Code | Title | Credits |
| Advanced Topics in Human Genetics | 1.5 |
| Introduction to Rigor and Reproducibility in Reseach | |
| Evolving Concepts of the Gene | 5 |
| Introduction to Responsible Conduct of Research | 1 |
| Human Genetics Boot Camp | 2 |
| Cell Structure and Dynamics | 1.5 |
| Molecular Biology and Genomics | 1.5 |
| Independent Research | 1 - 18 |
| Systems, genes and mechanisms in disease | 3 |
| Genomic Technologies: Tools for Illuminating Biology and Dissecting Disease | 1.5 |
| Understanding Genetic Disease | 0.5 |
| Pathways and Regulation | 2 |
Graduates from the Human Genetics program pursue careers in academia, medicine, industry, teaching, government, law, as well the private sector. Our trainees are encouraged to explore the full spectrum of professional venues in which their training my provide a strong foundation. Driven by curiosity and a desire for excellence, our trainees stand out as leaders in the chosen arenas of professional life. They are supported in the development of their career plans by a program faculty and administration who are dedicated to their success, and by a myriad of support networks across the Johns Hopkins University, many of which are provided by the Professional Development Career Office of the School of Medicine.
Molecular and Cellular Biology
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In this interdisciplinary program, you will interact with students and faculty who have diverse backgrounds in chemistry, marine biology, computational biology, and others. The skills you will learn in your first year include coding, how to write fellowships, and how to give scientific talks to a non-science audience. You will begin bonding with your small cohort of fellow students with an annual trip to Cape Cod to talk about science at the beginning of the academic year.
Dissertations that students have completed include "Characterization of the epigenetic regulator LSD1 as a Druggable Dependency in Treatment of Resistant Melanoma" and "Circadian Clocks in the Real World: Effects of Dynamic Light Regimes on the Regulation of Circadian Gene Expression in Cyanobacteria."
Graduates have secured positions in industry with companies such as Google, Genentech, and Novartis. Others serve in academic positions at many prestigious schools including Harvard, Caltech, Stanford, and MIT among others.
Additional information on the graduate program is available from the Department of Molecular and Cellular Biology , and requirements for the degree are detailed in Policies .
Areas of Study
Molecules, Cells, and Organisms
Admissions Requirements
Please review admissions requirements and other information before applying. You can find degree program-specific admissions requirements below and access additional guidance on applying from the Department of Molecular and Cellular Biology .
Academic Background
Applicants should have a record of introductory courses in chemistry, biology, physics, and mathematics. While the following courses should not be regarded as prerequisites for admission to graduate study, most admitted students have completed these courses as undergraduates:
- Biology (at least one general course in biology and two terms of biology at a more advanced level)
- Biochemistry
- Organic chemistry
- Physical chemistry
- Physics (a general course)
- Mathematics (a basic knowledge of differential and integral calculus). Competence in elementary programming is also desirable.
- Laboratory in biology, biochemistry, or instrumental analysis.
Statement of Purpose
Describe your reasons and motivations for pursuing a graduate degree in your chosen degree program, noting the experiences that shaped your research ambitions, indicating briefly your career objectives and concisely stating your past work in your intended field of study and in related fields. Your statement should not exceed 1,000 words.
In addition to the above guidance, your statement of purpose should also address the following questions:
- The focus of this question should be a discovery in which you had substantial engagement and personal impact on the research. Do not reference a large group project simply because it was interesting.
- If you have not had significant research experience, please describe a scientific discovery that motivated you to pursue research.
- Using simple language, describe what you or others did, why, and what it means.
- Molecular Mechanism
- Cell and Developmental Biology
- Molecular Ecology and Evolution
- Choose two MCO faculty members that you are interested to work with and explain why using a specific example from their published work.
Standardized Tests
GRE General: Not Accepted iBT TOEFL preferred minimum score: 100 IELTS preferred minimum score: 7
Theses & Dissertations
Theses & Dissertations for Molecular and Cellular Biology
See list of Molecular and Cellular Biology faculty
APPLICATION DEADLINE
Questions about the program.
Graduate School
![molecular biology phd topics Home](https://gradschool.princeton.edu/sites/g/files/toruqf846/files/gradschool_logo.png)
Molecular Biology
General information, program offerings:, director of graduate studies:, graduate program administrator:.
The graduate program in the Department of Molecular Biology fosters the intellectual development of modern biologists. We welcome students from a variety of educational backgrounds and offer an educational program that goes well beyond traditional biology. The molecular biology department at Princeton is a tightly knit, cohesive group of scientists that includes undergraduate and graduate students, postdoctoral fellows, and faculty with diverse but overlapping interests. Graduate students have a wide choice of advisers, with a broad spectrum of interdisciplinary interests and research objectives.
The graduate program offers all entering students the opportunity, with the help of faculty advisers, to design the intellectual program that best meets their unique scientific interests. Each student chooses a series of research rotations with faculty members in molecular biology and associated departments (chemistry, computer science, ecology and evolutionary biology, chemical and biological engineering, physics, and neuroscience). Entering students, with the aid of the graduate committee, select core and elective courses from a large number of offerings in a variety of departments and disciplines. This combination of a cohesive department, one-on-one advising, and individualized programs of course work and research provides an ideal environment for graduate students to flourish as independent scientists.
Areas of concentration include biochemistry, biophysics, cancer, cell biology, computation and modeling, development, evolution, genetics, genomics, microbiology and virology, policy, and structural biology.
Program Offerings
Program offering: ph.d..
By the end of the first year, students must have completed four core courses, achieving an average of B or better. Students may take additional elective courses that are closely related to their research topic.
By the end of the third year, students must have completed MOL 561 - Scientific Integrity in the Practice of Molecular Biology.
Additional pre-generals requirements
Rotations Students must complete three laboratory rotations with different advisers as part of their research training during the first year of study (MOL 540, MOL 541 Research Projects); a fourth rotation is optional. Students who complete a full rotation (approximately 8 weeks of research) the summer before entering graduate school are assigned a rotation in September along with other entering students. A student may elect to work with any faculty member or associated faculty member of the program. Students who desire to work with faculty outside the program may do so only with the approval of the director of graduate studies.
Faculty/Student Research Talks In the fall of their first year, graduate students attend a series of informal talks given by each faculty mentor. These discussions are designed to introduce first-year students to current research projects that might serve as rotation and thesis topics.
Molecular Biology Annual Retreat The molecular biology annual retreat is a two-day symposium of research talks and poster sessions held in the fall and attended by all graduate students, postdoctoral fellows, and faculty in molecular biology and associated departments.
Mol Bio Colloquia Graduate students, together with postdoctoral fellows and faculty, attend weekly research seminars given by graduate students and postdoctoral fellows. This colloquium provides both experience in the presentation of research results and a forum for scientific discussion with peers.
General exam
The general examination is usually administered in the January general examination period of the second year of study, after students have met all formal course requirements. This three-hour oral examination is administered by three faculty members from the graduate program, none of whom may be the student’s thesis adviser. The examination consists of two parts: the thesis proposal and second topic.
The thesis proposal probes depth of knowledge in the chosen research field and examines the ability of the student to justify and defend the goals, significance, and the experimental logic and methods of the proposed plan.
The second topic, or mini-proposal, is a two-page written document that uses an assigned research paper as the foundation for a research proposal. The student will propose a question and experiments to follow up on the results and/or conclusions in the assigned second topic paper.
Qualifying for the M.A.
The Master of Arts (M.A.) degree is normally an incidental degree on the way to full Ph.D. candidacy and is earned after successfully passing all parts of the general examination. It may also be awarded to students who, for various reasons, leave the Ph.D. program, provided that the following requirements are met: completion of the formal courses and three laboratory rotations required for Ph.D. students, and demonstration of an appropriate level of research competency. Research experience must include at least one year of independent work in the laboratory, and competency must be demonstrated in writing. A faculty mentor and the graduate committee must approve the master’s paper.
Students are normally required to teach in two undergraduate-level courses. The first assignment is normally a laboratory course, while the second is normally a major undergraduate lecture course. Students may have the opportunity to do additional teaching if they wish to gain more experience.
Post-Generals requirements
Committee Meetings Each graduate student chooses a thesis committee that consists of the thesis adviser and two other faculty members who are knowledgeable in the student’s area of research. The thesis committee meets formally with the graduate student at least once per year, and sometimes more frequently on an informal basis. The responsibility of this committee is to advise students during the course of their research.
Dissertation and FPO
When the research is completed, the student writes the dissertation, which is first read by the adviser then by two additional readers chosen by the student. Usually, the second readers are the other members of the student’s thesis committee. Upon acceptance of the dissertation, the student gives a final, public oral presentation of the research to the department.
The Ph.D. is awarded after the candidate’s doctoral dissertation has been accepted and the final public oral examination sustained.
Program Offering: M.D./Ph.D.
Program description.
The Princeton Graduate School has a partnership with the Robert Wood Johnson Medical School (RWJMS) and the Rutgers University (New Brunswick) Graduate School of Biomedical Sciences to serve as a Ph.D. site for students enrolled in the M.D./Ph.D. program of RWJMS.
Students admitted to the M.D./Ph.D. program at RWJMS perform laboratory rotations at Princeton during the summer before and the summer after the first year of the pre-clinical portion of the program, prior to their enrollment as doctoral students, and subject to the approval of the faculty member and the Princeton MD/PhD program co-director. Following the second rotation, a student will choose a laboratory for Ph.D. research by mutual agreement with a faculty adviser and approval by the Princeton MD/PhD program co-director, the chair of the Molecular Biology admissions committee, and the Graduate School.
Students who are accepted to work with a faculty member in, or an affiliated faculty member of, the Department of Molecular Biology will enter the Ph.D. program and receive that degree from Princeton. These students will fulfill Graduate School and departmental requirements, including the one-year residence requirement, taking and passing the general examination, and sustaining the final public oral examination. (Pre-clinical coursework at RWJMS will typically substitute for the department’s core curriculum.)
The Ph.D. portion of the joint program is expected to take three to four years. Extension beyond a fourth year requires approval from the Academic Affairs Committee of the joint degree program.
For those students considering the dual degree program, please take time to review the M.D./Ph.D General information page .
M.D./Ph.D. students in the Department of Molecular Biology must take two courses, which can be either core or elective courses, from the approved departmental course list.
Molecular Biology Annual Retreat The molecular biology annual retreat is a two-day symposium of research talks and poster sessions held in the fall and attended by all graduate students, postdoctoral fellows, and faculty in molecular biology and associated departments.
The general examination is usually administered in the September/October general examination period of the second year of study, after students have met all formal course requirements. This two-hour oral examination is administered by three faculty members from the graduate program, none of whom may be the student’s thesis adviser.
The examination consists of a thesis proposal which probes the depth of knowledge in the chosen research field and examines the ability of the student to justify and defend the goals, significance, and the experimental logic and methods of the proposed plan.
The Master of Arts (M.A.) degree is normally an incidental degree on the way to full Ph.D. candidacy and is earned after successfully passing all parts of the general examination. It may also be awarded to students who, for various reasons, leave the Ph.D. program, provided that the following requirements are met: completion of the formal course requirements and demonstration of an appropriate level of research competency. Research experience must include at least one year of independent work in the laboratory, and competency must be demonstrated in writing. A faculty mentor and the graduate committee must approve the master’s paper.
When the research is completed, the student writes the dissertation, which is first read by the adviser then by two additional readers chosen by the student. Usually the second readers are the other members of the student’s thesis committee. Upon acceptance of the dissertation, the student gives a final, public oral presentation of the research to the department.
Associate Chair
Director of Graduate Studies
Director of Undergraduate Studies
- Elizabeth R. Gavis
- Rebecca D. Burdine
- Zemer Gitai
- Frederick M. Hughson
- Alexei V. Korennykh
- Michael S. Levine
- Coleen T. Murphy
- Alexander Ploss
- Paul D. Schedl
- Stanislav Y. Shvartsman
- Thomas J. Silhavy
- Jeffry B. Stock
- Ned S. Wingreen
Associate Professor
- Mohamed S. Abou Donia
- Danelle Devenport
- Martin C. Jonikas
- Sabine Petry
- Jared E. Toettcher
- Martin Helmut Wühr
Assistant Professor
- Brittany Adamson
- John F. Brooks
- Michelle M. Chan
- Ricardo Mallarino
- Cameron A. Myhrvold
- Eszter Posfai
- AJ te Velthuis
Associated Faculty
- José L. Avalos, Chemical and Biological Eng
- Lisa M. Boulanger, Princeton Neuroscience Inst
- Clifford P. Brangwynne, Chemical and Biological Eng
- Mark P. Brynildsen, Chemical and Biological Eng
- Daniel J. Cohen, Mechanical & Aerospace Eng
- Thomas Gregor, Physics
- Ralph E. Kleiner, Chemistry
- A. James Link, Chemical and Biological Eng
- Lindy McBride, Ecology & Evolutionary Biology
- Tom Muir, Chemistry
- Celeste M. Nelson, Chemical and Biological Eng
- Joshua D. Rabinowitz, Chemistry
- Mohammad R. Seyedsayamdost, Chemistry
- Joshua W. Shaevitz, Physics
- Stanislav Y. Shvartsman, Chemical and Biological Eng
- Mona Singh, Computer Science
- Howard A. Stone, Mechanical & Aerospace Eng
- John D. Storey, Integrative Genomics
- Olga G. Troyanskaya, Computer Science
- Samuel S. Wang, Princeton Neuroscience Inst
- Bridgett M. vonHoldt, Ecology & Evolutionary Biology
Professor Emeritus (teaching)
Professor of the Practice
University Lecturer
Senior Lecturer
- Jodi Schottenfeld-Roames
- Georgina D. Benn
- Anthar S. Darwish
- Grace E. Johnson
- Laurel Lorenz
- Karin R. McDonald
Visiting Lecturer with Rank of Professor
For a full list of faculty members and fellows please visit the department or program website.
Permanent Courses
Courses listed below are graduate-level courses that have been approved by the program’s faculty as well as the Curriculum Subcommittee of the Faculty Committee on the Graduate School as permanent course offerings. Permanent courses may be offered by the department or program on an ongoing basis, depending on curricular needs, scheduling requirements, and student interest. Not listed below are undergraduate courses and one-time-only graduate courses, which may be found for a specific term through the Registrar’s website. Also not listed are graduate-level independent reading and research courses, which may be approved by the Graduate School for individual students.
CHM 542 - Principles of Macromolecular Structure: Protein Folding, Structure and Design (also MOL 542)
Cos 551 - introduction to genomics and computational molecular biology (also mol 551/qcb 551), mat 586 - computational methods in cryo-electron microscopy (also apc 511/mol 511/qcb 513), mol 504 - cellular biochemistry, mol 506 - cell biology and development, mol 514 - molecular biology, mol 518 - quantitative methods in cell and molecular biology, mol 523 - molecular basis of cancer, mol 540 - research projects in molecular biology (laboratory rotations), mol 541 - research projects in molecular biology (laboratory rotations), mol 559 - viruses: strategy and tactics, mol 561 - scientific integrity in the practice of molecular biology, mol 567 - electron microscopy in structural biology (half-term) (also mse 542), neu 501a - cellular and circuits neuroscience (also mol 501a), neu 501b - neuroscience: from molecules to systems to behavior (also mol 501b), neu 502a - systems and cognitive neuroscience (also mol 502a/psy 502a), neu 502b - from molecules to systems to behavior (also mol 502b), neu 503 - neurogenetics of behavior (also mol 503), neu 537 - systems neuroscience: computing with populations of neurons (also mol 537/psy 517), qcb 515 - method and logic in quantitative biology (also chm 517/eeb 517/mol 515/phy 570).
- Molecular, Cellular, & Developmental Biology
Research in the Department of Molecular, Cellular, & Developmental Biology spans biology from the organismal to the molecular levels. Topics in genetics and molecular biology include studies of non-coding RNAs, genome engineering, genome organization and regulation, gene dosage, bacterial chemotaxis, oncogenes, and systems and synthetic biology. Research topics in cellular and developmental biology include structure and dynamics of the cell cytoskeleton, molecular motors, chemical biology, the nuclear envelope, lncRNAs, regeneration, developmental biomechanics, vertebral column development, stem cell biology, and systems developmental biology. Research in neurobiology focuses on growth cone motility, neural differentiation, synaptogenesis, visual perception, olfaction, and the formation of topographic maps. Research in the plant sciences provides training in the molecular genetics of flowering, meristematic activity, epigenetics, the physiology of hormone action, sex determination, and the circadian clock. Because of the breadth of the department, students are provided with unique training and research opportunities for interdisciplinary studies.
- Programs of Study
- PhD - Doctor of Philosophy
Farren Isaacs
Director of Graduate Studies
Marylynn Visaggio
Departmental Registrar
Admission Requirements
Standardized testing requirements.
GRE is not accepted.
English Language Requirement
TOEFL iBT or IELTS Academic is required of most applicants whose native language is not English. BBS requires a score of at least 600 on the paper version, 250 on the computer-based exam, and 100 on the internet-based exam. Please take the test no later than November and no earlier than 24 months prior to submitting your application. Use institution code 3987 when reporting your scores; you may enter any department code.
You may be exempt from this requirement if you have received (or will receive) an undergraduate degree from a college or university where English is the primary language of instruction, and if you have studied in residence at that institution for at least three years.
Admission Information
Molecular, Cellular, & Developmental Biology participates in the Combined Program in the Biological and Biomedical Sciences (BBS) , and applicants interested in pursuing a degree in cell biology should apply to the Biochemistry, Quantitative Biology, Biophysics, and Structural Biology Track , the Plant Molecular Biology Track , or the Molecular Cell Biology, Genetics and Development Track within BBS.
Academic Information
Program Advising Guidelines
GSAS Advising Guidelines
Academic Resources
Academic calendar.
The Graduate School's academic calendar lists important dates and deadlines related to coursework, registration, financial processes, and milestone events such as graduation.
Featured Resource
Registration Information and Dates
https://registration.yale.edu/
Students must register every term in which they are enrolled in the Graduate School. Registration for a given term takes place the semester prior, and so it's important to stay on top of your academic plan. The University Registrar's Office oversees the systems that students use to register. Instructions about how to use those systems and the dates during which registration occurs can be found on their registration website.
Financial Information
Phd stipend & funding.
PhD students at Yale are normally full-funded for a minimum of five years. During that time, our students receive a twelve-month stipend to cover living expenses and a fellowship that covers the full cost of tuition and student healthcare.
- PhD Student Funding Overview
- Graduate Financial Aid Office
- PhD Stipends
- Health Award
- Tuition and Fees
Alumni Insights
Below you will find alumni placement data for our departments and programs.
- Student/Faculty Portal
- Learning Hub (Brightspace)
- Continuous Professional Development
Biochemistry and Molecular Biology
Biochemistry and molecular biology track.
specialty areas: biochemistry and structural biology, cell biology and genetics, and cancer biology
internationally renowned researchers and scientists dedicated to our program
Guaranteed 5-year internal fellowship
includes full tuition, stipend and benefits
Molecular biology, biochemistry and genetics are fundamental approaches implemented at the forefront of scientific discovery, leading the way toward understanding the molecular mechanisms of diseases. By getting to the core of how living organisms work and unlocking the innermost secrets of the cell, scientists can uncover new ways to detect and attack disease, and answer other fundamental questions about human life.
As a student in the Biochemistry and Molecular Biology (BMB) Track within the Ph.D. Program at Mayo Clinic Graduate School of Biomedical Sciences, you’ll learn to conduct hypothesis-driven, molecular research in a variety of areas spanning basic to applied science using a multitude of approaches ranging from model organisms to human specimens.
You’ll have the opportunity to work with researchers from across Mayo Clinic’s diverse scientific specialties, with access to state-of-the-art facilities for analyses at whole organ, cellular, molecular and atomic levels.
Current areas of research within our three foci include:
- Protein and lipid trafficking
- Genetic and epigenetic studies in monogenic and multigenic disorders
- Protein folding and disease
- Regulation of gene expression
- Cell signaling
- Organelle function and dynamics
- Hormone-based diseases
- Genome editing
- Musculoskeletal biology
- Cancer biology and progression
Most projects are directly related to human disease, with a view to understanding pathogenesis and development of effective therapies. Investigators within the BMB Track employ human disease specimens and an array of model systems including mice, zebrafish, drosophila and yeast in their studies.
As a student, you begin the program by discussing your career goals and research interests with track leadership in order to begin tailoring your individual educational trajectory. Subsequent to this discussion, you’ll select a minimum of three laboratories in which to perform eight- to 10-week rotations. You’ll spend a minimum of 20 hours each week in these rotations and use these experiences to select a thesis mentor.
In conjunction with the laboratory rotations, you begin fulfilling the graduate school core curriculum requirements and the track-specific requirements. The BMB Track requires 42 credits accumulated from four required core courses and the remaining built by the student from any course offered by the graduate school and tailored to their interests and research project.
![molecular biology phd topics Profile photo of Brooke Tader](https://college.mayo.edu/media/mccms/content-assets/academics/biomedical-research-training/phd-program/curriculumx2ftracks/BMBTrack_Tader_512x512.jpg)
Being in a collaborative and open environment really excites me about being in the Ph.D. program at Mayo Clinic. Everyone is approachable and more than willing to help you when you run into issues with your experiments. I also appreciate the camaraderie of the students. We cheer each other on and help each other through the tougher parts of obtaining our degrees.
Brooke Tader Ph.D. student, Biochemistry and Molecular Biology Track
![molecular biology phd topics Profile photo of Scott Johnson](https://college.mayo.edu/media/mccms/content-assets/academics/biomedical-research-training/phd-program/curriculumx2ftracks/BMBTrack_Johnson_512x512.jpg)
The Ph.D. program specifically empowers students to be able to select mentors not on funding availability, but on the mentorship they can provide for your training interests. This demonstrates the graduate school’s understanding that proper mentorship drives effective training and develops mature graduates. In my own life this has led to a developed trust with my mentor that frees me to conduct my research according to my own personality and preferences.
Scott Johnson Ph.D. student, Biochemistry and Molecular Biology Track
![molecular biology phd topics Profile photo of Esther Rodman](https://college.mayo.edu/media/mccms/content-assets/academics/biomedical-research-training/phd-program/curriculumx2ftracks/BMBTrack_Rodman_512x512.jpg)
The Ph.D. Program curriculum and laboratory work emphasizes experimental design, hypothesis generation, scientific writing, and communication, as well as develops our leadership, mentorship, and critical thinking skills – all of which are essential to our ability to securing top post-doctoral fellowships, industry jobs, scientific writing roles, and many more careers.
Esther Rodman Ph.D. student, Biochemistry and Molecular Biology Track
Recent thesis topics
- “Exploiting Mosaic Variegated Aneuploidy Syndrome Mutations to Elucidate BubR1's Role in Cancer and Aging,” Cynthia Sieben, Ph.D. (Mentor: Jan van Deursen, Ph.D.)
- “Identifying and Addressing Roles of Proteases and Protease Inhibitors in Progression of Metastasis of Ovarian Clear Cell Carcinoma,” Christine Mehner, Ph.D. (Mentor: Evette S. Radisky, Ph.D.)
- “Regulation of Hepatocyte Growth and Metabolism by the Small Rab GTPases,” Kristina Drizyte-Miller, Ph.D. (Mentor: Mark A. McNiven, Ph.D.)
- “Cellular Senescence in Neurodegenerative Disease,” Tyler Bussian, Ph.D. (Mentor: Darren J. Baker, Ph.D., M.S.)
- “Cytoskeletal and Membrane Remodeling at the Leading Edge Drives Pancreatic Tumor Cell Invasion and Growth,” Kevin Burton, Ph.D. (Mentor: Mark A. McNiven, Ph.D.)
- “The Role of Ceramides in Human Skeletal Muscle Insulin Resistance Development,” Paola Ramos, Ph.D. (Mentor: Michael D. Jensen, M.D.)
- “Alterations in Centrosome Separation and the Actomyosin Cortex as a Source of Tumor Promoting Chromosomal Instability,” Jazeel Limzerwala, Ph.D. (Mentor: Bruce F. Horazdovsky, Ph.D.)
- “Estrogen Receptor Beta Elicits Anti-Cancer Effects in Triple Negative Breast Cancer through Suppression of NFκB Signaling,” Kirsten Aspros, Ph.D. (Mentor: John R. Hawse, Ph.D.)
- “Determining the Mechanisms of Endoxifen Resistance in Estrogen Receptor Alpha Positive Breast Cancer,” Calley Jones, Ph.D. (Mentor: John R. Hawse, Ph.D.)
- “The Role of BubR1 in Vascular Biology,” Annyoceli Santiago, Ph.D. (Mentor: Bruce F. Horazdovsky, Ph.D.)
- “Automated Segmentation of CT Abdomen for Quantifying Body Composition Using Deep Learning,” Khaled Aziz, M.D., Ph.D. (Mentor: Bradley J. Erickson, M.D., Ph.D.)
- “Therapeutic Modulation of the Phagocytosis Axis as a Novel Glioblastoma Immunotherapy,” Christina von Roemeling, Ph.D. (Mentor: Yon Son Betty Kim, M.D., Ph.D.)
- “Regulation of Metalloprotease Action During Cancer Cell Metastasis,” Li Qiang, Ph.D. (Mentor: Mark A. McNiven, Ph.D.)
- “IPF Pathogenesis is Dependent Upon TGFβ Induction of IGF-1,” Danielle Hernandez, Ph.D. (Mentor: Edward B. Leof, Ph.D.)
- “Roles of TMPRSS2-ERG Gene Fusions During Prostate Adenocarci Noma Initiation and Progression,” Alexandra M. Blee, Ph.D. (Mentor: Haojie Huang, Ph.D.)
- “Genetic Status of KRAS Influences Transforming Growth Factor Beta (TGFb) Signaling in Tumorigenesis,” Sneha Vivekanandhan, Ph.D. (Mentor: Debabrata Mukhopadhyay, Ph.D.)
- “Epigenetic Abnormalities in Brain Tumors,” Xiaoyue Chen, Ph.D. (Mentor: Jann Sarkaria, M.D.)
- “Mechanisms Regulating Epigenetic Information Passage and Development-Associated Chromatin Remodeling,” Yuan Gao, Ph.D. (Mentor: Zhenkun Lou, Ph.D.)
- “Role of DNA Replication-Coupled Nucleosome Assembly in Cell Fate Determination During Development,” Liang Cheng, Ph.D. (Mentor: Tamas Ordog, M.D.)
- “Characterizing Cyclophilin-Mediated Survival in Glioblastoma Multiforme,” Lin Wang, Ph.D. (Mentor: Richard Bram, M.D., Ph.D.)
- “The Role of Protein Kinase D in Focal Adhesion Signaling and Cell Adhesion,” Nisha C. Durand, Ph.D. (Mentor: Peter Storz, Ph.D.)
- “Nucleosome Assembly and Cellular Senescence,” Jong-Sun Lee, Ph.D. (Mentor: Zhiguo Zhang)
- “Spartan, a Novel Regulator of Replication Stress Response and Genome Stability,” Reeja Maskey, Ph.D. (Mentor: Yuichi Machida, Ph.D.)
- “Modulation of the AAA-ATPase Vps4 by the V Domain of the ESC RT-Associated Factor Bro1,” Shirley E. Bradley Dean, Ph.D. (Mentor: David Katzmann, Ph.D.)
- “Evaluation and Analysis of DNA Supercoiling and Protein Mediated DNA Loops in vivo and in vitro FAP,” Lauren S. Mogil, Ph.D. (Mentor: Louis J. Maher III, Ph.D.)
- “The Role of Histone Deacetylase 3 in Chondrocyte Maturation During Endochondral Ossification,” Lomeli C. Shull, Ph.D. (Mentor: Jennifer Jane Westendorf, Ph.D.)
- “Epigenetic Regulation of Interstitial Cell Fates and Function in the Gastrointestinal Tract,” Sabriya A. Syed, Ph.D. (Mentor: Tamas Ordog, M.D.)
- “Engineered Gold Nanoparticles for Identification of Novel Ovarian Cancer Biomarkers,” Karuna Giri, Ph.D. (Mentor: Y.S. Prakash, M.D., Ph.D.)
Your future
The BMB Track offers a broad range of research opportunities in laboratories supported by state-of-the-art core facilities. A particular emphasis of the BMB department at Mayo Clinic is the study of the molecular mechanisms of human disease with a view to understanding pathogenesis and development of effective therapies.
After successfully graduating from this program, you’ll have a skill set that is ideally matched for a wide range of careers, including biomedical research, industry, education, government, or health care liaison.
Meet the director
![molecular biology phd topics John Hawse, IV, Ph.D. (318x318)](https://college.mayo.edu/media/mccms/content-assets/academics/biomedical-research-training/phd-program/faculty---biochem-amp-biomedical-eng/john-hawse318x318.jpg)
The track has three areas of specialty: Biochemistry and Structural Biology, Cancer Biology, and Cell Biology and Genetics.
This track also holds the largest faculty and student population of any Mayo Clinic Graduate School of Biomedical Sciences track, with more than 100 faculty members and more than 40 students.
John Hawse, Ph.D. Biochemistry and Molecular Biology Track Director Associate Professor of Biochemistry and Molecular Biology Email: [email protected] Phone: 507-284-4268 See research interests
Browse a list of Biochemistry and Molecular Biology Track faculty members
![molecular biology phd topics UCLA Graduate Division](https://grad.ucla.edu/wp-content/themes/grad-ucla/img/ucla-grad-logo.png)
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UCLA Graduate Programs
![molecular biology phd topics Diverse students in medical lab coats in front of blue molecule structures](https://grad.ucla.edu/wp-content/uploads/2015/09/ucla-prestige-molecular-biology-2-2.jpg)
Graduate Program: Molecular Biology
UCLA's Graduate Program in Molecular Biology offers the following degree(s):
Doctor of Philosophy (Ph.D.)
Master of Science (M.S.)
With questions not answered here or on the program’s site (above), please contact the program directly.
Molecular Biology Graduate Program at UCLA 172 Boyer Hall 611 Charles E. Young Drive East Box 951570 Los Angeles, CA 90095-1570
Visit the Molecular Biology’s faculty roster
COURSE DESCRIPTIONS
Visit the registrar's site for the Molecular Biology’s course descriptions
- Admission Requirements
- Program Statistics
(310) 794-4256
[email protected]
MAJOR CODE: MOLECULAR BIOLOGY
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Molecular biology articles from across Nature Portfolio
Molecular Biology is the field of biology that studies the composition, structure and interactions of cellular molecules such as nucleic acids and proteins that carry out the biological processes essential for the cells functions and maintenance.
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Translational control by VARS in melanoma
Aminoacyl-tRNA synthetases can promote or suppress cancer progression by regulating codon-dependent translation. A study now shows that valine aminoacyl-tRNA synthetase (VARS) promotes therapeutic resistance of melanoma to MAPK pathway inhibitors by enhancing translation of valine-enriched genes, including the fatty acid oxidation gene HADH .
- Qiushuang Wu
- Sohail F. Tavazoie
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High-resolution structure of a novel fluorogenic RNA aptamer
Fluorogenic RNA aptamers have previously been developed to enhance RNA imaging. We determined the tertiary complex structures of a newly discovered Clivia aptamer, which exhibits a small size and a large Stokes shift. Structural insights into the fluorescence activation mechanism of Clivia build a strong foundation for its efficient use in RNA imaging.
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Father’s diet influences son’s metabolic health through sperm RNA
DNA from organelles called mitochondria is not inherited from the father. But mitochondrial RNAs that sense paternal diet and mitochondrial quality are delivered from sperm to egg, affecting offspring metabolism.
Related Subjects
- Cell division
- Chromosomes
- CRISPR-Cas systems
- DNA damage and repair
- DNA metabolism
- DNA recombination
- DNA replication
- Epigenetics
- Non-coding RNAs
- Nuclear organization
- Post-translational modifications
- Protein folding
- Proteolysis
- Riboswitches
- RNA metabolism
- Single-molecule biophysics
- Transcription
- Transcriptomics
- Translation
- Transposition
Latest Research and Reviews
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Surface modified niosomal quercetin with cationic lipid: an appropriate drug delivery system against Pseudomonas aeruginosa Infections
- Jaber Hemmati
- Mohsen Chiani
- Mohammad Reza Arabestani
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The GEA pipeline for characterizing Escherichia coli and Salmonella genomes
- Aaron M. Dickey
- John W. Schmidt
- Manita Guragain
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Suppression of smooth muscle cell inflammation by myocardin-related transcription factors involves inactivation of TANK-binding kinase 1
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Stress-related transcriptomic changes associated with GFP transgene expression and active transgene silencing in plants
- Paraskevi Kallemi
- Frederic Verret
- Kriton Kalantidis
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Modulation of macrophage transcript and secretion profiles by Sargassum Serratifolium extract is associated with the suppression of muscle atrophy
- Heeyeon Ryu
- Hyeon Hak Jeong
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Microbiological quality assessment of Clarias gariepinus , Bagrus bajad , and Pangasianodon hypophthalmus fillets
- Noha M. El-Gendy
- Mahmoud Abou-Okada
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News and Comment
Monitoring subcellular protein localization at scale in live cells.
In this Tools of the Trade article, Reiniš and Reicher (Kubicek Lab) describe the development of a multicolour protein-tagging strategy that allows live-cell monitoring of multiple proteins.
- Jiří Reiniš
- Andreas Reicher
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A histone code controls positional identity in limb regeneration
Kawaguchi et al. identify a chromatin code based on repressive histone 3 lysine 27 trimethylation (H3K27me3) that serves as a segment-specific positional marker in connective tissue cells of axolotls, enabling correct patterning during limb regeneration.
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A bright green tag for RNA imaging
To understand the complex dynamics and diverse functions of RNA, robust technologies for labeling and imaging RNA are highly desirable. A newly developed green fluorescent aptamer named Okra enables the imaging of mRNA dynamics in living cells.
- Dhrisya Sathyan
- Murat Sunbul
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Molecular and Cell Biology
Ph.D. Program Information
- Laboratory Rotations and Presentations
Oral/Qualifying Examination
Research, dissertation and beyond.
The Department offers a Ph.D. program that has a standard completion time of 5.5 to six years. [Note: We do not admit students who wish to take the terminal Master's degree. However, when a student experiences a significant change in career orientation after successful completion of the oral exam, a M.A. degree may be awarded.]
![molecular biology phd topics timeline](https://mcb.berkeley.edu/sites/default/files/images/grad/timeline.jpg)
The Department provides as much flexibility as possible to students as they develop their scientific interests. Individual curricula and research are arranged in consultation with the student's academic Adviser and Thesis Mentor, and formal course work is usually taken during the first two to three semesters at Berkeley. Because the emphasis of the program is largely on training in research, requirements are defined on the basis of individual needs, enabling students to select from the wide range of courses offered by the Department. Other courses of interest to students are offered in the departments of: Chemistry, Plant and Microbial Biology, Integrative Biology, Physics, Nutritional Sciences and Toxicology, Bioengineering, Public Health and Biomedical and Environmental Health Sciences. While some students elect to concentrate their coursework in specialized research topics, many students ''choose" to construct programs that will provide them with intensive study in more general areas of molecular and cell biology.
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Lab Rotations and Presentations
Before selecting a thesis adviser, students will complete three 9 week laboratory rotations. Each rotation involves an individual research project selected by the chosen faculty member and student. Laboratory assignments are based on student preference and are arranged so that each student gets his/her first choice for at least one rotation. Credit and grades for the research conducted during the rotations are provided through enrollment in MCB 291A-B with each mentor grading individual rotations and the Head Graduate Adviser reviewing all comments and grades for the final course grade.
FERPs (Faculty Evening Research Presentations) and SMS (Student Micro-Symposia) set the groundwork for new students in the department. During the first 5-6 weeks of the Fall semester, faculty discuss the research taking place in their laboratories, providing a great opportunity to hear about research being done throughout the department. In SMS, each student describes the overall objectives of his/her rotation projects, the experimental approaches used, and the results obtained. SMS is moderated by faculty instructors and is designed to both familiarize students with and instruct them in the skills necessary to present research findings in a clear and incisive manner. SMS takes place during the last week of the Fall and Spring semesters.
First year course work includes: MCB 291A-B (rotations), MCB 293A (FERPs), MCB 293C (Ethical conduct of research), Fundamentals of Molecular and Cell Biology (MCB 200A-200B) and two Advanced Topics courses. All courses must be completed with a grade of B or better. Courses required by the department are marked below with a plus (+). Courses marked with one or two asterisks meet the Advanced Topics requirement; two stars indicate that the course is highly recommended by the Division. All course work must be completed prior to taking the qualifying exam (a.k.a. orals) in the spring semester of the second year. With the approval of the student's academic Adviser, a course offered by another department may be substituted for one of the two Advanced Topics courses. Some Divisions may recommend additional courses as appropriate to their disciplinary areas. Following the successful completion of the qualifying examination, all students must enroll in three semesters of special topics seminars (MCB 290) offered by faculty in areas of current research in the field of molecular and cell biology (typically 6 offerings per semester).
Anticipating future careers which may include teaching, all graduate students participate in undergraduate instruction by serving as Graduate Student Instructors (GSIs) for two semesters. Typically a student teaches during the Fall semester of the second year and the Spring semester of the third year in the doctoral program. These assignments usually include both lecture and laboratory courses and are, in most instances, based upon student preferences. Students who have passed their oral exams (i.e. advanced to candidacy) can also organize seminars for junior- and senior-level undergraduates for additional teaching experience (and credit for one of the three required MCB 290 seminars). A student may also be allowed to serve as a GSI for a third semester if they obtain the approval of their thesis mentor and Dissertation Committee ( see policy ).
During the second year, each student takes an oral/qualifying examination, usually held during the Spring semester. In this exam, the student demonstrates his/her ability to recognize research problems of fundamental importance, to propose appropriate experimental approaches to address these problems, and to display comprehensive knowledge of his/her disciplinary area and related subject areas. The oral examination itself is administered by a committee composed of four faculty approved by the Graduate Division with three faculty from MCB and one from another department on campus.
The qualifying examination will include a written proposal on the thesis work that will be discussed during the oral examination. The second part of the exam will involve questioning the students on a body of scientific material. The body of scientific material will be defined by 16 journal articles chosen by each division from 4 different areas (i.e. 4 papers in each area). Each student will be responsible for all 4 areas of the inside division and those from 2 areas of the outside division.
Though the examination is intended to be challenging, it is unusual for a student not to pass. Passage of the examination is required before a student is advanced to candidacy for the doctoral degree.
The Department is full of opportunities for expanding research in the areas of molecular and cell biology as well as in the expanding and emerging fields of structural biology, genomics, evolution and development, and computational biology. Students may join journal clubs and/or participate in laboratory group meetings of faculty whose work interests them, but in whose laboratories they are not currently conducting research. Many laboratories share research meetings and there are many area meetings between Stanford, UC San Francisco and UC Berkeley.
After advancing to candidacy a student meets each Fall semester with their Thesis Committee to discuss the dissertation project, to review results, and to chart research directions and timelines for the following year up to the completion of the dissertation. In the final year, students complete a dissertation based on original laboratory research.
It is also during the final year that most students present at national conferences and begin their search for a post-doctoral position and funding. The MCB 295 careers course offered in the spring is useful for those looking beyond academia as well as those planning to stay within academia. The campus also has a dedicated biological and physical sciences Ph.D. counselor in the Career Center to help students with the job search including resume writing, interviewing skills, conducting the job search, creating a teaching portfolio and more.
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Molecular Cell Biology (4 years) MPhil/PhD
London, Bloomsbury
The Laboratory for Molecular Cell Biology (LMCB) at UCL is dedicated to research aimed at understanding the molecular and cellular basis of cell behaviour relevant to human disease.
UK tuition fees (2024/25)
Overseas tuition fees (2024/25), programme starts, applications accepted.
Applications open
A minimum of an upper second-class UK Bachelor's degree in an appropriate subject or an overseas qualification of an equivalent standard, or a recognised Master's degree in an appropriate subject.
The English language level for this programme is: Level 2
UCL Pre-Master's and Pre-sessional English courses are for international students who are aiming to study for a postgraduate degree at UCL. The courses will develop your academic English and academic skills required to succeed at postgraduate level.
Further information can be found on our English language requirements page.
If you are intending to apply for a time-limited visa to complete your UCL studies (e.g., Student visa, Skilled worker visa, PBS dependant visa etc.) you may be required to obtain ATAS clearance . This will be confirmed to you if you obtain an offer of a place. Please note that ATAS processing times can take up to six months, so we recommend you consider these timelines when submitting your application to UCL.
Equivalent qualifications
Country-specific information, including details of when UCL representatives are visiting your part of the world, can be obtained from the International Students website .
International applicants can find out the equivalent qualification for their country by selecting from the list below. Please note that the equivalency will correspond to the broad UK degree classification stated on this page (e.g. upper second-class). Where a specific overall percentage is required in the UK qualification, the international equivalency will be higher than that stated below. Please contact Graduate Admissions should you require further advice.
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About this degree
This four-year Molecular Cell Biology PhD programme at the Laboratory for Molecular Cell Biology (LMCB) provides a broad in-depth training in molecular cell biology and fundamental aspects of biomedical science. The programme provides students with the opportunity to carry out cutting-edge research in an internationally renown environment. First-year rotations through three different laboratories and a bespoke tutorial series just are some of the programme highlights.
Who this course is for
Inquisitive, smart, adaptable and ambitious applicants.
What this course will give you
The goals of our training are to produce scientists who have explored one area and one level of analysis in great depth, but who are familiar with the full scope of molecular and cell biology. They should be able to move from one level to another in a critical and creative manner. We also try to develop an appreciation for translational research that bears on human disease.
During their first year, students have a free choice of three laboratories from the groups within the LMCB, and spend three months in each, working on research projects.
Students also participate in twice-weekly tutorials that are designed to broaden their understanding of molecular cell biology, developmental biology, neurobiology, immunology and the cell biology of disease.
Towards the end of their first year, students select a supervisor and lab in which they will carry out their three-year thesis project. Overall our programme is designed to offer training in fundamental aspects of molecular and cell biology, and to provide an opportunity to carry out cutting-edge research in a vibrant and internationally competitive environment.
The foundation of your career
Throughout the course of the PhD programme students gain a wide range of employability skills, these include but are not limited to, training in presentation skills, computer literacy, reading and analysis of scientific papers, team working, committee membership, event organisation (including outreach events) and cutting-edge microscopy training.
Employability
Recent graduates have secured positions as research fellows and postdoctoral researchers at leading UK universities including the University of Cambridge and UCL, and at overseas organisations such as Memorial Sloane-Kettering Cancer Center, USA and the Agency for Science Technology and Research (A*STAR), Singapore. Graduates of the programme have also established careers within the scientific technology and pharmaceutical industries.
Students in their first year share tutorials, practical courses and informal discussion meetings. They also join the wider cohort of LMCB graduate students that influences all aspects of LMCB strategy, outreach and social activities.
Teaching and learning
Students have access to a wide range training in soft and academic skills as well as access to training from other programmes.
You will do an upgrade from MPhil to PhD, and then a viva for your final examination.
The contact hours will be agreed between the research supervisor and the student. The hours of self-directed study will vary depending on the work being undertaken.
Research areas and structure
The programme offers research projects in areas including:
- Cell Signalling/Transcription
- Cytoskeleton
- Membrane Trafficking
- Growth Control
- Developmental Biology
- Neurobiology
- Human Disease
- Clinical Session
Research environment
The Laboratory for Molecular Cell Biology (LMCB) is a division within the UCL Faculty of Life Sciences . The Faculty has been associated with nine Nobel Laureates and presents an unrivalled environment for students and researchers in life science disciplines ranging from the biology of molecules, cells and organisms through to neuroscience and behavioural sciences.
Our research leaders, staff and PhD students work together to understand the fundamental principles of cell biology relevant to human disease. We are located in the heart of the Bloomsbury Campus of UCL and are funded by Cancer Research UK, Wellcome and University College London.
As an LMCB MPhil/PhD student, you will have the opportunity to learn from, and contribute to, this research culture by pursuing original research and making a distinct and significant contribution to your field. We are committed to the quality and relevance of the research supervision we offer, and as an MPhil/PhD candidate you could work with academics at the cutting-edge of cell biology. Furthermore as a research student, you will be an integral part of our collaborative and thriving research community.
We provide a bespoke tutorial series designed to offer a broad training in cellular and molecular aspects of biomedical science, as well as an opportunity to carry out cutting-edge research in an internationally competitive environment.
In the first year, students rotate through three laboratories of their choice within the LMCB. Students then choose any one of these laboratories for their three-year thesis project. The first year of the programme also includes weekly tutorials run by experts in various fields of cell and molecular biology, as well as discussion sessions and debates on wider issues in science.
This crucial first year allows students to broaden their understanding of biomedical science and, most importantly, sample different laboratories in order to make an informed choice of thesis area and mentor.
The length of registration for our PhD Programme lasts four years full-time, with the initial rotation year consisting of three ten-week projects.
You are required to register initially for the MPhil degree with the expectation of transfer to PhD after successful completion of an upgrade viva 9-12 months after starting your PhD project (second year of the programme).
Upon successful completion of your approved period of registration you may register as a completing research student (CRS), for up to one year, while you write up your thesis.
Within three months of joining your PhD lab, you are expected to agree with your supervisor the basic structure of your research project, an appropriate research method and a realistic plan of work. You will produce and submit a detailed outline of your proposed research to your PhD supervisory committee for their comments and feedback. Towards the end of the first year of your PhD project, you will have an opportunity to present your research before an audience of LMCB staff and fellow PhD students.
Additionally, in this year you will be expected to upgrade from an MPhil to a PhD. To successfully upgrade to a PhD you are required to submit a short dissertation describing the progress of your work to date. You are also required to present and answer questions about this work to your thesis committee who determine whether your upgrade to PhD is justified.
The PhD programme is expected to be completed within four years. If you are not ready to submit at the end of the fourth year, you may be able to go onto CRS for up to one additional year.
Year 1: First lab rotation: normally the rotation is 3 months for full-time students, but can be extended to up to 6 months for part-time students
Year 2: Second and third lab rotations
Year 3 – 6: PhD research in a laboratory of the student’s choice, thesis preparation and submission.
Accessibility
Details of the accessibility of UCL buildings can be obtained from AccessAble accessable.co.uk . Further information can also be obtained from the UCL Student Support and Wellbeing team .
Fees and funding
Fees for this course.
Fee description | Full-time | Part-time |
Tuition fees (2024/25) | £6,035 | £3,015 |
Tuition fees (2024/25) | £34,400 | £17,200 |
The tuition fees shown are for the year indicated above. Fees for subsequent years may increase or otherwise vary. Where the programme is offered on a flexible/modular basis, fees are charged pro-rata to the appropriate full-time Master's fee taken in an academic session. Further information on fee status, fee increases and the fee schedule can be viewed on the UCL Students website: ucl.ac.uk/students/fees .
Additional costs
Your research degree may be subject to an Additional Fee Element (AFE). The AFE (also known as bench fees) is an additional cost, incurred by yourself or your sponsor. It is levied to cover the costs related to consumables, equipment and materials etc which are not included in the tuition fee. As each research project is unique in nature, the AFE is calculated on a student by student basis and is determined by your academic supervisor.
For more information on additional costs for prospective students please go to our estimated cost of essential expenditure at Accommodation and living costs .
Funding your studies
The programme is open to any student with their own funding source. For a comprehensive list of the funding opportunities available at UCL, including funding relevant to your nationality, please visit the UCL Scholarships and Funding website.
For a comprehensive list of the funding opportunities available at UCL, including funding relevant to your nationality, please visit the Scholarships and Funding website .
Prospective students can contact the Programme Tutor ([email protected]) if they need help with the application process.
Please note that you may submit applications for a maximum of two graduate programmes (or one application for the Law LLM) in any application cycle.
Choose your programme
Please read the Application Guidance before proceeding with your application.
Year of entry: 2024-2025
Got questions get in touch.
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- Recent Ph.D. Dissertation Research Topics
August of 2017
Novel Cell Surface Anchoring Mechanism of Prokaryotic Secreted Protein - Mohd Farid Abdul Halim, Ph.D.
The Genetic Architecture Underlying Rapid Seasonal Evolution in Natural Populations of Drosophila melanogaster - Emily Behrman, Ph.D.
Developmental Functions of MIR156 and MIR157 in Arabidopsis - Jia He, Ph.D.
Dedifferentiation of Cytotoxic Lympthocyte into Central Memory CD8+T Cells: Lessons from Antiviral T-Stem Cells on the Architecture of Aging and Immunotherapy - Jonathan Johnnidis, Ph.D.
Class of 2017
Proteolytic Activation by ADAMTS3 Defines Distinct Mechanisms of Lymphangiogenesis Mediated by VEGFC and VEGFD - Hung Bui, Ph.D.
Transcript Diversity in the Protozoan Parasite Toxoplasma Gondii - Maria Diaz, Ph.D.
Plant-soil Feedback and Succession in Heavy Metal Soils - Lee Dietterich, Ph.D.
Genome Editing Approach to Uncover Microtubule-Actin Crosslinking Factor (MACF1) Essential Domains in Establishing Oocyte Polarity and Nuclear Positioning - Matias Escobar, Ph.D.
Investigation of the Spatiotemporal Dynamics of cAMP and PKA Signaling and the Role of HCN4 Subunits in Anxiety-Related Behavior and Memory - Vincent Luczak, Ph.D.
The C-REL Transcription Factor Controls Metabolism and Proliferation of Human T Cells - George Luo, Ph.D.
Space, Time and Change: Investigations in Soil Bacterial Diversity in the Montane Steppe of Mongalia - Aurora MacRae-Crerar, Ph.D .
Population Genetics of Borrelia Burgdorferi in the Eastern and Midwestern United States - Stephanie Seifert, Ph.D.
Hypermutability in Asexuals: Investigating the Effects of Deleterious Mutations - Tanya Singh, Ph.D.
Class of 2016
Molecular and Cellular Approaches Toward Understanding Dynein-Driven Motility - Swathi Ayloo, Ph.D.
Cell Biology of Cheating - Mechanisms of Chromosomes Segregation during Female Meiosis - Lukas Chmatal, Ph.D.
Detecting Selection on Noncoding Nucleotide Variations: Methods and Applications - Yang Ding, Ph.D.
Short Term Adult Plasticity in Drosophila melanogaster and its Role in Climatic A daptation - Vinayak Mathur. Ph.D.
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Selective Forces that Shape the VLS Antigenic Variation System in Borrelia Burgdorferi - Wei Zhou, Ph.D.
Class of 2015
A Role of SWI/SNF Complex in ABA-dependent Drought Responsive Gene Expression in Arabidopsis thaliana - Soon Ki Han, Ph.D.
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The Genetic Basis of Phenotypic Plasticity in Natural Populations of Drosophila - Katherine O'Brien, Ph.D.
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Class of 2014
Change and Impact of microRNA Modification with Age in Drosophila melanogaster - Masashi Abe, Ph.D.
Mitotic Kinases in Meiosis - Olga Davydenko, Ph.D.
Higher-Order Chromatin Organization in Hematopoietic Transcription - Wulan Deng, Ph.D.
Effects of Temperature on Global Gene Expression in Natural Strains of Budding Yeast - Hoa Giang, Ph.D.
Regulators of Mouse and Human Beta Cell Proliferation - Yang Jiao, Ph.D.
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Class of 2013
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Structure and Function of H. volcanii flagella - Manuela Tripepi, Ph.D.
Class of 2012
Investigation of the Methane Cycle and Associated Microbial Community of a Pine Forest Soil - Emma Aronson, Ph.D.
A Role for Late Meristem Identity2 in the Reproductive Development of Arabidopsis - Jennifer Pastore, Ph.D.
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Selection on Mutators in Experimental Saccharomyces Cerevisiae Populations: Recombination, Clonal Interference, and the Evolution of Mutation Rates - Yevgeniy Raynes, Ph.D.
Class of 2011
Socioecology, Acoustic Communication and Demography of Asian Elephants in Sri Lanka - Shermin deSilva, Ph.D.
The Role of Exocyst in Exocytosis and Cell Migration - Jianglan Liu, Ph.D.
YY1 Controls Immunoglobulin Class Switch Recombination and Nuclear Aid Levels - Kristina Zaprazna, Ph.D.
Mechanisms of HDAC2 Function in the Regulation of Adult Cardiac Hypertrophy and Embryonic Myocyte Proliferation - Wenting Zhu, Ph.D.
Actin-Independent Mechanisms of Targeting Formin mDIA2 to the Plasma Membrane - Roman Gorelik, Ph.D.
Roles of Protein Factors in Regulation of Imprinted Gene Expression - Shu Lin, Ph.D.
Functional Plasticity of Hippocampal Glutamatergic Synapses in Development and Disease - Xiaoyu Peng, Ph.D.
Physiological Bases of Plant Shrinkage and its Demographic Implications - Roberto Salguero-Gomez, Ph.D.
Class of 2010
Unplugged/Musk Signaling Coordinates Pre- and Post-synaptic Development at the Neuromuscular Junction - Lili Jing, PhD
Spatially Varying Selection on Shell Color Phenotype in the Flat Periwinkle Littorina Obtusata - Megan Phifer-Rixey, PhD
Niche Partitioning Among Arbuscular Mycorrhizal Fungi and Consequences for Host Plant Performance - Jennifer H. Doherty, PhD
Microrna Pathways Modulate Aging and Neurodegenerative Diseases - Nan Liu, PhD
The Rab3A Locus: Studies of Neuronal Expression and Effects on Behavior - Rui Liu, PhD
The Evolutionary Genetics of Life History in Drosophila Melanogaster - Annalise Bloss Paaby, PhD
Using Evolutionary Genomics to Elucidate Parasite Biology and Host-Pathogen Interactions - Lucia Peixoto, PhD
Class of 2009
Characterizing the Role of the Exocyst Component EX070 in Exocytosis and Actin Dynamics in Budding Yeast Saccharomyces Cerevisiae - Bing He, PhD
Slit Down-Regulates CRGAP Function to Mediate Axon Repulsion in the Embryonic Drosphila CNS - Ming Li, PhD
Molecular Basis of Chve Function in Sugar Binding and Virulence in Agrobacterium Tumefaciens - Fanglian He, PhD
Spatial and Temporal Variation in Streambed Bacterial Community Composition and Correlation with Einvironmental Variables and Disturbance - Karen Rowley Hogan, PhD
Squint, The Arabidopsis Ortholog of Cyclophilin40, Affects RNA Silencing - Michael Smith, PhD
Spatial Regulation of CDC42 by its GTPase-Activating Proteins RGA1 and BEM2 in Budding Yeast Saccharomyces Cerevisiae - Zongtian Tong, PhD
Class of 2008
Molecular and Cellular Mechanism of Axon Guidance During Visual System Development in Zebrafis h - Michael Gyda, PhD
Phylogeny and Evolution of Prokaryotic Genomes - Fan Ge, PhD
The Role of the Exocyst Complex in Polarized Exocytosis - Puyue Wang, PhD
Evolutionary Ecology of Host Plant Use by an Insect Herbivore in a Highly Seasonal Neotropical Dry Forest - Salvatore Agosta, PhD
Variation Among Dogwhelks (Nucella lapillus) Modifies Predator-prey Interactions within Intertidal Assemblages - Jonathan Fisher, PhD
Peeking into the Black Box: The Structure and Function of Soil Microbial Communities in Response to Increasing Nitrogen Availability - Richard Lucas, PhD
Taxonomic and Functional Diversity of AM Fungi in Serpentine and Prairie Grasslands - Baoming Ji, PhD
Dissecting Different Modules of Cytochrome C Maturation in Rhodobacter Capsulatu s - Serdar Turkarslan, PhD
Role of Exocytosis in Cell Polarization - Xiaoli Sun, PhD
Class of 2007
The Analysis of the PI3K/AKT Pathway in Human Ovarian Cancer with a Combination of Genomic and Genetic Appoaches - Jia Huang, PhD
Examination of the Twin-Arginine Translocation Pathway in Bacteria and Archaea - Kieran Dilks, PhD
Spatial Orientation in Columbian Ground Squirrels (Spermophilus Columbianus) - Anna Vlasak, PhD
From Protein to RNA: Study of SCA3 Polyglutamine Disease in Drosophila - Lingbo Li, PhD
Novel Insignts Into Vir Gene Regulation in Agrobacterium Tumefaciens - Gauri Nair, PhD
Spatial and Genetic Patterns of Crane Flies (Diptera: Tipuloidea) from Lake Hovsgol Region, Mongolia - Bazartseren Boldgiv, PhD
Aging in Plants at Multiple Scales - Lori Spindler, PhD
Metabolic Pool, Metabolic Rates and Diapause in Drosophila Melanogster - Christine Wills, PhD
Phylogenetics and Diversification of the Neotropical Serrasalminae (Ostariophysi: Characiformes) - Wasila Dahdal, PhD
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University of Colorado Denver | Anschutz Denver | Anschutz Medical Campus
2024-2025 academic catalog, molecular biology (phd).
The Molecular Biology Program is dedicated to providing rigorous training to its students in a supportive environment. Molecular Biology faculty are members of many different departments and are applying the techniques of molecular biology to answer questions in diverse areas. Molecular biology, the science of how living things work at the molecular level, has led the recent revolution in our understanding of human disease and gave birth to the biotechnology industry. In almost all aspects of modern biomedical research, a professional knowledge of molecular biology is essential. Our training program is designed to equip students for careers at the cutting edge of biology.
Admissions Requirements
To apply for admission applicants must submit the following:
- Personal Statement
- Research Experience explanation (more in-depth than what is provided in the resume requirement)
- Resume: The applicant’s current resume or curriculum vitae, including professional work/practice since graduating with a bachelor’s degree (or equivalent).
- Diversity, Equity and Inclusion Statement
- Three recommendations: to be completed by people who know your professional, academic and/or personal achievements or qualities well. As such, references must be from professional contacts, such as employers, supervisors, former faculty, preceptors, or professional colleagues.
- Official Transcripts from all post-secondary colleges and/or universities attended by the applicant.
- Application Fee: A nonrefundable application fee of $50.00 (U.S. dollars – Domestic Applicants). Checks or money orders should be made out to the University of Colorado.
- Interview: If selected, candidates will be contacted to attend a recruitment weekend[HS2] , including interviewing with current MOLB Faculty and Students.
- Transcripts: Official transcripts from all post-secondary colleges and/or universities should be sent directly to:
University of Colorado Denver
Graduate School
Mail Stop C296
Fitzsimons Building, W5107
13001 E. 17th Place
Aurora, CO 80045
OR Electronic Transcripts should be sent to: [email protected] (preferred)
International students must meet ALL the requirements listed above along with those required by the Office of International Affairs. The application fee for international students is $75.00.
Degree Requirements
Plan of Study Grid First Year |
Fall | Hours |
| Core I: Foundations in Biomedical Sciences | 6 |
| Core Topics in Biomedical Science | 2 |
| Research in Molecular Biology | 1-10 |
| Hours | 9-18 |
Spring |
| Advanced Topics in Molecular Biology | 3-4 |
| Research in Molecular Biology | 1-10 |
Elective of student's choosing | |
| Hours | 4-14 |
Summer |
| Doctoral Thesis in Molecular Biology | 1 |
| Hours | 1 |
| Total Hours | 14-33 |
Second Year
Plan of Study Grid Second Year |
Fall | Hours |
| Molecular Biology Seminar | 1 |
| Research in Molecular Biology | 1-10 |
| Informatics and Statistics for Molecular Biology | 3 |
| Hours | 5-14 |
Spring |
| Molecular Biology Seminar | 1 |
| Research in Molecular Biology | 1-10 |
Elective of student's choosing | |
| Hours | 2-11 |
Summer |
| Doctoral Thesis in Molecular Biology | 1-10 |
| Hours | 1-10 |
| Total Hours | 8-35 |
Third Year through PhD Completion
Plan of Study Grid Fall | Hours |
| Doctoral Thesis in Molecular Biology | 5 |
| Hours | 5 |
Spring |
| Doctoral Thesis in Molecular Biology | 5 |
| Hours | 5 |
Summer |
| Doctoral Thesis in Molecular Biology | 1 |
| Hours | 1 |
| Total Hours | 11 |
Learning Objectives
The MOLB Program has defined five objectives that convey our approach to research and professional training.
Objective 1 is to provide broad training in foundational molecular and cellular biology with focused research opportunities in diverse disciplines (e.g., bioinformatics, cell biology, cancer biology, developmental biology, epigenetics, immunology, microbiology, RNA biology, and structural biology). Our broad interdisciplinary training is key to the success of our trainees and a defining feature of MOLB relative to other AMC training programs. The scientific breadth of our faculty exposes our trainees to many different techniques and provides opportunities for students to combine different approaches to answer their own scientific questions. We cultivate a collegial environment across the program, encouraging intellectual exchange and collaboration between labs from many departments and measure our success by the number and quality of research publications produced by our trainees and the number of external grants that they are awarded based on their research.
Objective 2 is to provide student-oriented and well-balanced training that emphasizes development of creative and independent thinking, strong communication skills, and professional responsible conduct. A key to MOLB training is its focus on developing professional skills including teamwork, science communication, project management, and leadership. The MOLB Program incorporates many technical, operational, and professional elements to provide balanced training for our students.
Objective 3 is to develop and apply the newest techniques that drive advances in science. As the late Sydney Brenner articulated, “ Progress in science depends on new techniques, new discoveries, and new ideas, probably in that order .” A primary objective of the MOLB Program is to position our graduates to lead the forefront of scientific technology deployment and development. We develop scientists who are well-versed in existing scientific techniques and capable of developing their own experimental approaches to answer new questions. We combine rigorous “wet” and “dry” laboratory training, intensive discussion of current literature, workshops, and mini-courses that focus on emerging techniques for molecular and cell biology research, and we measure our success by our trainees’ performance in preliminary and comprehensive examinations, and laboratory research.
Objective 4 is to create and sustain an inclusive and diverse research training environment. We value diversity in our program and the scientific community, and developed several approaches to increase the cultural, racial, and social diversity in the MOLB Program. Some of these include MOLB-specific recruitment and retention strategies and diversity training for our faculty and students.
Objective 5 is to promote the career advancement of our trainees and introduce them to a broad range of career choices. The MOLB program provides skills and opportunities for experiential learning needed to succeed in many science-related careers, including academic research, consulting, teaching, government and public policy, technology transfer and patent law, science writing, and science communication, and measure our success by the diversity of science-related careers that our trainees pursue.
Course Descriptions
Please refer to the Graduate School Policies page .
Rytis Prekeris, Ph.D. Program Director [email protected] https://www.prekerislab.com/ @prekerislab
Michael McMurray, Ph.D. Associate Program Director [email protected] https://medschool.cuanschutz.edu/cell-and-developmental-biology/faculty/michael-mcmurray
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CU Denver Undergraduate Catalog
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Students explore a multitude of other career possibilities while working toward their degree. Alumni from the Cell, Molecular and Cancer Biology graduate program have successful careers in biomedical research, both in university and industrial biotech settings.
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| Jun 11, 2024 | | 2024-2025 University Catalog | | | 2024-2025 University Catalog | | | Biochemistry and Molecular Biology Graduate ProgramConcentrations:. - Biochemistry - Molecular Biology
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![molecular biology phd topics Man working with a machine](https://medschool.umich.edu/sites/default/files/styles/large_16_9/public/2023-08/mcpath-3200x1800.jpg?h=b108ec0b&itok=xDcW0tfK) An enhanced educational experience in "bench to bedside" approaches. Program OverviewThe mission of the Molecular and Cellular Pathology (MCP) Graduate Program is to train the next generation of "Bench to Bedside" scientists with a focus on the study of the molecular and cellular mechanisms underlying the pathogenesis of human diseases. Inaugurated in 1992, the MCP program is hosted by the Department of Pathology and takes advantage of its unique position in a department that bridges basic and clinical sciences to encourage interdisciplinary projects and interdepartmental cooperation. The Department of Pathology is also home to a large and diverse group of more than 180 faculty members, including basic science researchers, physician-scientists and clinicians. This well-funded (ranked #9 nationwide for NIH support) and collaborative environment provides a unique opportunity for the approximately 30 students enrolled in the MCP program to perform transformative research, ranging from basic to translational research. Apply through our PIBS application MCP students train in one of the 40 MCP research labs under the supervision of an exceptional team of MCP faculty mentors, co-mentors and senior staff/trainees, and are immersed in a research environment that features internationally renowned professors. Many of our faculty members hold joint appointments with other biomedical science departments and graduate programs at the University of Michigan, offering students an interdisciplinary approach to their training. MCP students are immersed in a didactic and research culture that provides a solid foundation for the student’s training and progression towards becoming an independent scientist. The MCP program integrates mentor-guided laboratory research with a comprehensive and customizable curriculum designed to both: - Provide a strong foundation in basic areas of biology for in-depth study of the molecular and cellular aspects of pathogenesis
- Meet the individual needs of each student toward their academic goals and career aspirations by providing a wide range of training options and opportunities, e.g., the embedded Master's Degree in Computational Medicine and Bioinformatics or the T32 Training Program in Translational Research
After passing the preliminary exam, students focus on their dissertation research project and are required to present each year at the Pathology Research Seminar Series. This departmental weekly series showcase visiting speakers, local research faculty and trainees, thus providing MCP students with a stimulating learning environment. PIBS Application Overview Using a wide range of experimental approaches to understand the pathogenesis of human diseases, the research areas of interest in the MCP program include: - Molecular and cellular mechanisms of cancer
- Immunopathology and inflammatory diseases
- Neuropathology and applied neurobiology
- Stem cell and developmental biology
- Translational research
- Epigenetics and gene regulation
- Drug discovery and experimental therapeutics
- Biomarkers (diagnostic and prognostic)
The MCP curriculum includes core courses designed to deliver graduate students with a strong background in basic areas of biological sciences, providing a rigorous intellectual foundation for the study of the mechanisms underlying the pathogenesis of human diseases. In their first year, MCP students attend two out of four basic science courses, including Human Genetics, Cell & Developmental Biology, Biochemistry, Cancer Biology, Computational Biology or an alternative course of their choice. In their winter term, first year students attend PATH 581, which introduces students to basic pathophysiologic mechanisms, the molecular basis for disease and the morphologic expression of human disease. In the fall term of their second year, MCP students take PATH 582, which introduces current topics in molecular pathology and emphasizes critical analysis of primary literature. Our diverse research faculty investigate a broad range of disease topics and integrates their knowledge into the course curriculum. The MCP curriculum also includes in the third year a course in Translational Pathology PATH 862 designed to help meet the growing need for scientists and medical professionals who can bridge the gap between basic science and clinical practice. This multi-disciplinary course trains both graduate students and clinical residents in the methods and principles involved in translating basic science findings into clinically useful interventions to improve human disease outcomes. The central objective is to illustrate how basic science applied to human disease can lead to the discovery of its pathophysiology, which in turn can be used to develop therapeutics and diagnostic tests. Preliminary ExaminationThe preliminary examination ("prelim") aims to test the student’s ability to identify a novel scientific hypothesis and to develop a rational research plan to test this hypothesis. During the prelim, which is typically held during the fall term of the second year, a faculty committee evaluates the student’s capacity to communicate effectively about their research plan in both written and oral presentations. The research proposal addresses a student-selected topic relevant to the field of experimental pathology and may focus on the student’s planned thesis research ("on-topic"). On-topic prelim scientific exams jump-start student-mentor dissertation project discussions, offer feedback and critical review of the dissertation project by an external committee at a very early stage of its development and generates a research proposal foundation for future extramural fellowship applications. Departmental Seminar SeriesMCP students are broadly exposed to basic and applied research at weekly departmental seminar series, which showcase visiting speakers, local research faculty and trainees, thus providing MCP students with a stimulating learning environment. Attending the pathology research seminar series helps students further develop their critical thinking and their presentation skills. Giving a presentation at this seminar series also provide students the opportunity to discuss their research project in a scientific forum and to receive feedback on their work. Transitional ResearchThe Department of Pathology is also home to the T32 Training Program in Translational Research (TPTR), which is led by MCP mentors Drs. Andrew Lieberman and Zaneta Nikolovska-Coleska. TPTR offers an interdisciplinary program of study and research that prepares graduate students for successful careers at the interface between basic biomedical science and clinical medicine. This program is designed for predoctoral PhD students and aims to address the widely recognized shortage of rigorously trained scientists who can successfully work together with medical professionals to bridge the gap between basic science and clinical practice. Along with additional coursework in translational pathology, trainees participate in a mentored clinical rotation in an area relevant to their thesis research, complementing the experimental work with exposure to disease-related clinical problems. Teaching RequirementMCP has no formal teaching requirement but offers optional access and training to students who wish to have a teaching experience. The MCP program is designed for students to graduate within ~five to six years (5.2 on average). Expected Length of ProgramProgram is designed for students to graduate in five years of training. MCP Student CouncilThe MCP Student Council, which is currently led by fourth year MCP student Noah Puleo (DiFeo Lab), hosts monthly meetings and coordinates multiple social events throughout the year, including student/faculty mixers, camping trips, ice cream socials and community outreach projects. An MCP Student representative selected by MCP Student Council serves on the MCP Steering Committee to provide students’ perspectives, feedback and suggestions on the program. MCP Research Symposium: By the Students, for the StudentsOne of the marquee events in the Department of Pathology is our Annual MCP Research Symposium. The symposium, which is organized by third year MCP students, features oral and poster presentations by our faculty and trainees, highlighting the innovative research undertaken in the Department of Pathology and a career panel to discuss career pathways for PhD and MD/PhD graduates. The symposium has a long tradition of hosting internationally renowned external keynote speakers, such as Dr. Ralph Steinman, the 2011 Nobel Prize in Medicine Laureate. The symposium provides numerous opportunities for exciting and stimulating interactions between our students and faculty through discussions and sharing ideas. Financial Support and Awards- MCP Conference Travel Grants: To facilitate and ensure that MCP students attend extramural scientific meetings and present their research, the graduate program provides financial support for travel on a yearly basis by awarding MCP Travel Grant Awards.
- MCP Student Research Grant : MCP supports graduate students by awarding the MCP Student Research Grant, a competitive award (internal competition) designed to support a student-initiated research project and to advance their progress toward their degree. This grant is intended to support an exploratory research question relevant to the student’s thesis and to encourage the independent research work of the students by providing support for novel/risky ideas that might provide proof of concept for feasibility and further study.
- MCP Outstanding Research and Service Awards: Every year, MCP celebrates the many outstanding contributions of our MCP students with several honors, including the MCP Outstanding Research and Service Awards, at the Annual MCP Research Symposium. The MCP Outstanding Research Award recognizes the outstanding research and scholarly accomplishments of the student awardee. The MCP Outstanding Service Award distinguishes a student who has shown great commitment of time and effort towards service to the department and the community.
Social EventsThe MCP community meets regularly to socialize. Latest events in 2023 include: introduction to the French game of pétanque at Gallup Park (July 2023), ice-cream social to welcome first year MCP students into our community (August 2023), happy hour at Casa Dominick's (October 2023), upscale dinner at the Gandy Dancer to kick off the 22nd Annual MCP Research Symposium (November 2023). Next on the MCP calendar: taste of global flavors at the multicultural potluck to celebrate our culinary differences before the holiday season (December 2023). MCP students value spending fun bonding time together. Every summer, students organize an MCP-sponsored camping trip. The 2023 trip upheld this beloved tradition and was a great success as everyone carpooled up to the Pinckney Recreational Area for a weekend. Community Service and OutreachMany MCP students give back to the community through educational and community outreach programs. MCP students have a long track record of being impactful benefactors in their community. For example, in 2016, during the water crisis in our neighboring city of Flint, Michigan, MCP students organized a trip to support the local Red Cross organization by hand-delivering bottled water and related supplies to senior Flint residents. The selfless dedication of our students to community service is recognized with one student named the MCP Outstanding Service Award recipient annually at the Annual MCP Research Symposium. The MCP Graduate Program bridges basic and clinical sciences and promotes interdisciplinary translational research to advance the application of scientific discoveries, providing an enhanced educational experience and training in “Bench to Bedside” approaches. MCP students produce high-quality research that has resulted in publications in top-tier journals, present their work at national and international conferences and are the recipients of prestigious awards and fellowships from the NIH, DOD, professional societies or disease foundations. Our goal is to recruit a diverse group of talented MCP students and to provide you with the best educational environment to train and to prepare for the next stage of your career in academia, the biotech/pharma industry, teaching, scientific publishing, clinical research or governmental/regulatory agencies. Learn more about the Department of Molecular & Cellular Pathology. We transform lives through bold discovery, compassionate care and innovative education. - Diversity, Equity & Inclusion
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Digital Commons @ USF > College of Arts and Sciences > Molecular Biosciences > Theses and Dissertations Molecular Biosciences Theses and DissertationsTheses/dissertations from 2023 2023. Exploring strain variation and bacteriophage predation in the gut microbiome of Ciona robusta , Celine Grace F. Atkinson Distinct Nrf2 Signaling Thresholds Mediate Lung Tumor Initiation and Progression , Janine M. DeBlasi Thermodynamic frustration of TAD2 and PRR contribute to autoinhibition of p53 , Emily Gregory Utilization of Detonation Nanodiamonds: Nanocarrier for Gene Therapy in Non-Small Cell Lung Cancer , Allan E. Gutierrez Role of HLA-DRB1 Fucosylation in Anti-Melanoma Immunity , Daniel K. Lester Targeting BET Proteins Downregulates miR-33a To Promote Synergy with PIM Inhibitors in CMML , Christopher T. Letson Regulated Intramembrane Proteolysis by M82 Peptidases: The Role of PrsS in the Staphylococcus aureus Stress Response , Baylie M. Schott Histone Deacetylase 8 is a Novel Therapeutic Target for Mantle Cell Lymphoma and Preserves Natural Killer Cell Cytotoxic Function , January M. Watters Theses/Dissertations from 2022 2022Regulation of the Heat Shock Response via Lysine Acetyltransferase CBP-1 and in Neurodegenerative Disease in Caenorhabditis elegans , Lindsey N. Barrett Determining the Role of Dendritic Cells During Response to Treatment with Paclitaxel/Anti-TIM-3 , Alycia Gardner Cell-free DNA Methylation Signatures in Cancer Detection and Classification , Jinyong Huang The Role Of Eicosanoid Metabolism in Mammalian Wound Healing and Inflammation , Kenneth D. Maus A Holistic Investigation of Acidosis in Breast Cancer , Bryce Ordway Characterizing the Impact of Postharvest Temperature Stress on Polyphenol Profiles of Red and White-Fruited Strawberry Cultivars , Alyssa N. Smith Theses/Dissertations from 2021 2021Multifaceted Approach to Understanding Acinetobacter baumannii Biofilm Formation and Drug Resistance , Jessie L. Allen Cellular And Molecular Alterations Associated with Ovarian and Renal Cancer Pathophysiology , Ravneet Kaur Chhabra Ecology and diversity of boletes of the southeastern United States , Arian Farid CircREV1 Expression in Triple-Negative Breast Cancer , Meagan P. Horton Microbial Dark Matter: Culturing the Uncultured in Search of Novel Chemotaxonomy , Sarah J. Kennedy The Multifaceted Role of CCAR-1 in the Alternative Splicing and Germline Regulation in Caenorhabditis elegans , Doreen Ikhuva Lugano Unraveling the Role of Novel G5 Peptidase Family Proteins in Virulence and Cell Envelope Biogenesis of Staphylococcus aureus , Stephanie M. Marroquin Cytoplasmic Polyadenylation Element Binding Protein 2 Alternative Splicing Regulates HIF1α During Chronic Hypoxia , Emily M. Mayo Transcriptomic and Functional Investigation of Bacterial Biofilm Formation , Brooke R. Nemec A Functional Characterization of the Omega (ω) subunit of RNA Polymerase in Staphylococcus aureus , Shrushti B. Patil The Role Of Cpeb2 Alternative Splicing In TNBC Metastasis , Shaun C. Stevens Screening Next-generation Fluorine-19 Probe and Preparation of Yeast-derived G Proteins for GPCR Conformation and Dynamics Study , Wenjie Zhao Theses/Dissertations from 2020 2020Understanding the Role of Cereblon in Hematopoiesis Through Structural and Functional Analyses , Afua Adutwumwa Akuffo To Mid-cell and Beyond: Characterizing the Roles of GpsB and YpsA in Cell Division Regulation in Gram-positive Bacteria , Robert S. Brzozowski Spatiotemporal Changes of Microbial Community Assemblages and Functions in the Subsurface , Madison C. Davis New Mechanisms That Regulate DNA Double-Strand Break-Induced Gene Silencing and Genome Integrity , Dante Francis DeAscanis Regulation of the Heat Shock Response and HSF-1 Nuclear Stress Bodies in C. elegans , Andrew Deonarine New Mechanisms that Control FACT Histone Chaperone and Transcription-mediated Genome Stability , Angelo Vincenzo de Vivo Diaz Targeting the ESKAPE Pathogens by Botanical and Microbial Approaches , Emily Dilandro Succession in native groundwater microbial communities in response to effluent wastewater , Chelsea M. Dinon Role of ceramide-1 phosphate in regulation of sphingolipid and eicosanoid metabolism in lung epithelial cells , Brittany A. Dudley Allosteric Control of Proteins: New Methods and Mechanisms , Nalvi Duro Microbial Community Structures in Three Bahamian Blue Holes , Meghan J. Gordon A Novel Intramolecular Interaction in P53 , Fan He The Impact of Myeloid-Mediated Co-Stimulation and Immunosuppression on the Anti-Tumor Efficacy of Adoptive T cell Therapy , Pasquale Patrick Innamarato Investigating Mechanisms of Immune Suppression Secondary to an Inflammatory Microenvironment , Wendy Michelle Kandell Posttranslational Modification and Protein Disorder Regulate Protein-Protein Interactions and DNA Binding Specificity of p53 , Robin Levy Mechanistic and Translational Studies on Skeletal Malignancies , Jeremy McGuire Novel Long Non-Coding RNA CDLINC Promotes NSCLC Progression , Christina J. Moss Genome Maintenance Roles of Polycomb Transcriptional Repressors BMI1 and RNF2 , Anthony Richard Sanchez IV The Ecology and Conservation of an Urban Karst Subterranean Estuary , Robert J. Scharping Biological and Proteomic Characterization of Cornus officinalis on Human 1.1B4 Pancreatic β Cells: Exploring Use for T1D Interventional Application , Arielle E. Tawfik Evaluation of Aging and Genetic Mutation Variants on Tauopathy , Amber M. Tetlow Theses/Dissertations from 2019 2019Investigating the Proteinaceous Regulome of the Acinetobacter baumannii , Leila G. Casella Functional Characterization of the Ovarian Tumor Domain Deubiquitinating Enzyme 6B , Jasmin M. D'Andrea Integrated Molecular Characterization of Lung Adenocarcinoma with Implications for Immunotherapy , Nicholas T. Gimbrone The Role of Secreted Proteases in Regulating Disease Progression in Staphylococcus aureus , Brittney D. Gimza Advanced Proteomic and Epigenetic Characterization of Ethanol-Induced Microglial Activation , Jennifer Guergues Guergues Understanding immunometabolic and suppressive factors that impact cancer development , Rebecca Swearingen Hesterberg Biochemical and Proteomic Approaches to Determine the Impact Level of Each Step of the Supply Chain on Tomato Fruit Quality , Robert T. Madden Enhancing Immunotherapeutic Interventions for Treatment of Chronic Lymphocytic Leukemia , Kamira K. Maharaj Characterization of the Autophagic-Iron Axis in the Pathophysiology of Endometriosis and Epithelial Ovarian Cancers , Stephanie Rockfield Understanding the Influence of the Cancer Microenvironment on Metabolism and Metastasis , Shonagh Russell Modeling of Interaction of Ions with Ether- and Ester-linked Phospholipids , Matthew W. Saunders Novel Insights into the Multifaceted Roles of BLM in the Maintenance of Genome Stability , Vivek M. Shastri Conserved glycine residues control transient helicity and disorder in the cold regulated protein, Cor15a , Oluwakemi Sowemimo A Novel Cytokine Response Modulatory Function of MEK Inhibitors Mediates Therapeutic Efficacy , Mengyu Xie Novel Strategies on Characterizing Biologically Specific Protein-protein Interaction Networks , Bi Zhao Theses/Dissertations from 2018 2018Characterization of the Transcriptional Elongation Factor ELL3 in B cells and Its Role in B-cell Lymphoma Proliferation and Survival , Lou-Ella M.m. Alexander Identification of Regulatory miRNAs Associated with Ethanol-Induced Microglial Activation Using Integrated Proteomic and Transcriptomic Approaches , Brandi Jo Cook Molecular Phylogenetics of Floridian Boletes , Arian Farid MYC Distant Enhancers Underlie Ovarian Cancer Susceptibility at the 8q24.21 Locus , Anxhela Gjyshi Gustafson Quantitative Proteomics to Support Translational Cancer Research , Melissa Hoffman A Systems Chemical Biology Approach for Dissecting Differential Molecular Mechanisms of Action of Clinical Kinase Inhibitors in Lung Cancer , Natalia Junqueira Sumi Investigating the Roles of Fucosylation and Calcium Signaling in Melanoma Invasion , Tyler S. Keeley Synthesis, Oxidation, and Distribution of Polyphenols in Strawberry Fruit During Cold Storage , Katrina E. Kelly Investigation of Alcohol-Induced Changes in Hepatic Histone Modifications Using Mass Spectrometry Based Proteomics , Crystina Leah Kriss Off-Target Based Drug Repurposing Using Systems Pharmacology , Brent M. Kuenzi Investigation of Anemarrhena asphodeloides and its Constituent Timosaponin-AIII as Novel, Naturally Derived Adjunctive Therapeutics for the Treatment of Advanced Pancreatic Cancer , Catherine B. MarElia The Role of Phosphohistidine Phosphatase 1 in Ethanol-induced Liver Injury , Daniel Richard Martin Theses/Dissertations from 2017 2017Changing the Pathobiological Paradigm in Myelodysplastic Syndromes: The NLRP3 Inflammasome Drives the MDS Phenotype , Ashley Basiorka Modeling of Dynamic Allostery in Proteins Enabled by Machine Learning , Mohsen Botlani-Esfahani Uncovering Transcriptional Activators and Targets of HSF-1 in Caenorhabditis elegans , Jessica Brunquell The Role of Sgs1 and Exo1 in the Maintenance of Genome Stability. , Lillian Campos-Doerfler Mechanisms of IKBKE Activation in Cancer , Sridevi Challa Discovering Antibacterial and Anti-Resistance Agents Targeting Multi-Drug Resistant ESKAPE Pathogens , Renee Fleeman Functional Roles of Matrix Metalloproteinases in Bone Metastatic Prostate Cancer , Jeremy S. Frieling Disorder Levels of c-Myb Transactivation Domain Regulate its Binding Affinity to the KIX Domain of CREB Binding Protein , Anusha Poosapati Role of Heat Shock Transcription Factor 1 in Ovarian Cancer Epithelial-Mesenchymal Transition and Drug Sensitivity , Chase David Powell Cell Division Regulation in Staphylococcus aureus , Catherine M. Spanoudis A Novel Approach to the Discovery of Natural Products From Actinobacteria , Rahmy Tawfik Non-classical regulators in Staphylococcus aureus , Andy Weiss Theses/Dissertations from 2016 2016In Vitro and In Vivo Antioxidant Capacity of Synthetic and Natural Polyphenolic Compounds Identified from Strawberry and Fruit Juices , Marvin Abountiolas Quantitative Proteomic Investigation of Disease Models of Type 2 Diabetes , Mark Gabriel Athanason CMG Helicase Assembly and Activation: Regulation by c-Myc through Chromatin Decondensation and Novel Therapeutic Avenues for Cancer Treatment , Victoria Bryant Computational Modeling of Allosteric Stimulation of Nipah Virus Host Binding Protein , Priyanka Dutta Cell Cycle Arrest by TGFß1 is Dependent on the Inhibition of CMG Helicase Assembly and Activation , Brook Samuel Nepon-Sixt Gene Expression Profiling and the Role of HSF1 in Ovarian Cancer in 3D Spheroid Models , Trillitye Paullin VDR-RIPK1 Interaction and its Implications in Cell Death and Cancer Intervention , Waise Quarni Regulation of nAChRs and Stemness by Nicotine and E-cigarettes in NSCLC , Courtney Schaal Targeting Histone Deacetylases in Melanoma and T-cells to Improve Cancer Immunotherapy , Andressa Sodre De Castro Laino Nonreplicative DNA Helicases Involved in Maintaining Genome Stability , Salahuddin Syed Advanced Search - Email Notifications and RSS
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Home | About | Help | My Account | Accessibility Statement | Language and Diversity Statements Privacy Copyright Department of Molecular Biology![molecular biology phd topics Home](https://molbio.princeton.edu/sites/g/files/toruqf5546/files/MolBio_OrangeBlackGray60-transparent-bg.png) MolBio Scholars ProgramThe Application Portal Opens: April 26, 2024 Apply now... Application Deadline: June 15, 2024 The Princeton Molecular Biology graduate program invites prospective students interested in graduate training in molecular and cellular biology to participate in the MolBio Scholars program. Scholars will participate in a fully funded visit to the beautiful Princeton campus to learn more about graduate admissions, interact with Molecular Biology faculty, postdocs, and graduate students, and attend the departmental retreat. The Department of Molecular Biology is committed to increasing the participation of students with exceptional ability and promise. Students who will bring a diversity of viewpoints and cultures to the sciences, and who have demonstrated interest and passion for research in the broad field of Molecular and Cellular Biology, are invited to apply for and be appointed as a 2024 MolBio Scholar. Application Deadline is June 15, 2024 ![molecular biology phd topics See caption.](https://molbio.princeton.edu/sites/g/files/toruqf5546/files/styles/freeform_1440w/public/2024-04/2022%20MolBio%20Scholars-DSCF3527.png?itok=kRruZes4) 2022 MolBio Scholars: (l-r) Amy Wuwu, Lance Li, Spencer Danner-Bocks, Peyton Carpen, Shukuru Rushanika, Nivitha Murali, Rafaella Shima, Kirsten Underwood, and Cayetana Lazcano Etchebarne. Program OutlineScholars will arrive on September 26th and depart on September 29th. Scholars will attend workshops on the process of applying to and interviewing for graduate school, resources available to our graduate students, as well as participate in the annual Department of Molecular Biology retreat. At the retreat, graduate students and postdocs from each lab in the department highlight their recent research. MolBio Scholars will also be given the opportunity to present a poster on their prior research, as well as to engage in informal and formal networking interactions with MolBio faculty and graduate students. It is a great way to preview Princeton and the department and gain insights into the process of applying to graduate school. EligibilityScholars will be selected from a competitive national applicant pool of junior and senior undergraduates. U.S. citizens or permanent residents currently enrolled in U.S. colleges or universities (including U.S. territories, Guam and Puerto Rico). Eligible applicants should hold an academic status of junior, senior or postbaccalaureate scholar by September 2024. We strongly encourage applications from Minority Serving Institutions such as Historically Black Colleges and Universities or Hispanic Serving Institution. Application Requirements- Transcripts
- 2 Letters of Recommendation. List two people who will write letters of recommendation in support of your application. Letters should be sent directly to [email protected] .
- Personal/Professional Statement
MolBio Scholars Program FAQFor the online application it is acceptable to submit an unofficial transcript. Those individuals moving into the final stages of the selection process will be asked to submit an official copy. No. The MolBio Scholars staff will arrange to pay for your airfare or train transportation directly. You may need to pay for transportation to and from the airport, but you will be reimbursed for those expenses. Dress is business casual/comfortable. No. This program is tied to our Departmental Retreat, so we are not able to offer alternative dates. Either Newark International Airport (EWR) or Philadelphia (PHL) is fine, with Newark slightly more convenient. Many NJ Transit trains on the Northeast Corridor line leave from Newark Airport and stop at Princeton Junction, where you can transfer to the "Dinky" Princeton line to get to campus. Send your inquiry to: [email protected] MolBio Scholars ArchiveSee MolBio Scholars of prior years, their undergraduate institution, and who ultimately joined the department. Note that admission offers were made to more students than accepted. (They had other good choices!) Peyton Carpen Cornell University, class of 2023 Major: Biology and Society Spencer Danner-Bocks University of Nevada, Reno, class of 2020 Major: Biotechnology Cayetana Lazcano Etchebarne University of Puerto Rico, Río Piedras, class of 2020 Major: Cellular and Molecular Biology Nivitha Murali RV College of Engineering, class of 2019 Major: Biotechnology Shukuru Rushanika University of Northern Colorado, class of 2023 Major: Biology/Biological Sciences Rafaella Shima Earlham College, class of 2021 Major: Biochemistry Kirsten Underwood Danielle Bolton George Washington University, class of 2019 Major: Biology Admitted: Fall 2021 Carlos Escoto-Diaz Winthrop College, class of 2022 Major: Biology ![molecular biology phd topics See caption.](https://molbio.princeton.edu/sites/g/files/toruqf5546/files/styles/freeform_1440w/public/2024-04/2020%20MolBio%20Scholars%20collage.png?itok=lhg_DtPZ) 2020 MolBio Scholars: (l-r, top-bottom) Isaac Chizhik, Elizabeth Dolbeck, Garrett Freeman, Daniel Groso, Seraya Jones, Sidney Martin, Claudia Melo-Perez, Alexis Moody, Christian Lagares-Linares, Monique Porter, Celeste Rodriguez, Alexandra Salazar, Austre Schiaffino, Shanaika Vargas, and Hannah Wilkins. Isaac Chizhik William Jewel College, class of 2020 Major: Molecular Biology Elizabeth Dolbeck University of Arizona, class of 2020 Major: Molecular and Cell Biology Garrett Freeman University of Maryland, Baltimore, class of 2020 Major: Biochemistry Daniel Groso University of Florida, class of 2021 Major: Biology Seraya Jones Grambling State University, class of 2020 Major: Biological Sciences Admitted: Fall 2020 Sidney Martin University of Alabama in Huntsville, class of 2021 Major: Biology and Chemistry Claudia Melo-Perez Brooklyn College, class of 2020 Major: Biology and Chemistry Alexis Moody Hampton University, class of 2020 Major: Biology Christian Lagares-Linares University of Puerto Rico, Cayey, class of 2020 Major: Natural Sciences Monique Porter Pennsylvania State University, class of 2020 Major: Microbiology Celeste Rodriguez Brown University, class of 2020 Major: Biochemistry and Molecular Biology Admitted: Fall 2020 Alexandra Salazar San Jose State University, class of 2020 Major: Molecular Biology Austre Schiaffino University of Texas at El Paso, class of 2020 Major: Cell and Molecular Biochemistry Shanaika Vargas Interamerican University of Puerto Rico, Aguadilla, class of 2020 Major: Biotechnology Hannah Wilkins University of North Carolina, Chapel Hill, class of 2020 Major: Biology and Hispanic Literature Original PDF directory with this information. ![molecular biology phd topics See caption.](https://molbio.princeton.edu/sites/g/files/toruqf5546/files/styles/freeform_1440w/public/2024-04/2019-MolBio-Scholars-group%20photo.png?itok=SniDRZVI) 2019 MolBio Scholars: (clockwise from bottom left) Jonathan Kepple, Adriana Velez, Oscar Molina, Shania Sanchez, Andrea Valenzuela, Arianna Broad, Gabriel Romero, and Julie Kiss. Arianna Broad Florida State University, class of 2020 Major: Biological Sciences Nora Gilliam Indiana University-Purdue, class of 2021 Major: Chemistry Jonathan Kepple University of Texas at San Antonio, class of 2018 Major: Microbiology and Immunology Julie Kiss, BS John Jay College, class of 2017 Major: Cellular and Molecular Biology Oscar Molina University of California, Los Angeles, class of 2020 Major: Biochemistry Andrew Palacios Columbia University, class of 2020 Major: Chemical Engineering Gabriel Romero University of Puerto Rico, Cayey, class of 2021 Major: Biology Shania Sanchez University of New Mexico, class of 2020 Major: Biology Andrea Valenzuela Northeastern Illinois University, class of 2019 Major: Chemistry Adriana Velez University of Puerto Rico, Rio Peidras, class of 2020 Major: Cellular and Molecular Biology ![molecular biology phd topics See caption.](https://molbio.princeton.edu/sites/g/files/toruqf5546/files/styles/freeform_1440w/public/2024-04/2018-MolBio-Scholars-group%20photob_0.png?itok=8xRCw7zh) 2018 MolBio Scholars: (front row) Karina Flores, Jayme Jackson, Rachel Steckbeck, Brianna Marsh, (second row) Brandon Trejo, Yohaniz Ortega, Anaya Ferris, Ciara Hosea, Antonio Serrano, (third row) Alexys Riddick, Vanessa Gonzalez, Lizett Gonzalez, (back row) Jacob Marogi, Kenneth Martinez, Dezmond Cole, Irving Estevez. Alexys Riddick North Carolina A&T, class of 2019 Major: Chemistry Anaya Ferris University of the Virgin Islands, class of 2019 Major: Biology Antonio Serrano Northern New Mexico College, class of 2020 Major: Biology Brandon Trejo UCLA, class of 2019 Major: Molecular and Cell Biology Admitted: Fall 2019 Brianna Marsh University of Kansas, class of 2019 Major: Neurosciences Ciara Hosea, BS Kennesaw University, class of 2018 Major: Biology Dezmond Cole University of Montevallo, class of 2019 Major: Biology Irving Estevez, BS City College of New York, class of 2018 Major: Biology Jacob Marogi Gettysburg College, class of 2019 Major: Biochemistry Admitted: Fall 2019 Jayme Jackson University of Arizona, class of 2019 Major: Microbiology Karina Flores University of Oklahoma, class of 2020 Major: Biology Kenneth Martinez University of Puerto Rico, Cayey, class of 2020 Major: Biology Lizett Gonzalez, BS California State University, Dominguez Hills, class of 2019 Major: Biology Rachel Steckbeck Messiah College, class of 2020 Major: Molecular Biology Vanessa Gonzalez Johnbs Hopkins University, class of 2019 Major: Cell Biology Admitted: Fall 2019 Yohaniz Ortega University of Puerto Rico, Humacao, class of 2019 Major: Industrial Chemistry ![molecular biology phd topics See caption.](https://molbio.princeton.edu/sites/g/files/toruqf5546/files/styles/freeform_1440w/public/2024-04/2017-MolBio-Scholars-group%20photob.png?itok=JBF8vy-v) 2017 MolBio Scholars: (clockwise from bottom left) Grace Jean, Zakiyah Henry, Dylan Maghini, George Walters-Marrah, Jorge Moreno, Alex Frese, Kelcee Everett, Breanna Titchen, and Olivia Gorushi. Kelcee Everett Johns Hopkins University, class of 2018 Major: Bioengineering Zakiya Henry Winston Salem State University, class of 2019 Major: Biology Jorge Moreno University of Iowa, class of 2018 Major: Genetics and Evolution Admitted: Fall 2018 Alex Frese Arizona State University, class of 2018 Major: Microbiology and Computational Biology Admitted: Fall 2018 Grace Jean University of Miami, class of 2018 Major: Biology Breanna Titchen Gettysburg College, class of 2018 Major: Biochemistry and Molecular Biology Olivia Gorushi University of Arizona, class of 2018 Major: Microbiology Dylan Maghini Davidson College, class of 2018 Major: Bioinformatics George Walters-Marrah University of Central Florida, class of 2019 Major: Molecular Biology and Biotechnology Related links- New Initiative Brings Prospective Doctoral Students to Campus
Ready to start planning your care? Call us at 800-525-2225 to make an appointment. RNA Biology, Stem Cells, and Cancer: At Work with MSK’s Michael KharasBy Matthew Tontonoz Wednesday, June 5, 2024 ![molecular biology phd topics Michael Kharas](https://www.mskcc.org/sites/default/files/styles/large/public/node/303356/main_image/210210-km-keshari_kharas-12-12x8.jpg) Dr. Michael Kharas's research into RNA biology is shedding new light on leukemia and other cancers. “The blueprint of life.” “The genetic code.” The metaphors we used to describe DNA make it sound almost sacred. Proteins, too, are revered. They are the “workhorses of the cell.” They make things happen. RNA, by contrast, has not been so exalted. It is simply “the messenger,” a humble scribe relaying information from the nucleus, where DNA lives, to the cytoplasm, where proteins are made. Transcription is the process of making a messenger RNA copy of a DNA sequence. It occurs in the cell nucleus. Translation is the process of making a protein using the messenger RNA sequence in the cytoplasm. It occurs in the cell cytoplasm. This popular textbook picture doesn’t tell the whole story, says Michael Kharas, PhD , a member of the Molecular Pharmacology Program in the Sloan Kettering Institute at Memorial Sloan Kettering Cancer Center (MSK), whose current work focuses on RNA biology, stem cells, and cancer. “One of the quickest and most effective ways to change a cell’s fate is by altering which RNAs get translated into protein,” he says. “That makes RNA, and the proteins that bind to it, an attractive target for potential drugs to treat cancer.” RNA as a Link Between Leukemia and Blood Stem CellsWhile today Dr. Kharas is fascinated by RNA biology, he didn’t start his career being interested in it. That’s just where his scientific journey led him. It began with his postdoctoral training at Harvard Medical School in the mid-2000s. Scientists were increasingly intrigued by a connection between cancer and stem cells — those perpetually youthful cells that divide repeatedly to replenish our tissues. His advisor and others had found that certain aggressive cancers appear to mimic the traits of stem cells — like being able to divide indefinitely. Dr. Kharas was already familiar with one such aggressive cancer from his PhD work on leukemia , a type of blood cancer. That led him to wonder: might leukemia cells have something in common with the stem cells that make blood? To answer that question, Dr. Kharas began comparing the genes that were active — that is, being transcribed and translated into protein — in both leukemia and blood-forming stem cells. He was looking specifically for proteins that were more abundant in both the stem cells and the cancer cells when compared with normal blood cells. “That’s when we found Musashi,” he says. Musashi: A Cell Fate Samurai![molecular biology phd topics An ukiyo-e of Miyamoto Musashi and Tsukahara Bokuden](https://www.mskcc.org/sites/default/files/node/303356/inline_images/1024px-musashi_vs.bokuden.jpg) A nineteenth-century illustration showing Miyamoto Musashi, left, fighting with wooden swords against an opponent. Image: Public domain via Wikimedia Commons Musashi is a protein that binds to RNA. Like all RNA-binding proteins, Musashi’s role is to regulate what happens to the messenger RNA transcript once it’s been copied from DNA — for example, whether it is translated into protein, spliced into different forms, or degraded. The name Musashi comes from a mutant fly with two bristles instead of one and in that sense resembles the famous Japanese samurai who fought with two swords. (Fruit fly researchers have tended to name genes more colorfully than in other parts of science.) When Dr. Kharas compared the two cell types, he found that both leukemia cells and blood-forming stem cells had lots and lots of the Musashi protein. That was the first clue that it was doing something important. To find out what exactly it was doing, Dr. Kharas and his colleagues performed additional experiments to ask what would happen if they changed the amount of the Musashi protein present in the two types of cells. The results were dramatic: lowering the amount of Musashi in blood stem cells reduced their ability to make new blood cells, while raising the amount of Musashi in blood stem cells led to an aggressive leukemia. In leukemia cells, lowering the amount of Musashi led to decreased cell growth and division, while raising it made the cancer cells more aggressive. What’s more, the results of these laboratory experiments mirrored what was happening in patients. The amount of Musashi present in leukemia cells from patients correlated with patient survival. The more Musashi, the worse the survival. Dr. Kharas’s conclusion was that Musashi is part of the normal process that determines the fate of a blood-forming stem cell — instructing it to either remain a stem cell or to start differentiating into a blood cell. He also concluded that leukemia cells rely on Musashi to become more like stem cells and therefore more aggressive. And how was Musashi was doing all this? Simply by regulating which RNAs get translated into proteins and which do not. Potential Drugs to Halt Leukemia ProgressionThese days, people are much more aware of the power of manipulating RNA for therapeutic effect. The COVID vaccines were based on RNA, for example. But back when Dr. Kharas got hooked on RNA biology, scientists were just starting to become interested in it. “This was a space that at that time was just really emerging,” he says. “It’s really exploded in the last few years.” Since his initial discovery of Musashi’s role in leukemia, he’s been exploring the network of processes that Musashi is a part of. It’s been an especially rich vein to mine. Targeting IKZF2 and CK1α Proteins To Treat Leukemia in MiceMost recently, he and his team collaborated with researchers at Harvard to develop drugs that can degrade one of Musashi’s main accomplices, IKZF2, and another leukemia-associated protein called CK1a. These proteins are necessary for leukemia progression, and degrading them with drugs can arrest leukemia progression in laboratory mice. The drugs aren’t yet approved for use in people, but the team is working to develop versions that might one day be used in the clinic. Targeting RNA methylation in cancerThey’ve also been exploring the wider world of RNA biology, unrelated to Musashi. Along with Samie Jaffrey, MD, PhD at Weill Cornell Medicine, Dr. Kharas and his team were among the first to show that RNA methylation is important in cancer . Methylation is the process whereby cells add small molecules, called methyl groups, to other molecules. Like DNA methylation, RNA methylation is a powerful way to control what genes get translated into proteins. Dr. Kharas found that the machinery that methylates RNAs is ramped up in leukemia. Drugs that target the RNA methylation machinery in cancer cells are now in phase 1 clinical trials. MSK’s Leadership in RNA Biology ResearchKharas credits MSK with providing the kind of collaborative and supportive environment necessary for scientists to conduct world-class research. “Everyone here is mission-driven and curious,” Dr. Kharas says. “The competition we feel isn’t with each other. It’s more about competing with the world, trying to drive the important scientific questions as leaders in the field. People look to us to be the role models of doing science in the best possible way.” As for Musashi, there is still plenty to learn, Kharas says, but he expects that new technologies coming down the pike will allow them to take RNA biology to the next level. He adds: “It’s been an adventure and I’m excited to see what happens next.” Biochemistry and Molecular Biology Biostatistics Environmental Health and Engineering Epidemiology Health Policy and Management Health, Behavior and Society International Health Mental Health Molecular Microbiology and Immunology Population, Family and Reproductive Health - Program Finder
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Master of Science in Public Health (MSPH)The Master of Science in Public Health (MSPH) is a professional degree alternative to the Master of Public Health (MPH) degree for students who want more focused skills in a specific field of public health or who lack two years of health-related work experience to begin or advance a career as a public health professional. MSPH programs generally require one academic year of coursework, followed by a field placement. The field placement duration and location vary by department/concentration. ![molecular biology phd topics johns hopkins msph class](https://publichealth.jhu.edu/sites/default/files/styles/image_component/public/2023-12/50-50-msph2022.jpg?h=ca6532a2&itok=s70_6tL2) Why Choose the Johns Hopkins Bloomberg School of Public Health?Ranked by U.S. News & World Report since 1994 and Largest School of Public Health Courses Offered Research Centers and Institutes Alumni Living in over 160 Countries Degree Programs Certificate Programs Student-to-Primary-Faculty Ratio Our DepartmentsMeet our faculty. Our faculty are world-renowned experts, and trusted advisers to our students, public health leaders, and the public. ![Kellogg Schwab Kellogg Schwab](https://publichealth.jhu.edu/sites/default/files/styles/people_card_360/public/images/813.jpg?h=ea95bb15&itok=hxIgb8w6) Kellogg J. SchwabKellogg Schwab, PhD, integrates engineering, public health, and human behavior by researching water and wastewater contaminants of public health concern. ![Maria Knoll Maria Knoll](https://publichealth.jhu.edu/sites/default/files/styles/people_card_360/public/images/69.jpg?h=e139969c&itok=vMP-7ctL) Maria Deloria KnollMaria Deloria Knoll, PhD ’00, is an epidemiologist who conducts policy-driven studies and evidence synthesis evaluating vaccine performace and vaccine-preventable diseases. ![Amrita Rao Amrita Rao](https://publichealth.jhu.edu/sites/default/files/styles/people_card_360/public/images/4433.jpg?h=b9d22d3e&itok=JHi2isFA) Amrita Rao, PhD ’22, ScM '16, works to understand and address the HIV prevention and treatment needs of historically marginalized populations, including sexual and gender minorities and female sex workers. ![Subhra Chakraborty Subhra Chakraborty](https://publichealth.jhu.edu/sites/default/files/styles/people_card_360/public/images/2148.jpg?h=8f0b2d98&itok=rvx5WyWX) Subhra ChakrabortySubhra Chakraborty, PhD, MPH ’13, MSc, leads research to eliminate mortality and reduce morbidity due to infectious diseases by using improved diagnostics, epidemiology, and vaccines. Join Us in BaltimorePursue a degree at the #1 school of public health in one of America's best cities. With 50+ museums, a bustling restaurant scene, gorgeous parks, and more, Baltimore is a great place to study and live. LEARN ABOUT BALTIMORE Support Our WorkOur work is made possible in part by contributions from Bloomberg School donors. ![molecular biology phd topics The University of Arizona](https://mcb.arizona.edu/sites/default/files/ua-logo2-2x_0.png) ![molecular biology phd topics Twitter](https://mcb.arizona.edu/sites/default/files/facebook_003.png) - Diversity, Equity and Inclusion
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You are hereGraduate student award for teaching: mollie wiegand. ![molecular biology phd topics](https://mcb.arizona.edu/sites/default/files/styles/small_image/public/mollie_wiegand_2.jpeg?itok=KwckPheS) The 2024 Graduate Award for Teaching is Mollie Wiegand! Mollie completed her undergraduate degree at the University of Arizona from 2014-2018, with a major in Veterinary Science and a minor in Molecular and Cellular Biology. She started her PhD in the fall of 2019 and is doing her research in the Charest lab. This is how Mollie explained her research to me - “Our lab previously identified an interaction between the small GTPase RAS and the signaling complex mTORC2 in the model organism Dictyostelium, which is often used to study cell migration processes. I helped finish a follow-up project demonstrating that RAS and mTORC2 each mediate cell migration processes in a normal breast epithelial cell line and breast cancer cell lines, and that perturbations to RAS activity in these systems indicate that RAS facilitates mTORC2 activity in these human cell lines as well. I am currently working to establish a system in the normal breast epithelial cell line to determine whether wildtype and mutant RAS affect different subcellular pools of mTORC2 activity, and how dependent these different pools might be on another protein called PI3K. Understanding the basic interactions between these proteins in human cells may also lead to a better understanding of cancer cell signaling and metastatic processes. RAS and PI3K are considered proto-oncogenes, and mTORC2's role in cell migration implicates it in cancer metastasis.” Clearly, Mollie has a passion for teaching which is also recognized by the faculty in MCB. Preceptoring for Dr. Susan Jorstad's MCB181 classes as an undergraduate was the first place that she felt like she belonged to a community during her undergraduate times. “I love helping students build their own mental frameworks to understand and remember information. Dr. Jorstad encouraged us to never give students the answer, but to ask guiding questions that would help them build such a personally useful framework.” Mollie also likes it when she has been able to share and pass on some excitement about the material itself - “when I'm in this excited mode I find myself referring to different proteins as "this guy" - it's like they're my friends or something!” Teaching runs in the family. Mollie’s mom was an elementary school teacher and librarian, helped write the educational curriculum for Kartchner Caverns State Park, and wrote grants for artists to visit her small-town school. “There is probably some modeling and love for education passed on there.” Mollie said. Mollie has secured quite a bit of teaching experience in MCB. “I preceptored for Dr. Jorstad's MCB181 four semesters as an undergraduate, TA'd with Dr. Charest for MCB325 Biology of Cancer three semesters, TA'd with Dr. Joyce Schroeder for MCB425 Cancer Discoveries one semester, and TA'd with Dr. Nicole Leitner for MCB181 one semester.” Some PhD students have a clear vision of their post-graduation plans, while others are still exploring their options. Mollie finds herself in the latter group, facing some uncertainty about her future academic career. Ideally, she aspires to become a professor and teach one day. However, her immediate goal is to dedicate more time to her own research and enhance her wet lab skills. By focusing on these areas, she hopes to successfully graduate and pursue a research-focused postdoctoral position. Mollie chose UArizona because it offered the right balance for her transition from a small town to a larger city and university. Growing up near Benson, she wanted to give herself time to adjust to the new environment. Although she once considered becoming a veterinarian and helping run her family's ranch in Cochise, her passion for research, especially in Cancer Biology, guided her towards a different path. The prospect of such a significant change was daunting, but UArizona provided a manageable step forward. Mollie decided to pursue a PhD in Molecular and Cellular Biology (MCB) because of Dr. Charest's presence in the department, her involvement with the MCB community as an undergraduate, and her finding inspiration to pursue research in Dr. Schroeder's Cancer Discoveries course as an undergraduate. We are excited about what the future holds for Mollie, and are sure that whether she ends up teaching, doing research or becoming a veterinarian, she will do it with passion and compassion! - The Student Experience
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Search formMichael d. cole, professor of molecular and systems biology. Our studies that focus on the genetic events involved in the induction of cancer provide an opportunity to define the molecular basis of the disease and to study the regulation and function of important eukaryotic genes that control cell proliferation. CMB Committees: 2024-2025Coordinating committee , faculty committee chairs. - CMB Program Chair: David Wassarman
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Faculty Focus Group Chairs- Cancer Biology: Caroline Alexander
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Student Coordinating Committee Members- Rachel Kirchner (MD/PhD representative)
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- Sutichot (Dex) Nimkulrat
- Nicole West
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Introduction. Molecular Biology is a branch of biology that deals with the composition, structure, and communications of cellular molecules like proteins and nucleic acids responsible for various biological procedures for maintaining and functioning cells. It mainly involves multiple biomolecules such as amino acids, lipids, proteins, nucleic ...
In the Biochemistry and Molecular Biology PhD program, faculty, and students work together to increase knowledge of the biochemical and molecular bases of normal and abnormal cellular processes. Our program trains students to be successful independent scientists and gives them the knowledge, research training, and leadership skills to continue ...
As a PhD student in Molecular Biology, you'll develop extensive laboratory skills including DNA sequencing, expression cloning, gene knockout, and DNA or protein arrays. Your understanding of the range of techniques available to you will continually improve as you'll read the latest publications in the field. Some typical research topics in ...
Research Areas. Biochemistry, Biophysics & Structural Biology. Biochemistry and Biophysics are the foundation of all cellular processes and systems. Biochemical processes account for the functions of cellular building blocks, from nucleic acids and proteins to lipids and metabolites, and the formation of complex networks that make a cell or ...
The overall objective of the Human Genetics program is to provide our students with a strong foundation in basic science by exposure to a rigorous graduate education in genetics, genomics, molecular biology, cell biology, biochemistry and biostatistics as well as a core of medically-related courses selected to provide knowledge of human biology in health and disease.
The Molecules, Cells, and Organisms PhD program in the Department of Molecular and Cellular Biology provides a view of the broad range of the constantly evolving world of scientific experience. In this interdisciplinary program, you will interact with students and faculty who have diverse backgrounds in chemistry, marine biology, computational ...
The molecular biology department at Princeton is a tightly knit, cohesive group of scientists that includes undergraduate and graduate students, postdoctoral fellows, and faculty with diverse but overlapping interests. Graduate students have a wide choice of advisers, with a broad spectrum of interdisciplinary interests and research objectives.
Research in the Department of Molecular, Cellular, & Developmental Biology spans biology from the organismal to the molecular levels. Topics in genetics and molecular biology include studies of non-coding RNAs, genome engineering, genome organization and regulation, gene dosage, bacterial chemotaxis, oncogenes, and systems and synthetic biology. Research topics in cellular and developmental ...
The track has three areas of specialty: Biochemistry and Structural Biology, Cancer Biology, and Cell Biology and Genetics. This track also holds the largest faculty and student population of any Mayo Clinic Graduate School of Biomedical Sciences track, with more than 100 faculty members and more than 40 students. John Hawse, Ph.D.
Potential research topics include structural biology, signal transduction, drug development, regulation of gene expression, cancer biology and metabolic disorders. ... G852, G825, G826, G848) along with other courses required of IBMG and Biochemistry and Molecular Biology PhD students (GRDM-G505, G655, G855, BIOC-B803 and B890 [4x]). Thesis ...
The CMB Program has been an integrative force that aims to tie together the various disciplines of genetics, biochemistry, microbiology, immunology, cell biology and others. The goal of CMB is to train our students to examine scientific problems from many perspectives through individualized, flexible programs of coursework and research. Apply ...
ADDRESS. Molecular Biology Graduate Program at UCLA. 172 Boyer Hall. 611 Charles E. Young Drive East. Box 951570. Los Angeles, CA 90095-1570.
Molecular biology articles from across Nature Portfolio. Molecular Biology is the field of biology that studies the composition, structure and interactions of cellular molecules such as nucleic ...
The program places special emphasis on modern approaches within three core and interrelated areas listed below. The research conducted under the Tetrad umbrella encompasses a wide range of structural, molecular, cellular, physiological, and pathophysiological questions. The Tetrad program was among the first graduate programs nationwide to ...
Coursework. First year course work includes: MCB 291A-B (rotations), MCB 293A (FERPs), MCB 293C (Ethical conduct of research), Fundamentals of Molecular and Cell Biology (MCB 200A-200B) and two Advanced Topics courses. All courses must be completed with a grade of B or better. Courses required by the department are marked below with a plus (+).
This four-year Molecular Cell Biology PhD programme at the Laboratory for Molecular Cell Biology (LMCB) provides a broad in-depth training in molecular cell biology and fundamental aspects of biomedical science. The programme provides students with the opportunity to carry out cutting-edge research in an internationally renown environment.
Class of 2016. Molecular and Cellular Approaches Toward Understanding Dynein-Driven Motility - Swathi Ayloo, Ph.D. Cell Biology of Cheating - Mechanisms of Chromosomes Segregation during Female Meiosis - Lukas Chmatal, Ph.D. Detecting Selection on Noncoding Nucleotide Variations: Methods and Applications - Yang Ding, Ph.D.
The Molecular Biology Program is dedicated to providing rigorous training to its students in a supportive environment. Molecular Biology faculty are members of many different departments and are applying the techniques of molecular biology to answer questions in diverse areas. ... Comp. biology class aimed at biology PhD students. Topics ...
The Cell, Molecular and Cancer Biology PhD program is an interdisciplinary graduate program that involves faculty researchers from multiple departments on the Indiana University School of Medicine—Bloomington campus. The emphasis of the program is on the fundamental molecular and cellular mechanisms that lead to the proliferative growth associated with cancer.
For help with this page, contact Office of the Registrar at [email protected] . Purdue University. Jun 07, 2024. 2024-2025 University Catalog. Whole Word/Phrase. Catalog Navigation. Catalog Home. Purdue University In Indianapolis. Programs Lists.
Senior Academic Program Coordinator. [email protected]. The 5-year PhD program allows students to focus on the cellular and molecular mechanisms that drive infectious and immune diseases, the opportunity to take courses focused on a specific research area, and to benefit from lab rotations, mentored research, and professional development.
The mission of the Molecular and Cellular Pathology (MCP) Graduate Program is to train the next generation of "Bench to Bedside" scientists with a focus on the study of the molecular and cellular mechanisms underlying the pathogenesis of human diseases. Inaugurated in 1992, the MCP program is hosted by the Department of Pathology and takes ...
Theses/Dissertations from 2022. PDF. Regulation of the Heat Shock Response via Lysine Acetyltransferase CBP-1 and in Neurodegenerative Disease in Caenorhabditis elegans, Lindsey N. Barrett. PDF. Determining the Role of Dendritic Cells During Response to Treatment with Paclitaxel/Anti-TIM-3, Alycia Gardner. PDF.
Professor of Molecular and Systems Biology; Chair of Biomedical Data Sciences; ... Information about the services available to Dartmouth's graduate students. Graduate Student Services. Close. People Program Administrator Janet Cheney [email protected] 603-646-5201. Find Us Address .
Program Outline. Scholars will arrive on September 26th and depart on September 29th. Scholars will attend workshops on the process of applying to and interviewing for graduate school, resources available to our graduate students, as well as participate in the annual Department of Molecular Biology retreat. At the retreat, graduate students and ...
This popular textbook picture doesn't tell the whole story, says Michael Kharas, PhD, a member of the Molecular Pharmacology Program in the Sloan Kettering Institute at Memorial Sloan Kettering Cancer Center (MSK), whose current work focuses on RNA biology, stem cells, and cancer. "One of the quickest and most effective ways to change a cell's fate is by altering which RNAs get ...
The Master of Public Health (MPH) is our most flexible degree. With 12 concentrations to choose from, students can tailor their degree to their unique goals while completing classes at their own pace on campus, fully online, or a mix of the two. We are accepting applications for the online/part-time format starting in November 2024 or January 2025.
The 2024 Graduate Award for Teaching is Mollie Wiegand! Mollie completed her undergraduate degree at the University of Arizona from 2014-2018, with a major in Veterinary Science and a minor in Molecular and Cellular Biology. She started her PhD in the fall of 2019 and is doing her research in the Charest lab.
Professor of Molecular and Systems Biology. ... Information about the services available to Dartmouth's graduate students. Graduate Student Services. Close. People Program Administrator Janet Cheney [email protected] 603-646-5201. Find Us Address . 7560 Kellogg Hall, Room 119
Virology: Paul Ahlquist. Student Coordinating Committee Members. Rachel Kirchner (MD/PhD representative) Lainy Von Bank. Sutichot (Dex) Nimkulrat. Nicole West. Coordinating Committee Faculty Committee Chairs CMB Program Chair: David Wassarman CQCI Chair: Kevin Eliceiri Admissions Committee Chair: Daniela Drummond-Barbosa Advising & Orientation ...