Klebsiella pneumoniae : an increasing threat to public health
The higher rates of colonization are primarily related to the increasing use of antibiotics [3, 17, 18]. The increase in colonization rate of K. pneumoniae as observed in these clinical samples is of epidemiological important because, Klebsiella nosocomial infection was four times higher in stool carriers compared with non-carriers [19].
Recent advances in the understanding and management of Klebsiella
Abstract. Klebsiella pneumoniae, a gram-negative bacillus of the Enterobacteriaceae family, is a component of the normal human microbiota and a common cause of community- and healthcare-associated infections.The increasing prevalence of antimicrobial resistance among K. pneumoniae isolates, particularly among those causing healthcare-associated infections, is an important public health concern.
Clinical Epidemiology, Risk Factors, and Control Strategies of
Introduction. Klebsiella pneumoniae is a Gram-negative, encapsulated, non-motile, facultatively anaerobic bacteria (Ray and Ryan, 2004).It was first isolated from the airways of a patient dying of pneumonia by Edwin Klebs in 1875 and later described by Carl Friedländer in 1882, leading it to be called Friedlander's bacillus for some time (Köhler and Mochmann, 1987).
Klebsiella pneumoniae : an increasing threat to public health
Objectives This review fills the paucity of information on K. pneumoniae as a nosocomial pathogen by providing pooled data on epidemiological risk factors, resistant trends and profiles and resistant and virulent genes of this organism in Asia. Methods Exhaustive search was conducted using PubMed, Web of Science, and Google scholar for most studies addressing the prevalence, risk factors, drug ...
Clinical characteristics, risk factors and outcomes of Klebsiella
Klebsiella pneumoniae (KP) is a gram-negative, encapsulated, bacterium in the environment [].The bacterium typically colonizes human mucosal surfaces, including the gastrointestinal (GI) tract and oropharynx [].Once the bacteria enter the body, they can exhibit a high degree of toxicity and antibiotic resistance [].KP pneumonia accounts for approximately 11.8% of all hospital-acquired ...
Risk factors associated with multidrug-resistant Klebsiella pneumoniae
Klebsiella pneumoniae is a significant global public health burden, especially in low-income countries and regions with fragile healthcare infrastructures, due to its ability to cause severe infections, increase mortality rates, and its rising antimicrobial resistance. This study aimed to estimate the proportion of multidrug-resistant (MDR) K. pneumoniae infections and identify associated risk ...
Full article: Interactions and Implications of Klebsiella pneumoniae
Abstract. Klebsiella pneumoniae (K. pneumoniae), a significant contributor to the global challenge of antibiotic resistance, is not only a ubiquitous component of the human microbiome but also a potent pathogen capable of causing a spectrum of diseases.This review provides a thorough analysis of the intricate interactions between K. pneumoniae and the human immune system, elucidating its ...
Genetic characteristics of clinical carbapenem-resistant Klebsiella
Klebsiella pneumoniae is a clinically important bacterial pathogen that is capable of causing serious nosocomial infections 1.In particular, carbapenem-resistant K. pneumoniae (CRKP) is usually ...
Klebsiella pneumoniae is considered an opportunistic pathogen, constituting an ongoing health concern for immunocompromised patients, the elderly, and neonates. Reports on the isolation of K. pneumoniae from other sources are increasing, many of which express multidrug-resistant (MDR) phenotypes. Three phylogroups were identified based on nucleotide differences.
A genomic surveillance framework and genotyping tool for Klebsiella
Klebsiella pneumoniae is a leading cause of antimicrobial-resistant (AMR) healthcare-associated infections, neonatal sepsis and community-acquired liver abscess, and is associated with chronic ...
Klebsiella pneumoniae clinical isolates with features of both multidrug
Klebsiella pneumoniae is a highly diverse human pathogen and a major cause of antimicrobial resistance-related deaths globally 1,2.Bacteria of this species has been categorized into two broadly ...
Klebsiella pneumoniae: a major worldwide source and shuttle for
Abstract. Klebsiella pneumoniae is an important multidrug-resistant (MDR) pathogen affecting humans and a major source for hospital infections associated with high morbidity and mortality due to limited treatment options. We summarize the wide resistome of this pathogen, which encompasses plentiful chromosomal and plasmid-encoded antibiotic resistance genes (ARGs).
Antibiotic Resistance and Virulence Profiles of Klebsiella pneumoniae
ISGlobal, Hospital Clínic—Universitat de Barcelona, Barcelona, Spain; Klebsiella pneumoniae is a Gram-negative bacterium capable of colonizing, invading, and causing infections in different anatomical sites of the human body. Its ability to evade the immune system, its increasing antimicrobial resistance and the emergence of hypervirulent pathotypes have become a major challenge in the ...
Clinical characteristics and prognosis of Klebsiella pneumoniae
Klebsiella pneumoniae (KP) is a gram-negative bacterium that can induce pneumonia, liver abscess, bacteremia, meningitis, and other infections [5].According to drug susceptibility testing, KP can be classified into carbapenem-resistant Klebsiella pneumoniae (CRKP) and carbapenem-susceptible Klebsiella pneumoniae (CSKP). KP can also be divided into classical KP and hypervirulent Klebsiella ...
Full article: Mechanisms of Antibiotic Resistance and Developments in
Introduction. Klebsiella pneumoniae (K. pneumoniae) is a gram-negative bacterium found primarily in the respiratory tract and intestines of humans, often causes nosocomial infections, leading to illnesses such as pneumonia, liver abscesses, soft tissue infections, urinary tract infections, bacteremia, and in some cases death. Citation 1-3 Due to the irrational use of some antibiotics and the ...
Conformational ensembles in Klebsiella pneumoniae FimH impact ...
Klebsiella pneumoniae is recognized by the CDC as a pathogen of urgent concern, due to the increase of multidrug-resistant strains.K. pneumoniae use type 1 pili tipped with the two-domain FimH adhesin to cause urinary tract infections (UTIs). FimH interdomain interactions result in a conformational equilibrium between low-affinity and high-affinity forms.
Overcoming Klebsiella pneumoniae antibiotic resistance: new insights
Klebsiella pneumoniae is an ubiquitous gram-negative facultative anaerobic bacteria []. K. pneumoniae lives in many different environments, including the respiratory and gastrointestinal systems of humans and animals []. K. pneumoniae infection accounts for over 95% of Klebsiella infection.K. pneumoniae infection can trigger various infections and mostly affect the individuals with weakened ...
Population genomics of Klebsiella pneumoniae
Population structure. Typical K. pneumoniae genomes are ~5-6 Mbp in size, encoding ~5,000-6,000 genes. Approximately 1,700 genes are conserved in all members of the species (core genes ...
Current Positioning against Severe Infections Due to Klebsiella
1. Introduction. Infections caused by Klebsiella pneumoniae have increased in hospitalization wards, especially critical care settings, in the last decade, and they pose a severe problem when antimicrobial resistance is present. This point-of-view article summarizes the recently published literature on the management of carbapenemase-producing Enterobacterales (CPE) infections in critically ...
Klebsiella species: Taxonomy, hypervirulence and multidrug resistance
Various strains in the genus Klebsiella have evolved to become a major clinical and public health threat worldwide. 1 Klebsiella spp. are opportunistic pathogens which are normally found in the flora of healthy individuals' nose, throat, skin, and intestinal tract, but can also cause a range of infections, including pneumonia, soft tissue and surgical wound infections, urinary tract ...
Klebsiella pneumoniae causes bacteremia using factors that mediate
Author summary Gram-negative bacteremia is a deadly family of infections that initiate sepsis, a leading cause of global morbidity and mortality. Only a small number of Gram-negative species contribute to the majority of clinical bacteremia. Klebsiella pneumoniae is the second leading cause of Gram-negative bacteremia, and the third leading cause of overall bloodstream infection. K. pneumoniae ...
Article Review :Klebsiella Pneumonia: Epidemiology, Virulence Factors. and Treatment. Saif T. Jasim 1 and Ahmed Sami Farhan 2. 1 Department of Al-Qaim Education, General Directorate of Education ...
Treatment and diagnosis of severe KPC-producing Klebsiella pneumoniae
Carbapenem resistance in the Gram-negative pathogen Klebsiella pneumoniae is mostly due to the production of carbapenemases ... Seegene, Setlance, Shionogi, Symcel, Thermo Fisher, VenatorX, Zambon. Outside the submitted work, MB reports research grants and/or personal fees for advisor/consultant and/or speaker/chairman from Bayer, BioMérieux ...
ESBL-producing Klebsiella pneumoniae in a University hospital
The worldwide spread of Klebsiella pneumoniae producing extended-spectrum β-lactamase (ESBL-Kp) is a significant threat. Specifically, various pandemic clones of ESBL-Kp are involved in hospital outbreaks and caused serious infections. In that context, we assessed the phenotypic and molecular features of a collection of ESBL-Kp isolates in a French university hospital and evaluated the ...
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The higher rates of colonization are primarily related to the increasing use of antibiotics [3, 17, 18]. The increase in colonization rate of K. pneumoniae as observed in these clinical samples is of epidemiological important because, Klebsiella nosocomial infection was four times higher in stool carriers compared with non-carriers [19].
Abstract. Klebsiella pneumoniae, a gram-negative bacillus of the Enterobacteriaceae family, is a component of the normal human microbiota and a common cause of community- and healthcare-associated infections.The increasing prevalence of antimicrobial resistance among K. pneumoniae isolates, particularly among those causing healthcare-associated infections, is an important public health concern.
Introduction. Klebsiella pneumoniae is a Gram-negative, encapsulated, non-motile, facultatively anaerobic bacteria (Ray and Ryan, 2004).It was first isolated from the airways of a patient dying of pneumonia by Edwin Klebs in 1875 and later described by Carl Friedländer in 1882, leading it to be called Friedlander's bacillus for some time (Köhler and Mochmann, 1987).
Objectives This review fills the paucity of information on K. pneumoniae as a nosocomial pathogen by providing pooled data on epidemiological risk factors, resistant trends and profiles and resistant and virulent genes of this organism in Asia. Methods Exhaustive search was conducted using PubMed, Web of Science, and Google scholar for most studies addressing the prevalence, risk factors, drug ...
Klebsiella pneumoniae (KP) is a gram-negative, encapsulated, bacterium in the environment [].The bacterium typically colonizes human mucosal surfaces, including the gastrointestinal (GI) tract and oropharynx [].Once the bacteria enter the body, they can exhibit a high degree of toxicity and antibiotic resistance [].KP pneumonia accounts for approximately 11.8% of all hospital-acquired ...
Klebsiella pneumoniae is a significant global public health burden, especially in low-income countries and regions with fragile healthcare infrastructures, due to its ability to cause severe infections, increase mortality rates, and its rising antimicrobial resistance. This study aimed to estimate the proportion of multidrug-resistant (MDR) K. pneumoniae infections and identify associated risk ...
Abstract. Klebsiella pneumoniae (K. pneumoniae), a significant contributor to the global challenge of antibiotic resistance, is not only a ubiquitous component of the human microbiome but also a potent pathogen capable of causing a spectrum of diseases.This review provides a thorough analysis of the intricate interactions between K. pneumoniae and the human immune system, elucidating its ...
Klebsiella pneumoniae is a clinically important bacterial pathogen that is capable of causing serious nosocomial infections 1.In particular, carbapenem-resistant K. pneumoniae (CRKP) is usually ...
Klebsiella pneumoniae is considered an opportunistic pathogen, constituting an ongoing health concern for immunocompromised patients, the elderly, and neonates. Reports on the isolation of K. pneumoniae from other sources are increasing, many of which express multidrug-resistant (MDR) phenotypes. Three phylogroups were identified based on nucleotide differences.
Klebsiella pneumoniae is a leading cause of antimicrobial-resistant (AMR) healthcare-associated infections, neonatal sepsis and community-acquired liver abscess, and is associated with chronic ...
Klebsiella pneumoniae is a highly diverse human pathogen and a major cause of antimicrobial resistance-related deaths globally 1,2.Bacteria of this species has been categorized into two broadly ...
Abstract. Klebsiella pneumoniae is an important multidrug-resistant (MDR) pathogen affecting humans and a major source for hospital infections associated with high morbidity and mortality due to limited treatment options. We summarize the wide resistome of this pathogen, which encompasses plentiful chromosomal and plasmid-encoded antibiotic resistance genes (ARGs).
ISGlobal, Hospital Clínic—Universitat de Barcelona, Barcelona, Spain; Klebsiella pneumoniae is a Gram-negative bacterium capable of colonizing, invading, and causing infections in different anatomical sites of the human body. Its ability to evade the immune system, its increasing antimicrobial resistance and the emergence of hypervirulent pathotypes have become a major challenge in the ...
Klebsiella pneumoniae (KP) is a gram-negative bacterium that can induce pneumonia, liver abscess, bacteremia, meningitis, and other infections [5].According to drug susceptibility testing, KP can be classified into carbapenem-resistant Klebsiella pneumoniae (CRKP) and carbapenem-susceptible Klebsiella pneumoniae (CSKP). KP can also be divided into classical KP and hypervirulent Klebsiella ...
Introduction. Klebsiella pneumoniae (K. pneumoniae) is a gram-negative bacterium found primarily in the respiratory tract and intestines of humans, often causes nosocomial infections, leading to illnesses such as pneumonia, liver abscesses, soft tissue infections, urinary tract infections, bacteremia, and in some cases death. Citation 1-3 Due to the irrational use of some antibiotics and the ...
Klebsiella pneumoniae is recognized by the CDC as a pathogen of urgent concern, due to the increase of multidrug-resistant strains.K. pneumoniae use type 1 pili tipped with the two-domain FimH adhesin to cause urinary tract infections (UTIs). FimH interdomain interactions result in a conformational equilibrium between low-affinity and high-affinity forms.
Klebsiella pneumoniae is an ubiquitous gram-negative facultative anaerobic bacteria []. K. pneumoniae lives in many different environments, including the respiratory and gastrointestinal systems of humans and animals []. K. pneumoniae infection accounts for over 95% of Klebsiella infection.K. pneumoniae infection can trigger various infections and mostly affect the individuals with weakened ...
Population structure. Typical K. pneumoniae genomes are ~5-6 Mbp in size, encoding ~5,000-6,000 genes. Approximately 1,700 genes are conserved in all members of the species (core genes ...
1. Introduction. Infections caused by Klebsiella pneumoniae have increased in hospitalization wards, especially critical care settings, in the last decade, and they pose a severe problem when antimicrobial resistance is present. This point-of-view article summarizes the recently published literature on the management of carbapenemase-producing Enterobacterales (CPE) infections in critically ...
Various strains in the genus Klebsiella have evolved to become a major clinical and public health threat worldwide. 1 Klebsiella spp. are opportunistic pathogens which are normally found in the flora of healthy individuals' nose, throat, skin, and intestinal tract, but can also cause a range of infections, including pneumonia, soft tissue and surgical wound infections, urinary tract ...
Author summary Gram-negative bacteremia is a deadly family of infections that initiate sepsis, a leading cause of global morbidity and mortality. Only a small number of Gram-negative species contribute to the majority of clinical bacteremia. Klebsiella pneumoniae is the second leading cause of Gram-negative bacteremia, and the third leading cause of overall bloodstream infection. K. pneumoniae ...
Article Review :Klebsiella Pneumonia: Epidemiology, Virulence Factors. and Treatment. Saif T. Jasim 1 and Ahmed Sami Farhan 2. 1 Department of Al-Qaim Education, General Directorate of Education ...
Carbapenem resistance in the Gram-negative pathogen Klebsiella pneumoniae is mostly due to the production of carbapenemases ... Seegene, Setlance, Shionogi, Symcel, Thermo Fisher, VenatorX, Zambon. Outside the submitted work, MB reports research grants and/or personal fees for advisor/consultant and/or speaker/chairman from Bayer, BioMérieux ...
The worldwide spread of Klebsiella pneumoniae producing extended-spectrum β-lactamase (ESBL-Kp) is a significant threat. Specifically, various pandemic clones of ESBL-Kp are involved in hospital outbreaks and caused serious infections. In that context, we assessed the phenotypic and molecular features of a collection of ESBL-Kp isolates in a French university hospital and evaluated the ...