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Blog Beginner Guides How To Make a Good Presentation [A Complete Guide]
Written by: Krystle Wong Jul 20, 2023
A top-notch presentation possesses the power to drive action. From winning stakeholders over and conveying a powerful message to securing funding — your secret weapon lies within the realm of creating an effective presentation .
Being an excellent presenter isn’t confined to the boardroom. Whether you’re delivering a presentation at work, pursuing an academic career, involved in a non-profit organization or even a student, nailing the presentation game is a game-changer.
In this article, I’ll cover the top qualities of compelling presentations and walk you through a step-by-step guide on how to give a good presentation. Here’s a little tip to kick things off: for a headstart, check out Venngage’s collection of free presentation templates . They are fully customizable, and the best part is you don’t need professional design skills to make them shine!
These valuable presentation tips cater to individuals from diverse professional backgrounds, encompassing business professionals, sales and marketing teams, educators, trainers, students, researchers, non-profit organizations, public speakers and presenters.
No matter your field or role, these tips for presenting will equip you with the skills to deliver effective presentations that leave a lasting impression on any audience.
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Step-by-step guide on how to prepare an effective presentation, 9 effective techniques to deliver a memorable presentation, faqs on making a good presentation, how to create a presentation with venngage in 5 steps.
When it comes to giving an engaging presentation that leaves a lasting impression, it’s not just about the content — it’s also about how you deliver it. Wondering what makes a good presentation? Well, the best presentations I’ve seen consistently exhibit these 10 qualities:
No one likes to get lost in a maze of information. Organize your thoughts into a logical flow, complete with an introduction, main points and a solid conclusion. A structured presentation helps your audience follow along effortlessly, leaving them with a sense of satisfaction at the end.
Regardless of your presentation style , a quality presentation starts with a clear roadmap. Browse through Venngage’s template library and select a presentation template that aligns with your content and presentation goals. Here’s a good presentation example template with a logical layout that includes sections for the introduction, main points, supporting information and a conclusion:
Hook your audience right from the start with an attention-grabbing statement, a fascinating question or maybe even a captivating anecdote. Set the stage for a killer presentation!
The opening moments of your presentation hold immense power – check out these 15 ways to start a presentation to set the stage and captivate your audience.
Make sure your content aligns with their interests and needs. Your audience is there for a reason, and that’s to get valuable insights. Avoid fluff and get straight to the point, your audience will be genuinely excited.
Picture this: a slide with walls of text and tiny charts, yawn! Visual aids should be just that—aiding your presentation. Opt for clear and visually appealing slides, engaging images and informative charts that add value and help reinforce your message.
With Venngage, visualizing data takes no effort at all. You can import data from CSV or Google Sheets seamlessly and create stunning charts, graphs and icon stories effortlessly to showcase your data in a captivating and impactful way.
Keep your language simple, and avoid jargon or complicated terms. Communicate your ideas clearly, so your audience can easily grasp and retain the information being conveyed. This can prevent confusion and enhance the overall effectiveness of the message.
Spice up your presentation with a sprinkle of enthusiasm! Maintain eye contact, use expressive gestures and vary your tone of voice to keep your audience glued to the edge of their seats. A touch of charisma goes a long way!
Turn your presentation into an interactive experience — encourage questions, foster discussions and maybe even throw in a fun activity. Engaged audiences are more likely to remember and embrace your message.
Transform your slides into an interactive presentation with Venngage’s dynamic features like pop-ups, clickable icons and animated elements. Engage your audience with interactive content that lets them explore and interact with your presentation for a truly immersive experience.
Who doesn’t love a good story? Weaving relevant anecdotes, case studies or even a personal story into your presentation can captivate your audience and create a lasting impact. Stories build connections and make your message memorable.
A great presentation background is also essential as it sets the tone, creates visual interest and reinforces your message. Enhance the overall aesthetics of your presentation with these 15 presentation background examples and captivate your audience’s attention.
Pace your presentation thoughtfully with well-designed presentation slides, neither rushing through nor dragging it out. Respect your audience’s time and ensure you cover all the essential points without losing their interest.
Last impressions linger! Summarize your main points and leave your audience with a clear takeaway. End your presentation with a bang , a call to action or an inspiring thought that resonates long after the conclusion.
In-person presentations aside, acing a virtual presentation is of paramount importance in today’s digital world. Check out this guide to learn how you can adapt your in-person presentations into virtual presentations .
Preparing an effective presentation starts with laying a strong foundation that goes beyond just creating slides and notes. One of the quickest and best ways to make a presentation would be with the help of a good presentation software .
Otherwise, let me walk you to how to prepare for a presentation step by step and unlock the secrets of crafting a professional presentation that sets you apart.
Before you dive into preparing your masterpiece, take a moment to get to know your target audience. Tailor your presentation to meet their needs and expectations , and you’ll have them hooked from the start!
Time to hit the books (or the internet)! Don’t skimp on the research with your presentation materials — dive deep into the subject matter and gather valuable insights . The more you know, the more confident you’ll feel in delivering your presentation.
No one wants to stumble through a chaotic mess of information. Outline your presentation with a clear and logical flow. Start with a captivating introduction, follow up with main points that build on each other and wrap it up with a powerful conclusion that leaves a lasting impression.
Delivering an effective business presentation hinges on captivating your audience, and Venngage’s professionally designed business presentation templates are tailor-made for this purpose. With thoughtfully structured layouts, these templates enhance your message’s clarity and coherence, ensuring a memorable and engaging experience for your audience members.
Don’t want to build your presentation layout from scratch? pick from these 5 foolproof presentation layout ideas that won’t go wrong.
Spice up your presentation with eye-catching visuals! Create slides that complement your message, not overshadow it. Remember, a picture is worth a thousand words, but that doesn’t mean you need to overload your slides with text.
Well-chosen designs create a cohesive and professional look, capturing your audience’s attention and enhancing the overall effectiveness of your message. Here’s a list of carefully curated PowerPoint presentation templates and great background graphics that will significantly influence the visual appeal and engagement of your presentation.
Practice makes perfect — rehearse your presentation and arrive early to your presentation to help overcome stage fright. Familiarity with your material will boost your presentation skills and help you handle curveballs with ease.
Don’t be afraid to ask for help and seek feedback from friends and colleagues. Constructive criticism can help you identify blind spots and fine-tune your presentation to perfection.
With Venngage’s real-time collaboration feature , receiving feedback and editing your presentation is a seamless process. Group members can access and work on the presentation simultaneously and edit content side by side in real-time. Changes will be reflected immediately to the entire team, promoting seamless teamwork.
Prepare for the unexpected by checking your equipment, internet connection and any other potential hiccups. If you’re worried that you’ll miss out on any important points, you could always have note cards prepared. Remember to remain focused and rehearse potential answers to anticipated questions.
As the big day approaches, give your presentation one last shine. Review your talking points, practice how to present a presentation and make any final tweaks. Deep breaths — you’re on the brink of delivering a successful presentation!
In competitive environments, persuasive presentations set individuals and organizations apart. To brush up on your presentation skills, read these guides on how to make a persuasive presentation and tips to presenting effectively .
Whether you’re an experienced presenter or a novice, the right techniques will let your presentation skills soar to new heights!
From public speaking hacks to interactive elements and storytelling prowess, these 9 effective presentation techniques will empower you to leave a lasting impression on your audience and make your presentations unforgettable.
Positive body language instantly captivates your audience, making them believe in your message as much as you do. Strengthen your stage presence and own that stage like it’s your second home! Stand tall, shoulders back and exude confidence.
Break down that invisible barrier and connect with your audience through their eyes. Maintaining eye contact when giving a presentation builds trust and shows that you’re present and engaged with them.
A little movement goes a long way! Emphasize key points with purposeful gestures and don’t be afraid to walk around the stage. Your energy will be contagious!
Weave the magic of storytelling into your presentation. Share relatable anecdotes, inspiring success stories or even personal experiences that tug at the heartstrings of your audience. Adjust your pitch, pace and volume to match the emotions and intensity of the story. Varying your speaking voice adds depth and enhances your stage presence.
Spice up your presentation with a dash of visual pizzazz! Use slides, images and video clips to add depth and clarity to your message. Just remember, less is more—don’t overwhelm them with information overload.
Turn your presentations into an interactive party! Involve your audience with questions, polls or group activities. When they actively participate, they become invested in your presentation’s success. Bring your design to life with animated elements. Venngage allows you to apply animations to icons, images and text to create dynamic and engaging visual content.
Laughter is the best medicine—and a fantastic presentation enhancer! A well-placed joke or lighthearted moment can break the ice and create a warm atmosphere , making your audience more receptive to your message.
Be attentive to your audience’s reactions and feedback. If they have questions or concerns, address them with genuine interest and respect. Your responsiveness builds rapport and shows that you genuinely care about their experience.
Apply the 10-20-30 presentation rule and keep it short, sweet and impactful! Stick to ten slides, deliver your presentation within 20 minutes and use a 30-point font to ensure clarity and focus. Less is more, and your audience will thank you for it!
Simplicity is key. Limit each slide to five bullet points, with only five words per bullet point and allow each slide to remain visible for about five seconds. This rule keeps your presentation concise and prevents information overload.
Simple presentations are more engaging because they are easier to follow. Summarize your presentations and keep them simple with Venngage’s gallery of simple presentation templates and ensure that your message is delivered effectively across your audience.
To kick off your presentation effectively, begin with an attention-grabbing statement or a powerful quote. Introduce yourself, establish credibility and clearly state the purpose and relevance of your presentation.
For a strong conclusion, summarize your talking points and key takeaways. End with a compelling call to action or a thought-provoking question and remember to thank your audience and invite any final questions or interactions.
To make your presentation interactive, encourage questions and discussion throughout your talk. Utilize multimedia elements like videos or images and consider including polls, quizzes or group activities to actively involve your audience.
In need of inspiration for your next presentation? I’ve got your back! Pick from these 120+ presentation ideas, topics and examples to get started.
Creating a stunning presentation with Venngage is a breeze with our user-friendly drag-and-drop editor and professionally designed templates for all your communication needs.
Here’s how to make a presentation in just 5 simple steps with the help of Venngage:
Step 1: Sign up for Venngage for free using your email, Gmail or Facebook account or simply log in to access your account.
Step 2: Pick a design from our selection of free presentation templates (they’re all created by our expert in-house designers).
Step 3: Make the template your own by customizing it to fit your content and branding. With Venngage’s intuitive drag-and-drop editor, you can easily modify text, change colors and adjust the layout to create a unique and eye-catching design.
Step 4: Elevate your presentation by incorporating captivating visuals. You can upload your images or choose from Venngage’s vast library of high-quality photos, icons and illustrations.
Step 5: Upgrade to a premium or business account to export your presentation in PDF and print it for in-person presentations or share it digitally for free!
By following these five simple steps, you’ll have a professionally designed and visually engaging presentation ready in no time. With Venngage’s user-friendly platform, your presentation is sure to make a lasting impression. So, let your creativity flow and get ready to shine in your next presentation!
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The 5 differences between a pitch and a presentation.
Persuade me. If you can.
“Tell me a little bit about yourself.”
“Pitch me your business idea.”
“Why should I do business with you?”
Where, exactly, does the story begin? In order to pitch your ideas - or your job skills - effectively, it’s important to understand the fundamental differences between a presentation and a pitch. Because a pitch is more than just an informational presentation. Beyond the constructs of the various TV shows, like Shark Tank , a pitch doesn’t necessarily inform. A good pitch compels . In other words, a pitch inspires action.
That’s right, “inspires”. Because if all you want to do is instruct, like an informational presentation, that’s not a pitch. True, your audience might get smarter. But are you getting any richer? What does “good” look like, when it comes to your pitch? Maybe it looks like a new job . A new promotion. Or a new initiative that’s delivered (persuasively) by none other than you. Would you invest in that pitch?
Consider these five key differences between a presentation and a pitch:
You don’t have to watch Shark Tank in order to see the value in a persuasive conversation. That’s right: a pitch is simply a conversation, if it’s done right. A conversation that’s compelling, clear and guided, so that your audience sees your vision. A vision that’s presented in a way that makes people say “yes”. Using the language of creation, a pitch builds to a “tell me more”, based on a story that gets your audience involved and connected with your vision. So, if you’re looking for a new job, or a new way to get your ideas across, consider how you might be able to create the one thing that every pitch needs: a connection to your audience. Instead of focusing intently on your background, your struggle, or your hero’s journey, consider instead how you can make your audience the hero. That kind of language just might help you create what’s missing. So, you’re invited to change the conversation - and change your results - whenever you’re ready to win.
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What is PowerPoint? This blog will walk you through “what is Microsoft PowerPoint”. Discover its features, uses, and the art of crafting compelling slideshows. Whether you're a student, professional, or simply curious, explore the power of Microsoft PowerPoint and learn how you can create impactful presentations effortlessly.
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According to Glassdoor , a PowerPoint designer's average salary in the UK is about £37,811 annually. Who knew there was big money in presentations alone? In this blog, you will learn What PowerPoint is, its key features, its benefits, and how to use it, as well as learn some tips for creating effective presentations.
Table of contents
1) What is PowerPoint?
2) Understanding the PowerPoint interface
3) Key features of PowerPoint
4) How to use PowerPoint to create a presentation?
5) Benefits of PowerPoint
6) Tips for creating effective PowerPoint Presentations
7) Alternatives to PowerPoint
8) Conclusion
PowerPoint is an essential multifunctional tool for making presentations which had been created by MS. As a part of the Microsoft Office Suite, it offers a toolbox to organise the presentation by using different tools and features to make it visually pleasant and attractive. MS PowerPoint gives the opportunity for the text, graphics, multimedia objects, and animation elements to be combined in one place to allow the users to present information in a more effective way.
In the course of time, PowerPoint has become a very functional tool to produce high-quality presentations Moreover, a secure system would be established to manage risks of data leakage or theft. First released in 1987 for Apple computers, it defies to the competition with its easy Graphical User Interface (GUIGUI)) and its large range of functions. With every new release, MS PowerPoint offered new functionality and boasted significant improvements, staying the wonder of the world of presentations.
The PowerPoint Program provides the presenter with an easy-to-use interface for designing and updating the presentation. It is important to master its main functions in order to conduct operations using this software with a level of proficiency.Here's a breakdown of the MS PowerPoint interface:
1) Ribbon: The Ribbon is located at the top of the MS PowerPoint window and has several tabs which include Home, Insert, Design, Transitions, etc.
2) Slides pane: Slide pane which is positioned to the far left of the window, is the PowerPoint window. You will see there a collection of your slides examples (thumbnails) which enables you to adjust and customize them with greater ease. The floating pane of the editor lets you not only add, delete, duplicate, but also hide slides from there.
3) Notes pane : The Notes pane is located below the Slides pane. It provides space for adding speaker notes or additional information related to each slide.
4) Slide area : The Slide area occupies the central part of the PowerPoint window. It displays the selected slide, where you can add and arrange content such as text, images, charts, and multimedia elements .
5) Task panes : Task panes are additional panels on the PowerPoint window's right side. They offer various functionalities such as formatting options, slide layouts, animations, etc. Task panes can be opened or closed based on your specific needs.
Understanding the MS PowerPoint interface will help you navigate the software effectively and make the most of its features. Whether you are creating slides, adding content, or applying formatting, having a good grasp of the interface ensures a smooth and productive experience .
When it comes to creating captivating and professional presentations, MS PowerPoint stands out as versatile and feature-rich software. Its array of tools and functionalities enables users to bring their imagination and ideas to life. Moreover, it also helps engage their audience effectively .
From slide templates to multimedia integration, there are various Features of PowerPoint ; let's discuss some of them below.
1) Slide Templates : PowerPoint provides a collection of pre-designed templates that make it easy to create visually appealing slides.
2) Slide Master : The Slide Master feature allows users to define the overall layout, font styles, and colour scheme for the entire presentation .
3) Animations and transitions : PowerPoint offers various animation effects and slide transitions to add visual interest and captivate the audience .
4) Multimedia integration : Users can embed images, videos, and audio files directly into their presentations, enhancing the overall impact .
5) Collaboration tools : MS PowerPoint allows multiple users to work on a presentation simultaneously, making it ideal for team projects and remote collaboration .
6) Presenter View : The Presenter View feature gives presenters access to speaker notes, a timer, and a preview of upcoming slides, enabling a seamless presentation experience .
These features collectively contribute to PowerPoint's versatility and make it a powerful tool for developing engaging and impactful presentations.
Take your Microsoft Office skills to the next level – sign up for our Power Apps and Power Automate Training !
Creating a presentation in PowerPoint is a straightforward process. Whether it's simple animations or explainer videos learning H ow to use PowerPoint is an extremely valuable skill. Here's a step-by-step guide on how to create a presentation:
1) Launch PowerPoint and choose a template or start with a blank slide.
2) Add slides by clicking "New Slide" or using the shortcut key (Ctrl + M).
3) Customise slide content by entering text and inserting visuals.
4) Rearrange slides for a logical flow by dragging them in the slide navigation pane.
5) Apply slide transitions for visual effects in the "Transitions" tab.
6) Add animations to objects in the "Animations" tab.
7) Preview your presentation by clicking "Slide Show".
8) Save your presentation and choose a format (.pptx or .pdf).
9) Share your presentation via email, cloud storage, or collaboration tools.
By following these steps, you can create a well-structured and visually appealing presentation in Microsoft PowerPoint. Remember to keep your content concise, use engaging visuals, and practice your presentation skills to deliver an impactful presentation .
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PowerPoint is a very popular presentation software and for a good reason. It offers numerous benefits for users, from easy collaboration to ease of use. These are some of the key benefits of PowerPoint.
1) Visual appeal : Microsoft PowerPoint allows you to create visually appealing presentations with its wide range of design tools and features. You can use templates, themes, and customisable layouts to make your slides visually engaging and professional .
2) Easy to use : PowerPoint has a user-friendly interface, making it accessible to users of all levels. The intuitive tools and straightforward navigation make it easy to create, edit, and deliver presentations efficiently .
3) Flexibility : PowerPoint provides flexibility in terms of content creation. You can include various types of content, such as text, images, charts, graphs, videos, and audio files, to enhance your message and engage your audience effectively.
4) Organisation and structure : PowerPoint offers features to help you organise and structure your content. You can create multiple slides, use slide masters for consistent formatting, and arrange the sequence of slides to create a logical flow .
5) Presenter tools : PowerPoint includes built-in presenter tools that aid in delivering presentations smoothly. You can use presenter view to see your notes and upcoming slides while your audience sees only the presentation. Additionally, features like slide transitions and animations add visual interest and help you control the flow of information .
6) Collaboration and sharing : PowerPoint allows for easy collaboration and sharing of presentations. Several users can simultaneously work on the same presentation, making it convenient for team projects. You can also share your presentations via email, cloud storage, or online platforms, ensuring easy access for viewers .
7) Integration with other tools : PowerPoint can seamlessly integrate with other Microsoft Office applications, such as Word and Excel. You can import data and charts from Excel or copy and paste content between different Office applications, saving time and effort .
8) Presenter-audience interaction : PowerPoint provides features that facilitate interaction between the presenter and the audience. You can include interactive elements like hyperlinks, buttons, and quizzes to engage your audience and make your presentations more dynamic.
9) Portable and accessible : PowerPoint presentations can be saved in various formats, such as .pptx or .pdf, making them easily accessible on different devices. This portability allows you to deliver presentations on laptops, tablets, or even projectors without compatibility issues .
10) Time and effort savings : PowerPoint simplifies the process of creating presentations, saving you time and effort. The pre-designed templates, slide layouts, and formatting options enable you to create professional-looking presentations efficiently .
PowerPoint presentations can be powerful tools for communicating information and engaging an audience. Consider the following PowerPoint Tips to create effective presentations .
1) Simplicity is key : Keep your slides clean and uncluttered. Use concise bullet points and simple visuals to convey your message effectively .
2) Visuals matter : Incorporate relevant, high-quality visuals such as images, charts, and diagrams to enhance understanding and engagement .
3) Limit text : Avoid overwhelming your audience with excessive text on slides. Use brief phrases or keywords to communicate key points .
4) Choose legible fonts : Opt for clear and readable fonts that are easy to read, even from a distance. Maintain consistency in font styles throughout your presentation .
5) Consistent design : Maintain a consistent design theme, including colours, fonts, and layout, to create a visually appealing and professional presentation.
6) Emphasise important points : Use visual hierarchy techniques, such as font size, colour, and formatting, to draw attention to essential information .
7) Use transitions and animations sparingly : Incorporate slide transitions and animations thoughtfully, focusing on enhancing content and transitions without distracting the audience .
8) S lide notes for guidance : Utilise the slide notes feature to include additional details, explanations, or reminders for a well-prepared and confident presentation.
9) Practice and time yourself : Rehearse your presentation to ensure smooth delivery and stay within the allocated time. Practice helps you refine your content and delivery.
10) Engage the audience : Encourage audience participation through interactive elements, questions, or discussions to foster engagement and make your presentation more memorable.
By implementing these tips, you can create effective MS PowerPoint presentations that capture attention, communicate information clearly, and engage your audience effectively.
Most of you are used to using PowerPoint for your presentation needs since it was the first option available to us through our academics. However, if you wish to check out alternative options to Powerpoint know if they work better for you, here are ten options that is worth a short:
5) Slidebean
6) Zoho Show
7) Google Slide
9) Beautiful.ai
10) Microsoft Sway
This blog walked you through What is PowerPoint and how it can aid you in curating compelling visual representations of the message you wish to get across. We discussed it features and the process of how you can create presentations on PowerPoint. Now take what you know and run with it explore your options with your templates and building new ones, let your creativity take its course.
Learn how to create customised slide shows in MS PowerPoint with our Microsoft PowerPoint MO300 Training .
Well, making a presentation can be tricky business. Here are some of the common mistakes people make:
1) Adding too much text! The presentation needs to have brief and simple points you elaborate on in person.
2) Bad colour schemes for template and font colour. Sometimes the clash of colour may make the text illegible.
3) Too many elements! Crowding of elements may lose your audience’s attention.
Yes, you most definitely can! You can use PowerPoint online with a Microsoft Office 360 plug in that allows you to use all Microsoft applications on your browser.
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Remember: Less is more.
A strong presentation is so much more than information pasted onto a series of slides with fancy backgrounds. Whether you’re pitching an idea, reporting market research, or sharing something else, a great presentation can give you a competitive advantage, and be a powerful tool when aiming to persuade, educate, or inspire others. Here are some unique elements that make a presentation stand out.
As an intern or early career professional, chances are that you’ll be tasked with making or giving a presentation in the near future. Whether you’re pitching an idea, reporting market research, or sharing something else, a great presentation can give you a competitive advantage, and be a powerful tool when aiming to persuade, educate, or inspire others.
What is public speaking? In this article, you'll learn what speaking in public is about and the importance of public speaking in business.
If you’ve been asked to give a public speech, you may wonder: what is public speaking and why is public speaking important? Those questions are quite logical if you’ve never thought much about public speaking before.
Public speaking is important in business, education, and the public arena. There are many benefits to speaking in public, whether you’re an individual or a business.
In this article, we’ll define public speaking for you. We’ll discuss the importance of public speaking in general. We’ll also cover the importance of public speaking in business. Plus, we’ll share some resources to help you become a better public speaker. This includes some public speaking examples.
Also, if you want to pursue speaking in public yourself, download our free eBook: The Complete Guide to Making Great Presentations . It’ll help you master the complete presentation process.
If you’re reading this, you’re probably asking the question “ what is public speaking “? You may even be faced with the prospect of creating a public speech yourself.
Or maybe you just want to know “ why is public speaking important “? Whatever your situation, we’ve got you covered with this short video that gives a public speaking definition and provides you with some tips to make a better public speech.
To learn even more about public speaking and why it’s important, study the written tutorial below.
So what exactly is public speaking? Basically, it’s a presentation that’s given live before an audience. Public speeches can cover a wide variety of different topics. The goal of the speech may be to educate, entertain, or influence the listeners. Often, visual aids in the form of an electronic slideshow are used to supplement the speech. This makes it more interesting to the listeners.
A quality public communication definition should explain how it’s different from an online presentation, which is why we’ll cover it here. Here’s a description of some of the differences:
Because speaking in public is done before a live audience, you need to consider some special factors. We’ll touch on those shortly.
Now that you’ve got an understanding of the meaning of public speaking, let’s take a quick look at the history of (and the importance of) public speaking.
What is the history of public speaking? And why is public speaking important?
There’s a good chance that there’s been public speech, in one form or another, as long as there’ve been people. But most public speaking experts involved with public speaking in business communication trace the origins of modern public speaking back to ancient Greece and Rome.
Of course, those societies didn’t have slideshows, but they did have a need for speaking in public. As a result, they developed public speaking methods that are still studied today.
The ancient Greeks used public speech primarily to praise or persuade others. At one point, all Greek citizens had the right to suggest or oppose laws during their assemblies. This resulted in a need for skilled public speakers. Speaking in public became a desirable skill and was taught. Public speaking in the time of the Greeks was called rhetoric. Later, when Rome came to power, speaking in public was used during the Roman senate sessions. The Romans adopted the public speaking rhetoric methods of the Greeks. In fact, most public speaking teachers of the time were Greek.
The Latin style of public speaking was popular in the U.S. and Europe until the mid-20th century . After World War II, a less formal and more conversational speaking style of speaking became popular. Also, electronic tools became available to enhance public presentations.
Towards the end of the 20th century, electronic tools migrated to the computer. They evolved into the computer software tools, like PowerPoint , that we know and use today.
Don’t be fooled, though. Even though today’s public speeches are less formal, they still need to be well organized. More on that later. Now, let’s take a look at the importance of public speaking.
If you ask most people, they’ll probably say they don’t like public speech. They may even admit to being afraid of it since fear of public speaking is very common. Or they may just be shy or introverted. For those reasons, many people avoid speaking in public if they can. If you’re one of those people who avoid speaking in public, you’re missing out.
You may be wondering, “What is public communication and how can it benefit me?” Over the years, public speaking in communication has played a major role in education, government, and business. Words have the power to inform, persuade, educate, and even entertain. And the spoken word can be even more powerful than the written word in the hands of the right speaker.
Whether you’re a small business owner or a student, you’ll benefit from improving your public speaking skills. Some benefits of speaking in public include:
Speaking in public is especially important for businesses to market their offers. This allows them to get their message in front of potential customers. Salespeople and executives are often expected to have good public speaking skills. To learn more about some of the benefits of speaking in public, review this article .
Next, let’s explore the methods you can use to become better at speaking in public.
Okay, so now you understand the benefits of public speaking. You might be a little more interested in the topic. Still, you might think it’s not for you. Maybe you gave a speech once and it didn’t go well. Maybe you’re afraid of speaking in public. Or maybe you think you don’t have a natural ability for giving speeches.
The truth is that speaking in public is a skill. And you can learn any skill. While some people may have more natural speaking ability than others, anyone can learn to be a better public speaker. It just takes some know-how and some effort.
To help you become better at giving public speeches, we’ll take a look at these five areas:
We’ll start with writing the speech.
The first thing you’ll want to do is work on writing a well-organized, engaging speech. Even a great speaking voice or a great deal of charisma isn’t enough if your material isn’t any good.
Specifically, it’s crucial to research your audience beforehand so that you can target your speech directly to them as much as possible. Become familiar with their wants and needs, as well as any problems you can solve for them. This will drive the actual topic that you actually select for your speech, as well as how you research it.
The more research you do, the easier writing your speech will be.
Fear of public speaking is very real and can hold you back if you let it. If you don’t feel confident when giving your speech, your listeners may pick up on that. This can make your presentation less effective.
Fortunately, there are some techniques to help manage the fear of speaking in public. They also help you become more confident.
First, let’s tackle fear of public speaking. If you’ve already written an effective speech, then you’ve already taken an important first step. The more familiar you are with your speech, the less worried you’ll be on presentation day.
Besides knowing your topic well, be sure to practice, practice, practice! And remember that if you do make any mistakes on presentation day, it’ll be less obvious to your audience than you think.
Next, let’s work on improving your confidence.
Even if you’re not afraid of speaking in public, practice helps you give a more effective speech. If you’re in a rush, you may be tempted to skip practicing your speech to save time. While skipping practice may seem like a good idea, it’s really not.
Practicing your speech improves your public presentation skills. It also increases your familiarity with the presentation. As a result, your speech will go smoothly. You can go over this handy checklist to help you practice your speech.
Your slide design needs to be on point. You’ll want to make sure it looks professional and is easy to read. Luckily, you can find plenty of modern and professional presentation templates on Envato Elements.
You’ll also want to download The Complete Guide to Making Great Presentations eBook now. Download it for FREE with a subscription to the Tuts+ Business Newsletter. Learn how to get your ideas formed into a powerful presentation that’ll move your audience.
Don’t forget to make good use of tools like PowerPoint , Google Slides , or Keynote . The right template for your slide deck can make a huge difference in your presentation.
You’ve written a good speech. You feel more confident about giving a speech in public, and you’ve practiced. You’re ready to actually give the speech. There are some tips and tricks you can use on the day of your speech to make it go more smoothly, though.
Remember, you’re giving a presentation before a live audience at a specific place and time. So, you’ve got some concerns about the speaking venue that those who give online presentations don’t have to worry about.
Some common concerns for public speakers include:
Public speaking examples are great for learning or improving a new skill. That applies to speaking in public as well. If you get the chance to listen to some top-rated public speakers, you should do it. You can observe how other speakers go about giving their speech. In the process, you’ll improve your own speaking skills.
One great source of recorded public speeches is Ted Talks , which is a series of short presentations on a wide variety of topics. Ted Talks are known for attracting world-class and celebrity speakers. You can find my favorite Ted Talks in this article .
Envato Elements is the perfect place to find modern PowerPoint templates . For a single monthly fee, access unlimited downloads of PowerPoint themes, photos, fonts, and other resources to use in your next presentation.
Elements gives you the best bang for your buck. And thanks to the unlimited downloads, you can try out a variety of slide designs as you build out your public speaking PowerPoint presentation.
PowerPoint templates from Envato Elements have plenty of features to help you create a stunning presentation, such as:
Thanks to these templates, you’ll be able to create a modern, standout presentation to go with your public speech.
1. minimalism clean powerpoint presentation.
Try this template if you’re looking for a clean and simple PowerPoint slide design. The template features a versatile layout. Use it for any type of presentation or topic. It includes 50+ unique slide designs, tons of customization options, and vector elements. The template was designed in widescreen format.
The Kaspa PowerPoint template has a modern and trendy design. It’s best suited for presentations that need a lot of photos to share information. The template can be customized completely. It comes with slide animations and transitions. The template also includes vector icons.
The Guava PowerPoint has a dramatic, yet elegant design. You’ll notice dark image overlays and elegant typography that makes your message stand out. The template comes with 50+ unique designs, image placeholders, and master slides. It was designed in widescreen resolution.
The Dauna template is another minimalist PowerPoint design. It works well for any type of business presentation. You’ll find 30 unique slides and two color variations. The template comes with image placeholders and plenty of customization options.
If you’re looking for a colorful and bold PowerPoint, the Pastelize template is the perfect choice. The template includes many slide designs, three color variations and color themes, and image placeholders.
We also have the perfect complement to this tutorial, which will walk you through the complete presentation process. Learn how to write your presentation, design it like a pro, and prepare it to present powerfully.
Download our new eBook: The Complete Guide to Making Great Presentations . It’s available for free with a subscription to the Tuts+ Business Newsletter.
So what is public communication in terms of what it can do for you, your career, or your business?
In a nutshell, a world of potential! In this article, we defined public speaking and why it’s so important in your business. Hopefully, the public speaking meaning we explored will help dispel any fear you may have.
We discussed a thorough public communication definition so that you can be adequately prepared for your next speech. Besides the public speaking definition, you learned a bit about the history of public speaking and how it evolved to modern standards today.
We also shared some helpful tools to help you learn how to give a public speech and provided you with a source for good public speaking examples that you can learn from.
You should now be ready to grow as a public speaker. Be sure to check out the sleek PowerPoint templates on Envato Elements as you prepare for your next speech. You’ll find a ton of inspiration for your next presentation!
So go ahead. Write that public speech and give it. You’ll be glad you did!
There’s no single recipe for creating a successful investor pitch deck. Many authors, venture capitalists, startup founders, and evangelists have created different versions of the required content structure for successfully pitching investors. The reality is that different industries, company stages, and round sizes require slightly different approaches to business storytelling.
We’ve compiled a list of the 35 best pitch deck examples from successful startups, accelerator programs, and industry experts (updated to 2024), in the hope that it helps you craft your next investor presentation.
These are our best 35+ startup pitch decks:, 1. airbnb pitch deck template.
The Airbnb Pitch Deck is one of the most searched references on the internet, probably because it’s a company so familiar to us all. This is a classic 10-slide Investor Deck template that many startups find useful to fit their startup into. We’ve reimagined the original deck and created our fill-in-the-blank template.
2. the startup pitch deck template.
What you should include in your pitch deck is a question that entrepreneurs have been asking themselves for years. The template we created, distilled from benchmarking dozens of venture-backed startups, takes this into account so all users will have more clarity on where their strengths are!
3. investor deck template by 500 startups.
500 Startups is a leading global venture capital seed fund and startup accelerator headquartered in Silicon Valley with over $350M AUM.
This investor deck template is ideal for initial VCs and Angel Investors. If they ask to see your pitch deck , this is what you want to send.
The outline of the investor deck mainly focuses on your startup's growth metrics and traction.
4. investment proposal template by nextview ventures.
An investment proposal is the driving tool during a meeting with potential investors. This investor deck contains all the information they require. It was created based on the NextView Ventures template.
5. uber pitch deck template.
For the ninth anniversary of the founding of Uber, it's co-founder Garret Camp shared the first slides they created in late 2008. At the beginning, Uber was originally called UberCab, and it has evolved from a simple idea into a major platform that has improved the car service industry.
Here you have Uber's 25 slide deck! There's a lot to be learned from their first ever pitch:
6. business plan template.
The Business Plan is a crucial step in starting your own business because it represents the goals you want to achieve and outlines how they will be accomplished.
7. sequoia capital pitch deck.
Since Sequoia Capital has quite a reputation for investments, taking a page out of their book makes sense. The slides included in the Sequoia Capital Pitch Deck Template each have a specific purpose that leads them down the path of discovery into your pitch
Related read : What is a pitch deck presentation
8. doordash pitch deck template.
DoorDash is one of the most well-known food delivery companies in the United States right now. The Doordash investor deck is an excellent example of a pitch using traction to back up your business.
9. facebook pitch deck template.
Facebook’s original pitch deck was a media kit containing the company’s value proposition, key metrics, and Online Marketing Services .
At that time, the company wasn’t making any money from The Facebook, so they bet on solid numbers such as user engagement, customer base, and growth metrics.
10. ycombinator pitch deck template.
YCombinator came out with a pitch deck template that's not aesthetically pleasing. We get it. They wanted to give you the “blank canvas” so your company branding could shine, but maybe they went too far. In any case, we've taken matters into our own hands and made some style changes for better aesthetics and more functionality. We hope this helps.
11. guy kawasaki pitch deck template.
Guy Kawasaki is a well-known Silicon Valley startup guru. He is the author of several books and was one of the original Apple employees. His 10 pitch deck slides have inspired many, and his 20-minute presentation format will help you get your point across efficiently.
12. youtube pitch deck template.
Youtube’s pitch deck was used in 2005 when it had less than 10,000 users. It was actually quite straightforward. They used an elementary version of a 10 slide pitch deck to go up in front of Sequoia Capital for fundraising. Still, the company was able to raise $3.5M in that Series A round November of that year. This cost around 30% of the stakes in the company.
13. slidebean pitch deck.
Our slide deck at the 500 Startups demo day was the culmination of 2 startup accelerator processes, hours of rehearsal, and dozens of adjustments thanks to feedback from our mentors. Pitching at a Demo Day event differs from pitching to an investor in a one-on-one meeting.
14. peloton pitch deck template.
Peloton broke the fitness industry with its stationary bike system, which connects users and trainers via the internet. Do you have a business idea for this industry in mind? We recreated the pitch deck Peloton used to raise their Series F.
15. go to market strategy template.
The go-to-market strategy is a presentation that details how an organization will place its products in the market to reach maximum penetration and profitability. What is your go-to-market strategy? This template will help you summarize it engagingly!
16. elevator pitch deck template.
This is an elevator pitch deck template designed for initial approaches to investors. Share this template when they ask for your elevator pitch deck. With this template, you can effectively communicate your value proposition, market opportunity, key achievements, and financial projections, aiming to get the investors' curiosity and interest for further discussions.
17. tinder pitch deck template.
10 billion matches later, Tinder has changed how people meet around the world. It’s so much more than a dating app. Tinder is a powerful tool for meeting people. Here’s the deck Tinder used in the IAC Hatch Labs Incubator in 2012.
WeWork fuels entrepreneurial spirit and corporate success with powerful real estate solutions. Founded in 2010, it has since blossomed into a buzzing global community transforming the way companies do business by providing physical spaces that nurture productivity, well-being, efficiency and growth - all backed up by an impressive $1 billion funding valuation of $10 billion!
19. snapchat pitch deck template.
The Snapchat Pitch Deck Template helps you create a persuasive presentation inspired by Snapchat's successful pitch to investors. It offers visually engaging slides and a structured format for showcasing your business idea, growth plans, and revenue strategy.
LinkedIn has skyrocketed to success, becoming the world's largest professional social networking site with a vast population of users growing daily. Reid Hoffman later publicly released his Series B pitch deck, which included advice on how it should be constructed so that other aspiring entrepreneurs would also have insight.
21. lunchbox pitch deck template.
With a mission to empower restaurants to compete in an increasingly tech-driven market, Try our Pitch Deck Template inspired by the one they used to raise $2 million in its seed round.
This is the presentation deck Buffer used to raise $500,000 for their startup, as redesigned by Slidebean. The highlight of this deck is the traction slide, which the founders describe as the critical one for their success.
23. cannabis investor pitch deck template.
Leverage our Cannabis Investor Pitch, influenced by the CannaBusinessPlans deck, to effectively showcase the distinctive attributes and growth potential of your cannabis business. Utilize this tailored presentation as a powerful tool to attract essential funding from potential investors
A well-designed pitch deck can help an entrepreneur communicate their story in a clear and concise way and can be a key tool in securing funding. However, designing a pitch deck can be a challenge, as it requires distilling complex information into bite-sized chunks and conveying it in an engaging way. That's why we decided to redesign Aircall's pitch deck as an example. We wanted to show how a pitch deck can be both informative and visually appealing.
Here's the result from our design challenge:
25. intercom pitch deck template.
The Intercom Pitch Deck Template is your key to crafting a compelling pitch presentation, modeled after Intercom's own successful pitch.
It's your tool to create a persuasive presentation that mirrors Intercom's winning pitch style. This template empowers you to clearly communicate your business vision, product strategy, and growth prospects to potential investors.
A cryptocurrency pitch deck is a dynamic presentation outlining the unique attributes of a digital currency project. It showcases use cases, team expertise, and financial projections to attract funding and build investor confidence.
Copy.ai offers the convenience of composing emails, website content, and heartfelt love letters. Here's the pitch deck that convinced investors like Wing, Sequoia, and Tiger Global to contribute $11 million in funding.
Splitwise makes it super easy to divvy up bills and expenses among friends or groups with their simple app. Check out our Pitch Deck Template, inspired by Splitwise's $20 million Series A round, to show investors what you're all about and kickstart your journey to success.
Demo days pack together dozens of pitch decks from wildly different companies. Communicating your value prop effectively and concisely is key. This template provides the structure to accomplish pitching your startup in under 3 minutes.
30. sparkcharge pitch deck.
Sparcharge is a startup that raised $7 million in seed funding, and Slidebean was responsible for writing and designing their pitch deck. The deck was very successful in conveying the company's value proposition and vision, and it helped them to secure funding from top venture capitalists. The design of the deck was clean and professional, and it made use of strong visuals to help tell the company's story. The slides were also easy to navigate, which made it easy for investors to understand the information presented. Overall, the pitch deck was an important part of Sparcharge's success in raising funding , and it served as a great example of the power of a well-designed presentation.
31. dwolla pitch deck template.
Dwolla is advertised as "the best way to move money." 28-year-old Ben Milne has found a way to transfer money from the consumer or merchant to make a payment. This is Dwolla's Pitch Deck.
According to their website, Evervault's mission "is to make data privacy simple and accessible for all" by allowing developers to integrate data privacy in their apps. How did they gain their attention (and money)? Here's the pitch deck that made that happen, as redesigned by Slidebean.
33. vettery pitch deck template.
Here’s the Vettery pitch deck used to raise $9 million Series A on August 16, 2016, by co-founders Brett Adcock and Adam Goldstein.
34. dutchie pitch deck template.
Dutchie is one of the fastest-growing cannabis companies in the world. They provide e-commerce and point-of-sale solutions for dispensaries across North America.
35. sololearn pitch deck template.
Sololearn, the Armenia-based instructional coding app, revolutionizes how people learn to code, with interactive lessons and peer-to-peer guidance.
What is a pitch deck.
A pitch deck is usually a simple 10-20 slide presentation designed to help founders raise venture capital.
It should give a brief and compelling presentation of a new business idea that entrepreneurs give to potential investors, customers, or partners. It's a chance for them to showcase their vision, explain their unique value proposition, and demonstrate their growth potential.
To create an effective pitch deck, it's crucial to cover a few key points, such as the problem the startup is addressing, the market opportunity it has identified, the team's expertise, and the execution plan. Moreover, highlighting the competitive advantage and potential return on investment can attract investors' attention and interest.
A successful pitch can lead to funding, partnerships, and growth opportunities. However, crafting one requires in-depth knowledge of the market, audience, and business model, as well as excellent communication and storytelling skills.
When creating a pitch deck presentation, it's important to remember that you only have a limited amount of time to capture your audience's attention and persuade them to invest in your company. Your deck should be concise and easy to understand, while still providing enough information to show that your business is worth investing in.
Some key things to include in your pitch deck are an overview of your business, information about your target market and competitors, your product or service, how you plan to make money, and a summary of your team. You should also have a section highlighting the risks and challenges associated with your business, as well as what sets you apart from the competition.
Most authors agree on the following investor pitch deck outline requirements :
If you're looking for more specific advice on creating a pitch the Slidebean team can guide you through the whole process.
Remember, investors have limited time, so be sure to prioritize key elements like the problem you're solving, your target market, the competitive landscape, your unique value proposition, and your financial projections.
How to create a great pitch deck.
Your pitch deck is one of the most important tools in your arsenal. If you're pitching your startup idea or product, it's an opportunity to make a lasting impression on potential investors. And while there are many different types of decks out there, the best ones focus on three key points:
1. What problem do you solve?
2. How do you solve that problem?
3. Why should someone invest in you?
The presentation itself shouldn't take longer than 15 minutes, and it should be easy to follow along.
A pitch deck is an important tool when pitching investors. It helps you present your business idea clearly and concisely, so they understand exactly why their investment will be profitable.
The first step is to create a list of all the things that need to be included in your pitch deck. For example, you may want to include:
- A clear description of your product/service
- An overview of your company's mission statement
- Your target market
- The benefits your product offers
- How much money you expect to raise
- Why your startup is unique
- What are your plans for growth
Once you have created this list, you can begin designing your pitch deck. You'll need to choose a template that best suits your needs. We offer over 100+ different pitch deck templates that can be used as inspiration.
Mastering the art of creating an irresistible pitch deck can seem like a daunting task, but it shouldn’t. We're here to guide you through the process. First and foremost, you need a compelling narrative that showcases your business idea, market opportunity, and growth potential. Keep your pitch deck concise and visually appealing, with clear, simple language that gets straight to the point.
Now, if you're feeling a bit overwhelmed or simply want to supercharge your pitch deck, Slidebean's Agency Team is here to save the day. Our seasoned experts have a proven track record of helping companies raise more than $300 million in funds, and they're eager to help you reach the same heights. From crafting a compelling narrative to designing stunning visuals that captivate investors, our Agency Team will work with you every step of the way to create a pitch deck that not only looks great but also delivers results. With Slidebean by your side, you can focus on what you do best - building your business - while we take care of the rest.
Slidebean provides a premium service for startups, entrepreneurs, investors, and creatives who want to make better presentations. Our team of experts designs amazing slide decks every week. We want your audience to understand what you do and why you do it. If you want to start a new project, you can do it here: Slidebean Presentation Design Service
Besides the pitch deck examples we shared here, we have created, curated and redesigned several investor deck and set them as templates on our platform. Our presentation templates provide a fill-in-the-blank outline that can kick start your presentation workflow. Create a pitch deck that gets you funded. Browse templates from the most successful startups on the planet. Check them all here.
What is the goal of a company pitch deck.
The main goal of a company pitch decks is to:
- Attract investment from potential investors. - Clearly explain what the company does and why it's valuable. - Build trust in the team and business strategy. - Show the market opportunity and growth potential. - Highlight achievements and progress. - Present financial projections. - Request a specific amount of funding. - Spark interest for further discussions.
There is no one-size-fits-all answer to this question, as the cost of making a pitch deck will vary depending on the level of detail and complexity involved. However, on average, you can expect to pay around $1,200-$6,000 for a high-quality investor deck. You can check Slidebean's prices here.
A demo day refers to an event where entrepreneurs and startups showcase their products or services to potential investors, industry experts, and the general public. It is typically organized by incubators, accelerators, or venture capital firms to provide a platform for startups to present their business ideas, prototypes, or early-stage products.
During a demo day, each participating startup is given a specific amount of time, usually ranging from a few minutes to around 10 minutes, to deliver a presentation or pitch. The objective is to captivate the audience, generate interest in their venture, and attract potential investors or partners.
The text you provided highlights some key considerations when preparing for a demo day presentation versus a pitch deck presentation. For a demo day, the emphasis is on delivering a visually appealing presentation with minimal text. Since the audience may be seated at a distance, it is important to focus on visual elements that can be easily seen and understood. The presenter plays a crucial role in conveying the information and engaging the audience.
In contrast, a pitch presentation that is intended to be emailed should be self-explanatory, as it may be viewed on a laptop monitor where smaller fonts can be read comfortably. It is beneficial to track the recipient's activity on the presentation, such as whether they have read all the slides, as this information can inform the frequency of follow-up emails and help gauge their level of interest.
These considerations and tools for tracking viewer engagement are particularly valuable when seeking investment opportunities. Startups can utilize pitch deck platforms that offer features to monitor investor activity, which can play a critical role in securing funding.
Unlock your full pitching potential with Slidebean! Say goodbye to design headaches and hello to a seamless experience focused on your pitch content. With customizable templates, stunning visuals, and automated formatting, Slidebean ensures your pitch deck stands out from the competition. Don't waste another minute wrestling with design software. Try Slidebean now and take your pitches to the next level!
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Lesson Plan
June 17, 2024, 6:05 a.m.
A Juneteenth celebration in Richmond, Virginia, 1905. Library of Congress
This lesson was originally published on June 16, 2021, and was updated on June 16, 2024.
For a Google version of this lesson plan, click here . (Note: you will need to make a copy of the document to edit it).
In this lesson, students will explore and discuss the history and context around the Juneteenth holiday in the United States. Topics explored will include the history of racial injustice in the U.S., the Civil War and the limitations of the Emancipation Proclamation. Additionally, students will be encouraged to explore the modern significance of Juneteenth and its long-term impact.
One 50-60 minute class period
Grades 6-12
On June 15, 2021, the Senate unanimously approved a bill approving June 19 as a federal holiday for “Juneteenth National Independence Day.” The House passed the bill one day later. Still, many Americans are still unaware of the history and significance of June 19.
On Jan. 1, 1863, President Abraham Lincoln issued the Emancipation Proclamation declaring “that all persons held as slaves” in the Confederacy “shall be free.” While this may have freed some enslaved people on paper, the reality was much more complicated.
Source: PBS NewsHour via Associated Press
For instance, the Emancipation Proclamation only freed those slaves held under the Confederacy, not in border states loyal to the Union, including Kentucky, West Virginia and Delaware, where slavery was still legal after the Emancipation Proclamation. In fact, slavery was still legal in Kentucky until Dec. 1865, when the 13th Amendment was passed, though Kentucky voted against ratifying the amendment.
Confederate states and slaveholders also resisted emancipation, and many people remained enslaved in Confederate states after the proclamation, even as many enslaved people fought for their freedom or escaped behind Union lines. On June 19, 1865, Major General Gordon Granger of the Union issued an order in Galveston, Texas, alerting all enslaved persons that they were legally free.
At this point in 1865, Texas was the westernmost state in America and one of the last Confederate states to be occupied by the Union. Many slaveholders had fled Union advances in other parts of the South to Texas, along with the people they had enslaved.
While it took time for the logistics of “freeing” enslaved people to come into effect, the importance of June 19, or “Juneteenth” lived on. Considering how complicated emancipation was, many dates were considered for holding celebrations of emancipation, but over 150 years later, June 19 remains.
What originally was a holiday mainly observed by Texans has grown to be recognized all over the country. Each year on “Juneteenth,” (or more formally Juneteenth National Freedom Day), communities all around the United States gather and celebrate and reflect on the history of slavery and struggle for civil rights and equality, including the work that still remains after conditional advances such as the Emancipation Proclamation.
As a class, watch the BrainPop video (8 minutes) below found here introducing Juneteenth. While watching the video, answer the following discussion questions.
Source: BrainPop
After watching the video, separate into groups of 3-4 to discuss the focus questions (5 minutes).
If classrooms finish and plan a celebratory activity, please share your ideas with us on social media @NewsHourEXTRA on Twitter.
This lesson was written by Cecilia Curran, NewsHour Classroom intern, while she was a rising sophomore at Amherst College. This lesson was edited by NewsHour Classroom's education producer and former history teacher Vic Pasquantonio.
Fill out this form to share your thoughts on Classroom’s resources. Sign up for NewsHour Classroom’s ready-to-go Daily News Lessons delivered to your inbox each morning.
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Journal of Medical Case Reports volume 18 , Article number: 279 ( 2024 ) Cite this article
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Glycated hemoglobin is a well-known marker for evaluating long-term glycemic control. However, the accuracy of glycated hemoglobin measurement can be affected by the presence of hemoglobin variants, which makes the determination and interpretation of glycated hemoglobin values in terms of glycemic control not only difficult but also misleading. Here we present the first ever case of a patient with type 2 diabetes with hemoglobin E from Nepal, diagnosed incidentally because of spurious glycated hemoglobin levels.
A 45-year-old Hindu Mongolian female with a history of type 2 diabetes for around 9 years but not very compliant with follow-ups was referred to our facility for plasma fasting and postprandial blood glucose levels and glycated hemoglobin. Fasting and postprandial blood sugars were found to be high. A consistent very low glycated hemoglobin by two different high-performance liquid chromatography (HPLC) methods compelled us to call the patient for a detailed clinical history and for the records of investigations done in the past. The patient has been a known case of type 2 diabetes for around 9 years and presented irregularly for follow-up visits. Around 4 years ago, she presented to a healthcare facility with fatigue, severe headaches, pain in the abdomen, discomfort, and dizziness for a couple of months, where she was shown to have high blood glucose. She was referred to a tertiary-level hospital in Kathmandu, where she was prescribed metformin 500 mg once daily (OD). Due to her abnormal hemoglobin A1c reports, she was then sent to the National Public Health Laboratory for repeat investigations. Her blood and urine investigations were sent. Complete blood count findings revealed high red blood cell and white blood cell counts, a low mean corpuscular volume, and a high red cell distribution width-coefficient of variation. Other parameters, including serum electrolytes, renal function tests, liver function tests, and urine routine examinations, were within normal limits. A peripheral blood smear revealed microcytic hypochromic red cells with some target cells. Hemoglobin electrophoresis showed a very high percentage of hemoglobin E, a very low percentage of hemoglobin A2, and normal proportions of hemoglobin A and hemoglobin F. A diagnosis of homozygous hemoglobin E was made, and family screening was advised.
Clinicians should be aware of the limitations of glycated hemoglobin estimation by ion exchange high-performance liquid chromatography in patients with hemoglobin E and other hemoglobin variants. If the clinical impression and glycated hemoglobin test results do not match, glycated hemoglobin values should be determined with a second method based on a different principle, and glycemic status should be confirmed through alternative investigations, preferably those that are not influenced by the presence of hemoglobin variants (for example, boronate affinity chromatography, fructosamine test, glycated albumin test, the oral glucose tolerance test, continuous glucose monitoring, etc.). Consistent or even doubtful results should also raise the suspicion of a hemoglobin variant, which should be confirmed through further evaluation and investigations.
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Glycated hemoglobin (HbA1c), initially identified as “unusual” hemoglobin in patients with diabetes over half a century ago [ 1 ], has now become a well-known marker of long-term glycemic control in individuals with diabetes mellitus [ 2 ], reflecting an average blood glucose level over a period of around 3 months. Glycemic control being an important factor for the progression to long-term complications, HbA1c strongly correlates with the risk of developing chronic complications associated with diabetes as well [ 3 ]; hence, it has become not only a diagnostic tool but also a screening tool for individuals at risk of diabetes [ 4 ]. However, the accuracy of HbA1c measurement can be affected by various factors such as erythropoiesis, glycation, erythrocyte destruction, and the presence of hemoglobin (Hb) variants [ 5 ], which makes the determination and interpretation of HbA1c values in terms of glycemic control not only difficult but also misleading [ 6 ]. Here, we present a case of a variant of Hb, the HbE, diagnosed incidentally in a patient with type 2 diabetes mellitus suspected initially because of repeated abnormal HbA1c levels detected with an ion-exchange high-performance liquid chromatography (HPLC) and hence subjected to further investigations by Hb capillary electrophoresis to confirm the diagnosis. To our knowledge, this is the first ever incidentally diagnosed case of HbE in a patient with type 2 diabetes from Nepal, all because of spurious HbA1c levels.
A 45-year-old Hindu Mongolian female, with a history of type 2 diabetes for 9 years and under medication for the last 4 months, visited the National Public Health Laboratory (NPHL), Teku, to test for plasma fasting and postprandial blood glucose levels and HbA1c.
We tested HbA1c by high-performance liquid chromatography (HPLC) Biorad VARIANT II, which showed HbA1c to be only 1.1% (Fig. 1 ). The control test run for the day was within range. Fasting and postprandial blood sugars were found to be 173 mg/dL and 280 mg/dL, respectively. The patient sample was rechecked with HPLC TOSO 7234X, which showed HbA1c of 2.1%. In view of this, the patient was contacted and advised to have a complete blood count (CBC) and hemoglobin electrophoresis. We took a detailed history of the patient and requested the records of investigations done in the past.
HbA1c detection by HPLC
According to the patient, she was apparently well around 9 years ago (the patient herself was not sure about the exact date) when she started developing increased urination, increased thirst, weakness, and occasional dizziness for a couple of months. She then visited a local health care facility near her hometown, where she was examined and sent for some blood and urine investigations (she has misplaced the lab reports, or probably lost them, according to her). According to her, she was told that she has high blood sugar levels and was advised to make some lifestyle modifications, such as dietary changes and increasing physical activities. She was also prescribed medication (she has no records of the medications prescribed then) and was asked to follow up in the next 3 months. Thereafter, she was doing fine with no complaints for a couple of years, and she never followed up with any healthcare facility until around 3–4 years ago (May 2020), when she presented herself to a healthcare facility in Kathmandu city with complaints of fatigue, severe headaches, pain and discomfort in the abdomen, and occasional dizziness and a feeling of lightheadedness for a couple of months. She also complained of weakness and decreased tolerance for physical activity. Physical examination was unremarkable, and laboratory investigations revealed high blood glucose and serum triglyceride levels (fasting blood glucose: 175 mg/dL; postprandial blood glucose: 193 mg/dL; serum triglyceride: 290 mg/dL). Other investigations were within normal limits (Table 1 ).
With these reports, she was referred to a tertiary-level hospital in Kathmandu. On 1 January 2021, she visited Shree Birendra Hospital (a tertiary-level hospital in Kathmandu), where she was further evaluated. At this time, she also admitted having a history of a slight decrease in vision for the last few months and was evaluated for any eye findings. Apart from a slightly presbyopic finding, everything else was normal. Intraocular pressure was within normal limits. There were no findings suggestive of diabetic retinopathy. The fundus examination was normal. Further lab workup findings revealed the following: TLC: 11,660 cells/mcL; Differential Count (DC): Neutrophils = 76, Lymphocytes = 17, Monocytes = 5, Eosinophils = 1, Basophils = 1; MCV: 64.4 fL; MCH: 21.9 pg; RDW-SD: 36.1 fL; RDW-CV: 17.3 fL; postprandial (PP) blood glucose (two hours after taking a meal): 294 mg/dL; and HbA1c: 2.1%. Ultrasonography (USG) of the abdomen and pelvis showed a bulky uterus. All other investigations were within normal limits (Table 1 ).
She was prescribed metformin 500 mg OD and advised to make lifestyle modifications once again. She was then referred to the National Public Health Laboratory (NPHL), the central reference laboratory in Nepal, for repeat investigations to confirm the abnormal HbA1c reports and for all other relevant investigations. On arrival at NPHL (21 January 2021), she was thoroughly interviewed for a detailed medical history. She was a nonvegetarian, and she did not smoke tobacco or consume alcohol. She had never received a blood transfusion before. Apart from the metformin prescribed earlier, she was not on any other medications. There was no family history of low hemoglobin levels or blood transfusions. There was no other significant medical history in any of her family members, as far as the patient could remember. She gave a history of iron supplementation a long time ago (around 9 years ago when she first presented to a healthcare facility) for around 3 months but not thereafter. She denies any history of any means of blood loss. She has been married for around 25 years and has two kids (elder son: 23 years old, younger daughter: 21 years old). Physical examination was unremarkable and provided the following data: height: 5 feet; weight: 68 kg; body mass index (BMI): 29.3. Laboratory investigations are as follows:
CBC findings revealed hemoglobin of 13.6 g/dL, RBC of 6.2 × 10 6 cells/mcL, total leucocyte counts of 13,700 cells/mcL ( N = 77, L = 18, M = 4, E = 1, B = 0), platelet count of 2.8 × 10 5 cells/mcL, and packed cell volume (PCV) of 42.1%. Red cell indices included mean corpuscular volume (MCV), mean hemoglobin concentration (MCH), mean corpuscular hemoglobin concentration (MCHC), and RDW-CV%, which were found to be 67 fL, 21.7 pg, 32.3 g/dL, and 17.9%, respectively. All other investigations were within normal limits (Table 1 ).
The ultrasonography (USG) report of the abdomen and pelvis revealed a bulky uterus and was otherwise unremarkable.
Hb electrophoresis was performed in the SEBIA MINICAP FLEX PIERCING electrophoretogram, which showed 93.2% HbE, 2.4% HbA2, 2.9% HbF, and 1.5% HbA (Fig. 2 ). A peripheral blood smear revealed microcytic hypochromic red cells with some target cells. White blood cell (WBC) and platelet morphology seem to have no abnormalities.
Detection of HbE by capillary electrophoresis
On the basis od these findings, a diagnosis of homozygous HbE was made, and family screening was advised.
Glycated hemoglobin (HbA1c), an effective and objective retrospective marker reflecting an average blood glucose level over a period of around 3 months, has now become a well-known indicator of long-term glycemic control in individuals with diabetes mellitus. However, there are various factors that may influence and falsely alter the level of HbA1c and its measurement and hence need to be considered in patients with abnormal readings.
HbA1c levels seem to inversely correlate with the rate of erythropoiesis, and hence factors that decrease the rate of erythropoiesis (including iron, vitamin B 12 , and folate deficiency) and/or increase erythrocyte life span (for example, due to splenectomy) falsely increase the level of HbA1c. Conversely, administration of erythropoietin, iron, and vitamin B 12 and conditions associated with reticulocytosis and decreased erythrocyte lifespan (for example, splenomegaly or even pregnancy) tend to falsely decrease the level of HbA1c [ 1 , 7 ]. There has been evidence of a false increase in HbA1c in cases of alcoholism and in patients with chronic kidney disease (CKD), as well, possibly through the same mechanism (alcohol interferes with folate metabolism, and patients with CKD have decreased erythropoietin levels) [ 1 , 7 , 8 ]. Several other conditions, for example, hyperbilirubinemia, carbamylated hemoglobin, chronic opiate use, etc., are also seen to be associated with a high HbA1c level [ 1 ]. However, chronic liver disease, rheumatoid arthritis, hypertriglyceridemia, and even the use of drugs such as ribavirin and dapsone have been shown to be associated with decreased HbA1c [ 1 , 7 , 9 , 10 ]. Genetic or chemical alterations in hemoglobin undoubtedly have some associations with HbA1c, and hence certain hemoglobinopathies, including the HbE disease, the presence of HbF, and methemoglobinemia, may also alter the level of HbA1c [ 1 , 7 , 11 ]. Here we discuss the presence of HbE and the misleading value of HbA1c levels.
Hemoglobin E, a variant hemoglobin, is characterized by a mutation in the β globin gene ( HBB gene) causing substitution of glutamic acid for lysine at position 26 of the β globin chain, resulting in a heterogeneous group of disorders whose phenotypes range from asymptomatic to severe disease [ 12 , 13 ]. HbE trait and HbEE are mild disorders, while a combination of HbE with other forms of hemoglobinopathies does exist that can have a markedly different and more serious clinical course, producing a wide range of clinical syndromes of varying severity [ 13 , 14 ]. The heterozygous form of HbE is usually characterized by minimal red cell morphological abnormalities and normal red cell indices, while homozygotes for HbE can have red cells with significant morphological abnormalities, including increased numbers of target cells, and can present with mild microcytic hypochromic anemia [ 14 ].
Despite advances in the standardization of methods for glycohemoglobins, including HbA1c, an increasing number of hemoglobinopathies have been shown to interfere with the accurate measurements and determination of these glycohemoglobins. Even the most commonly used methods, that is, the HPLC methods for HbA1c determination, lacked the resolution necessary to differentiate hemoglobin variants [ 6 ]. The demonstration of additional peaks in the chromatograms and either too low or too high values of HbA1c has been shown as compared with the nondiabetic reference range in different types of hemoglobinopathies [ 15 ].
Patients homozygous for HbE, that is, those receiving mutated genes from both parents, have a very low HbA level, with around 80% of Hb being HbE itself. The mutation associated with HbE tends to alter the ionic charges on Hb and hence interferes with the measurement of HbA1c via the ion-exchange HPLC method, especially in homozygous cases [ 16 , 17 ]. Unique mutation(s) on the N-terminal of β-globin in some hemoglobinopathies such as the Hb Graz and the Hb Long Island variants also seem to cause inappropriately high and low apparent HbA1c titers via HPLC methods. However, estimations with the boronate affinity technique and the immunoassay technique seem to be unaffected. The boronate affinity method has shown values in an acceptable and clinically reasonable range for all hemoglobin variants, as evidenced by several studies [ 18 , 19 ]. In fact, affinity methods have already been suggested as an acceptable and more useful method for reflecting glycemic control because they mainly measure glycohemoglobin regardless of the glycation site and hence may be clinically more accurate [ 15 ]. Studies have shown that results from the HbA1c immunoassays were also comparable to those from HPLC assays, showing good correlation, appropriate precision, and low bias [ 20 ]. Immunoassays utilizing various antibodies raised against specific epitopes of hemoglobin, for example, the Amadori product of glucose plus the first eight amino acids on the N-terminal end of the beta chain of hemoglobin, and many more, have shown good correlation with established methods for estimating glycohemoglobin [ 21 ]. However, as the quality of an immunoassay typically depends on the specificity of the antibody to the specific epitope on HbA, specific mutations altering the common epitopes used for the assays will hinder the accuracy of the test. One such example includes the hemoglobin variant with mutations affecting or altering the epitope at the N-terminal chain. The mutation seems to affect the ability of the monoclonal antibody that is used in the assay to detect hemoglobin [ 22 ]. Some uncommonly occurring variants that span the commonly used epitope include HbE and HbD (Los Angeles), where mutations occur at β26 and β121, respectively. There are some other evidences/studies that have reported that immunoassays have been shown to produce false HbA1c results in certain Hb variants [ 23 , 24 , 25 , 26 ]. Hence, choosing a method where the antibody epitope does not span the specific area in the Hb variant is crucial. However, it is not practical or even feasible to produce several specific antibodies (according to the individual patient) at each facility, and hence understanding the effects of such hemoglobinopathies while estimating the glycohemoglobins is crucial. To be precise, the effect of various hemoglobinopathies on HbA1c measurements is highly method-dependent. So, it is always better to be correlated clinically, and whenever the HbA1c results do not fit the clinical picture, some additional peaks in HPLC chromatograms are displayed, or any such doubtful scenario has been presented, it should not be ignored, and further investigations are advisable. Glycemic status over a short period of time (1–3 weeks) can also be reflected by the fructosamine test. Some researchers have therefore recommended confirmation with the fructosamine test or the glycated albumin test as an alternative [ 14 , 24 , 27 , 28 ]. Fructosamine results depend on the glycation of serum proteins and are not influenced by hemoglobin variants [ 19 ]. However, falsely low levels may occur in patients with hypoalbuminemia, for example, in patients with nephrotic syndrome or severe liver disease [ 29 ]. The glycated albumin test, reported as a percentage of total albumin, also reflects short-term glycemic status, typically over the preceding 2–3 weeks, and is not influenced by situations that falsely alter A1C levels [ 29 , 30 ]. Moreover, the tests that rely purely on blood glucose levels, including the oral glucose tolerance test (OGTT) and even continuous glucose monitoring, could possibly be the ones that are least affected by various factors, as discussed earlier. The OGTT is advocated for screening and diagnosis, and self-monitoring of blood glucose levels is advised for management during pregnancy [ 29 ]. Continuous glucose monitoring for up to 5 days has also been shown to correlate well with HbA1c levels [ 29 ].
The mutations associated with hemoglobin E disease are primarily seen to be prevalent in the eastern half of the Indian subcontinent and throughout Southeast Asia [ 12 , 23 ]. In 1954, Chernoff and colleagues first described that it has occurred in conjunction with β thalassemia, in which case it presents with a severe form of the disease known as the compound heterozygosity for hemoglobin E/β thalassemia [ 24 ], and since then several other cases have been reported from several parts of Southeast Asia [ 25 , 26 , 27 , 31 ]. Cases have been reported from some parts of Nepal, as well, but to our knowledge, this case report is the first ever report of an incidentally diagnosed HbE variant in a patient with type 2 diabetes mellitus in Nepal.
Several studies have evidenced and reported that various hemoglobinopathies, including HbE disease, interfere with accurate measurements of glycosylated hemoglobin, including HbA1c. A study conducted on the prevalence of hemoglobin variants and their effect on HbA1c measurement among the indigenous population of north Bengal showed Hb variants to have a significant effect on HbA1c measurement [ 32 ]. A clinically silent and very rare hemoglobinopathy, hemoglobin Himeji, has been reported in a Portuguese patient with diabetes with a discrepancy between fasting plasma glucose and HbA1c [ 33 ]. Yet another case series of two female Malay patients with HbJ, an Hb variant, showed persistently high HbA1c levels despite good glycemic control [ 34 ].
Because of the local occurrence of Hb variants and the ethnic origin of a given population, every individual laboratory must establish and validate its own assay method. Also, while managing patients with diabetes, knowledge of hemoglobinopathies influencing HbA1c determination methods is essential. Moreover, in populations with a high prevalence of hemoglobinopathies, hemoglobin typing should be considered basic information prior to HbA1c measurement, as suggested by some other studies, as well [ 35 ].
Hence, to conclude, clinicians should be aware of this limitation of HbA1c estimation by ion-exchange HPLC in patients with HbE and other Hb variants, though HPLC has been an important and one of the most commonly used modalities [ 26 ], among the several others such as immunoassay techniques, boronate affinity chromatography, etc., to detect it [ 18 ]. If the clinical impression and HbA1c test results do not match, then HbA1c values should be determined with a second method based on a different principle and confirmation of the glycemic status through alternative investigations. The boronate affinity method has been shown to be clinically reasonable for all hemoglobin variants. Similarly, the fructosamine test and the glycated albumin test could also be used as alternatives, as they are also not influenced by the presence of hemoglobin variants. The OGTT and continuous glucose monitoring can obviously be other reliable alternatives, though they have their own disadvantages, such as the fact that they will not reflect glycemic control over a longer period of time, as does the HbA1c, and need repeated measurements. Moreover, an abnormal HbA1c level in a diabetic patient or any other subject during routine evaluation or screening for diabetes could raise the suspicion of an Hb variant. Therefore, physicians and especially endocrinologists should take this fact into account and immediately seek further evaluation and investigations to confirm the diagnosis of Hb variants in such patients and advise the patients to screen their family members.
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Rashmi Karki, Samir Lamichhane, and Rekha Manandhar have contributed equally to this work.
National Public Health Laboratory (NPHL), Kathmandu, Nepal
Rashmi Karki, Runa Jha & Rekha Manandhar
Department of Clinical Pharmacology, Maharajgunj Medical Campus (MMC), Institute of Medicine (IOM), Tribhuvan University (TU), Kathmandu, Nepal
Samir Lamichhane
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RK and RM conceptualized and designed the case report. The acquisition, analysis, and interpretation of patient data were also performed by RK and RM. The collection and assembly of relevant literature and background information, as well as writing and revising the manuscript focusing on the clinical aspects of the case, were done by SL. RK assisted SL in drafting and revising the manuscript, with a focus on the literature review. RK also contributed to the intellectual content and critical revision of the manuscript. Supervision and mentorship throughout the case report development were done by RJ and RM. All authors have read and approved the final version of the manuscript to be published.
Correspondence to Samir Lamichhane .
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Karki, R., Lamichhane, S., Jha, R. et al. An incidental finding of a hemoglobin E variant in a diabetic patient with an abnormal glycated hemoglobin level: a case report. J Med Case Reports 18 , 279 (2024). https://doi.org/10.1186/s13256-024-04518-y
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Ms. Litman is a professor at the University of Michigan Law School, a host of the “Strict Scrutiny” podcast and a former clerk to the Supreme Court justice Anthony Kennedy.
For those looking for the hidden hand of politics in what the Supreme Court does, there’s plenty of reason for suspicion on Donald Trump’s as-yet-undecided immunity case given its urgency. There are, of course, explanations that have nothing to do with politics for why a ruling still hasn’t been issued. But the reasons to think something is rotten at the court are impossible to ignore.
On Feb. 28, the justices agreed to hear Mr. Trump’s claim that he is immune from prosecution on charges that he plotted to subvert the 2020 election. The court scheduled oral arguments in the case for the end of April. That eight-week interval is much quicker than the ordinary Supreme Court briefing process, which usually extends for at least 10 weeks . But it’s considerably more drawn out than the schedule the court established earlier this year on a challenge from Colorado after that state took Mr. Trump off its presidential primary ballot. The court agreed to hear arguments on the case a mere month after accepting it and issued its decision less than a month after the argument. Mr. Trump prevailed, 9-0.
Nearly two months have passed since the justices heard lawyers for the former president and for the special counsel’s office argue the immunity case. The court is dominated by conservatives nominated by Republican presidents. Every passing day further delays a potential trial on charges related to Mr. Trump’s efforts to remain in office after losing the 2020 election and his role in the events that led to the storming of the Capitol; indeed, at this point, even if the court rules that Mr. Trump has limited or no immunity, it is unlikely a verdict will be delivered before the election.
The immunity case is not the only big case hanging fire. Some two dozen remain undecided that were argued even before the April 25 oral argument over Mr. Trump’s immunity. A case on gun rights for domestic abusers under a restraining order was argued in November; cases involving the power of federal agencies and a multibillion-dollar settlement for opioid victims were heard in December and January; the court also has yet to decide whether upwind states must cut emissions that affect the air quality in downwind states. That case was argued in February.
The court is a busy place, though the justices are completing decisions at the second slowest rate since the 1946 term, according to a recent article in The Wall Street Journal. The court tries to wrap up its business for the term that began in October by the end of June. It’s not shocking that cases argued later in the term end up being decided later, especially because by the end of April, when the immunity case was heard, the court was still working to finish cases argued months earlier. April was also among the court’s busiest months: The justices heard 10 cases.
But these seemingly mundane, process explanations overlook some of the particulars in the immunity case. Mr. Trump’s lawyers put together a set of arguments that are so outlandish they shouldn’t take much time to dispatch. Among them is the upside-down claim that, because the Constitution specifies that an officer who is convicted in an impeachment proceeding may subsequently face a criminal trial, the Constitution actually requires an impeachment conviction before there is any criminal punishment.
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BACKGROUND AND PURPOSE: Overuse of computed tomography (CT)-based cerebrovascular imaging in the emergency department (ED) and inpatient settings, notably CT angiography of the head and neck (CTAHN) for minor and non-focal neurological presentations, stresses imaging services and exposes patients to radiation and contrast. Furthermore, such CT-based imaging is often insufficient for definitive diagnosis, necessitating additional MR imaging. Recent advances in fast MRI may allow for timely assessment and reduced need for CTAHN in select populations.
MATERIALS AND METHODS: We identified inpatients or ED patients who underwent CTAHN (including non-contrast and post-contrast CTH, with or without CT perfusion [CTP] imaging) followed within 24 hours by a 3T MRI study that included NeuroMix (an unenhanced 2.5 min multi-contrast sequence) and intracranial time-of-flight MR angiography (MRA; a 5 min sequence) during a 9-month period (April to December 2022). Cases were classified by 4 radiologists in consensus as to whether NeuroMix and NeuroMix+MRA detected equivalent findings, detected unique findings, or missed findings relative to CTAHN.
RESULTS: 174 cases (mean age 67±16 yrs; 56% female) met the inclusion criteria. NeuroMix alone and NeuroMix+MRA protocols were determined to be equivalent or better compared to CTAHN in 71% and 95% of patients, respectively. NeuroMix always provided equivalent or better assessment of the brain parenchyma, with unique findings on NeuroMix and NeuroMix+MRA in 35% and 36% of cases, respectively, most commonly acute infarction or multiple microhemorrhages. In 8/174 cases (5%), CTAHN identified vascular abnormalities not seen on the NeuroMix+MRA protocol due to CTAHN’s wider coverage of the cervical arteries.
CONCLUSIONS: A fast MR imaging protocol consisting of NeuroMix+MRA provided equivalent or better information compared to CTAHN in 95% of cases in our population of patients with an acute neurological presentation. The findings provide a deeper understanding of the benefits and challenges of a fast unenhanced MR-first approach with NeuroMix+MRA, which could be used to design prospective trials in select patient groups, with the potential to reduce radiation dose, mitigate adverse contrast-related patient and environmental effects, and lessen the burden on radiologists and healthcare systems.
ABBREVIATIONS: CTAHN = CTA Head and Neck including non-contrast and delayed post-contrast CT Head with or without CT perfusion, NeuroMix = unenhanced multi-contrast MR brain sequence.
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BACKGROUND AND PURPOSE: Overuse of computed tomography (CT)-based cerebrovascular imaging in the emergency department (ED) and inpatient settings, notably CT angiography of the head and neck (CTAHN) for minor and non-focal neurological presentations, stresses imaging services and exposes patients to radiation and contrast. Furthermore, such CT-based imaging is often insufficient for definitive ...