lancet oncology research in context

The International Collaboration for Research methods Development in Oncology (CReDO) workshops: shaping the future of global oncology research

Affiliations.

• 1 Department of Anaesthesiology, Critical Care and Pain, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, Maharashtra, India. Electronic address: [email protected].
• 2 Division of Paediatric Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, Maharashtra, India.
• 3 Department of Medical Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, Maharashtra, India.
• 4 Research Administration Council, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, Maharashtra, India.
• 5 Department of Head and Neck Surgical Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, Maharashtra, India.
• 6 Indian Council of Medical Research, New Delhi, India.
• 7 Departments of Oncology and Public Health Sciences, Queen's University, Kingston, ON, Canada.
• 8 International Drug Development Institute, Louvain-la-Neuve, Belgium; Data Science Institute, Hasselt University, Diepenbeek, Belgium.
• 9 Tata Trusts, Mumbai, India.
• 10 Departments of Medicine and Psychological Medicine, University of Otago, Christchurch, New Zealand.
• 11 Center for Global Health, National Cancer Institute, Rockville, MD, USA.
• 12 Cancer Research UK, London, UK.
• 13 Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA.
• 14 Medical Research Council Clinical Trials Unit at University College London, London, UK.
• 15 National Centre for Disease Informatics and Research, Bengaluru, India.
• 16 University of Versailles Saint-Quentin-en-Yvelines, Versailles, France; Department of Biostatistics, Institut Curie, Saint-Cloud, France; Department of Statistics for Precision Medicine, INSERM U900, Paris, France.
• 17 School of Cancer and Pharmaceutical Sciences, King's College London, London, UK.
• 18 American Society of Clinical Oncology, Alexandria, VA, USA.
• 19 US Department of Health and Human Services, Washington, DC, USA; US Embassy, New Delhi, India.
• 20 NHMRC Clinical Trials Centre, University of Sydney, Sydney, NSW, Australia.
• 21 Institute of Cancer Policy, King's College London, London, UK.
• 22 World Health Organization, Geneva, Switzerland.
• 23 Division of Medical Oncology, Princess Margaret Cancer Centre and University of Toronto, Toronto, ON, Canada.
• 24 Office of the Director, National Cancer Institute, NIH, US Department of Health and Human Services, Washington, DC, USA.
• 25 Departments of Administration and Surgical Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, Maharashtra, India.
• PMID: 34216541
• PMCID: PMC8328959
• DOI: 10.1016/S1470-2045(21)00077-2

Low-income and middle-income countries (LMICs) have a disproportionately high burden of cancer and cancer mortality. The unique barriers to optimum cancer care in these regions necessitate context-specific research. The conduct of research in LMICs has several challenges, not least of which is a paucity of formal training in research methods. Building capacity by training early career researchers is essential to improve research output and cancer outcomes in LMICs. The International Collaboration for Research methods Development in Oncology (CReDO) workshop is an initiative by the Tata Memorial Centre and the National Cancer Grid of India to address gaps in research training and increase capacity in oncology research. Since 2015, there have been five CReDO workshops, which have trained more than 250 oncologists from India and other countries in clinical research methods and protocol development. Participants from all oncology and allied fields were represented at these workshops. Protocols developed included clinical trials, comparative effectiveness studies, health services research, and observational studies, and many of these protocols were particularly relevant to cancer management in LMICs. A follow-up of these participants in 2020 elicited an 88% response rate and showed that 42% of participants had made progress with their CReDO protocols, and 73% had initiated other research protocols and published papers. In this Policy Review, we describe the challenges to research in LMICs, as well as the evolution, structure, and impact of CReDO and other similar workshops on global oncology research.

Copyright © 2021 Elsevier Ltd. All rights reserved.

Publication types

• Research Support, N.I.H., Extramural
• Research Support, N.I.H., Intramural
• Research Support, Non-U.S. Gov't
• Capacity Building
• Developing Countries
• Health Services Research*
• Medical Oncology / education*

Grants and funding

• 001/WHO_/World Health Organization/International
• 15015/CRUK_/Cancer Research UK/United Kingdom
• MC_UU_00004/02/MRC_/Medical Research Council/United Kingdom
• Z99 CA999999/ImNIH/Intramural NIH HHS/United States

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Recent advances in lung cancer research: unravelling the future of treatment

• Review Article
• Published: 06 April 2024

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• Luca Bertolaccini   ORCID: orcid.org/0000-0002-1153-3334 1 ,
• Monica Casiraghi 1 , 2 ,
• Clarissa Uslenghi 1 ,
• Sebastiano Maiorca 1 &
• Lorenzo Spaggiari 1 , 2  

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Lung cancer, a multifaceted disease, demands tailored therapeutic approaches due to its diverse subtypes and stages. This comprehensive review explores the intricate landscape of lung cancer research, delving into recent breakthroughs and their implications for diagnosis, therapy, and prevention. Genomic profiling and biomarker identification have ushered in the era of personalised medicine, enabling targeted therapies that minimise harm to healthy tissues while effectively combating cancer cells. The relationship between pulmonary tuberculosis and lung cancer is examined, shedding light on potential mechanisms linking these two conditions. Early detection methods, notably low-dose computed tomography scans, have significantly improved patient outcomes, emphasising the importance of timely interventions. There has been a growing interest in segmentectomy as a surgical intervention for early-stage lung cancer in recent years. Immunotherapy has emerged as a transformative approach, harnessing the body's immune system to recognise and eliminate cancer cells. Combining immunotherapy with traditional treatments, such as chemotherapy and targeted therapies, has shown enhanced efficacy, addressing the disease's heterogeneity and overcoming drug resistance. Precision medicine, guided by genomic profiling, has enabled the development of targeted therapies like tyrosine kinase inhibitors, offering personalised treatments tailored to individual patients. Challenges such as drug resistance and limited accessibility to advanced therapies persist, emphasising the need for collaborative efforts and innovative technologies like artificial intelligence. Despite challenges, ongoing interdisciplinary collaborations and technological advancements offer hope for a future where lung cancer is treatable and preventable, reducing the burden on patients and healthcare systems worldwide.

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SEOM clinical guidelines for the treatment of non-small cell lung cancer (2018)

Expression patterns of HNF4α, TTF-1, and SMARCA4 in lung adenocarcinomas: impacts on clinicopathological and genetic features

Healthcare disparities, screening, and molecular testing in the changing landscape of non–small cell lung cancer in the United States: a review

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Acknowledgements

This work was partially supported by the Italian Ministry of Health with Ricerca Corrente and 5x1000 funds.

Ministero della Salute, 5 × 1000, Ricerca Corrente.

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Luca Bertolaccini, Monica Casiraghi, Clarissa Uslenghi, Sebastiano Maiorca & Lorenzo Spaggiari

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Bertolaccini, L., Casiraghi, M., Uslenghi, C. et al. Recent advances in lung cancer research: unravelling the future of treatment. Updates Surg (2024). https://doi.org/10.1007/s13304-024-01841-3

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DOI : https://doi.org/10.1007/s13304-024-01841-3

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