

The hypothesis is a prediction, but it involves more than a guess. Most of the time, the hypothesis begins with a question which is then explored through background research. At this point, researchers then begin to develop a testable hypothesis.

Unless you are creating an exploratory study, your hypothesis should always explain what you  expect  to happen.

In a study exploring the effects of a particular drug, the hypothesis might be that researchers expect the drug to have some type of effect on the symptoms of a specific illness. In psychology, the hypothesis might focus on how a certain aspect of the environment might influence a particular behavior.

Remember, a hypothesis does not have to be correct. While the hypothesis predicts what the researchers expect to see, the goal of the research is to determine whether this guess is right or wrong. When conducting an experiment, researchers might explore numerous factors to determine which ones might contribute to the ultimate outcome.

In many cases, researchers may find that the results of an experiment  do not  support the original hypothesis. When writing up these results, the researchers might suggest other options that should be explored in future studies.

In many cases, researchers might draw a hypothesis from a specific theory or build on previous research. For example, prior research has shown that stress can impact the immune system. So a researcher might hypothesize: "People with high-stress levels will be more likely to contract a common cold after being exposed to the virus than people who have low-stress levels."

In other instances, researchers might look at commonly held beliefs or folk wisdom. "Birds of a feather flock together" is one example of folk adage that a psychologist might try to investigate. The researcher might pose a specific hypothesis that "People tend to select romantic partners who are similar to them in interests and educational level."

Elements of a Good Hypothesis

So how do you write a good hypothesis? When trying to come up with a hypothesis for your research or experiments, ask yourself the following questions:

• Is your hypothesis based on your research on a topic?
• Can your hypothesis be tested?
• Does your hypothesis include independent and dependent variables?

Before you come up with a specific hypothesis, spend some time doing background research. Once you have completed a literature review, start thinking about potential questions you still have. Pay attention to the discussion section in the  journal articles you read . Many authors will suggest questions that still need to be explored.

How to Formulate a Good Hypothesis

To form a hypothesis, you should take these steps:

• Collect as many observations about a topic or problem as you can.
• Evaluate these observations and look for possible causes of the problem.
• Create a list of possible explanations that you might want to explore.
• After you have developed some possible hypotheses, think of ways that you could confirm or disprove each hypothesis through experimentation. This is known as falsifiability.

In the scientific method ,  falsifiability is an important part of any valid hypothesis. In order to test a claim scientifically, it must be possible that the claim could be proven false.

Students sometimes confuse the idea of falsifiability with the idea that it means that something is false, which is not the case. What falsifiability means is that  if  something was false, then it is possible to demonstrate that it is false.

One of the hallmarks of pseudoscience is that it makes claims that cannot be refuted or proven false.

The Importance of Operational Definitions

A variable is a factor or element that can be changed and manipulated in ways that are observable and measurable. However, the researcher must also define how the variable will be manipulated and measured in the study.

Operational definitions are specific definitions for all relevant factors in a study. This process helps make vague or ambiguous concepts detailed and measurable.

For example, a researcher might operationally define the variable " test anxiety " as the results of a self-report measure of anxiety experienced during an exam. A "study habits" variable might be defined by the amount of studying that actually occurs as measured by time.

These precise descriptions are important because many things can be measured in various ways. Clearly defining these variables and how they are measured helps ensure that other researchers can replicate your results.

Replicability

One of the basic principles of any type of scientific research is that the results must be replicable.

Replication means repeating an experiment in the same way to produce the same results. By clearly detailing the specifics of how the variables were measured and manipulated, other researchers can better understand the results and repeat the study if needed.

Some variables are more difficult than others to define. For example, how would you operationally define a variable such as aggression ? For obvious ethical reasons, researchers cannot create a situation in which a person behaves aggressively toward others.

To measure this variable, the researcher must devise a measurement that assesses aggressive behavior without harming others. The researcher might utilize a simulated task to measure aggressiveness in this situation.

Hypothesis Checklist

• Does your hypothesis focus on something that you can actually test?
• Does your hypothesis include both an independent and dependent variable?
• Can you manipulate the variables?
• Can your hypothesis be tested without violating ethical standards?

The hypothesis you use will depend on what you are investigating and hoping to find. Some of the main types of hypotheses that you might use include:

• Simple hypothesis : This type of hypothesis suggests there is a relationship between one independent variable and one dependent variable.
• Complex hypothesis : This type suggests a relationship between three or more variables, such as two independent and dependent variables.
• Null hypothesis : This hypothesis suggests no relationship exists between two or more variables.
• Alternative hypothesis : This hypothesis states the opposite of the null hypothesis.
• Statistical hypothesis : This hypothesis uses statistical analysis to evaluate a representative population sample and then generalizes the findings to the larger group.
• Logical hypothesis : This hypothesis assumes a relationship between variables without collecting data or evidence.

A hypothesis often follows a basic format of "If {this happens} then {this will happen}." One way to structure your hypothesis is to describe what will happen to the  dependent variable  if you change the  independent variable .

The basic format might be: "If {these changes are made to a certain independent variable}, then we will observe {a change in a specific dependent variable}."

A few examples of simple hypotheses:

• "Students who eat breakfast will perform better on a math exam than students who do not eat breakfast."
• "Students who experience test anxiety before an English exam will get lower scores than students who do not experience test anxiety."​
• "Motorists who talk on the phone while driving will be more likely to make errors on a driving course than those who do not talk on the phone."
• "Children who receive a new reading intervention will have higher reading scores than students who do not receive the intervention."

Examples of a complex hypothesis include:

• "People with high-sugar diets and sedentary activity levels are more likely to develop depression."
• "Younger people who are regularly exposed to green, outdoor areas have better subjective well-being than older adults who have limited exposure to green spaces."

Examples of a null hypothesis include:

• "There is no difference in anxiety levels between people who take St. John's wort supplements and those who do not."
• "There is no difference in scores on a memory recall task between children and adults."
• "There is no difference in aggression levels between children who play first-person shooter games and those who do not."

Examples of an alternative hypothesis:

• "People who take St. John's wort supplements will have less anxiety than those who do not."
• "Adults will perform better on a memory task than children."
• "Children who play first-person shooter games will show higher levels of aggression than children who do not." 

Collecting Data on Your Hypothesis

Once a researcher has formed a testable hypothesis, the next step is to select a research design and start collecting data. The research method depends largely on exactly what they are studying. There are two basic types of research methods: descriptive research and experimental research.

Descriptive Research Methods

Descriptive research such as  case studies ,  naturalistic observations , and surveys are often used when  conducting an experiment is difficult or impossible. These methods are best used to describe different aspects of a behavior or psychological phenomenon.

Once a researcher has collected data using descriptive methods, a  correlational study  can examine how the variables are related. This research method might be used to investigate a hypothesis that is difficult to test experimentally.

Experimental Research Methods

Experimental methods  are used to demonstrate causal relationships between variables. In an experiment, the researcher systematically manipulates a variable of interest (known as the independent variable) and measures the effect on another variable (known as the dependent variable).

Unlike correlational studies, which can only be used to determine if there is a relationship between two variables, experimental methods can be used to determine the actual nature of the relationship—whether changes in one variable actually  cause  another to change.

The hypothesis is a critical part of any scientific exploration. It represents what researchers expect to find in a study or experiment. In situations where the hypothesis is unsupported by the research, the research still has value. Such research helps us better understand how different aspects of the natural world relate to one another. It also helps us develop new hypotheses that can then be tested in the future.

Thompson WH, Skau S. On the scope of scientific hypotheses .  R Soc Open Sci . 2023;10(8):230607. doi:10.1098/rsos.230607

Taran S, Adhikari NKJ, Fan E. Falsifiability in medicine: what clinicians can learn from Karl Popper [published correction appears in Intensive Care Med. 2021 Jun 17;:].  Intensive Care Med . 2021;47(9):1054-1056. doi:10.1007/s00134-021-06432-z

Eyler AA. Research Methods for Public Health . 1st ed. Springer Publishing Company; 2020. doi:10.1891/9780826182067.0004

Nosek BA, Errington TM. What is replication ?  PLoS Biol . 2020;18(3):e3000691. doi:10.1371/journal.pbio.3000691

Aggarwal R, Ranganathan P. Study designs: Part 2 - Descriptive studies .  Perspect Clin Res . 2019;10(1):34-36. doi:10.4103/picr.PICR_154_18

Nevid J. Psychology: Concepts and Applications. Wadworth, 2013.

By Kendra Cherry, MSEd Kendra Cherry, MS, is a psychosocial rehabilitation specialist, psychology educator, and author of the "Everything Psychology Book."

A concise guide to reproducible research using secondary data

Chapter 2 formulating a hypothesis.

“There is no single best way to develop a research idea.” ( Pischke 2012 )

2.1 How do you develop a research question and formulate a hypothesis?

You decide to undertake a scientific project. Where do you start? First, you need to find a research question that interests you and formulate a hypothesis. We will introduce some key terminology, steps you can take, and examples how to develop research questions. Note that .

What if someone assigns a topic to me? For students attending undergraduate and graduate courses that often pick topics from a list, all of these steps are equally important and necessary. You still need to formulate a research question and a hypothesis. And it is important to clarify the relevance of your topic for yourself.

When thinking about a research question, you need to identify a topic that is:

• Relevant , important in the world and interesting to you as a researcher: Does working on the topic excites you? You will spend many hours thinking about it and working on it. Therefore, it should be interesting and engaging enough for you to motivate your continued work on this topic.
• Specific : not too broad and not too narrow
• Feasible to research within a given time frame: Is it possible to answer the research question based on your time budget, data and additional resources.

How do you find a topic or develop a feasible research idea in the first place? Finding an idea is not difficult, the critical part is to find a good idea. How do you do that? There is no one specific way how one gets an idea, rather there is a myriad of ways how people come up with potential ideas (for example, as stated by Varian ( 2016 ) ).

You can find inspiration by

• Looking at insights from the world around you: your own life and experiences, observe the behavior of people around you
• Talking to people around you, experts, other students, family members
• Talking to individuals outside your field (non-economists)
• Talking to professionals working in the area you are interested in (you may use social media and professional platforms like LinkedIN or Twitter to make contact)
• Reading journal articles from other non-economic social sciences and the medical literature
• What are the issues being discussed?
• How do these issues affect people’s lives?

In addition you could

• Go to virtual and in-person seminars, for example, the Essen Health Economics Seminar
• Look at abstracts of scientific articles and working papers
• Look at the literature in a specific field you are interested in, for example, screening complete issues of journals or editorials about certain research advancements. By reading this literature you might come up with the idea on how to extend and refine previous research.

Once you identified a research question that is of interest to you, you need to define a hypothesis.

2.2 What is a hypothesis?

A hypothesis is a statement that introduces your research question and suggests the results you might find. It is an educated guess. You start by posing an economic question and formulate a hypothesis about this question. Then you test it with your data and empirical analysis and either accept or reject the hypothesis. It constitutes the main basis of your scientific investigation and you should be careful when creating it.

2.2.1 Develop a hypothesis

Before you formulate your hypothesis, read up on the topic of interest. This should provide you with sufficient information to narrow down your research question. Once you find your question you need to develop a hypothesis, which contains a statement of your expectations regarding your research question’s results. You propose to prove your hypothesis with your research by testing the relationship between two variables of interest. Thus, a hypothesis should be testable with the data at hand. There are two types of hypotheses: alternative or null. Null states that there is no effect. Alternative states that there is an effect.

There is an alternative view on this that suggests one should not look at the literature too early on in the idea-generating process to not be influenced and shaped by someone else’s ideas ( Varian 2016 ) . According to this view you can spend some time (i.e. a few weeks) trying to develop your own original idea. Even if you end up with an idea that has already been pursued by someone else, this will still provide you with good practice in developing publishable ideas. After you have developed an idea and made sure that it was not yet investigated in the literature, you can start conducting a systematic literature review. By doing this, you can find some other interesting insights from the work of others that you can synthesize in your own work to produce something novel and original.

2.2.2 Identify relevant literature

For your research project you will need to identify and collect previous relevant literature. It should involve a thorough search of the keywords in relevant databases and journals. Place emphasis on articles from high-ranking journals with significant numbers of citations. This will give you an indication of the most influential and important work in the field. Once you identify and collect the relevant literature for your topic, you will need to critically synthesize it in your literature review.

When you perform your literature review, consider theories that may inform your research question. For example, when studying physician behavior you may consider principal-agent theory.

2.2.3 Research question or literature review: the chicken or the egg problem?

Whether you start reading the literature first or by developing an idea may depend on your level (graduate student, early career researcher) and other goals. However, thinking freely about what you like to investigate first may help to critically develop a feasible and interesting research question.

We highlight an example how to start with investigating the real world and subsequently posing a research question ( “How to Write a Strong Hypothesis Steps and Examples ” 2019 ; “Developing Strong Research Questions Criteria and Examples ” 2019 ; Schilbach 2019 ) . For example, based on your observation you notice that people spend extensive amount of time looking at their smartphones. Maybe even you yourself engage in the same behavior. In addition, you read a BBC News article Social media damages teenagers’ mental health, report says .

(#fig:social_media)Social media and mental health

Source: BBC

You decide to translate this article and your observations into a research question : How does social media use affect mental health? Before you formulate your hypothesis, read up on the topic of interest. Read economic, medical and other social science literature on the topic. There is likely to be a vast amount of literature from non-economic fields that are doing research on your topic of interest, for example, psychology or neuroscience. Familiarize yourself with it and master it. Do not get distracted by different scientific methodologies and techniques that might seem not up-to-par to the economic studies (small sample sizes, endogeneity, uncovering association rather than causation, etc.), but rather focus on suggestions of potential mechanisms.

A hypothesis is then your research question distilled into a one sentence statement, which presents your expectations regarding the results. You propose to prove your hypothesis by testing the relationship between two variables of interest with the data at hand. There are two types of hypotheses: alternative or null. The null hypothesis states that there is no effect. The alternative hypothesis states that there is an effect.

A hypothesis related to the above-stated research question could be: The increased use of social media among teenagers leads to (is associated with) worse mental health outcomes, i.e. increased incidence of depression, eating disorders, worse well-being and lower self-esteem. It suggests a direction of a relationship that you expect to find that is guided by your observations and existing evidence. It is testable with scientific research methods by using statistical analysis of the relevant data.

Your hypothesis suggests a relationship between two variables: social media use (your independent variable \(X\) ) and mental health (dependent variable \(Y\) ). It could be framed in terms of correlation (is associated with) or causation (leads to). This should be reflected in the choice of scientific investigation you decide to undertake.

The null hypothesis is: There is no relationship between social media use among teenagers and their mental health .

2.3 Resources box

2.3.1 how to develop strong research questions.

• The form of the research process
• Varian, H. R. (2016). How to build an economic model in your spare time. The American Economist, 61(1), 81-90.

2.3.2 Identify relevant literature from major general interest and field literature

To identify the relevant literature you can

• use academic search engines such as Google Scholar, Web of Science, EconLit, PubMed.
• search working paper series such as the National Bureau of Economic Research , NetEc or IZA
• search more general resource sites such as Resources for Economists
• go to the library/use library database

2.3.3 Assess the quality of a journal article

Several rankings may help to assess the quality of research you consider

• Journals of general interest and by field in economics and management - For German-speaking countries, consider the VWL / BWL Handelsblatt Ranking for economics and management - The German Association of Management Scholars provides an expert-based ranking VHB JourQual 3.0, Teilranking Management im Gesundheitswesen - Web of Science Impact Factors - Scimago
• Health Economics, Health Services and Health Care Managment Research: Health Economics Journals List
• Be aware that like in any other domain there are predatory publishing practices .

Use tools to investigate how a journal article is connected to other works

• Citationgecko
• Connected papers
• scite_ – a tool to get a first impression whether a study is disputed or academic consensus

2.3.4 Organize your literature

• Zotero (free of charge)
• Mendeley (free of charge)
• EndNote (potentially free of charge via your university)
• Citavi (potentially free of charge via your university)
• BibTEX if you work with TEX
• Excel spread sheet

2.4 Checklist to get started with formulating your hypothesis

• Find an interesting and relevant research topic, if not assigned
• Try to suck up all information you can easily obtain from various sources within and outside academic literature
• Formulate one compelling research question
• Find the best available empirical and theoretical evidence that is related to your research question
• Formulate a hypothesis
• Check whether data are available for analysis
• Challenge your idea with your fellows or senior researchers

2.5 Example: Hellerstein ( 1998 )

As an illustration of the research process of formulating a hypothesis, designing a study, running a study, collecting and analyzing the data and, finally, reporting the study, we provide an example by replicating Judith K. Hellerstein’s paper “The Importance of the Physician in the Generic versus Trade-Name Prescription Decision” that was published in 1998 in the RAND Journal of Economics.

Hellerstein’s 1998 paper has impacted discussion about behavioral factors of physician decisions and pharmaceutical markets over two decades. The study received 448 citations on Google Scholar since 1998 by 27/03/2022, including recent mentions in top field journals such as Journal of Public Economics (2021) , Journal of Health Economics (2019) , and Health Economics (2019) .

Figure 2.1: Connected graph of Hellerstein ( 1998 ) , February 2022

Figure 2.1 shows a connected graph of prior and derivative works related to the study.

The work has impacted the literature researching the role of physician behavior and its influence on access, adoption and diffusion of health services, moral hazard and incentives in prescription and treatment decisions and the influence of different payment schemes, and a vast body of literature studying the pharmaceutical market.

The research that has been influenced by Hellerstein includes evidence on:

• generic drug entries and market efficiency
• the effectiveness of pharmaceutical promotion
• the effectiveness of price regulations
• the role of patents and dynamics of market segmentation

At the end of each chapter, we demonstrate insights into this study that we replicate.

2.5.1 Context of the study - escalating health expenditures

In the United States, the total prescription drug expenditure in 2020 marked about 358.7 billion US Dollars ( Statista n.d. ) . The prescription of generic drugs in comparison to more expensive brand-name versions is an option in reducing the total health care expenditure. Generic drugs are bioequivalent in the active ingredients and can serve as a channel to contain prescription expenditure ( Kesselheim 2008 ) as generic drugs are between 20 and 90% cheaper than their trade-name alternatives ( Dunne et al. 2013 ) .

2.5.2 Research question - How does a patient’s insurance status influence the physician’s choice between generic compared to brand-name drugs?

Physicians are faced with a multitude of medication options, including the choice between generic and trade-name drugs. Physicians ideally act as agents for their patients to identify the best available treatment option based on their needs. Choosing the best treatment entails cost of coordination and cognition. The prescription of generic drugs may serve as an example to what extent physicians customize treatments according to patients’ needs with regards to cost. From an economic point of view we may expect that once a generic drug is available, a perfectly rational agent (i.e. physician) would prescribe a generic drug instead of the trade-name version if therapeutically identical ( Dranove 1989 ) . This leads to the following research question: “Do physicians vary their prescription decisions on a patient-by-patient basis or do they systematically prescribe the same version, trade-name or generic, to all patients?” .

The 1998 Hellerstein’s study examines two hypotheses:

• The physician prescribing choice influences the selection of a generic over a brand-name drug
• The patient’s insurance status influences the physician’s choice between generic and brand-name drugs.

For the purpose of this example and in the replication exercise we focus on the second aspect.

2.5.3 Hypothesis

The paper formulates the following hypothesis:

Physicians are more likely to prescribe generics to patients who do not have insurance coverage for prescription pharmaceuticals (moral hazard in insurance)

Hellerstein ( 1998 ) discusses that, based on insurance status, some patients may demand certain care more than others. If, for example, the prescription drug is reimbursed by the patient’s health insurance, this may cause overconsumption. This behavior can potentially differ by the patient’s insurance scheme. A patient that has no insurance and, thus, does not get any reimbursement for prescription drugs, might have a higher incentive to demand cheaper generic drugs ( Danzon and Furukawa 2011 ) than a patient with insurance that covers prescription drugs, either generic or trade-name. Given that the United States have different insurance schemes with varying prescription drug coverage, it is of interest to investigate the role of a patient’s insurance status in the physician’s choice between generic compared to brand-name drugs.

Hellerstein ( 1998 ) considers a patient’s insurance status as a matter of dividing the study population in groups for which the choice between generic and brand-name drugs differs. She suggests that There is a relationship between the prescription of a generic drug and insurance status of a patient. ( Hellerstein 1998 ) .

Providing answers to a research question requires formulating and testing a hypothesis. Based on logic, theory or previous research, a hypothesis proposes an expected relationship within the given data. According to her research question, Hellerstein hypothesizes that: Physicians are more likely to prescribe generics to patients who do not have insurance coverage for prescription pharmaceuticals.

Specifically, she writes “if there is moral hazard in insurance when it comes to physician prescription behavior, there will be differences in the propensity of physicians to prescribe low-cost generic drugs, and these differences will be (partially) a function of the insurance held by the patient. In particular, if moral hazard exists, patients with extensive insurance coverage for prescription drugs (like those on Medicaid in 1989) should receive prescriptions written for generic drugs less frequently than patients with no prescription drug coverage.” ( Hellerstein 1998, 113 )

Based on Hellerstein’s considerations, we expect the effect of the insurance status on whether a patient receives a generic to be different from zero. To obtain a testable null hypothesis, we reformulate this relationship so that we reject the hypothesis if our expectations are correct. This means, if we expect to see an effect of insurance on prescriptions of generics, our null hypothesis is that insurance status has no effect on the outcome (prescription of generic drugs). No moral hazard arises from having obtained insurance.

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What is a Hypothesis – Types, Examples and Writing Guide

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Definition:

Hypothesis is an educated guess or proposed explanation for a phenomenon, based on some initial observations or data. It is a tentative statement that can be tested and potentially proven or disproven through further investigation and experimentation.

Hypothesis is often used in scientific research to guide the design of experiments and the collection and analysis of data. It is an essential element of the scientific method, as it allows researchers to make predictions about the outcome of their experiments and to test those predictions to determine their accuracy.

Types of Hypothesis

Types of Hypothesis are as follows:

Research Hypothesis

A research hypothesis is a statement that predicts a relationship between variables. It is usually formulated as a specific statement that can be tested through research, and it is often used in scientific research to guide the design of experiments.

Null Hypothesis

The null hypothesis is a statement that assumes there is no significant difference or relationship between variables. It is often used as a starting point for testing the research hypothesis, and if the results of the study reject the null hypothesis, it suggests that there is a significant difference or relationship between variables.

Alternative Hypothesis

An alternative hypothesis is a statement that assumes there is a significant difference or relationship between variables. It is often used as an alternative to the null hypothesis and is tested against the null hypothesis to determine which statement is more accurate.

Directional Hypothesis

A directional hypothesis is a statement that predicts the direction of the relationship between variables. For example, a researcher might predict that increasing the amount of exercise will result in a decrease in body weight.

Non-directional Hypothesis

A non-directional hypothesis is a statement that predicts the relationship between variables but does not specify the direction. For example, a researcher might predict that there is a relationship between the amount of exercise and body weight, but they do not specify whether increasing or decreasing exercise will affect body weight.

Statistical Hypothesis

A statistical hypothesis is a statement that assumes a particular statistical model or distribution for the data. It is often used in statistical analysis to test the significance of a particular result.

Composite Hypothesis

A composite hypothesis is a statement that assumes more than one condition or outcome. It can be divided into several sub-hypotheses, each of which represents a different possible outcome.

Empirical Hypothesis

An empirical hypothesis is a statement that is based on observed phenomena or data. It is often used in scientific research to develop theories or models that explain the observed phenomena.

Simple Hypothesis

A simple hypothesis is a statement that assumes only one outcome or condition. It is often used in scientific research to test a single variable or factor.

Complex Hypothesis

A complex hypothesis is a statement that assumes multiple outcomes or conditions. It is often used in scientific research to test the effects of multiple variables or factors on a particular outcome.

Applications of Hypothesis

Hypotheses are used in various fields to guide research and make predictions about the outcomes of experiments or observations. Here are some examples of how hypotheses are applied in different fields:

• Science : In scientific research, hypotheses are used to test the validity of theories and models that explain natural phenomena. For example, a hypothesis might be formulated to test the effects of a particular variable on a natural system, such as the effects of climate change on an ecosystem.
• Medicine : In medical research, hypotheses are used to test the effectiveness of treatments and therapies for specific conditions. For example, a hypothesis might be formulated to test the effects of a new drug on a particular disease.
• Psychology : In psychology, hypotheses are used to test theories and models of human behavior and cognition. For example, a hypothesis might be formulated to test the effects of a particular stimulus on the brain or behavior.
• Sociology : In sociology, hypotheses are used to test theories and models of social phenomena, such as the effects of social structures or institutions on human behavior. For example, a hypothesis might be formulated to test the effects of income inequality on crime rates.
• Business : In business research, hypotheses are used to test the validity of theories and models that explain business phenomena, such as consumer behavior or market trends. For example, a hypothesis might be formulated to test the effects of a new marketing campaign on consumer buying behavior.
• Engineering : In engineering, hypotheses are used to test the effectiveness of new technologies or designs. For example, a hypothesis might be formulated to test the efficiency of a new solar panel design.

How to write a Hypothesis

Here are the steps to follow when writing a hypothesis:

Identify the Research Question

The first step is to identify the research question that you want to answer through your study. This question should be clear, specific, and focused. It should be something that can be investigated empirically and that has some relevance or significance in the field.

Conduct a Literature Review

Before writing your hypothesis, it’s essential to conduct a thorough literature review to understand what is already known about the topic. This will help you to identify the research gap and formulate a hypothesis that builds on existing knowledge.

Determine the Variables

The next step is to identify the variables involved in the research question. A variable is any characteristic or factor that can vary or change. There are two types of variables: independent and dependent. The independent variable is the one that is manipulated or changed by the researcher, while the dependent variable is the one that is measured or observed as a result of the independent variable.

Formulate the Hypothesis

Based on the research question and the variables involved, you can now formulate your hypothesis. A hypothesis should be a clear and concise statement that predicts the relationship between the variables. It should be testable through empirical research and based on existing theory or evidence.

Write the Null Hypothesis

The null hypothesis is the opposite of the alternative hypothesis, which is the hypothesis that you are testing. The null hypothesis states that there is no significant difference or relationship between the variables. It is important to write the null hypothesis because it allows you to compare your results with what would be expected by chance.

Refine the Hypothesis

After formulating the hypothesis, it’s important to refine it and make it more precise. This may involve clarifying the variables, specifying the direction of the relationship, or making the hypothesis more testable.

Examples of Hypothesis

Here are a few examples of hypotheses in different fields:

• Psychology : “Increased exposure to violent video games leads to increased aggressive behavior in adolescents.”
• Biology : “Higher levels of carbon dioxide in the atmosphere will lead to increased plant growth.”
• Sociology : “Individuals who grow up in households with higher socioeconomic status will have higher levels of education and income as adults.”
• Education : “Implementing a new teaching method will result in higher student achievement scores.”
• Marketing : “Customers who receive a personalized email will be more likely to make a purchase than those who receive a generic email.”
• Physics : “An increase in temperature will cause an increase in the volume of a gas, assuming all other variables remain constant.”
• Medicine : “Consuming a diet high in saturated fats will increase the risk of developing heart disease.”

Purpose of Hypothesis

The purpose of a hypothesis is to provide a testable explanation for an observed phenomenon or a prediction of a future outcome based on existing knowledge or theories. A hypothesis is an essential part of the scientific method and helps to guide the research process by providing a clear focus for investigation. It enables scientists to design experiments or studies to gather evidence and data that can support or refute the proposed explanation or prediction.

The formulation of a hypothesis is based on existing knowledge, observations, and theories, and it should be specific, testable, and falsifiable. A specific hypothesis helps to define the research question, which is important in the research process as it guides the selection of an appropriate research design and methodology. Testability of the hypothesis means that it can be proven or disproven through empirical data collection and analysis. Falsifiability means that the hypothesis should be formulated in such a way that it can be proven wrong if it is incorrect.

In addition to guiding the research process, the testing of hypotheses can lead to new discoveries and advancements in scientific knowledge. When a hypothesis is supported by the data, it can be used to develop new theories or models to explain the observed phenomenon. When a hypothesis is not supported by the data, it can help to refine existing theories or prompt the development of new hypotheses to explain the phenomenon.

When to use Hypothesis

Here are some common situations in which hypotheses are used:

• In scientific research , hypotheses are used to guide the design of experiments and to help researchers make predictions about the outcomes of those experiments.
• In social science research , hypotheses are used to test theories about human behavior, social relationships, and other phenomena.
• I n business , hypotheses can be used to guide decisions about marketing, product development, and other areas. For example, a hypothesis might be that a new product will sell well in a particular market, and this hypothesis can be tested through market research.

Characteristics of Hypothesis

Here are some common characteristics of a hypothesis:

• Testable : A hypothesis must be able to be tested through observation or experimentation. This means that it must be possible to collect data that will either support or refute the hypothesis.
• Falsifiable : A hypothesis must be able to be proven false if it is not supported by the data. If a hypothesis cannot be falsified, then it is not a scientific hypothesis.
• Clear and concise : A hypothesis should be stated in a clear and concise manner so that it can be easily understood and tested.
• Based on existing knowledge : A hypothesis should be based on existing knowledge and research in the field. It should not be based on personal beliefs or opinions.
• Specific : A hypothesis should be specific in terms of the variables being tested and the predicted outcome. This will help to ensure that the research is focused and well-designed.
• Tentative: A hypothesis is a tentative statement or assumption that requires further testing and evidence to be confirmed or refuted. It is not a final conclusion or assertion.
• Relevant : A hypothesis should be relevant to the research question or problem being studied. It should address a gap in knowledge or provide a new perspective on the issue.

Advantages of Hypothesis

Hypotheses have several advantages in scientific research and experimentation:

• Guides research: A hypothesis provides a clear and specific direction for research. It helps to focus the research question, select appropriate methods and variables, and interpret the results.
• Predictive powe r: A hypothesis makes predictions about the outcome of research, which can be tested through experimentation. This allows researchers to evaluate the validity of the hypothesis and make new discoveries.
• Facilitates communication: A hypothesis provides a common language and framework for scientists to communicate with one another about their research. This helps to facilitate the exchange of ideas and promotes collaboration.
• Efficient use of resources: A hypothesis helps researchers to use their time, resources, and funding efficiently by directing them towards specific research questions and methods that are most likely to yield results.
• Provides a basis for further research: A hypothesis that is supported by data provides a basis for further research and exploration. It can lead to new hypotheses, theories, and discoveries.
• Increases objectivity: A hypothesis can help to increase objectivity in research by providing a clear and specific framework for testing and interpreting results. This can reduce bias and increase the reliability of research findings.

Limitations of Hypothesis

Some Limitations of the Hypothesis are as follows:

• Limited to observable phenomena: Hypotheses are limited to observable phenomena and cannot account for unobservable or intangible factors. This means that some research questions may not be amenable to hypothesis testing.
• May be inaccurate or incomplete: Hypotheses are based on existing knowledge and research, which may be incomplete or inaccurate. This can lead to flawed hypotheses and erroneous conclusions.
• May be biased: Hypotheses may be biased by the researcher’s own beliefs, values, or assumptions. This can lead to selective interpretation of data and a lack of objectivity in research.
• Cannot prove causation: A hypothesis can only show a correlation between variables, but it cannot prove causation. This requires further experimentation and analysis.
• Limited to specific contexts: Hypotheses are limited to specific contexts and may not be generalizable to other situations or populations. This means that results may not be applicable in other contexts or may require further testing.
• May be affected by chance : Hypotheses may be affected by chance or random variation, which can obscure or distort the true relationship between variables.

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• How to Write a Strong Hypothesis | Guide & Examples

How to Write a Strong Hypothesis | Guide & Examples

Published on 6 May 2022 by Shona McCombes .

A hypothesis is a statement that can be tested by scientific research. If you want to test a relationship between two or more variables, you need to write hypotheses before you start your experiment or data collection.

Table of contents

What is a hypothesis, developing a hypothesis (with example), hypothesis examples, frequently asked questions about writing hypotheses.

A hypothesis states your predictions about what your research will find. It is a tentative answer to your research question that has not yet been tested. For some research projects, you might have to write several hypotheses that address different aspects of your research question.

A hypothesis is not just a guess – it should be based on existing theories and knowledge. It also has to be testable, which means you can support or refute it through scientific research methods (such as experiments, observations, and statistical analysis of data).

Variables in hypotheses

Hypotheses propose a relationship between two or more variables . An independent variable is something the researcher changes or controls. A dependent variable is something the researcher observes and measures.

In this example, the independent variable is exposure to the sun – the assumed cause . The dependent variable is the level of happiness – the assumed effect .

Prevent plagiarism, run a free check.

Step 1: ask a question.

Writing a hypothesis begins with a research question that you want to answer. The question should be focused, specific, and researchable within the constraints of your project.

Step 2: Do some preliminary research

Your initial answer to the question should be based on what is already known about the topic. Look for theories and previous studies to help you form educated assumptions about what your research will find.

At this stage, you might construct a conceptual framework to identify which variables you will study and what you think the relationships are between them. Sometimes, you’ll have to operationalise more complex constructs.

Step 3: Formulate your hypothesis

Now you should have some idea of what you expect to find. Write your initial answer to the question in a clear, concise sentence.

Step 4: Refine your hypothesis

You need to make sure your hypothesis is specific and testable. There are various ways of phrasing a hypothesis, but all the terms you use should have clear definitions, and the hypothesis should contain:

• The relevant variables
• The specific group being studied
• The predicted outcome of the experiment or analysis

Step 5: Phrase your hypothesis in three ways

To identify the variables, you can write a simple prediction in if … then form. The first part of the sentence states the independent variable and the second part states the dependent variable.

In academic research, hypotheses are more commonly phrased in terms of correlations or effects, where you directly state the predicted relationship between variables.

If you are comparing two groups, the hypothesis can state what difference you expect to find between them.

Step 6. Write a null hypothesis

If your research involves statistical hypothesis testing , you will also have to write a null hypothesis. The null hypothesis is the default position that there is no association between the variables. The null hypothesis is written as H 0 , while the alternative hypothesis is H 1 or H a .

Hypothesis testing is a formal procedure for investigating our ideas about the world using statistics. It is used by scientists to test specific predictions, called hypotheses , by calculating how likely it is that a pattern or relationship between variables could have arisen by chance.

A hypothesis is not just a guess. It should be based on existing theories and knowledge. It also has to be testable, which means you can support or refute it through scientific research methods (such as experiments, observations, and statistical analysis of data).

A research hypothesis is your proposed answer to your research question. The research hypothesis usually includes an explanation (‘ x affects y because …’).

A statistical hypothesis, on the other hand, is a mathematical statement about a population parameter. Statistical hypotheses always come in pairs: the null and alternative hypotheses. In a well-designed study , the statistical hypotheses correspond logically to the research hypothesis.

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McCombes, S. (2022, May 06). How to Write a Strong Hypothesis | Guide & Examples. Scribbr. Retrieved 26 August 2024, from https://www.scribbr.co.uk/research-methods/hypothesis-writing/

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Formulating Hypotheses for Different Study Designs

Durga prasanna misra.

1 Department of Clinical Immunology and Rheumatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.

Armen Yuri Gasparyan

2 Departments of Rheumatology and Research and Development, Dudley Group NHS Foundation Trust (Teaching Trust of the University of Birmingham, UK), Russells Hall Hospital, Dudley, UK.

Olena Zimba

3 Department of Internal Medicine #2, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine.

Marlen Yessirkepov

4 Department of Biology and Biochemistry, South Kazakhstan Medical Academy, Shymkent, Kazakhstan.

Vikas Agarwal

George d. kitas.

5 Centre for Epidemiology versus Arthritis, University of Manchester, Manchester, UK.

Generating a testable working hypothesis is the first step towards conducting original research. Such research may prove or disprove the proposed hypothesis. Case reports, case series, online surveys and other observational studies, clinical trials, and narrative reviews help to generate hypotheses. Observational and interventional studies help to test hypotheses. A good hypothesis is usually based on previous evidence-based reports. Hypotheses without evidence-based justification and a priori ideas are not received favourably by the scientific community. Original research to test a hypothesis should be carefully planned to ensure appropriate methodology and adequate statistical power. While hypotheses can challenge conventional thinking and may be controversial, they should not be destructive. A hypothesis should be tested by ethically sound experiments with meaningful ethical and clinical implications. The coronavirus disease 2019 pandemic has brought into sharp focus numerous hypotheses, some of which were proven (e.g. effectiveness of corticosteroids in those with hypoxia) while others were disproven (e.g. ineffectiveness of hydroxychloroquine and ivermectin).

Graphical Abstract

DEFINING WORKING AND STANDALONE SCIENTIFIC HYPOTHESES

Science is the systematized description of natural truths and facts. Routine observations of existing life phenomena lead to the creative thinking and generation of ideas about mechanisms of such phenomena and related human interventions. Such ideas presented in a structured format can be viewed as hypotheses. After generating a hypothesis, it is necessary to test it to prove its validity. Thus, hypothesis can be defined as a proposed mechanism of a naturally occurring event or a proposed outcome of an intervention. 1 , 2

Hypothesis testing requires choosing the most appropriate methodology and adequately powering statistically the study to be able to “prove” or “disprove” it within predetermined and widely accepted levels of certainty. This entails sample size calculation that often takes into account previously published observations and pilot studies. 2 , 3 In the era of digitization, hypothesis generation and testing may benefit from the availability of numerous platforms for data dissemination, social networking, and expert validation. Related expert evaluations may reveal strengths and limitations of proposed ideas at early stages of post-publication promotion, preventing the implementation of unsupported controversial points. 4

Thus, hypothesis generation is an important initial step in the research workflow, reflecting accumulating evidence and experts' stance. In this article, we overview the genesis and importance of scientific hypotheses and their relevance in the era of the coronavirus disease 2019 (COVID-19) pandemic.

DO WE NEED HYPOTHESES FOR ALL STUDY DESIGNS?

Broadly, research can be categorized as primary or secondary. In the context of medicine, primary research may include real-life observations of disease presentations and outcomes. Single case descriptions, which often lead to new ideas and hypotheses, serve as important starting points or justifications for case series and cohort studies. The importance of case descriptions is particularly evident in the context of the COVID-19 pandemic when unique, educational case reports have heralded a new era in clinical medicine. 5

Case series serve similar purpose to single case reports, but are based on a slightly larger quantum of information. Observational studies, including online surveys, describe the existing phenomena at a larger scale, often involving various control groups. Observational studies include variable-scale epidemiological investigations at different time points. Interventional studies detail the results of therapeutic interventions.

Secondary research is based on already published literature and does not directly involve human or animal subjects. Review articles are generated by secondary research. These could be systematic reviews which follow methods akin to primary research but with the unit of study being published papers rather than humans or animals. Systematic reviews have a rigid structure with a mandatory search strategy encompassing multiple databases, systematic screening of search results against pre-defined inclusion and exclusion criteria, critical appraisal of study quality and an optional component of collating results across studies quantitatively to derive summary estimates (meta-analysis). 6 Narrative reviews, on the other hand, have a more flexible structure. Systematic literature searches to minimise bias in selection of articles are highly recommended but not mandatory. 7 Narrative reviews are influenced by the authors' viewpoint who may preferentially analyse selected sets of articles. 8

In relation to primary research, case studies and case series are generally not driven by a working hypothesis. Rather, they serve as a basis to generate a hypothesis. Observational or interventional studies should have a hypothesis for choosing research design and sample size. The results of observational and interventional studies further lead to the generation of new hypotheses, testing of which forms the basis of future studies. Review articles, on the other hand, may not be hypothesis-driven, but form fertile ground to generate future hypotheses for evaluation. Fig. 1 summarizes which type of studies are hypothesis-driven and which lead on to hypothesis generation.

STANDARDS OF WORKING AND SCIENTIFIC HYPOTHESES

A review of the published literature did not enable the identification of clearly defined standards for working and scientific hypotheses. It is essential to distinguish influential versus not influential hypotheses, evidence-based hypotheses versus a priori statements and ideas, ethical versus unethical, or potentially harmful ideas. The following points are proposed for consideration while generating working and scientific hypotheses. 1 , 2 Table 1 summarizes these points.

Evidence-based data

A scientific hypothesis should have a sound basis on previously published literature as well as the scientist's observations. Randomly generated (a priori) hypotheses are unlikely to be proven. A thorough literature search should form the basis of a hypothesis based on published evidence. 7

Unless a scientific hypothesis can be tested, it can neither be proven nor be disproven. Therefore, a scientific hypothesis should be amenable to testing with the available technologies and the present understanding of science.

Supported by pilot studies

If a hypothesis is based purely on a novel observation by the scientist in question, it should be grounded on some preliminary studies to support it. For example, if a drug that targets a specific cell population is hypothesized to be useful in a particular disease setting, then there must be some preliminary evidence that the specific cell population plays a role in driving that disease process.

Testable by ethical studies

The hypothesis should be testable by experiments that are ethically acceptable. 9 For example, a hypothesis that parachutes reduce mortality from falls from an airplane cannot be tested using a randomized controlled trial. 10 This is because it is obvious that all those jumping from a flying plane without a parachute would likely die. Similarly, the hypothesis that smoking tobacco causes lung cancer cannot be tested by a clinical trial that makes people take up smoking (since there is considerable evidence for the health hazards associated with smoking). Instead, long-term observational studies comparing outcomes in those who smoke and those who do not, as was performed in the landmark epidemiological case control study by Doll and Hill, 11 are more ethical and practical.

Balance between scientific temper and controversy

Novel findings, including novel hypotheses, particularly those that challenge established norms, are bound to face resistance for their wider acceptance. Such resistance is inevitable until the time such findings are proven with appropriate scientific rigor. However, hypotheses that generate controversy are generally unwelcome. For example, at the time the pandemic of human immunodeficiency virus (HIV) and AIDS was taking foot, there were numerous deniers that refused to believe that HIV caused AIDS. 12 , 13 Similarly, at a time when climate change is causing catastrophic changes to weather patterns worldwide, denial that climate change is occurring and consequent attempts to block climate change are certainly unwelcome. 14 The denialism and misinformation during the COVID-19 pandemic, including unfortunate examples of vaccine hesitancy, are more recent examples of controversial hypotheses not backed by science. 15 , 16 An example of a controversial hypothesis that was a revolutionary scientific breakthrough was the hypothesis put forth by Warren and Marshall that Helicobacter pylori causes peptic ulcers. Initially, the hypothesis that a microorganism could cause gastritis and gastric ulcers faced immense resistance. When the scientists that proposed the hypothesis themselves ingested H. pylori to induce gastritis in themselves, only then could they convince the wider world about their hypothesis. Such was the impact of the hypothesis was that Barry Marshall and Robin Warren were awarded the Nobel Prize in Physiology or Medicine in 2005 for this discovery. 17 , 18

DISTINGUISHING THE MOST INFLUENTIAL HYPOTHESES

Influential hypotheses are those that have stood the test of time. An archetype of an influential hypothesis is that proposed by Edward Jenner in the eighteenth century that cowpox infection protects against smallpox. While this observation had been reported for nearly a century before this time, it had not been suitably tested and publicised until Jenner conducted his experiments on a young boy by demonstrating protection against smallpox after inoculation with cowpox. 19 These experiments were the basis for widespread smallpox immunization strategies worldwide in the 20th century which resulted in the elimination of smallpox as a human disease today. 20

Other influential hypotheses are those which have been read and cited widely. An example of this is the hygiene hypothesis proposing an inverse relationship between infections in early life and allergies or autoimmunity in adulthood. An analysis reported that this hypothesis had been cited more than 3,000 times on Scopus. 1

LESSONS LEARNED FROM HYPOTHESES AMIDST THE COVID-19 PANDEMIC

The COVID-19 pandemic devastated the world like no other in recent memory. During this period, various hypotheses emerged, understandably so considering the public health emergency situation with innumerable deaths and suffering for humanity. Within weeks of the first reports of COVID-19, aberrant immune system activation was identified as a key driver of organ dysfunction and mortality in this disease. 21 Consequently, numerous drugs that suppress the immune system or abrogate the activation of the immune system were hypothesized to have a role in COVID-19. 22 One of the earliest drugs hypothesized to have a benefit was hydroxychloroquine. Hydroxychloroquine was proposed to interfere with Toll-like receptor activation and consequently ameliorate the aberrant immune system activation leading to pathology in COVID-19. 22 The drug was also hypothesized to have a prophylactic role in preventing infection or disease severity in COVID-19. It was also touted as a wonder drug for the disease by many prominent international figures. However, later studies which were well-designed randomized controlled trials failed to demonstrate any benefit of hydroxychloroquine in COVID-19. 23 , 24 , 25 , 26 Subsequently, azithromycin 27 , 28 and ivermectin 29 were hypothesized as potential therapies for COVID-19, but were not supported by evidence from randomized controlled trials. The role of vitamin D in preventing disease severity was also proposed, but has not been proven definitively until now. 30 , 31 On the other hand, randomized controlled trials identified the evidence supporting dexamethasone 32 and interleukin-6 pathway blockade with tocilizumab as effective therapies for COVID-19 in specific situations such as at the onset of hypoxia. 33 , 34 Clues towards the apparent effectiveness of various drugs against severe acute respiratory syndrome coronavirus 2 in vitro but their ineffectiveness in vivo have recently been identified. Many of these drugs are weak, lipophilic bases and some others induce phospholipidosis which results in apparent in vitro effectiveness due to non-specific off-target effects that are not replicated inside living systems. 35 , 36

Another hypothesis proposed was the association of the routine policy of vaccination with Bacillus Calmette-Guerin (BCG) with lower deaths due to COVID-19. This hypothesis emerged in the middle of 2020 when COVID-19 was still taking foot in many parts of the world. 37 , 38 Subsequently, many countries which had lower deaths at that time point went on to have higher numbers of mortality, comparable to other areas of the world. Furthermore, the hypothesis that BCG vaccination reduced COVID-19 mortality was a classic example of ecological fallacy. Associations between population level events (ecological studies; in this case, BCG vaccination and COVID-19 mortality) cannot be directly extrapolated to the individual level. Furthermore, such associations cannot per se be attributed as causal in nature, and can only serve to generate hypotheses that need to be tested at the individual level. 39

IS TRADITIONAL PEER REVIEW EFFICIENT FOR EVALUATION OF WORKING AND SCIENTIFIC HYPOTHESES?

Traditionally, publication after peer review has been considered the gold standard before any new idea finds acceptability amongst the scientific community. Getting a work (including a working or scientific hypothesis) reviewed by experts in the field before experiments are conducted to prove or disprove it helps to refine the idea further as well as improve the experiments planned to test the hypothesis. 40 A route towards this has been the emergence of journals dedicated to publishing hypotheses such as the Central Asian Journal of Medical Hypotheses and Ethics. 41 Another means of publishing hypotheses is through registered research protocols detailing the background, hypothesis, and methodology of a particular study. If such protocols are published after peer review, then the journal commits to publishing the completed study irrespective of whether the study hypothesis is proven or disproven. 42 In the post-pandemic world, online research methods such as online surveys powered via social media channels such as Twitter and Instagram might serve as critical tools to generate as well as to preliminarily test the appropriateness of hypotheses for further evaluation. 43 , 44

Some radical hypotheses might be difficult to publish after traditional peer review. These hypotheses might only be acceptable by the scientific community after they are tested in research studies. Preprints might be a way to disseminate such controversial and ground-breaking hypotheses. 45 However, scientists might prefer to keep their hypotheses confidential for the fear of plagiarism of ideas, avoiding online posting and publishing until they have tested the hypotheses.

SUGGESTIONS ON GENERATING AND PUBLISHING HYPOTHESES

Publication of hypotheses is important, however, a balance is required between scientific temper and controversy. Journal editors and reviewers might keep in mind these specific points, summarized in Table 2 and detailed hereafter, while judging the merit of hypotheses for publication. Keeping in mind the ethical principle of primum non nocere, a hypothesis should be published only if it is testable in a manner that is ethically appropriate. 46 Such hypotheses should be grounded in reality and lend themselves to further testing to either prove or disprove them. It must be considered that subsequent experiments to prove or disprove a hypothesis have an equal chance of failing or succeeding, akin to tossing a coin. A pre-conceived belief that a hypothesis is unlikely to be proven correct should not form the basis of rejection of such a hypothesis for publication. In this context, hypotheses generated after a thorough literature search to identify knowledge gaps or based on concrete clinical observations on a considerable number of patients (as opposed to random observations on a few patients) are more likely to be acceptable for publication by peer-reviewed journals. Also, hypotheses should be considered for publication or rejection based on their implications for science at large rather than whether the subsequent experiments to test them end up with results in favour of or against the original hypothesis.

Hypotheses form an important part of the scientific literature. The COVID-19 pandemic has reiterated the importance and relevance of hypotheses for dealing with public health emergencies and highlighted the need for evidence-based and ethical hypotheses. A good hypothesis is testable in a relevant study design, backed by preliminary evidence, and has positive ethical and clinical implications. General medical journals might consider publishing hypotheses as a specific article type to enable more rapid advancement of science.

Disclosure: The authors have no potential conflicts of interest to disclose.

Author Contributions:

• Data curation: Gasparyan AY, Misra DP, Zimba O, Yessirkepov M, Agarwal V, Kitas GD.

How to Write a Hypothesis: A Step-by-Step Guide

Introduction

An overview of the research hypothesis, different types of hypotheses, variables in a hypothesis, how to formulate an effective research hypothesis, designing a study around your hypothesis.

The scientific method can derive and test predictions as hypotheses. Empirical research can then provide support (or lack thereof) for the hypotheses. Even failure to find support for a hypothesis still represents a valuable contribution to scientific knowledge. Let's look more closely at the idea of the hypothesis and the role it plays in research.

As much as the term exists in everyday language, there is a detailed development that informs the word "hypothesis" when applied to research. A good research hypothesis is informed by prior research and guides research design and data analysis , so it is important to understand how a hypothesis is defined and understood by researchers.

What is the simple definition of a hypothesis?

A hypothesis is a testable prediction about an outcome between two or more variables . It functions as a navigational tool in the research process, directing what you aim to predict and how.

What is the hypothesis for in research?

In research, a hypothesis serves as the cornerstone for your empirical study. It not only lays out what you aim to investigate but also provides a structured approach for your data collection and analysis.

Essentially, it bridges the gap between the theoretical and the empirical, guiding your investigation throughout its course.

What is an example of a hypothesis?

If you are studying the relationship between physical exercise and mental health, a suitable hypothesis could be: "Regular physical exercise leads to improved mental well-being among adults."

This statement constitutes a specific and testable hypothesis that directly relates to the variables you are investigating.

What makes a good hypothesis?

A good hypothesis possesses several key characteristics. Firstly, it must be testable, allowing you to analyze data through empirical means, such as observation or experimentation, to assess if there is significant support for the hypothesis. Secondly, a hypothesis should be specific and unambiguous, giving a clear understanding of the expected relationship between variables. Lastly, it should be grounded in existing research or theoretical frameworks , ensuring its relevance and applicability.

Understanding the types of hypotheses can greatly enhance how you construct and work with hypotheses. While all hypotheses serve the essential function of guiding your study, there are varying purposes among the types of hypotheses. In addition, all hypotheses stand in contrast to the null hypothesis, or the assumption that there is no significant relationship between the variables .

Here, we explore various kinds of hypotheses to provide you with the tools needed to craft effective hypotheses for your specific research needs. Bear in mind that many of these hypothesis types may overlap with one another, and the specific type that is typically used will likely depend on the area of research and methodology you are following.

Null hypothesis

The null hypothesis is a statement that there is no effect or relationship between the variables being studied. In statistical terms, it serves as the default assumption that any observed differences are due to random chance.

For example, if you're studying the effect of a drug on blood pressure, the null hypothesis might state that the drug has no effect.

Alternative hypothesis

Contrary to the null hypothesis, the alternative hypothesis suggests that there is a significant relationship or effect between variables.

Using the drug example, the alternative hypothesis would posit that the drug does indeed affect blood pressure. This is what researchers aim to prove.

Simple hypothesis

A simple hypothesis makes a prediction about the relationship between two variables, and only two variables.

For example, "Increased study time results in better exam scores." Here, "study time" and "exam scores" are the only variables involved.

Complex hypothesis

A complex hypothesis, as the name suggests, involves more than two variables. For instance, "Increased study time and access to resources result in better exam scores." Here, "study time," "access to resources," and "exam scores" are all variables.

This hypothesis refers to multiple potential mediating variables. Other hypotheses could also include predictions about variables that moderate the relationship between the independent variable and dependent variable .

Directional hypothesis

A directional hypothesis specifies the direction of the expected relationship between variables. For example, "Eating more fruits and vegetables leads to a decrease in heart disease."

Here, the direction of heart disease is explicitly predicted to decrease, due to effects from eating more fruits and vegetables. All hypotheses typically specify the expected direction of the relationship between the independent and dependent variable, such that researchers can test if this prediction holds in their data analysis .

Statistical hypothesis

A statistical hypothesis is one that is testable through statistical methods, providing a numerical value that can be analyzed. This is commonly seen in quantitative research .

For example, "There is a statistically significant difference in test scores between students who study for one hour and those who study for two."

Empirical hypothesis

An empirical hypothesis is derived from observations and is tested through empirical methods, often through experimentation or survey data . Empirical hypotheses may also be assessed with statistical analyses.

For example, "Regular exercise is correlated with a lower incidence of depression," could be tested through surveys that measure exercise frequency and depression levels.

Causal hypothesis

A causal hypothesis proposes that one variable causes a change in another. This type of hypothesis is often tested through controlled experiments.

For example, "Smoking causes lung cancer," assumes a direct causal relationship.

Associative hypothesis

Unlike causal hypotheses, associative hypotheses suggest a relationship between variables but do not imply causation.

For instance, "People who smoke are more likely to get lung cancer," notes an association but doesn't claim that smoking causes lung cancer directly.

Relational hypothesis

A relational hypothesis explores the relationship between two or more variables but doesn't specify the nature of the relationship.

For example, "There is a relationship between diet and heart health," leaves the nature of the relationship (causal, associative, etc.) open to interpretation.

Logical hypothesis

A logical hypothesis is based on sound reasoning and logical principles. It's often used in theoretical research to explore abstract concepts, rather than being based on empirical data.

For example, "If all men are mortal and Socrates is a man, then Socrates is mortal," employs logical reasoning to make its point.

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In any research hypothesis, variables play a critical role. These are the elements or factors that the researcher manipulates, controls, or measures. Understanding variables is essential for crafting a clear, testable hypothesis and for the stages of research that follow, such as data collection and analysis.

In the realm of hypotheses, there are generally two types of variables to consider: independent and dependent. Independent variables are what you, as the researcher, manipulate or change in your study. It's considered the cause in the relationship you're investigating. For instance, in a study examining the impact of sleep duration on academic performance, the independent variable would be the amount of sleep participants get.

Conversely, the dependent variable is the outcome you measure to gauge the effect of your manipulation. It's the effect in the cause-and-effect relationship. The dependent variable thus refers to the main outcome of interest in your study. In the same sleep study example, the academic performance, perhaps measured by exam scores or GPA, would be the dependent variable.

Beyond these two primary types, you might also encounter control variables. These are variables that could potentially influence the outcome and are therefore kept constant to isolate the relationship between the independent and dependent variables . For example, in the sleep and academic performance study, control variables could include age, diet, or even the subject of study.

By clearly identifying and understanding the roles of these variables in your hypothesis, you set the stage for a methodologically sound research project. It helps you develop focused research questions, design appropriate experiments or observations, and carry out meaningful data analysis . It's a step that lays the groundwork for the success of your entire study.

Crafting a strong, testable hypothesis is crucial for the success of any research project. It sets the stage for everything from your study design to data collection and analysis . Below are some key considerations to keep in mind when formulating your hypothesis:

• Be specific : A vague hypothesis can lead to ambiguous results and interpretations . Clearly define your variables and the expected relationship between them.
• Ensure testability : A good hypothesis should be testable through empirical means, whether by observation , experimentation, or other forms of data analysis.
• Ground in literature : Before creating your hypothesis, consult existing research and theories. This not only helps you identify gaps in current knowledge but also gives you valuable context and credibility for crafting your hypothesis.
• Use simple language : While your hypothesis should be conceptually sound, it doesn't have to be complicated. Aim for clarity and simplicity in your wording.
• State direction, if applicable : If your hypothesis involves a directional outcome (e.g., "increase" or "decrease"), make sure to specify this. You also need to think about how you will measure whether or not the outcome moved in the direction you predicted.
• Keep it focused : One of the common pitfalls in hypothesis formulation is trying to answer too many questions at once. Keep your hypothesis focused on a specific issue or relationship.
• Account for control variables : Identify any variables that could potentially impact the outcome and consider how you will control for them in your study.
• Be ethical : Make sure your hypothesis and the methods for testing it comply with ethical standards , particularly if your research involves human or animal subjects.

Designing your study involves multiple key phases that help ensure the rigor and validity of your research. Here we discuss these crucial components in more detail.

Literature review

Starting with a comprehensive literature review is essential. This step allows you to understand the existing body of knowledge related to your hypothesis and helps you identify gaps that your research could fill. Your research should aim to contribute some novel understanding to existing literature, and your hypotheses can reflect this. A literature review also provides valuable insights into how similar research projects were executed, thereby helping you fine-tune your own approach.

Research methods

Choosing the right research methods is critical. Whether it's a survey, an experiment, or observational study, the methodology should be the most appropriate for testing your hypothesis. Your choice of methods will also depend on whether your research is quantitative, qualitative, or mixed-methods. Make sure the chosen methods align well with the variables you are studying and the type of data you need.

Preliminary research

Before diving into a full-scale study, it’s often beneficial to conduct preliminary research or a pilot study . This allows you to test your research methods on a smaller scale, refine your tools, and identify any potential issues. For instance, a pilot survey can help you determine if your questions are clear and if the survey effectively captures the data you need. This step can save you both time and resources in the long run.

Data analysis

Finally, planning your data analysis in advance is crucial for a successful study. Decide which statistical or analytical tools are most suited for your data type and research questions . For quantitative research, you might opt for t-tests, ANOVA, or regression analyses. For qualitative research , thematic analysis or grounded theory may be more appropriate. This phase is integral for interpreting your results and drawing meaningful conclusions in relation to your research question.

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scientific hypothesis

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• National Center for Biotechnology Information - PubMed Central - On the scope of scientific hypotheses
• LiveScience - What is a scientific hypothesis?
• The Royal Society - Open Science - On the scope of scientific hypotheses

scientific hypothesis , an idea that proposes a tentative explanation about a phenomenon or a narrow set of phenomena observed in the natural world. The two primary features of a scientific hypothesis are falsifiability and testability, which are reflected in an “If…then” statement summarizing the idea and in the ability to be supported or refuted through observation and experimentation. The notion of the scientific hypothesis as both falsifiable and testable was advanced in the mid-20th century by Austrian-born British philosopher Karl Popper .

The formulation and testing of a hypothesis is part of the scientific method , the approach scientists use when attempting to understand and test ideas about natural phenomena. The generation of a hypothesis frequently is described as a creative process and is based on existing scientific knowledge, intuition , or experience. Therefore, although scientific hypotheses commonly are described as educated guesses, they actually are more informed than a guess. In addition, scientists generally strive to develop simple hypotheses, since these are easier to test relative to hypotheses that involve many different variables and potential outcomes. Such complex hypotheses may be developed as scientific models ( see scientific modeling ).

Depending on the results of scientific evaluation, a hypothesis typically is either rejected as false or accepted as true. However, because a hypothesis inherently is falsifiable, even hypotheses supported by scientific evidence and accepted as true are susceptible to rejection later, when new evidence has become available. In some instances, rather than rejecting a hypothesis because it has been falsified by new evidence, scientists simply adapt the existing idea to accommodate the new information. In this sense a hypothesis is never incorrect but only incomplete.

The investigation of scientific hypotheses is an important component in the development of scientific theory . Hence, hypotheses differ fundamentally from theories; whereas the former is a specific tentative explanation and serves as the main tool by which scientists gather data, the latter is a broad general explanation that incorporates data from many different scientific investigations undertaken to explore hypotheses.

Countless hypotheses have been developed and tested throughout the history of science . Several examples include the idea that living organisms develop from nonliving matter, which formed the basis of spontaneous generation , a hypothesis that ultimately was disproved (first in 1668, with the experiments of Italian physician Francesco Redi , and later in 1859, with the experiments of French chemist and microbiologist Louis Pasteur ); the concept proposed in the late 19th century that microorganisms cause certain diseases (now known as germ theory ); and the notion that oceanic crust forms along submarine mountain zones and spreads laterally away from them ( seafloor spreading hypothesis ).

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Hypothesis Testing | A Step-by-Step Guide with Easy Examples

Published on November 8, 2019 by Rebecca Bevans . Revised on June 22, 2023.

Hypothesis testing is a formal procedure for investigating our ideas about the world using statistics . It is most often used by scientists to test specific predictions, called hypotheses, that arise from theories.

There are 5 main steps in hypothesis testing:

• State your research hypothesis as a null hypothesis and alternate hypothesis (H o ) and (H a  or H 1 ).
• Collect data in a way designed to test the hypothesis.
• Perform an appropriate statistical test .
• Decide whether to reject or fail to reject your null hypothesis.
• Present the findings in your results and discussion section.

Though the specific details might vary, the procedure you will use when testing a hypothesis will always follow some version of these steps.

Table of contents

Step 1: state your null and alternate hypothesis, step 2: collect data, step 3: perform a statistical test, step 4: decide whether to reject or fail to reject your null hypothesis, step 5: present your findings, other interesting articles, frequently asked questions about hypothesis testing.

After developing your initial research hypothesis (the prediction that you want to investigate), it is important to restate it as a null (H o ) and alternate (H a ) hypothesis so that you can test it mathematically.

The alternate hypothesis is usually your initial hypothesis that predicts a relationship between variables. The null hypothesis is a prediction of no relationship between the variables you are interested in.

• H 0 : Men are, on average, not taller than women. H a : Men are, on average, taller than women.

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For a statistical test to be valid , it is important to perform sampling and collect data in a way that is designed to test your hypothesis. If your data are not representative, then you cannot make statistical inferences about the population you are interested in.

There are a variety of statistical tests available, but they are all based on the comparison of within-group variance (how spread out the data is within a category) versus between-group variance (how different the categories are from one another).

If the between-group variance is large enough that there is little or no overlap between groups, then your statistical test will reflect that by showing a low p -value . This means it is unlikely that the differences between these groups came about by chance.

Alternatively, if there is high within-group variance and low between-group variance, then your statistical test will reflect that with a high p -value. This means it is likely that any difference you measure between groups is due to chance.

Your choice of statistical test will be based on the type of variables and the level of measurement of your collected data .

• an estimate of the difference in average height between the two groups.
• a p -value showing how likely you are to see this difference if the null hypothesis of no difference is true.

Based on the outcome of your statistical test, you will have to decide whether to reject or fail to reject your null hypothesis.

In most cases you will use the p -value generated by your statistical test to guide your decision. And in most cases, your predetermined level of significance for rejecting the null hypothesis will be 0.05 – that is, when there is a less than 5% chance that you would see these results if the null hypothesis were true.

In some cases, researchers choose a more conservative level of significance, such as 0.01 (1%). This minimizes the risk of incorrectly rejecting the null hypothesis ( Type I error ).

The results of hypothesis testing will be presented in the results and discussion sections of your research paper , dissertation or thesis .

In the results section you should give a brief summary of the data and a summary of the results of your statistical test (for example, the estimated difference between group means and associated p -value). In the discussion , you can discuss whether your initial hypothesis was supported by your results or not.

In the formal language of hypothesis testing, we talk about rejecting or failing to reject the null hypothesis. You will probably be asked to do this in your statistics assignments.

However, when presenting research results in academic papers we rarely talk this way. Instead, we go back to our alternate hypothesis (in this case, the hypothesis that men are on average taller than women) and state whether the result of our test did or did not support the alternate hypothesis.

If your null hypothesis was rejected, this result is interpreted as “supported the alternate hypothesis.”

These are superficial differences; you can see that they mean the same thing.

You might notice that we don’t say that we reject or fail to reject the alternate hypothesis . This is because hypothesis testing is not designed to prove or disprove anything. It is only designed to test whether a pattern we measure could have arisen spuriously, or by chance.

If we reject the null hypothesis based on our research (i.e., we find that it is unlikely that the pattern arose by chance), then we can say our test lends support to our hypothesis . But if the pattern does not pass our decision rule, meaning that it could have arisen by chance, then we say the test is inconsistent with our hypothesis .

If you want to know more about statistics , methodology , or research bias , make sure to check out some of our other articles with explanations and examples.

• Normal distribution
• Descriptive statistics
• Measures of central tendency
• Correlation coefficient

Methodology

• Cluster sampling
• Stratified sampling
• Types of interviews
• Cohort study
• Thematic analysis

Research bias

• Implicit bias
• Cognitive bias
• Survivorship bias
• Availability heuristic
• Nonresponse bias
• Regression to the mean

Hypothesis testing is a formal procedure for investigating our ideas about the world using statistics. It is used by scientists to test specific predictions, called hypotheses , by calculating how likely it is that a pattern or relationship between variables could have arisen by chance.

A hypothesis states your predictions about what your research will find. It is a tentative answer to your research question that has not yet been tested. For some research projects, you might have to write several hypotheses that address different aspects of your research question.

A hypothesis is not just a guess — it should be based on existing theories and knowledge. It also has to be testable, which means you can support or refute it through scientific research methods (such as experiments, observations and statistical analysis of data).

Null and alternative hypotheses are used in statistical hypothesis testing . The null hypothesis of a test always predicts no effect or no relationship between variables, while the alternative hypothesis states your research prediction of an effect or relationship.

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What is a Research Hypothesis: How to Write it, Types, and Examples

Any research begins with a research question and a research hypothesis . A research question alone may not suffice to design the experiment(s) needed to answer it. A hypothesis is central to the scientific method. But what is a hypothesis ? A hypothesis is a testable statement that proposes a possible explanation to a phenomenon, and it may include a prediction. Next, you may ask what is a research hypothesis ? Simply put, a research hypothesis is a prediction or educated guess about the relationship between the variables that you want to investigate.  

It is important to be thorough when developing your research hypothesis. Shortcomings in the framing of a hypothesis can affect the study design and the results. A better understanding of the research hypothesis definition and characteristics of a good hypothesis will make it easier for you to develop your own hypothesis for your research. Let’s dive in to know more about the types of research hypothesis , how to write a research hypothesis , and some research hypothesis examples .  

Table of Contents

What is a hypothesis ?  

A hypothesis is based on the existing body of knowledge in a study area. Framed before the data are collected, a hypothesis states the tentative relationship between independent and dependent variables, along with a prediction of the outcome.  

What is a research hypothesis ?  

Young researchers starting out their journey are usually brimming with questions like “ What is a hypothesis ?” “ What is a research hypothesis ?” “How can I write a good research hypothesis ?”   

A research hypothesis is a statement that proposes a possible explanation for an observable phenomenon or pattern. It guides the direction of a study and predicts the outcome of the investigation. A research hypothesis is testable, i.e., it can be supported or disproven through experimentation or observation.     

Characteristics of a good hypothesis  

Here are the characteristics of a good hypothesis :  

• Clearly formulated and free of language errors and ambiguity  
• Concise and not unnecessarily verbose  
• Has clearly defined variables  
• Testable and stated in a way that allows for it to be disproven  
• Can be tested using a research design that is feasible, ethical, and practical   
• Specific and relevant to the research problem  
• Rooted in a thorough literature search  
• Can generate new knowledge or understanding.  

How to create an effective research hypothesis  

A study begins with the formulation of a research question. A researcher then performs background research. This background information forms the basis for building a good research hypothesis . The researcher then performs experiments, collects, and analyzes the data, interprets the findings, and ultimately, determines if the findings support or negate the original hypothesis.  

Let’s look at each step for creating an effective, testable, and good research hypothesis :  

• Identify a research problem or question: Start by identifying a specific research problem.   
• Review the literature: Conduct an in-depth review of the existing literature related to the research problem to grasp the current knowledge and gaps in the field.   
• Formulate a clear and testable hypothesis : Based on the research question, use existing knowledge to form a clear and testable hypothesis . The hypothesis should state a predicted relationship between two or more variables that can be measured and manipulated. Improve the original draft till it is clear and meaningful.  
• State the null hypothesis: The null hypothesis is a statement that there is no relationship between the variables you are studying.   
• Define the population and sample: Clearly define the population you are studying and the sample you will be using for your research.  
• Select appropriate methods for testing the hypothesis: Select appropriate research methods, such as experiments, surveys, or observational studies, which will allow you to test your research hypothesis .  

Remember that creating a research hypothesis is an iterative process, i.e., you might have to revise it based on the data you collect. You may need to test and reject several hypotheses before answering the research problem.  

How to write a research hypothesis  

When you start writing a research hypothesis , you use an “if–then” statement format, which states the predicted relationship between two or more variables. Clearly identify the independent variables (the variables being changed) and the dependent variables (the variables being measured), as well as the population you are studying. Review and revise your hypothesis as needed.  

An example of a research hypothesis in this format is as follows:  

“ If [athletes] follow [cold water showers daily], then their [endurance] increases.”  

Population: athletes  

Independent variable: daily cold water showers  

Dependent variable: endurance  

You may have understood the characteristics of a good hypothesis . But note that a research hypothesis is not always confirmed; a researcher should be prepared to accept or reject the hypothesis based on the study findings.  

Research hypothesis checklist  

Following from above, here is a 10-point checklist for a good research hypothesis :  

• Testable: A research hypothesis should be able to be tested via experimentation or observation.  
• Specific: A research hypothesis should clearly state the relationship between the variables being studied.  
• Based on prior research: A research hypothesis should be based on existing knowledge and previous research in the field.  
• Falsifiable: A research hypothesis should be able to be disproven through testing.  
• Clear and concise: A research hypothesis should be stated in a clear and concise manner.  
• Logical: A research hypothesis should be logical and consistent with current understanding of the subject.  
• Relevant: A research hypothesis should be relevant to the research question and objectives.  
• Feasible: A research hypothesis should be feasible to test within the scope of the study.  
• Reflects the population: A research hypothesis should consider the population or sample being studied.  
• Uncomplicated: A good research hypothesis is written in a way that is easy for the target audience to understand.  

By following this research hypothesis checklist , you will be able to create a research hypothesis that is strong, well-constructed, and more likely to yield meaningful results.  

Types of research hypothesis  

Different types of research hypothesis are used in scientific research:  

1. Null hypothesis:

A null hypothesis states that there is no change in the dependent variable due to changes to the independent variable. This means that the results are due to chance and are not significant. A null hypothesis is denoted as H0 and is stated as the opposite of what the alternative hypothesis states.   

Example: “ The newly identified virus is not zoonotic .”  

2. Alternative hypothesis:

This states that there is a significant difference or relationship between the variables being studied. It is denoted as H1 or Ha and is usually accepted or rejected in favor of the null hypothesis.  

Example: “ The newly identified virus is zoonotic .”  

3. Directional hypothesis :

This specifies the direction of the relationship or difference between variables; therefore, it tends to use terms like increase, decrease, positive, negative, more, or less.   

Example: “ The inclusion of intervention X decreases infant mortality compared to the original treatment .”   

4. Non-directional hypothesis:

While it does not predict the exact direction or nature of the relationship between the two variables, a non-directional hypothesis states the existence of a relationship or difference between variables but not the direction, nature, or magnitude of the relationship. A non-directional hypothesis may be used when there is no underlying theory or when findings contradict previous research.  

Example, “ Cats and dogs differ in the amount of affection they express .”  

5. Simple hypothesis :

A simple hypothesis only predicts the relationship between one independent and another independent variable.  

Example: “ Applying sunscreen every day slows skin aging .”  

6 . Complex hypothesis :

A complex hypothesis states the relationship or difference between two or more independent and dependent variables.   

Example: “ Applying sunscreen every day slows skin aging, reduces sun burn, and reduces the chances of skin cancer .” (Here, the three dependent variables are slowing skin aging, reducing sun burn, and reducing the chances of skin cancer.)  

7. Associative hypothesis:  

An associative hypothesis states that a change in one variable results in the change of the other variable. The associative hypothesis defines interdependency between variables.  

Example: “ There is a positive association between physical activity levels and overall health .”  

8 . Causal hypothesis:

A causal hypothesis proposes a cause-and-effect interaction between variables.  

Example: “ Long-term alcohol use causes liver damage .”  

Note that some of the types of research hypothesis mentioned above might overlap. The types of hypothesis chosen will depend on the research question and the objective of the study.  

Research hypothesis examples  

Here are some good research hypothesis examples :  

“The use of a specific type of therapy will lead to a reduction in symptoms of depression in individuals with a history of major depressive disorder.”  

“Providing educational interventions on healthy eating habits will result in weight loss in overweight individuals.”  

“Plants that are exposed to certain types of music will grow taller than those that are not exposed to music.”  

“The use of the plant growth regulator X will lead to an increase in the number of flowers produced by plants.”  

Characteristics that make a research hypothesis weak are unclear variables, unoriginality, being too general or too vague, and being untestable. A weak hypothesis leads to weak research and improper methods.   

Some bad research hypothesis examples (and the reasons why they are “bad”) are as follows:  

“This study will show that treatment X is better than any other treatment . ” (This statement is not testable, too broad, and does not consider other treatments that may be effective.)  

“This study will prove that this type of therapy is effective for all mental disorders . ” (This statement is too broad and not testable as mental disorders are complex and different disorders may respond differently to different types of therapy.)  

“Plants can communicate with each other through telepathy . ” (This statement is not testable and lacks a scientific basis.)  

Importance of testable hypothesis  

If a research hypothesis is not testable, the results will not prove or disprove anything meaningful. The conclusions will be vague at best. A testable hypothesis helps a researcher focus on the study outcome and understand the implication of the question and the different variables involved. A testable hypothesis helps a researcher make precise predictions based on prior research.  

To be considered testable, there must be a way to prove that the hypothesis is true or false; further, the results of the hypothesis must be reproducible.  

Frequently Asked Questions (FAQs) on research hypothesis  

1. What is the difference between research question and research hypothesis ?  

A research question defines the problem and helps outline the study objective(s). It is an open-ended statement that is exploratory or probing in nature. Therefore, it does not make predictions or assumptions. It helps a researcher identify what information to collect. A research hypothesis , however, is a specific, testable prediction about the relationship between variables. Accordingly, it guides the study design and data analysis approach.

2. When to reject null hypothesis ?

A null hypothesis should be rejected when the evidence from a statistical test shows that it is unlikely to be true. This happens when the test statistic (e.g., p -value) is less than the defined significance level (e.g., 0.05). Rejecting the null hypothesis does not necessarily mean that the alternative hypothesis is true; it simply means that the evidence found is not compatible with the null hypothesis.  

3. How can I be sure my hypothesis is testable?  

A testable hypothesis should be specific and measurable, and it should state a clear relationship between variables that can be tested with data. To ensure that your hypothesis is testable, consider the following:  

• Clearly define the key variables in your hypothesis. You should be able to measure and manipulate these variables in a way that allows you to test the hypothesis.  
• The hypothesis should predict a specific outcome or relationship between variables that can be measured or quantified.   
• You should be able to collect the necessary data within the constraints of your study.  
• It should be possible for other researchers to replicate your study, using the same methods and variables.   
• Your hypothesis should be testable by using appropriate statistical analysis techniques, so you can draw conclusions, and make inferences about the population from the sample data.  
• The hypothesis should be able to be disproven or rejected through the collection of data.  

4. How do I revise my research hypothesis if my data does not support it?  

If your data does not support your research hypothesis , you will need to revise it or develop a new one. You should examine your data carefully and identify any patterns or anomalies, re-examine your research question, and/or revisit your theory to look for any alternative explanations for your results. Based on your review of the data, literature, and theories, modify your research hypothesis to better align it with the results you obtained. Use your revised hypothesis to guide your research design and data collection. It is important to remain objective throughout the process.  

5. I am performing exploratory research. Do I need to formulate a research hypothesis?  

As opposed to “confirmatory” research, where a researcher has some idea about the relationship between the variables under investigation, exploratory research (or hypothesis-generating research) looks into a completely new topic about which limited information is available. Therefore, the researcher will not have any prior hypotheses. In such cases, a researcher will need to develop a post-hoc hypothesis. A post-hoc research hypothesis is generated after these results are known.  

6. How is a research hypothesis different from a research question?

A research question is an inquiry about a specific topic or phenomenon, typically expressed as a question. It seeks to explore and understand a particular aspect of the research subject. In contrast, a research hypothesis is a specific statement or prediction that suggests an expected relationship between variables. It is formulated based on existing knowledge or theories and guides the research design and data analysis.

7. Can a research hypothesis change during the research process?

Yes, research hypotheses can change during the research process. As researchers collect and analyze data, new insights and information may emerge that require modification or refinement of the initial hypotheses. This can be due to unexpected findings, limitations in the original hypotheses, or the need to explore additional dimensions of the research topic. Flexibility is crucial in research, allowing for adaptation and adjustment of hypotheses to align with the evolving understanding of the subject matter.

8. How many hypotheses should be included in a research study?

The number of research hypotheses in a research study varies depending on the nature and scope of the research. It is not necessary to have multiple hypotheses in every study. Some studies may have only one primary hypothesis, while others may have several related hypotheses. The number of hypotheses should be determined based on the research objectives, research questions, and the complexity of the research topic. It is important to ensure that the hypotheses are focused, testable, and directly related to the research aims.

9. Can research hypotheses be used in qualitative research?

Yes, research hypotheses can be used in qualitative research, although they are more commonly associated with quantitative research. In qualitative research, hypotheses may be formulated as tentative or exploratory statements that guide the investigation. Instead of testing hypotheses through statistical analysis, qualitative researchers may use the hypotheses to guide data collection and analysis, seeking to uncover patterns, themes, or relationships within the qualitative data. The emphasis in qualitative research is often on generating insights and understanding rather than confirming or rejecting specific research hypotheses through statistical testing.

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Research Paper Appendix: Format and Examples

How to Write a Research Hypothesis

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Since grade school, we've all been familiar with hypotheses. The hypothesis is an essential step of the scientific method. But what makes an effective research hypothesis, how do you create one, and what types of hypotheses are there? We answer these questions and more.

Updated on April 27, 2022

What is a research hypothesis?

General hypothesis.

Since grade school, we've all been familiar with the term “hypothesis.” A hypothesis is a fact-based guess or prediction that has not been proven. It is an essential step of the scientific method. The hypothesis of a study is a drive for experimentation to either prove the hypothesis or dispute it.

Research Hypothesis

A research hypothesis is more specific than a general hypothesis. It is an educated, expected prediction of the outcome of a study that is testable.

What makes an effective research hypothesis?

A good research hypothesis is a clear statement of the relationship between a dependent variable(s) and independent variable(s) relevant to the study that can be disproven.

Research hypothesis checklist

Once you've written a possible hypothesis, make sure it checks the following boxes:

• It must be testable: You need a means to prove your hypothesis. If you can't test it, it's not a hypothesis.
• It must include a dependent and independent variable: At least one independent variable ( cause ) and one dependent variable ( effect ) must be included.
• The language must be easy to understand: Be as clear and concise as possible. Nothing should be left to interpretation.
• It must be relevant to your research topic: You probably shouldn't be talking about cats and dogs if your research topic is outer space. Stay relevant to your topic.

How to create an effective research hypothesis

Pose it as a question first.

Start your research hypothesis from a journalistic approach. Ask one of the five W's: Who, what, when, where, or why.

A possible initial question could be: Why is the sky blue?

Do the preliminary research

Once you have a question in mind, read research around your topic. Collect research from academic journals.

If you're looking for information about the sky and why it is blue, research information about the atmosphere, weather, space, the sun, etc.

Write a draft hypothesis

Once you're comfortable with your subject and have preliminary knowledge, create a working hypothesis. Don't stress much over this. Your first hypothesis is not permanent. Look at it as a draft.

Your first draft of a hypothesis could be: Certain molecules in the Earth's atmosphere are responsive to the sky being the color blue.

Make your working draft perfect

Take your working hypothesis and make it perfect. Narrow it down to include only the information listed in the “Research hypothesis checklist” above.

Now that you've written your working hypothesis, narrow it down. Your new hypothesis could be: Light from the sun hitting oxygen molecules in the sky makes the color of the sky appear blue.

Write a null hypothesis

Your null hypothesis should be the opposite of your research hypothesis. It should be able to be disproven by your research.

In this example, your null hypothesis would be: Light from the sun hitting oxygen molecules in the sky does not make the color of the sky appear blue.

Why is it important to have a clear, testable hypothesis?

One of the main reasons a manuscript can be rejected from a journal is because of a weak hypothesis. “Poor hypothesis, study design, methodology, and improper use of statistics are other reasons for rejection of a manuscript,” says Dr. Ish Kumar Dhammi and Dr. Rehan-Ul-Haq in Indian Journal of Orthopaedics.

According to Dr. James M. Provenzale in American Journal of Roentgenology , “The clear declaration of a research question (or hypothesis) in the Introduction is critical for reviewers to understand the intent of the research study. It is best to clearly state the study goal in plain language (for example, “We set out to determine whether condition x produces condition y.”) An insufficient problem statement is one of the more common reasons for manuscript rejection.”

Characteristics that make a hypothesis weak include:

• Unclear variables
• Unoriginality
• Too general
• Too specific

A weak hypothesis leads to weak research and methods . The goal of a paper is to prove or disprove a hypothesis - or to prove or disprove a null hypothesis. If the hypothesis is not a dependent variable of what is being studied, the paper's methods should come into question.

A strong hypothesis is essential to the scientific method. A hypothesis states an assumed relationship between at least two variables and the experiment then proves or disproves that relationship with statistical significance. Without a proven and reproducible relationship, the paper feeds into the reproducibility crisis. Learn more about writing for reproducibility .

In a study published in The Journal of Obstetrics and Gynecology of India by Dr. Suvarna Satish Khadilkar, she reviewed 400 rejected manuscripts to see why they were rejected. Her studies revealed that poor methodology was a top reason for the submission having a final disposition of rejection.

Aside from publication chances, Dr. Gareth Dyke believes a clear hypothesis helps efficiency.

“Developing a clear and testable hypothesis for your research project means that you will not waste time, energy, and money with your work,” said Dyke. “Refining a hypothesis that is both meaningful, interesting, attainable, and testable is the goal of all effective research.”

Types of research hypotheses

There can be overlap in these types of hypotheses.

Simple hypothesis

A simple hypothesis is a hypothesis at its most basic form. It shows the relationship of one independent and one independent variable.

Example: Drinking soda (independent variable) every day leads to obesity (dependent variable).

Complex hypothesis

A complex hypothesis shows the relationship of two or more independent and dependent variables.

Example: Drinking soda (independent variable) every day leads to obesity (dependent variable) and heart disease (dependent variable).

Directional hypothesis

A directional hypothesis guesses which way the results of an experiment will go. It uses words like increase, decrease, higher, lower, positive, negative, more, or less. It is also frequently used in statistics.

Example: Humans exposed to radiation have a higher risk of cancer than humans not exposed to radiation.

Non-directional hypothesis

A non-directional hypothesis says there will be an effect on the dependent variable, but it does not say which direction.

Associative hypothesis

An associative hypothesis says that when one variable changes, so does the other variable.

Alternative hypothesis

An alternative hypothesis states that the variables have a relationship.

• The opposite of a null hypothesis

Example: An apple a day keeps the doctor away.

Null hypothesis

A null hypothesis states that there is no relationship between the two variables. It is posed as the opposite of what the alternative hypothesis states.

Researchers use a null hypothesis to work to be able to reject it. A null hypothesis:

• Can never be proven
• Can only be rejected
• Is the opposite of an alternative hypothesis

Example: An apple a day does not keep the doctor away.

Logical hypothesis

A logical hypothesis is a suggested explanation while using limited evidence.

Example: Bats can navigate in the dark better than tigers.

In this hypothesis, the researcher knows that tigers cannot see in the dark, and bats mostly live in darkness.

Empirical hypothesis

An empirical hypothesis is also called a “working hypothesis.” It uses the trial and error method and changes around the independent variables.

• An apple a day keeps the doctor away.
• Two apples a day keep the doctor away.
• Three apples a day keep the doctor away.

In this case, the research changes the hypothesis as the researcher learns more about his/her research.

Statistical hypothesis

A statistical hypothesis is a look of a part of a population or statistical model. This type of hypothesis is especially useful if you are making a statement about a large population. Instead of having to test the entire population of Illinois, you could just use a smaller sample of people who live there.

Example: 70% of people who live in Illinois are iron deficient.

Causal hypothesis

A causal hypothesis states that the independent variable will have an effect on the dependent variable.

Example: Using tobacco products causes cancer.

Final thoughts

Make sure your research is error-free before you send it to your preferred journal . Check our our English Editing services to avoid your chances of desk rejection.

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Step-by-Step Guide: How to Craft a Strong Research Hypothesis

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Table of Contents

A research hypothesis is a concise statement about the expected result of an experiment or project. In many ways, a research hypothesis represents the starting point for a scientific endeavor, as it establishes a tentative assumption that is eventually substantiated or falsified, ultimately improving our certainty about the subject investigated.   

To help you with this and ease the process, in this article, we discuss the purpose of research hypotheses and list the most essential qualities of a compelling hypothesis. Let’s find out!  

How to Craft a Research Hypothesis  

Crafting a research hypothesis begins with a comprehensive literature review to identify a knowledge gap in your field. Once you find a question or problem, come up with a possible answer or explanation, which becomes your hypothesis. Now think about the specific methods of experimentation that can prove or disprove the hypothesis, which ultimately lead to the results of the study.   

Enlisted below are some standard formats in which you can formulate a hypothesis¹ :  

• A hypothesis can use the if/then format when it seeks to explore the correlation between two variables in a study primarily.  

Example: If administered drug X, then patients will experience reduced fatigue from cancer treatment.  

• A hypothesis can adopt when X/then Y format when it primarily aims to expose a connection between two variables  

Example: When workers spend a significant portion of their waking hours in sedentary work , then they experience a greater frequency of digestive problems.  

• A hypothesis can also take the form of a direct statement.  

Example: Drug X and drug Y reduce the risk of cognitive decline through the same chemical pathways  

What are the Features of an Effective Hypothesis?  

Hypotheses in research need to satisfy specific criteria to be considered scientifically rigorous. Here are the most notable qualities of a strong hypothesis:  

• Testability: Ensure the hypothesis allows you to work towards observable and testable results.  
• Brevity and objectivity: Present your hypothesis as a brief statement and avoid wordiness.  
• Clarity and Relevance: The hypothesis should reflect a clear idea of what we know and what we expect to find out about a phenomenon and address the significant knowledge gap relevant to a field of study.   

Understanding Null and Alternative Hypotheses in Research  

There are two types of hypotheses used commonly in research that aid statistical analyses. These are known as the null hypothesis and the alternative hypothesis . A null hypothesis is a statement assumed to be factual in the initial phase of the study.   

For example, if a researcher is testing the efficacy of a new drug, then the null hypothesis will posit that the drug has no benefits compared to an inactive control or placebo . Suppose the data collected through a drug trial leads a researcher to reject the null hypothesis. In that case, it is considered to substantiate the alternative hypothesis in the above example, that the new drug provides benefits compared to the placebo.  

Let’s take a closer look at the null hypothesis and alternative hypothesis with two more examples:  

Null Hypothesis:  

The rate of decline in the number of species in habitat X in the last year is the same as in the last 100 years when controlled for all factors except the recent wildfires.  

In the next experiment, the researcher will experimentally reject this null hypothesis in order to confirm the following alternative hypothesis :  

The rate of decline in the number of species in habitat X in the last year is different from the rate of decline in the last 100 years when controlled for all factors other than the recent wildfires.  

In the pair of null and alternative hypotheses stated above, a statistical comparison of the rate of species decline over a century and the preceding year will help the research experimentally test the null hypothesis, helping to draw scientifically valid conclusions about two factors—wildfires and species decline.   

We also recommend that researchers pay attention to contextual echoes and connections when writing research hypotheses. Research hypotheses are often closely linked to the introduction ² , such as the context of the study, and can similarly influence the reader’s judgment of the relevance and validity of the research hypothesis.  

Seasoned experts, such as professionals at Elsevier Language Services, guide authors on how to best embed a hypothesis within an article so that it communicates relevance and credibility. Contact us if you want help in ensuring readers find your hypothesis robust and unbiased.  

References  

• Hypotheses – The University Writing Center. (n.d.). https://writingcenter.tamu.edu/writing-speaking-guides/hypotheses  
• Shaping the research question and hypothesis. (n.d.). Students. https://students.unimelb.edu.au/academic-skills/graduate-research-services/writing-thesis-sections-part-2/shaping-the-research-question-and-hypothesis  

Systematic Literature Review or Literature Review?

How to Write an Effective Problem Statement for Your Research Paper

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How to Write a Hypothesis

Last Updated: May 2, 2023 Fact Checked

This article was co-authored by Bess Ruff, MA . Bess Ruff is a Geography PhD student at Florida State University. She received her MA in Environmental Science and Management from the University of California, Santa Barbara in 2016. She has conducted survey work for marine spatial planning projects in the Caribbean and provided research support as a graduate fellow for the Sustainable Fisheries Group. There are 9 references cited in this article, which can be found at the bottom of the page. This article has been fact-checked, ensuring the accuracy of any cited facts and confirming the authority of its sources. This article has been viewed 1,035,078 times.

A hypothesis is a description of a pattern in nature or an explanation about some real-world phenomenon that can be tested through observation and experimentation. The most common way a hypothesis is used in scientific research is as a tentative, testable, and falsifiable statement that explains some observed phenomenon in nature. [1] X Research source Many academic fields, from the physical sciences to the life sciences to the social sciences, use hypothesis testing as a means of testing ideas to learn about the world and advance scientific knowledge. Whether you are a beginning scholar or a beginning student taking a class in a science subject, understanding what hypotheses are and being able to generate hypotheses and predictions yourself is very important. These instructions will help get you started.

Preparing to Write a Hypothesis

• If you are writing a hypothesis for a school assignment, this step may be taken care of for you.

• Focus on academic and scholarly writing. You need to be certain that your information is unbiased, accurate, and comprehensive. Scholarly search databases such as Google Scholar and Web of Science can help you find relevant articles from reputable sources.
• You can find information in textbooks, at a library, and online. If you are in school, you can also ask for help from teachers, librarians, and your peers.

• For example, if you are interested in the effects of caffeine on the human body, but notice that nobody seems to have explored whether caffeine affects males differently than it does females, this could be something to formulate a hypothesis about. Or, if you are interested in organic farming, you might notice that no one has tested whether organic fertilizer results in different growth rates for plants than non-organic fertilizer.
• You can sometimes find holes in the existing literature by looking for statements like “it is unknown” in scientific papers or places where information is clearly missing. You might also find a claim in the literature that seems far-fetched, unlikely, or too good to be true, like that caffeine improves math skills. If the claim is testable, you could provide a great service to scientific knowledge by doing your own investigation. If you confirm the claim, the claim becomes even more credible. If you do not find support for the claim, you are helping with the necessary self-correcting aspect of science.
• Examining these types of questions provides an excellent way for you to set yourself apart by filling in important gaps in a field of study.

• Following the examples above, you might ask: "How does caffeine affect females as compared to males?" or "How does organic fertilizer affect plant growth compared to non-organic fertilizer?" The rest of your research will be aimed at answering these questions.

• Following the examples above, if you discover in the literature that there is a pattern that some other types of stimulants seem to affect females more than males, this could be a clue that the same pattern might be true for caffeine. Similarly, if you observe the pattern that organic fertilizer seems to be associated with smaller plants overall, you might explain this pattern with the hypothesis that plants exposed to organic fertilizer grow more slowly than plants exposed to non-organic fertilizer.

Formulating Your Hypothesis

• You can think of the independent variable as the one that is causing some kind of difference or effect to occur. In the examples, the independent variable would be biological sex, i.e. whether a person is male or female, and fertilizer type, i.e. whether the fertilizer is organic or non-organically-based.
• The dependent variable is what is affected by (i.e. "depends" on) the independent variable. In the examples above, the dependent variable would be the measured impact of caffeine or fertilizer.
• Your hypothesis should only suggest one relationship. Most importantly, it should only have one independent variable. If you have more than one, you won't be able to determine which one is actually the source of any effects you might observe.

• Don't worry too much at this point about being precise or detailed.
• In the examples above, one hypothesis would make a statement about whether a person's biological sex might impact the way the person is affected by caffeine; for example, at this point, your hypothesis might simply be: "a person's biological sex is related to how caffeine affects his or her heart rate." The other hypothesis would make a general statement about plant growth and fertilizer; for example your simple explanatory hypothesis might be "plants given different types of fertilizer are different sizes because they grow at different rates."

• Using our example, our non-directional hypotheses would be "there is a relationship between a person's biological sex and how much caffeine increases the person's heart rate," and "there is a relationship between fertilizer type and the speed at which plants grow."
• Directional predictions using the same example hypotheses above would be : "Females will experience a greater increase in heart rate after consuming caffeine than will males," and "plants fertilized with non-organic fertilizer will grow faster than those fertilized with organic fertilizer." Indeed, these predictions and the hypotheses that allow for them are very different kinds of statements. More on this distinction below.
• If the literature provides any basis for making a directional prediction, it is better to do so, because it provides more information. Especially in the physical sciences, non-directional predictions are often seen as inadequate.

• Where necessary, specify the population (i.e. the people or things) about which you hope to uncover new knowledge. For example, if you were only interested the effects of caffeine on elderly people, your prediction might read: "Females over the age of 65 will experience a greater increase in heart rate than will males of the same age." If you were interested only in how fertilizer affects tomato plants, your prediction might read: "Tomato plants treated with non-organic fertilizer will grow faster in the first three months than will tomato plants treated with organic fertilizer."

• For example, you would not want to make the hypothesis: "red is the prettiest color." This statement is an opinion and it cannot be tested with an experiment. However, proposing the generalizing hypothesis that red is the most popular color is testable with a simple random survey. If you do indeed confirm that red is the most popular color, your next step may be to ask: Why is red the most popular color? The answer you propose is your explanatory hypothesis .

• An easy way to get to the hypothesis for this method and prediction is to ask yourself why you think heart rates will increase if children are given caffeine. Your explanatory hypothesis in this case may be that caffeine is a stimulant. At this point, some scientists write a research hypothesis , a statement that includes the hypothesis, the experiment, and the prediction all in one statement.
• For example, If caffeine is a stimulant, and some children are given a drink with caffeine while others are given a drink without caffeine, then the heart rates of those children given a caffeinated drink will increase more than the heart rate of children given a non-caffeinated drink.

• Using the above example, if you were to test the effects of caffeine on the heart rates of children, evidence that your hypothesis is not true, sometimes called the null hypothesis , could occur if the heart rates of both the children given the caffeinated drink and the children given the non-caffeinated drink (called the placebo control) did not change, or lowered or raised with the same magnitude, if there was no difference between the two groups of children.
• It is important to note here that the null hypothesis actually becomes much more useful when researchers test the significance of their results with statistics. When statistics are used on the results of an experiment, a researcher is testing the idea of the null statistical hypothesis. For example, that there is no relationship between two variables or that there is no difference between two groups. [8] X Research source

Hypothesis Examples

Community Q&A

• Remember that science is not necessarily a linear process and can be approached in various ways. [10] X Research source Thanks Helpful 0 Not Helpful 0
• When examining the literature, look for research that is similar to what you want to do, and try to build on the findings of other researchers. But also look for claims that you think are suspicious, and test them yourself. Thanks Helpful 0 Not Helpful 0
• Be specific in your hypotheses, but not so specific that your hypothesis can't be applied to anything outside your specific experiment. You definitely want to be clear about the population about which you are interested in drawing conclusions, but nobody (except your roommates) will be interested in reading a paper with the prediction: "my three roommates will each be able to do a different amount of pushups." Thanks Helpful 0 Not Helpful 0

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• ↑ https://undsci.berkeley.edu/for-educators/prepare-and-plan/correcting-misconceptions/#a4
• ↑ https://owl.purdue.edu/owl/general_writing/common_writing_assignments/research_papers/choosing_a_topic.html
• ↑ https://owl.purdue.edu/owl/subject_specific_writing/writing_in_the_social_sciences/writing_in_psychology_experimental_report_writing/experimental_reports_1.html
• ↑ https://www.grammarly.com/blog/how-to-write-a-hypothesis/
• ↑ https://grammar.yourdictionary.com/for-students-and-parents/how-create-hypothesis.html
• ↑ https://flexbooks.ck12.org/cbook/ck-12-middle-school-physical-science-flexbook-2.0/section/1.19/primary/lesson/hypothesis-ms-ps/
• ↑ https://iastate.pressbooks.pub/preparingtopublish/chapter/goal-1-contextualize-the-studys-methods/
• ↑ http://mathworld.wolfram.com/NullHypothesis.html
• ↑ http://undsci.berkeley.edu/article/scienceflowchart

About This Article

Before writing a hypothesis, think of what questions are still unanswered about a specific subject and make an educated guess about what the answer could be. Then, determine the variables in your question and write a simple statement about how they might be related. Try to focus on specific predictions and variables, such as age or segment of the population, to make your hypothesis easier to test. For tips on how to test your hypothesis, read on! Did this summary help you? Yes No

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How Do You Write an Hypothesis? Detailed Explanation and Examples

Writing a hypothesis is a fundamental step in the scientific research process. It serves as a tentative explanation or prediction that can be tested through experimentation and observation. A well-crafted hypothesis provides a clear direction for research and helps in drawing meaningful conclusions. This article will guide you through the process of writing a hypothesis, including understanding its concept, formulating it, and avoiding common pitfalls, with illustrative examples from various fields of study.

Key Takeaways

• A hypothesis is a testable and falsifiable statement that predicts an outcome based on certain conditions.
• There are different types of hypotheses, including null, alternative, and directional hypotheses, each serving a specific purpose in research.
• Formulating a hypothesis involves identifying research questions, conducting preliminary research, and crafting a clear and precise statement.
• A strong hypothesis is characterized by its testability, clarity, precision, and relevance to the research objectives.
• Common pitfalls in hypothesis writing include vague statements, overly complex hypotheses, and lack of testability.

Understanding the Concept of a Hypothesis

A hypothesis is a foundational element in scientific research, serving as a preliminary statement that proposes a potential relationship between variables. It is essential for guiding the direction of your study and providing a basis for data collection and analysis.

Steps to Formulate a Hypothesis

Identifying research questions.

The first step in formulating a hypothesis is to identify your research question . This involves observing the subject matter and recognizing patterns or relationships between variables. Crafting a clear, testable, and grounded hypothesis is essential for research success. By pinpointing the exact question you aim to answer, you lay the foundation for a focused and effective hypothesis.

Conducting Preliminary Research

Once you have your research question, the next step is to conduct preliminary research. This involves gathering as much information as possible about the topic. Evaluate these observations to identify potential causes and effects related to your research question. This stage helps you understand the existing knowledge and gaps, which is crucial for developing a well-informed hypothesis.

Formulating the Hypothesis Statement

After conducting preliminary research, you can begin formulating your hypothesis statement. This statement should clearly define the variables involved and the expected relationship between them. Ensure that your hypothesis is specific, testable, and falsifiable. A well-crafted hypothesis not only guides your research but also provides a clear direction for your experimental design and data collection methods.

Characteristics of a Strong Hypothesis

A strong hypothesis is essential for guiding your research and ensuring that your study is both meaningful and scientifically valid. Here are the key characteristics that define a robust hypothesis:

Testability and Falsifiability

A strong hypothesis must be testable, meaning you can design experiments to verify or refute it. Falsifiability is equally important; there should be a possibility to collect data that could disprove the hypothesis. This ensures that your hypothesis is grounded in empirical research rather than mere speculation.

Clarity and Precision

Your hypothesis should be clear and precise, leaving no room for ambiguity. This clarity helps in designing experiments and interpreting results. A well-defined hypothesis often begins with a specific research question and is articulated in simple, straightforward language.

Relevance to Research Objectives

A strong hypothesis is directly related to your research objectives. It should address the core question of your study and be aligned with the goals you aim to achieve. This relevance ensures that your hypothesis is not just an isolated statement but a crucial part of your overall research framework.

Common Pitfalls in Hypothesis Writing

When crafting a hypothesis, it's crucial to avoid common mistakes that can undermine your research. Vague statements are a frequent issue; they lack the specificity needed to be testable. For instance, saying "exercise improves health" is too broad. Instead, specify the type of exercise and the health outcome you are measuring.

Overly complex hypotheses can also be problematic. A hypothesis should be straightforward and focused. If it includes too many variables or conditions, it becomes difficult to test and analyze. Simplify your hypothesis to ensure clarity and feasibility.

Another major pitfall is the lack of testability. A hypothesis must be testable through empirical methods. If you cannot design an experiment or collect data to support or refute your hypothesis, it is not scientifically valid. Ensure your hypothesis can be tested with the resources and methods available to you.

Examples of Well-Written Hypotheses

In this section, you will explore various examples of well-crafted hypotheses across different fields of study. Understanding these examples will help you grasp the nuances of formulating a strong hypothesis.

Hypotheses in Natural Sciences

A well-written hypothesis in the natural sciences is both specific and testable. For instance, consider the hypothesis: "If plants are exposed to higher levels of sunlight, then their growth rate will increase." This statement clearly defines the variables and the expected relationship between them, making it a robust hypothesis for experimental testing.

Hypotheses in Social Sciences

In the social sciences, hypotheses often address complex human behaviors and societal trends. An example of a good hypothesis in this field is: "Individuals who participate in regular physical activity are more likely to report higher levels of mental well-being." This hypothesis is specific, testable, and relevant to the research objectives, providing a clear direction for the study.

Hypotheses in Applied Research

Applied research focuses on practical problem-solving. A strong hypothesis in this area might be: "Implementing a new software system will reduce the time required to complete administrative tasks by 20%." This hypothesis is not only testable but also directly applicable to real-world scenarios, making it highly valuable for applied research.

By examining these examples, you can better understand how to construct hypotheses that are clear, precise, and aligned with your research goals.

Testing and Refining Your Hypothesis

Designing experiments.

Before you dive into any experiment, you first formulate what you think will happen. This is where your hypothesis comes into play. A hypothesis in experimental design is essentially a testable prediction. Ensure that your hypothesis has clear and relevant variables, identifies the relationship between its variables, and is specific and testable. Designing a robust experiment involves controlling the independent variable and observing the dependent variable to validate or refute your hypothesis.

Data Collection Methods

Once your experiment is designed, the next step is to collect data. This involves choosing appropriate methods to gather data that will support or refute your hypothesis. Whether you use surveys, observations, or experiments, the key is to ensure that your data collection methods are reliable and valid. Remember, the priority of any scientific research is the conclusion, so collect data meticulously.

Analyzing Results and Making Adjustments

After data collection, the next step is to analyze the results. This involves statistical analysis to determine whether the data supports your hypothesis. If the data does not support your hypothesis, do not worry. This is a normal part of the scientific method. You may need to refine your hypothesis based on the findings. Use the results to identify weaknesses in your hypothesis and revise it if necessary. This iterative process helps in honing a more accurate and testable hypothesis.

The Importance of Hypotheses in Academic Writing

In academic writing, hypotheses serve as foundational elements that guide the direction and structure of your research. A well-formulated hypothesis not only provides a clear focus for your study but also helps in organizing your research methods and analysis. This is crucial for ensuring that your research remains coherent and targeted.

Guiding Research Direction

A hypothesis plays an important role in the scientific method by helping to create an appropriate experimental design. By establishing a specific, testable statement, you can streamline your research process and avoid unnecessary detours. This focused approach is essential for producing meaningful and reliable results.

Facilitating Critical Thinking

Formulating a hypothesis requires you to engage in critical thinking and problem-solving. This process helps you to clarify your research questions and objectives, making your study more robust and intellectually rigorous. It also encourages you to consider various outcomes and their implications, thereby enhancing the depth of your analysis.

Enhancing Academic Rigor

A well-constructed hypothesis adds a layer of academic rigor to your work. It demonstrates that you have a clear understanding of the theoretical framework and existing literature related to your topic. This not only strengthens your argument but also makes your research more credible and persuasive. In essence, a strong hypothesis is a testament to the quality and seriousness of your academic endeavor.

In academic writing, hypotheses play a crucial role in guiding research and providing a clear focus for your study. They help in formulating research questions and determining the direction of your investigation. If you're struggling with your thesis and need a structured approach, our Thesis Action Plan is here to help. Visit our website to claim your special offer now and overcome the challenges of thesis writing with ease.

In conclusion, writing a hypothesis is a fundamental step in the scientific research process that requires careful consideration and a structured approach. By observing the subject, identifying variables, and formulating a clear and testable statement, researchers can lay a solid foundation for their experiments. A well-crafted hypothesis not only guides the research but also provides a framework for analyzing results and drawing meaningful conclusions. As demonstrated in this article, understanding the components and steps involved in hypothesis writing is crucial for academic success and contributes significantly to the advancement of knowledge in various fields. By following the detailed explanations and examples provided, students and researchers can enhance their ability to construct effective hypotheses, thereby improving the quality and impact of their scientific inquiries.

Frequently Asked Questions

What is a hypothesis.

A hypothesis is a statement that predicts the outcome of a scientific study. It is an educated guess based on prior knowledge and observations.

Why is a hypothesis important in scientific research?

A hypothesis provides a focused direction for research. It helps researchers make predictions that can be tested through experiments and observations, thereby advancing scientific knowledge.

What are the types of hypotheses?

There are several types of hypotheses, including null hypotheses, alternative hypotheses, directional hypotheses, and non-directional hypotheses. Each serves a different purpose in research.

How do you formulate a hypothesis?

Formulating a hypothesis involves identifying a research question, conducting preliminary research, and then crafting a clear and testable statement that predicts an outcome.

What makes a hypothesis strong?

A strong hypothesis is testable, falsifiable, clear, precise, and relevant to the research objectives. It should be specific enough to be tested but broad enough to cover the scope of the research.

What are common pitfalls in writing a hypothesis?

Common pitfalls include making vague statements, creating overly complex hypotheses, and failing to ensure that the hypothesis is testable.

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How to Write a Hypothesis – Steps & Tips

Published by Alaxendra Bets at August 14th, 2021 , Revised On October 26, 2023

What is a Research Hypothesis?

You can test a research statement with the help of experimental or theoretical research, known as a hypothesis.

If you want to find out the similarities, differences, and relationships between variables, you must write a testable hypothesis before compiling the data, performing analysis, and generating results to complete.

The data analysis and findings will help you test the hypothesis and see whether it is true or false. Here is all you need to know about how to write a hypothesis for a  dissertation .

Research Hypothesis Definition

Not sure what the meaning of the research hypothesis is?

A research hypothesis predicts an answer to the research question  based on existing theoretical knowledge or experimental data.

Some studies may have multiple hypothesis statements depending on the research question(s).  A research hypothesis must be based on formulas, facts, and theories. It should be testable by data analysis, observations, experiments, or other scientific methodologies that can refute or support the statement.

Variables in Hypothesis

Developing a hypothesis is easy. Most research studies have two or more variables in the hypothesis, particularly studies involving correlational and experimental research. The researcher can control or change the independent variable(s) while measuring and observing the independent variable(s).

“How long a student sleeps affects test scores.”

In the above statement, the dependent variable is the test score, while the independent variable is the length of time spent in sleep. Developing a hypothesis will be easy if you know your research’s dependent and independent variables.

Once you have developed a thesis statement, questions such as how to write a hypothesis for the dissertation and how to test a research hypothesis become pretty straightforward.

Looking for dissertation help?

Researchprospect to the rescue then.

We have expert writers on our team who are skilled at helping students with quantitative dissertations across a variety of STEM disciplines. Guaranteeing 100% satisfaction!

Step-by-Step Guide on How to Write a Hypothesis

Here are the steps involved in how to write a hypothesis for a dissertation.

Step 1: Start with a Research Question

• Begin by asking a specific question about a topic of interest.
• This question should be clear, concise, and researchable.

Example: Does exposure to sunlight affect plant growth?

Step 2: Do Preliminary Research

• Before formulating a hypothesis, conduct background research to understand existing knowledge on the topic.
• Familiarise yourself with prior studies, theories, or observations related to the research question.

Step 3: Define Variables

• Independent Variable (IV): The factor that you change or manipulate in an experiment.
• Dependent Variable (DV): The factor that you measure.

Example: IV: Amount of sunlight exposure (e.g., 2 hours/day, 4 hours/day, 8 hours/day) DV: Plant growth (e.g., height in centimetres)

Step 4: Formulate the Hypothesis

• A hypothesis is a statement that predicts the relationship between variables.
• It is often written as an “if-then” statement.

Example: If plants receive more sunlight, then they will grow taller.

Step 5: Ensure it is Testable

A good hypothesis is empirically testable. This means you should be able to design an experiment or observation to test its validity.

Example: You can set up an experiment where plants are exposed to varying amounts of sunlight and then measure their growth over a period of time.

Step 6: Consider Potential Confounding Variables

• Confounding variables are factors other than the independent variable that might affect the outcome.
• It is important to identify these to ensure that they do not skew your results.

Example: Soil quality, water frequency, or type of plant can all affect growth. Consider keeping these constant in your experiment.

Step 7: Write the Null Hypothesis

• The null hypothesis is a statement that there is no effect or no relationship between the variables.
• It is what you aim to disprove or reject through your research.

Example: There is no difference in plant growth regardless of the amount of sunlight exposure.

Step 8: Test your Hypothesis

Design an experiment or conduct observations to test your hypothesis.

Example: Grow three sets of plants: one set exposed to 2 hours of sunlight daily, another exposed to 4 hours, and a third exposed to 8 hours. Measure and compare their growth after a set period.

Step 9: Analyse the Results

After testing, review your data to determine if it supports your hypothesis.

Step 10: Draw Conclusions

• Based on your findings, determine whether you can accept or reject the hypothesis.
• Remember, even if you reject your hypothesis, it’s a valuable result. It can guide future research and refine questions.

Three Ways to Phrase a Hypothesis

Try to use “if”… and “then”… to identify the variables. The independent variable should be present in the first part of the hypothesis, while the dependent variable will form the second part of the statement. Consider understanding the below research hypothesis example to create a specific, clear, and concise research hypothesis;

If an obese lady starts attending Zomba fitness classes, her health will improve.

In academic research, you can write the predicted variable relationship directly because most research studies correlate terms.

The number of Zomba fitness classes attended by the obese lady has a positive effect on health.

If your research compares two groups, then you can develop a hypothesis statement on their differences.

An obese lady who attended most Zumba fitness classes will have better health than those who attended a few.

How to Write a Null Hypothesis

If a statistical analysis is involved in your research, then you must create a null hypothesis. If you find any relationship between the variables, then the null hypothesis will be the default position that there is no relationship between them. H0 is the symbol for the null hypothesis, while the hypothesis is represented as H1. The null hypothesis will also answer your question, “How to test the research hypothesis in the dissertation.”

H0: The number of Zumba fitness classes attended by the obese lady does not affect her health.

H1: The number of Zumba fitness classes attended by obese lady positively affects health.

Also see:  Your Dissertation in Education

Hypothesis Examples

Research Question: Does the amount of sunlight a plant receives affect its growth? Hypothesis: Plants that receive more sunlight will grow taller than plants that receive less sunlight.

Research Question: Do students who eat breakfast perform better in school exams than those who don’t? Hypothesis: Students who eat a morning breakfast will score higher on school exams compared to students who skip breakfast.

Research Question: Does listening to music while studying impact a student’s ability to retain information? Hypothesis 1 (Directional): Students who listen to music while studying will retain less information than those who study in silence. Hypothesis 2 (Non-directional): There will be a difference in information retention between students who listen to music while studying and those who study in silence.

How can ResearchProspect Help?

If you are unsure about how to rest a research hypothesis in a dissertation or simply unsure about how to develop a hypothesis for your research, then you can take advantage of our dissertation services which cover every tiny aspect of a dissertation project you might need help with including but not limited to setting up a hypothesis and research questions,  help with individual chapters ,  full dissertation writing ,  statistical analysis , and much more.

Frequently Asked Questions

What are the 5 rules for writing a good hypothesis.

• Clear Statement: State a clear relationship between variables.
• Testable: Ensure it can be investigated and measured.
• Specific: Avoid vague terms, be precise in predictions.
• Falsifiable: Design to allow potential disproof.
• Relevant: Address research question and align with existing knowledge.

What is a hypothesis in simple words?

A hypothesis is an educated guess or prediction about something that can be tested. It is a statement that suggests a possible explanation for an event or phenomenon based on prior knowledge or observation. Scientists use hypotheses as a starting point for experiments to discover if they are true or false.

What is the hypothesis and examples?

A hypothesis is a testable prediction or explanation for an observation or phenomenon. For example, if plants are given sunlight, then they will grow. In this case, the hypothesis suggests that sunlight has a positive effect on plant growth. It can be tested by experimenting with plants in varying light conditions.

What is the hypothesis in research definition?

A hypothesis in research is a clear, testable statement predicting the possible outcome of a study based on prior knowledge and observation. It serves as the foundation for conducting experiments or investigations. Researchers test the validity of the hypothesis to draw conclusions and advance knowledge in a particular field.

Why is it called a hypothesis?

The term “hypothesis” originates from the Greek word “hypothesis,” which means “base” or “foundation.” It’s used to describe a foundational statement or proposition that can be tested. In scientific contexts, it denotes a tentative explanation for a phenomenon, serving as a starting point for investigation or experimentation.

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Make sure that your selected topic is intriguing, manageable, and relevant. Here are some guidelines to help understand how to find a good dissertation topic.

How to write a hypothesis for dissertation,? A hypothesis is a statement that can be tested with the help of experimental or theoretical research.

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