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Labs across the globe networked by AI discover state-of-the-art emitters for lasers

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Best-in-class emitter materials for organic solid state lasers have been discovered by laboratories spread across the world that were coordinated by an artificial intelligence. The researchers believe the technique could provide a blueprint for running experiments in parallel and thereby accelerating the discovery of other materials.

Source: © Science/AAAS

Overview of the described decentralised workflow for the accelerated discovery of small-molecule gain materials for organic solid state lasers

In recent years, the development of robotics and artificial intelligence has led to increasing interest in ‘self-driving labs’, with the design, synthesis, testing and analysis of molecules carried out automatically and used to select subsequent molecules for synthesis and analysis. In principle, this could be much more efficient if multiple labs pooled their analytical resources to work on the same problem – especially as different labs have different specialist equipment – but integrating the work of labs in real time is extremely challenging.

In the new work, researchers at the University of Toronto in Canada developed an artificial intelligence algorithm that could process data from laboratories as widespread as the University of Illinois Urbana–Champaign, US, University of Glasgow, UK, and Kyushu University in Japan. It coordinated a systematic search of more than 150,000 possible organic solid state materials produced by iterative Suzuki–Miyaura couplings to find the one with the lowest lasing threshold.

The algorithm constantly received results from laboratories around the world and used each new data point to update a list of the most promising molecules to synthesise and analyse next. This allowed laboratories to avoid duplicating one another’s results. ‘If we had multiple labs that had similar capabilities and could do the same experiments … then whenever a lab was free you could acquire that experiment and run it in the lab… The AI would then update the list and say “OK, now these are the most informative ones”,’ says joint first author Felix Strieth-Kalthoff at the University of Toronto. ‘The sun never set on this project: it was just going on around the globe,’ adds Martin Burke of the University of Illinois Urbana–Champaign.

Selected examples of automated gram-scale synthesis of Lego-like building blocks (top) and parallelised, small-scale synthesis of organic solid state laser target molecules (bottom) carried out at labs around the world

Moreover, it allowed parts of molecules to be prepared in one laboratory before being shipped to another for further synthesis and analysis. ‘If you buy a car in America, the chances are very high that it’s been made very heavily in Mexico and in Canada with parts going back and forth across the border several times,’ says Alán Aspuru-Guzik at the University of Toronto. This kind of delocalised production line chemistry has previously been almost impossible.

At the end of the project, the researchers arrived at 21 molecules with better stimulated emission than the previous state-of-the-art. ‘We’re at the dawn of the molecular industrial revolution because modularisation on the molecular scale is going to give us all the same advantages that drove the industrial revolution on the macroscale,’ says Burke. ‘This paper represents a very exciting example of what’s coming.’

Chemical engineer Milad Abolhasani of North Carolina State University, who was not part of the research, agrees. ‘Self-driving labs have been around for seven or eight years, but all prior self-driving labs have been confined within one lab,’ he says. ‘There are a lot of obstacles to address when you want to do these distributed, delocalised discovery campaigns and this paper is a great example of how to properly do that.’ He says the next steps are to expand the number of fully functional autonomous self-driving labs beyond the ‘handful’ currently in existence and to expand the range of reactions that can be automated. ‘Going beyond just liquid-phase organic synthesis and developing new tools that can handle more challenging reaction conditions is a must for the community,’ he says.

F Strieth-Kalthoff et al , Science, DOI: 10.1126/science.adk9227

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Organic Chemistry

UNDERSTANDING CARBON-BASED SUBSTANCES AND DEVELOPING ECONOMIC, GREEN STRATEGIES TO PRODUCE USEFUL NEW MOLECULES, REACTIONS AND MATERIALS 

Stanford chemists are developing more efficient and sustainable chemistries by exploring the structure, properties and reactions of organic compounds and materials. New reagents and catalysts are enabling greener industrial processes. Growing understanding of natural product properties, activities and synthesis are leading to potential new therapeutics, in close collaborations with researchers in the School of Medicine. These cutting-edge efforts build on a strong departmental history in organic synthesis.

Organic Synthesis

Invention of new tools and methods make it possible to create complex molecules from simple starting materials, more rapidly and cost-efficiently. Stanford chemists are developing new methods to synthesize target molecules with  potential applications as novel catalysts, antibiotics and antitumor therapies ; atomically efficient methods to create new  transition-metal-based non-protein catalysts ; new  atom and group transfer-type reaction processes  for natural product synthesis and chemical biology; and novel approaches to the  design and synthesis of exotic small and giant molecules for custom properties . Elusive, selective reactions at the  boundaries of modern organic synthesis  take inspiration from natural products – and answer questions about their properties and activities.

Molecular Design

Stanford chemists are crafted designers of a wide variety of molecules for applications in chemical synthesis, materials science, and biomedicine. Advancements in synthetic capabilities and efficiency allow for freedom of molecular design. Stanford chemists are designing new reactions, catalysts, and reagents for more efficient, selective, and robust chemical transformations; new molecular strategies to develop more effective drugs; new imaging agents, optical reporters, and molecular delivery vehicles to allow integration of biological systems and delivery of therapeutics into cells; new classes of biological probes for the study of cell surface glycans; fluorescent probes of DNA repair enzymes in cells and tissues; and novel classes of unusual molecular and polymeric materials with tailored optical, electronic, thermal, and mechanical properties.

Green Chemistries

Using mechanistic principles to develop new catalytic strategies, Stanford chemists synthesize complex, useful macromolecular architectures,  including sustainable polymers, synthetic fuels, and bioactive molecules ;  and develop cost-efficient catalysts and chemical reactions that  recycle CO2 into fuels and commodity chemicals  using renewable energy sources. To understand and reproduce the remarkable specificity and energy efficiency of metalloenzymes, Stanford chemist are studying the mechanism of  dioxygen activation by  copper-containing enzymes.

Biomedicine

Stanford researchers are employing organic methods to  explore the roles of cell-surface sugars and glycosylation in health, aging and illness , including cancer; to study and engineer enzymatic assembly lines that catalyze the biosynthesis of antibiotics in bacteria; and to  design nucleotides with unusual properties  such as fluorescence, enzyme reactivity, or altered shape and bonding ability, as tools to study nucleotide function and potential new probes for cancer diagnosis.

Computer Modeling

Computer studies of target molecules with desirable properties are finding ways to create  functionally similar species that require fewer steps to synthesize  – a technique called function oriented design and synthesis.

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Luca Sancineto

Luca Sancineto, PhD, University of Perugia (UNIPG), Italy. Dr. Sancineto got his PhD in Chemistry and Technology of Drugs at the UNIPG in 2012. After postdoctoral positions, and thanks to a Marie Curie Fellowship, he spent two years at the Centre of Molecular and Macromolecular Studies (Polish Academy of Science, Lodz). In 2018 he obtained the habilitation as associate professor in medicinal and organic chemistry. In 2019 he was hired by UNIPG as researcher and in 2022 he became associate professor. His main research interests lie in the development of green synthetic procedures and the preparation of pharmacologically active compounds.

Ornelio Rosati

Ornelio Rosati, Researcher in Organic Chemistry, Department of Pharmaceutical Sciences, University of Perugia, Italy. Dr. Rosati graduated from the University of Perugia (Italy) in Chemistry and Pharmaceutical Technologies in 1988. He holds a Ph.D. degree In "Bioecology of entomophages and biocontrol in the agroecosystem" in 1993. He is currently a permanent researcher at the Department of Pharmaceutical Sciences of the University of Perugia. His research activity is essentially oriented to the organic synthesis, catalysis, isolation and structural determination of natural compounds and their analogues with potential biological activity.

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Organic chemistry articles within Nature

Article | 23 May 2024

Stereospecific alkenylidene homologation of organoboronates by S N V reaction

• , Christian D. Knox
•  &  Guangbin Dong

Article | 02 May 2024

A deconstruction-reconstruction strategy for pyrimidine diversification

• Benjamin J. H. Uhlenbruck
• , Celena M. Josephitis
•  &  Andrew McNally

Article | 01 May 2024

Stereoselective amino acid synthesis by photobiocatalytic oxidative coupling

We report on the oxidative cross-coupling of organoboron reagents and amino acids via pyridoxal biocatalysis to produce non-canonical amino acids, uncovering stereoselective, intermolecular free-radical transformations.

• Tian-Ci Wang
• , Binh Khanh Mai
•  &  Yang Yang

News & Views | 03 April 2024

Trio of radicals choreographed for versatile chemical reaction

The idea that three different free radicals could be used together to carry out specific steps in a chemical reaction has long been implausible. A ‘radical sorting’ strategy now achieves this feat to make organic molecules.

• Kenneth F. Clark
•  &  John A. Murphy

Article | 28 March 2024

Copper-catalysed dehydrogenation or lactonization of C( sp 3 )–H bonds

Use of N -methoxyamides as oxidants enables controllable, redox-neutral, green catalysis of bimodal dehydrogenation/lactonization reactions with methanol as the only by-product.

• Shupeng Zhou
• , Zi-Jun Zhang
•  &  Jin-Quan Yu

Research Briefing | 18 March 2024

‘Bandit’ algorithms help chemists to discover generally applicable conditions for reactions

In organic chemistry, finding conditions that enable a broad range of compounds to undergo a particular type of reaction is highly desirable. However, conventional methods for doing so consume a lot of time and reagents. A machine-learning method has been developed that overcomes these problems.

Article | 13 March 2024

Couple-close construction of polycyclic rings from diradicals

A couple-close approach used to build semisaturated ring systems from dual radical precursors allows sampling of regions of underexplored chemical space, leading to an annulation that can be used for late-stage functionalization of pharmaceutical scaffolds.

• , Christian J. Oswood
•  &  David W. C. MacMillan

Article | 28 February 2024

Symmetry breaking and chiral amplification in prebiotic ligation reactions

A study of a new route to proteinogenic peptides reveals how heterochiral preference can lead to homochiral peptides in a prebiotic world.

• , Jinhan Yu
•  &  Donna G. Blackmond

Article | 13 February 2024

Alkene dialkylation by triple radical sorting

We use bimolecular homolytic substitution catalysis to sort an electrophilic radical and a nucleophilic radical across an unactivated alkene, accelerating access to pharmaceutically relevant C( sp 3 )-rich molecules and defining a mechanistic approach for alkene dialkylation.

• Johnny Z. Wang
• , William L. Lyon

Article 31 January 2024 | Open Access

Stereodivergent 1,3-difunctionalization of alkenes by charge relocation

We introduce a method for the direct 1,3-difunctionalization of alkenes, based on a concept termed ‘charge relocation’, which enables stereodivergent access to 1,3-difunctionalized products of either syn - or anti -configuration from unactivated alkenes.

• Bogdan R. Brutiu
• , Giulia Iannelli
•  &  Nuno Maulide

Where I Work | 15 January 2024

Giving thanks for a glovebox: helping to make medicines from natural substances

Richmond Sarpong wishes more people had access to the nitrogen-regulated device.

• James Mitchell Crow

Nature Careers Podcast | 24 November 2023

How ChatGPT and sounds from space brought a ‘luminous jelly’ to life

Engineer-turned-artist Diana Scarborough and inorganic chemist Anna Melekhova describe how their art–science collaboration gave voice and form to a new material.

• Julie Gould

Article | 01 November 2023

Carbon-to-nitrogen single-atom transmutation of azaarenes

A new type of transformation converting a heteroaromatic carbon atom into a nitrogen atom, turning quinolines into quinazolines to enable manipulation of molecular properties, is reported.

• , Colin Stein
•  &  Mark D. Levin

News & Views | 01 November 2023

Atom-swap chemistry could aid drug discovery

An unconventional route for modifying pharmaceutically relevant molecules swaps an atom of carbon for one of nitrogen. The resulting derivatives might open up avenues of research in medicinal-chemistry campaigns.

• Filippo Ficarra
•  &  Mattia Silvi

Article | 11 October 2023

Arenium-ion-catalysed halodealkylation of fully alkylated silanes

A new method is described that uses arenium-ion-catalysed halodealkylation of silanes with four alkyl groups, typically considered synthetic dead ends, to convert Me 4 Si and related quaternary silanes into orthogonally substituted (functionalized) silanes.

• , Hendrik F. T. Klare
•  &  Martin Oestreich

Article | 03 October 2023

Complex molecule synthesis by electrocatalytic decarboxylative cross-coupling

We report a radical-based Ni/Ag-electrocatalytic cross-coupling of substituted carboxylic acids, enabling an approach to accessing complex molecular architectures, which relies on a silver additive that forms an active Ag nanoparticle-coated electrode surface along with carefully chosen ligands.

• Benxiang Zhang
• , Jiayan He
•  &  Phil S. Baran

News & Views | 27 September 2023

An all-organic laser that is electrically driven

An organic light-emitting diode has been integrated with an optically driven organic laser to produce laser light from electricity. The design bypasses many of the challenges posed by direct electrical input in such devices.

• Stéphane Kéna-Cohen

Research Briefing | 20 September 2023

The chemical synthesis and anti-cancer properties of portimines

The natural toxins portimine A and B have attracted interest for their unusual chemical architecture and potent anti-cancer activity. The first total synthesis of portimines enables the identification of portimine A’s molecular target and reveals that the toxin induces programmed cell death in human cancer cells.

Article | 20 September 2023

A crystalline doubly oxidized carbene

The synthesis and isolation of a crystalline dication derived from a bis(imino)carbene through a two-electron oxidation/oxide-ion abstraction strategy is reported that bypasses the carbene radical cation, maintaining significant electrophilicity with two accessible vacant orbitals.

• Ying Kai Loh
• , Mohand Melaimi
•  &  Guy Bertrand

Geminal-atom catalysis for cross-coupling

Heterogeneous geminal-atom catalysts, which pair single-atom sites in specific coordination and spatial proximity, offer a new avenue for the sustainable manufacture of fine chemicals.

• , Yang Zheng
•  &  Jiong Lu

Synthesis of portimines reveals the basis of their anti-cancer activity

A scalable total synthesis of portimines enables structural reassignment of portimine B and in-depth functional evaluation of portimine A, revealing that portimine A induces translation inhibition selectively in human cancer cells and is efficacious in vivo tumour-clearance models.

• Junchen Tang
• , Weichao Li

Article 06 September 2023 | Open Access

A catalytically active oscillator made from small organic molecules

We report a small-organic-molecule oscillator that catalyses an independent chemical reaction in situ without impairing its oscillating properties, allowing the construction of complex systems enhancing applications in automated synthesis and systems and polymerization chemistry.

• Matthijs ter Harmsel
• , Oliver R. Maguire
•  &  Syuzanna R. Harutyunyan

Article | 06 September 2023

Hydrogen-bond-acceptor ligands enable distal C( sp 3 )–H arylation of free alcohols

Ligands enable alcohol-directed arylation of δ-C( sp 3 )–H bonds by stabilizing hydroxyl coordination to palladium through charge balance and hydrogen bonding.

• Daniel A. Strassfeld
• , Chia-Yu Chen

Article 23 August 2023 | Open Access

Light-enabled deracemization of cyclopropanes by Al-salen photocatalysis

Irradiation of chiral Al-salen complexes with violet light demonstrates efficient deracemization of cyclopropanes, enabling reactivity and enantioselectivity to be regulated simultaneously, negating the requirement for tailored catalyst–substrate recognition motifs.

• Carina Onneken
• , Tobias Morack
•  &  Ryan Gilmour

Article | 05 July 2023

Regioselective aliphatic C–H functionalization using frustrated radical pairs

Regioselective functionalization of aliphatic carbon–hydrogen bonds is achieved using frustrated radical pairs generated from disilazide donors and an N -oxoammonium acceptor.

• , Minsoo Ju
•  &  Song Lin

Article | 26 June 2023

Functional-group translocation of cyano groups by reversible C–H sampling

Using light-based, reversible C−H sampling catalysis, a cyano functional group can be swapped with a C−H bond in a molecule, providing access to valuable structures that are difficult to obtain by other methods.

• , Qingrui Zeng
•  &  Yan Xu

News & Views | 19 June 2023

Rarely used strained molecules step up for organic synthesis

Energy released from molecules under strain can promote difficult chemical reactions. A practical method has been developed that uses an overlooked, highly strained compound to rapidly construct complex organic products.

• Fahima I. M. Idiris
•  &  Christopher R. Jones

Research Briefing | 14 June 2023

Nickel catalyses a host of chemical reactions in a general method

A minimal but general method has been developed for catalysing many different cross-coupling reactions — those in which two chemical fragments are joined. It requires only the two substrate substances, a nickel salt as a catalyst precursor, a catalyst for light-driven redox reactions and, in some cases, a nitrogen-containing base.

Article | 31 May 2023

Transannular C–H functionalization of cycloalkane carboxylic acids

Quinuclidine-pyridone and sulfonamide-pyridone ligands enable transannular γ-methylene C–H arylation of cycloalkane carboxylic acids with a range of ring sizes, bringing us closer to molecular editing of saturated carbocycles.

• Guowei Kang
• , Daniel A. Strassfeld

Article | 19 April 2023

Strain-promoted reactions of 1,2,3-cyclohexatriene and its derivatives

The strained C 6 H 6 isomer 1,2,3-cyclohexatriene and its derivatives participate in a host of reaction modes which demonstrate their potential for selective chemical transformations and provide an unconventional entryway to complex scaffolds.

• Andrew V. Kelleghan
• , Ana S. Bulger
•  &  Neil K. Garg

Research Briefing | 05 April 2023

Enzyme-inspired catalyst helps to convert methane into methanol

A catalyst with a hydrophobic cavity that contains an active iron centre has been developed to convert methane into methanol. It has a ‘catch-and-release’ mechanism whereby a hydrophobic methane molecule enters the cavity for oxidation and the resulting hydrophilic methanol molecule is released into the surrounding aqueous solution.

Article | 04 April 2023

General access to cubanes as benzene bioisosteres

The synthesis of 1,3- and 1,2-disubstituted cubanes is achieved using a cyclobutadiene precursor and a photolytic carboxylation reaction, respectively, and copper-catalysed amination, arylation, alkylation and trifluoromethylation reactions have been developed enabling the use of cubanes as bioisosteres of benzenes in drug design.

• Mario P. Wiesenfeldt
• , James A. Rossi-Ashton

Article | 30 March 2023

Copper-catalysed enantioconvergent alkylation of oxygen nucleophiles

The enantioconvergent alkylation of oxygen nucleophiles is achieved using α-haloamides and a readily available copper catalyst, and the reaction proceeds under mild conditions in the presence of a wide variety of functional groups.

• Caiyou Chen
•  &  Gregory C. Fu

Article | 20 March 2023

Enantioconvergent Cu-catalysed N -alkylation of aliphatic amines

The chemoselective and enantioconvergent N -alkylation of aliphatic amines, including ammonia, is achieved using chiral tridentate anionic ligands and a copper catalyst; the method shows excellent enantioselectivity and functional-group tolerance.

• Ji-Jun Chen
• , Jia-Heng Fang
•  &  Xin-Yuan Liu

Article 15 March 2023 | Open Access

Control of stereogenic oxygen in a helically chiral oxonium ion

The design, synthesis and characterization of a helically chiral triaryloxonium ion is reported, which is an example of a chiral non-racemic and configurationally stable molecule in which the oxygen atom is the sole stereogenic centre.

• , Mihai V. Popescu
•  &  Martin D. Smith

Article | 14 February 2023

Enantioselective transition-metal catalysis via an anion-binding approach

Chiral hydrogen-bond donors bind anions of organometallic catalysts to achieve enantiocontrol and reaction-rate enhancement through ion pairing together with other non-covalent interactions.

• John M. Ovian
• , Petra Vojáčková
•  &  Eric N. Jacobsen

News | 01 February 2023

The surprising chemicals used to embalm Egyptian mummies

Resins used to prepare bodies for the afterlife are found in vessels in an ancient workshop.

• Ewen Callaway

News & Views | 25 January 2023

Machine learning classifies catalytic-reaction mechanisms

The study of how chemical reactions work is key to the design of new reactions, but relies on hard work and expert knowledge. A machine-learning tool has been developed that could change the way this challenge is approached.

• Danilo M. Lustosa
•  &  Anat Milo

Article | 25 January 2023

Organic reaction mechanism classification using machine learning

Mechanistic elucidation through currently available kinetic analysis is limited by mathematical approximations and human interpretation, here a deep neural network model has been trained to analyse ordinary kinetic data and automatically elucidate the corresponding mechanism class.

• Jordi Burés
•  &  Igor Larrosa

Article | 05 January 2023

Electrochemical reactor dictates site selectivity in N -heteroarene carboxylations

An electrochemical strategy is described in which the direct carboxylation of pyridines and related N -heteroarenes with CO 2 shows divergent site selectivity depending on the type of reactor used.

• Guo-Quan Sun

Research Highlight | 09 December 2022

Tinkering with molecular ‘backbones’ holds promise for drug discovery

A method to edit the backbones of molecules allows chemists to modify ring-shaped chemical structures with greater ease.

Article | 06 December 2022

Electrophotocatalytic oxygenation of multiple adjacent C–H bonds

Installation of multiple C–O bonds by concurrent oxygenation of contiguous C–H bonds in a selective fashion is highly desirable, and this is achieved by repeated operation of a potent oxidative catalyst via electrophotocatalysis.

• , Yi-Lun Li
•  &  Tristan H. Lambert

Outlook | 16 November 2022

How to make plastic less of an environmental burden

Plastic has long been an ecological problem. But emerging technologies and more awareness could make the ubiquitous material part of a circular economy.

• Sarah DeWeerdt

News & Views | 10 October 2022

A leap forward in the quest for general catalysts

Truly general chemical reactions work well regardless of the structural features and functional groups in the starting molecule. A new screening protocol speeds up the identification of such reactions in the field of asymmetric catalysis.

• Manuel J. Scharf
•  &  Benjamin List

News & Views | 29 September 2022

Machine assembly of carbohydrates with more than 1,000 sugar units

Efforts to probe the biological functions of carbohydrates have long been limited by the lack of such molecules with well-defined structures. An automated carbohydrate synthesizer has been developed that could remedy this.

• Hanchao Cheng
•  &  Peng George Wang

News & Views | 16 September 2022

A stable alternative to an explosive synthetic reaction

The ozonolysis reaction is a classic of organic synthesis, but involves the formation of potentially explosive reaction intermediates. A modern, safer spin on this process makes use of previously overlooked chemistry.

• Vignesh Palani
•  &  Alison Wendlandt

Article | 15 September 2022

Synthesis of meta -substituted arene bioisosteres from [3.1.1]propellane

The potential power of the saturated carbocycle bicyclo[3.1.1]heptane as a beneficial motif for improving the pharmacokinetic and physicochemical properties of drug candidates is demonstrated.

• , Jeremy Nugent
•  &  Edward A. Anderson

Article | 01 September 2022

Screening for generality in asymmetric catalysis

 The analytical workflow outlined in this study allows multiple crude reaction mixtures to be analysed simultaneously, with substantial reductions in method development and analysis time, and maximizes the chances of finding catalytic systems with broad substrate scope.

• Corin C. Wagen
• , Spencer E. McMinn

Article | 23 August 2022

Photoexcited nitroarenes for the oxidative cleavage of alkenes

Oxidative cleavage of alkenes is achieved using nitroarenes and light irradiation as an alternative to using ozone to break the carbon–carbon bonds, avoiding the explosive intermediates formed with ozone.

• Alessandro Ruffoni
• , Charlotte Hampton
•  &  Daniele Leonori

Article | 09 August 2022

Molecular editing of aza-arene C–H bonds by distance, geometry and chirality

A unified catalytic remote-directing template strategy enabled precise differentiation of remote and adjacent C6–H and C7–H bonds, and similar C3–H and C7–H bonds of a pharmaceutically relevant bicyclic aza-arene scaffold.

• Zhoulong Fan
• , Xiangyang Chen

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• ACS Publications

10 Hot Topics in Chemistry so far in 2022

• Jul 8, 2022

In any field, there are always some current topics that get pulses racing. Chemistry is no different, so today we bring you our top ten hot topics of the summer. Grab an iced drink, and see if you agree with our run down…

AI and Big Data

At number ten, it’s artificial intelligence and big data in water environments. These powerful new tools are increasingly being used in environmental science to assess risks, examine contaminants, identify and characterize pollution sources, and to model water treatment processes. But there remain opportunities and challenges in applying machine learning and data analytics to solving environmental problems, and it is hoped that new techniques will significantly advance water-related research in the coming years. 1

10 Hot Topics in Chemistry So Far in 2023

Thermochemical processing of waste and biomass.

Next up: recent advances in biomass and wastes thermochemical processing. Earlier in the year the ACS journal Energy & Fuels highlighted developments presented by participants at a virtual symposium organized by the Washington State University Pacific Northwest National Laboratory Bioproducts Institute. The world is gradually transitioning from an era fueled by fossil power to one characterized by sustainability and renewable resources. Recent progresses the understanding of biomass thermochemical reactions are allowing research communities to visualize these in practical solutions to mitigate environmental issues. Contents within the issue fall into four areas: (1) fundamentals of biomass thermochemical reactions, (2) liquefaction technologies, (3) catalytic upgrading/refining, and (4) techno-economic analysis/material. 2

Next Gen Active Materials

At eight, bioconjugate biomaterials, and the next generation of active materials. Biomaterials are redefining modern medicine – from new chemical strategies to modify hydrogels, or biocompatible methods to stabilize proteins and peptides, biomaterials are changing the detection and treatment of disease. In addition, engineered systems reveal new insights into biological processes, including stem cell signaling, cellular motions, and tissue repair, with many applications in human health. 3

Advances in TB drug discovery and diagnosis

Or how about drug discovery and diagnosis in tuberculosis? Before the emergence of SARS-CoV-2, tuberculosis was the leading cause of death from an infectious disease, with drug resistance limiting the effectiveness of current treatments. But recent advances in drug discovery and diagnostics promise new efforts to combat this global health threat, which may come back to the forefront as COVID recedes. 4

Smoking and chemical toxicology

At six, research into the chemical toxicology of smoking – with consideration of the use of cigarettes, e-cigarettes, and cannabis, particularly given the rise of lung injury cases associated with vaping. It is likely that both conventional and innovative chemical tools will play a major role in understanding the mechanisms of toxicity of tobacco and its related products, as well as the transformation of e-cigarette constituents during vaping. 5

Process safety in chemistry

Into the top five now, and our pick is process safety. Many industrial chemical incidents happen around the world every year, resulting in deaths, property damage, and disrupted supply chains. Systematically studying process performance and learning from the past is an effective way to prevent such incidents, with new research contributing to strategies for improving chemical safety across natural, social, management, and engineering sciences. 6

Catalysis and energy snapshot in China

At four, energy and catalysis, with a focus on China. Energy plays a central role in society, and the hunt for clean and sustainable resources is becoming one of the most important global issues of our time. Over the past decade, researchers in China have made extensive efforts and achieved significant advances in the fields of energy and catalysis – both in the understanding of fundamental mechanisms, and the development of efficient materials and devices. 7

Applied chemistry in healthcare

The top three hot topics in this selection all take us back into chemical applications in healthcare. At three is antifungal drug discovery. Fungal diseases cause millions of deaths each year, and can increase the morbidity of other bacterial and viral infections. Current treatments such as polyenes, azoles, and echinocandins are old, and often do not offer cure – as well as being associated with severe side effects. New research and development is needed to improve outcomes, and to keep pace with emerging pathogens. 8

Neglected tropical diseases

Coming in at number two, neglected tropical diseases, which affect more than a billion people worldwide in tropical areas and impoverished communities. This category of diseases includes schistosomiasis, which can damage the bladder, kidneys and liver, and other tropical parasites. ACS journals collaborated in a special virtual issue to showcase recent advances in the diagnosis and treatment of these illnesses. 9

And our number one hot topic for the summer of 2022 – it’s vaccines. As we have all seen in recent years, vaccines are a key mitigation strategy against viruses. But their application is wider than just inoculating against infectious pathogens; indeed, they show utility in cancer and other diseases, and are driving new options for personalized medicine. Now, new materials and conjugation methods may simplify production and enhance outcomes. Furthermore, new biomolecules and display modalities can expand the reach of vaccines to target emerging and endemic viruses. Improved strategies to deliver vaccines and induce immunogenicity are critical to protect against future outbreaks. 10

All these topics have been covered in recent special and virtual issues of ACS journals. Visit the website to explore more, and connect with us on social media to tell us about your own favourite hot topics in the world of chemistry.

• AI and Big Data in Water Environments. ACS EST Water Available at: https://pubs.acs.org/page/aewcaa/vi/ai-big-data-water-environments .
• Recent Advances in Biomass and Wastes Thermochemical Processing. Energy Fuels Available at: https://pubs.acs.org/page/enfuem/vi/thermochemical-processing
• Bioconjugate Biomaterials: Leveraging Biology for the Next Generation of Active Materials. Bioconjugate Chem Available at: https://pubs.acs.org/page/bcches/vi/bioconjugatebiomaterials
• Tuberculosis Drug Discovery and Diagnosis. ACS Infect Dis Available at: https://pubs.acs.org/page/vi/tuberculosis
• Chemical Toxicology of Cigarette, e-Cigarette and Cannabis Smoking. Chem Res Toxicol Available at: https://pubs.acs.org/page/crtoec/vi/chemical-toxicology-cigarette
• Process Safety from Bench to Pilot to Plant. A special collaboration issue. Available at: https://pubs.acs.org/page/vi/process-safety-bench-pilot-plant
• Energy and Catalysis in China. J Phys Chem C Available at: https://pubs.acs.org/page/jpccck/vsi/energy-catalysis-china
• Antifungal Drug Discovery. A special collaboration issue. Available at: https://pubs.acs.org/page/vi/antifungals
• Neglected tropical Diseases. A special collaboration issue. Available at: https://pubs.acs.org/page/vi/ntdday
• Vaccine Strategies. Bioconjugate Chem Available at: https://pubs.acs.org/page/bcches/vi/vaccinestrategies

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100+ Great Chemistry Research Topics

Table of contents

• 1 5 Tips for Writing Chemistry Research Papers
• 2 Chemical Engineering Research Topics
• 3 Organic Сhemistry Research Topics
• 4 Іnorganic Сhemistry Research Topics
• 5 Biomolecular Сhemistry Research Topics
• 6 Analytical Chemistry Research Topics
• 7 Computational Chemistry Research Topics
• 8 Physical Chemistry Research Topics
• 9 Innovative Chemistry Research Topics
• 10 Environmental Chemistry Research Topics
• 11 Green Chemistry Research Topics
• 12.1 Conclusion

Do you need a topic for your chemistry research paper? Are you unsure of where to start? Don’t worry – we’re here to help. In this post, we’ll go over a series of the best chemistry research paper topics as well as Tips for Writing Chemistry Research Papers on different topics. By the time you finish reading this post, you’ll have plenty of ideas to get started on your next research project!

There are many different subfields of chemistry, so it can be tough to find interesting chemistry topics to write about. If you’re struggling to narrow down your topic, we’ll go over lists of topics in multiple fields of study.

Doing research is important to help scientists learn more about the world around us. By researching different compounds and elements, we can learn more about how they interact with one another and how they can be used to create new products or improve existing ones.

There are many different topics that you can choose to research in chemistry. Here are just a few examples:

• The history of chemistry and how it has evolved over time
• How different chemicals react with one another
• How to create new compounds or improve existing ones
• The role of chemistry in the environment
• The health effects of different chemicals

5 Tips for Writing Chemistry Research Papers

Once you have chosen a topic for your research paper , it is important to follow some tips to ensure that your paper is well-written and accurate. Here are a few tips to get you started:

• Start by doing some background research on your topic. This will help you understand the basics of the topic and give you a good foundation to build your paper on.
• Make sure to cite all of the sources that you use in your paper. This will help to show where you got your information and will also help to add credibility to your work.
• Be sure to proofread your paper before you submit it. This will ensure that there are no errors and that your paper is clear and concise.
• Get help from a tutor or friend if you are struggling with your paper. They may be able to offer helpful advice or feedback.
• Take your time when writing your research paper . This is not a race, and it is important to make sure that you do a good job on your research.

By following these tips, you can be sure that your chemistry research paper will be a success! So what are you waiting for? Let’s go over some of the best research paper topics out there.

Chemical Engineering Research Topics

Chemical Engineering is a branch of engineering that deals with the design and application of chemical processes. If you’re wondering how to choose a paper topic, here are some ideas to inspire you:

• How to create new alloy compounds or improve existing ones
• The health effects of the food industry chemicals
• Chemical engineering and sustainable development
• The future of chemical engineering
• Chemical engineering and the food industry
• Chemical engineering and the pharmaceutical industry
• Chemical engineering and the cosmetics industry
• Chemical engineering and the petrochemical industry
• Biocompatible materials for drug delivery systems
• Membrane technology in water treatment
• Development of synthetic fibers for industrial use

These are just a few examples – there are many more possibilities out there! So get started on your research today. Who knows what you might discover!

Organic Сhemistry Research Topics

Organic chemistry is the study of carbon-containing molecules. There are many different organic chemistry research topics that a student could choose to focus on and here are just a few examples of possible research projects in organic chemistry:

• Investigating new methods for synthesizing chiral molecules
• Studying the structure and reactivity of carbon nanotubes
• Investigating metal complexes with organometallic ligands
• Designing benzene derivatives with improved thermal stability
• Exploring new ways to control the stereochemistry of chemical reactions
• Studying the role of enzymes in organic synthesis
• Investigating new strategies for combating drug resistance
• Developing new methods for detecting explosives residues
• Studying the photochemistry of organic molecules
• Studying the behavior of organometallic compounds in biological systems
• Synthetic routes for biodegradable plastics
• Catalysis in organic synthesis
• Development of non-toxic solvents

Іnorganic Сhemistry Research Topics

Inorganic Chemistry is the study of the chemistry of materials that do not contain carbon. Unlike other chemistry research topics, these include elements such as metals, minerals, and inorganic compounds. If you are looking for inorganic chemistry research topics on inorganic chemistry, here are some ideas to get you started:

• How different metals react with one another
• How to create new alloys or improve existing ones
• The role of inorganic chemistry in the environment
• Rare earth elements and their applications in electronics
• Inorganic polymers in construction materials
• Photoluminescent materials for energy conversion
• Inorganic chemistry and sustainable development
• The future of inorganic chemistry
• Inorganic chemistry and the food industry
• Inorganic chemistry and the pharmaceutical industry
• Atomic structure progressive scale grading
• Inorganiс Сhemistry and the cosmetics industry

Biomolecular Сhemistry Research Topics

Biomolecular chemistry is the study of molecules that are important for life. These molecules can be found in all living things, from tiny bacteria to the largest animals. Researchers who work in this field use a variety of techniques to learn more about how these molecules function and how they interact with each other.

If you are looking for essential biomolecular chemistry research topics, here are some ideas to get you started:

• The structure and function of DNA
• Lipidomics and its applications in disease diagnostics
• The structure and function of proteins
• The role of carbohydrates in the body
• The role of lipids in the body
• How enzymes work
• Protein engineering for therapeutic applications
• The role of biochemistry in heart disease
• Cyanides and their effect on the body
• The role of biochemistry in cancer treatment
• The role of biochemistry in Parkison’s disease treatment
• The role of biochemistry in the immune system
• Carbohydrate-based vaccines

The possibilities are endless for someone willing to dedicate some time to research.

Analytical Chemistry Research Topics

Analytical Chemistry is a type of chemistry that helps scientists figure out what something is made of. This can be done through a variety of methods, such as spectroscopy or chromatography. If you are looking for research topics, here are some ideas to get you started:

• How food chemicals react with one another
• Mass spectrometry
• Microplastics detection in marine environments
• Development of sensors for heavy metal detection in water
• Analytical aspects of gas and liquid chromatography
• Analytical chemistry and sustainable development
• Atomic absorption spectroscopy methods and best practices
• Analytical chemistry and the pharmaceutical industry in Ibuprofen consumption
• Analytical chemistry and the cosmetics industry in UV protectors
• High-throughput screening methods in pharmaceutical analysis
• Dispersive X-ray analysis of damaged tissues

Analytical chemistry is considered by many a complex science and there is a lot yet to be discovered in the field.

Computational Chemistry Research Topics

Computational chemistry is a way to use computers to help chemists understand chemical reactions. This can be done by simulating reactions or by designing new molecules. If you are looking for essential chemistry research topics in computational chemistry, here are some ideas to get you started:

• Molecular mechanics simulation
• Machine learning applications in predicting molecular properties
• Reaction rates of complex chemical reactions
• Designing new molecules: how can simulation help
• The role of computers in the study of quantum mechanics
• How to use computers to predict chemical reactions
• Using computers to understand organic chemistry
• The future of computational Chemistry in organic reactions
• The impacts of simulation on the development of new medications
• Combustion reaction simulation impact on engine development
• Quantum-chemistry simulation review
• Simulation of protein folding and misfolding in diseases
• Development of algorithms for chemical synthesis planning
• Applications of Metal-Organic Frameworks in water sequestration and catalysis

Computers are cutting-edge technology in chemical research and this relatively new field of study has a ton yet to be explored.

Physical Chemistry Research Topics

Physical chemistry is the study of how matter behaves. It looks at the physical and chemical properties of atoms and molecules and how they interact with each other. If you are looking for physical chemistry research topics, here are some ideas to get you started:

• Standardization of pH scales
• Structure of atom on a quantum scale
• Bonding across atoms and molecules
• The effect of temperature on chemical reactions
• The role of light in in-body chemical reactions
• Chemical kinetics
• Molecular dynamics in confined spaces
• Quantum computing for solving chemical problems
• Studies on non-Newtonian fluids in industrial processes
• Surface tension and its effects on mixtures
• The role of pressure in chemical reactions
• Rates of diffusion in gases and liquids
• The role of entropy in chemical reactions

Here are just a few samples, but there are plenty more options! Start your research right now!

Innovative Chemistry Research Topics

Innovative chemistry is all about coming up with new ideas and ways to do things. This can be anything from creating new materials to finding new ways to make existing products. If you are looking for ground-breaking chemistry research topics, here are some ideas to get you started:

• Amino acids side chain effects in protein folding
• Chemistry in the production of nanomaterials
• The role of enzymes in chemical reactions
• Photocatalysis in 3D printing
• Avoiding pesticides in agriculture
• Combining chemical and biological processes
• Gene modification in medicinal chemistry
• The role of quantum mechanics in chemical reactions
• Astrochemical research on extraterrestrial molecules
• Spectroscopy signatures of pressurized organic components
• Development of smart materials with responsive properties
• Chemistry in space: studying chemical reactions in microgravity
• Utilization of CO2 in chemical synthesis
• Use of black soldier fly carcasses for bioplastic production using extracted chitin
• Bioorthogonal chemistry for molecule synthesis inside living systems

If you need a hand, there are several sites that also offer research papers for sale and can be a great asset as you work to create your own research papers.

Whatever route you decide to take, good luck! And remember – the sky’s the limit when it comes to research! So get started today and see where your studies may take you. Who knows, you might just make a breakthrough discovery!

Environmental Chemistry Research Topics

Environmental Chemistry is the study of how chemicals interact with the environment. This can include anything from the air we breathe to the water we drink. If you are looking for environmental chemistry research topics, here are some ideas to get you started:

• Plastic effects on ocean life
• Urban ecology
• The role of carbon in climate change
• Air pollution and its effects
• Water pollution and its effects
• Chemicals in food and their effect on the body
• The effect of chemicals on plant life
• Earth temperature prediction models
• Effects of pharmaceuticals in aquatic environments
• Atmospheric chemistry and urban air quality
• Bioremediation techniques for oil spill cleanup
• Regulatory and environmental impact of Per- and Polyfluoroalkyl (PFA) substances
• Comparison of chemical regulation impacts like PFA with historical cases such as lead in fuel

A lot of research on the environment is being conducted at the moment because the environment is in danger. There are a lot of environmental problems that need to be solved, and research is the key to solving them.

Green Chemistry Research Topics

Green chemistry is the study of how to make products and processes that are environmentally friendly. This can include anything from finding new ways to recycle materials to developing new products that are biodegradable. If you are looking for green chemistry research topics, here are some ideas to get you started:

• Recycling and reuse of materials
• Developing biodegradable materials
• Improving existing recycling processes
• Green chemistry and sustainable development
• The future of green chemistry
• Green chemistry and the food industry
• Lifecycle assessment of chemical processes
• Green chemistry and the pharmaceutical industry
• Development of catalysts for green chemistry
• Green chemistry and the cosmetics industry
• Alternative energy sources for chemical synthesis

A more environmentally friendly world is something we all aspire for and a lot of research has been conducted on how we can achieve this, making this one of the most promising areas of study. The results have been varied, but there are a few key things we can do to make a difference.

Controversial Chemistry Research Topics

Controversial chemistry is all about hot-button topics that people are passionate about. This can include anything from the use of chemicals in warfare to the health effects of different chemicals. If you are looking for controversial topics to write about , here are some ideas to get you started:

• The use of chemicals in warfare
• Gene modification in human babies
• Bioengineering
• How fast food chemicals affect the human brain
• The role of the government in regulating chemicals
• Evolution of cigarette chemicals over time
• Chemical effects of CBD oils
• Ethical issues in genetic modification of organisms
• Nuclear energy: risks and benefits
• Use of chemicals in electronic waste recycling
• Antidepressant chemical reactions
• Synthetic molecule replication methods
• Gene analysis

Controversial research papers often appear in the media before it has been peer-reviewed and published in a scientific journal. The reason for this is that the media is interested in stories that are new, exciting, and generate a lot of debate.

Chemistry is an incredibly diverse and interesting field, with many controversial topics to write about. If you are looking for a research topic, consider the examples listed in this article. With a little bit of effort, you are sure to find a topic that is both interesting and within your skillset.

In order to be a good researcher, it is important to be able to think critically and solve problems. However, innovation in chemistry research can be challenging. When thinking about how to innovate, it is important to consider both the practical and theoretical aspects of your research. Additionally, try to build on the work of others in order to create something new and unique. With a little bit of effort, you are sure to be able to find a topic that is both interesting and within your skillset.

Happy writing!

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Researchers create materials with unique combo of stiffness, thermal insulation

Researchers have demonstrated the ability to engineer materials that are both stiff and capable of insulating against heat. This combination of properties is extremely unusual and holds promise for a range of applications, such as the development of new thermal insulation coatings for electronic devices.

"Materials that have a high elastic modulus tend to also be highly thermally conductive, and vice versa," says Jun Liu, co-corresponding author of a paper on the work and an associate professor of mechanical and aerospace engineering at North Carolina State University. "In other words, if a material is stiff, it does a good job of conducting heat. And if a material is not stiff, then it is usually good at insulating against heat.

"But there are instances where you'd want materials that are stiff, but are also good insulators," Liu says. "For example, you might want to create thermal insulation coatings to protect electronics from high temperatures. Historically, that's been a challenge.

"We've now discovered a range of materials that are both stiff and excellent thermal insulators. What's more, we can engineer the materials as needed to control how stiff they are and how thermally conductive they are."

Specifically, the researchers were working with a subset of the class of materials called two-dimensional hybrid organic-inorganic perovskites (2D HOIP).

"These are thin films consisting of alternating organic and inorganic layers in a highly ordered crystalline structure," says Wei You, co-corresponding author of this paper and professor of chemistry and applied physical sciences at the University of North Carolina at Chapel Hill. "And we can tune the composition of either the inorganic or organic layer."

"We found that we can control the elastic modulus and thermal conductivity of some 2D HOIPs by replacing some of the carbon-carbon chains in the organic layers with benzene rings," says Qing Tu, co-corresponding author of this paper and an assistant professor of materials science and engineering at Texas A&M University. "Basically -- within this specific subset of layered materials -- the more benzene rings we add, the stiffer the material gets, and the better able it is to insulate against heat."

"While discovering these materials in itself holds tremendous potential for a range of applications, as researchers we are particularly excited because we've identified the mechanism that is responsible for these characteristics -- namely the critical role that the benzene rings play," says Liu.

In experiments, the researchers found at least three distinct 2D HOIP materials that became less thermally conductive the stiffer they got.

"This work is exciting because it suggests a new pathway for engineering materials with desirable combinations of properties," Liu says.

The researchers also discovered another interesting phenomenon with 2D HOIP materials. Specifically, they found that by introducing chirality into the organic layers -- i.e., making the carbon chains in those layers asymmetrical -- they could effectively maintain the same stiffness and thermal conductivity even when making substantial changes to the composition of the organic layers.

"This raises some interesting questions about whether we might be able to optimize other characteristics of these materials without having to worry about how those changes might influence the material's stiffness or thermal conductivity," says Liu.

• Materials Science
• Civil Engineering
• Engineering and Construction
• Thermodynamics
• Organic Chemistry
• Nanotechnology
• Materials science
• Solar power
• Tissue engineering
• Pyroelectricity
• Nanoparticle
• Engineering

Story Source:

Materials provided by North Carolina State University . Original written by Matt Shipman. Note: Content may be edited for style and length.

Journal Reference :

• Ankit Negi, Liang Yan, Cong Yang, Yeonju Yu, Doyun Kim, Subhrangsu Mukherjee, Andrew H. Comstock, Saqlain Raza, Ziqi Wang, Dali Sun, Harald Ade, Qing Tu, Wei You, Jun Liu. Anomalous Correlation between Thermal Conductivity and Elastic Modulus in Two-Dimensional Hybrid Metal Halide Perovskites . ACS Nano , 2024; DOI: 10.1021/acsnano.3c12172

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50 Research Ideas in Organic Chemistry

Unlocking the Potential: 50 Intriguing Organic Chemistry Research Ideas

In the world of science, organic chemistry is like the hidden language of life. It’s the study of carbon and its dance with other elements to create everything from medicines that heal to materials that make our world. Today, iLovePhD delves into 50 intriguing research ideas in this fascinating field, uncovering the secrets and innovations that drive progress in science.

50 Intriguing Organic Chemistry Research Ideas

• Green Synthesis of Organic Compounds : Explore eco-friendly methods for synthesizing organic molecules.
• Applications of Organometallic Chemistry : Discuss the use of organometallic compounds in catalysis and materials science.
• Designing Sustainable Polymers : Investigate the development of biodegradable and recyclable polymers.
• Catalytic Asymmetric Synthesis : Examine recent advances in creating chiral organic compounds.
• Supramolecular Chemistry in Drug Design : Discuss how non-covalent interactions can be harnessed for drug discovery.
• Functionalization of C-H Bonds : Explore methods for selectively functionalizing carbon-hydrogen bonds.
• Natural Product Synthesis : Highlight recent total syntheses of complex natural products.
• Electroorganic Chemistry : Discuss the use of electricity as a reagent in organic reactions.
• Molecular Machines : Explore the design and applications of synthetic molecular machines.
• Metal-Organic Frameworks (MOFs) : Investigate the use of MOFs in gas storage and separation.
• Enzyme Mimicry in Catalysis : Discuss synthetic catalysts that mimic enzyme behavior.
• Chemical Biology : Explore the interface between chemistry and biology for drug discovery.
• Organic Photovoltaics : Discuss the development of organic materials for solar cells.
• Peptide Chemistry : Investigate the synthesis and applications of peptides in drug design.
• Click Chemistry : Highlight the versatility of click reactions in organic synthesis.
• Chemoinformatics : Discuss the use of computational methods in organic chemistry.
• Bioorthogonal Chemistry : Explore reactions that are compatible with living systems.
• Green Solvents in Organic Synthesis : Examine environmentally friendly solvents for organic reactions.
• Nanocatalysis : Discuss the role of nanoparticles in catalytic processes.
• Fluorine Chemistry : Investigate the unique properties of fluorinated organic compounds.
• Carbohydrate Chemistry : Explore the synthesis and functions of carbohydrates.
• Chemical Sensors : Discuss the design of organic sensors for detecting analytes.
• Synthetic Biology : Explore the engineering of biological systems for chemical production.
• Organic Chemistry in Medicine : Highlight the role of organic chemistry in drug development.
• Heterocyclic Chemistry : Investigate the synthesis and reactivity of heterocycles.
• Chemistry of Aromatics : Discuss reactions and applications of aromatic compounds.
• Polycyclic Aromatic Hydrocarbons (PAHs) : Explore the environmental and health impact of PAHs.
• Green Extraction Methods : Investigate eco-friendly techniques for extracting natural products.
• Organic Chemistry in Food : Discuss the chemistry behind food flavor and preservation.
• Chemistry of Natural Dyes : Explore the use of organic compounds as dyes.
• Artificial Sweeteners : Investigate the chemistry of sugar substitutes.
• Chemistry of Medicinal Plants : Highlight the organic compounds found in medicinal plants.
• Organic Synthesis with Flow Chemistry : Discuss continuous-flow methods in organic synthesis.
• Stereochemistry : Explore the importance of stereochemistry in organic reactions.
• Chirality in Pharmaceuticals : Discuss the role of chirality in drug design.
• Green Chemistry Metrics : Investigate metrics for assessing the sustainability of organic reactions.
• Photochemistry : Explore the use of light in driving organic reactions.
• Chemistry of Natural Toxins : Highlight the structures and effects of natural toxins.
• Chemistry of Pharmaceuticals : Discuss the synthesis and mechanisms of action of common drugs.
• Organic Chemistry in Cosmetics : Explore the chemistry of cosmetic products.
• Organic Chemistry in Art Conservation : Investigate the role of organic chemistry in preserving artworks.
• Radical Chemistry : Discuss the use of radicals in organic synthesis.
• Chemistry of Terpenes : Explore the diverse structures and functions of terpenes.
• Organic Chemistry of Vitamins : Highlight the organic compounds essential for health.
• Biocatalysis : Discuss the use of enzymes in organic synthesis.
• Chemistry of Lipids : Investigate the structure and functions of lipids.
• Chemistry of Amino Acids : Explore the building blocks of proteins.
• Chemistry of DNA : Discuss the structure and chemical properties of DNA.
• Nucleic Acid Chemistry : Investigate the synthesis and modification of nucleic acids.
• Organic Chemistry in Environmental Remediation : Highlight the use of organic compounds for cleaning up pollutants.

In closing, organic chemistry isn’t just about molecules; it’s about endless possibilities. These 50 research ideas showcase the diverse avenues researchers explore , from green synthesis to life-saving drugs. As we continue to unravel the mysteries of carbon, we can look forward to a future where science and innovation walk hand in hand, shaping a brighter world for us all.

• Aromatic chemistry
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• Bioorthogonal reactions
• Carbon compounds
• Catalysis Sustainable polymers
• Chiral compounds Chemical biology
• Click chemistry Computational chemistry
• DNA chemistry
• Drug discovery
• Environmental remediation
• Flow chemistry Stereochemistry
• Green metrics
• Green solvents
• Green synthesis
• Nanocatalysis Heterocyclic compounds
• Organic Chemistry
• Organic photovoltaics
• Peptide synthesis
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Organic & Biomolecular Chemistry  

About Organic & Biomolecular Chemistry

Organic synthesis, supramolecular chemistry, chemical biology and more. Editorial Board Chair: Anthony Davis Impact factor: 3.2 Time to first decision (peer reviewed only): 15 days

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Establishing Novel Carbon Dioxide Chemistry through Nano-Clustering in Water-Lean Solvents

Water-lean solvents form clusters that drive new reaction pathways unavailable to other solvents

Water-lean solvents form nano-sized micelles that enable unique reactivity and computationally derived structures show the tetrameric clusters and their packing modes.

(Image by Michael Perkins | Pacific Northwest National Laboratory)

The Science

Capturing carbon dioxide (CO 2 ) is a critical piece of reaching net-zero carbon emissions goals. Water-lean solvents have been previously shown to effectively capture CO 2 and new work identifies the unique chemistry possible with these solvents. Researchers observed the formation of micellar-like nano-size clusters of four solvent molecules. The inside of these clusters has an active site core, similar to enzymes, that enables the formation of CO 2 -containing species by mechanisms not previously seen in carbon capture solvents. This represents a potential paradigm shift for the reactivity possible in carbon capture solvents.

Reaching global net-zero carbon goals requires scientific innovation. This work opens a new focus in designing solvents for carbon capture. The discovery of the unique reactivities enabled by the solvent clusters can lead to new design principles that move beyond single carbon capture. The cooperativity and reactivity observed in this work may help researchers develop more effective and efficient carbon capture solvents, leading to a net-zero future.

Carbon capture, utilization, and storage is a key yet cost-intensive technology for the fight against climate change. In a combined experimental and modelling study of a single-component water-lean solvent, researchers found that CO 2 capture is accompanied by the self-assembly of reverse micelle-like tetrameric clusters in solution. This spontaneous aggregation leads to stepwise capture phenomena with highly contrasting kinetic and thermodynamic features. The emergence of well-defined supramolecular architectures displaying an H-bonded internal core, reminiscent of enzymatic active sites, enables the formation of unprecedented CO 2 -containing molecular species such as carbamic acid, carbamic-anhydride, and alkoxy carbamic anhydrides. This dynamic system based on a single absorbent and CO 2 extends the scope of adducts and mechanisms observed during carbon capture. It opens the way to new materials with a higher CO 2 storage capacity and potential cooperative binding and also provides a means for carbamates to potentially act as initiators for future oligomerization or polymerization of CO 2 .

David Heldebrandt, Pacific Northwest National Laboratory, [email protected]

French authors were supported by the LABEX iMUST of the University of Lyon (ANR-10-LABX-0064), created within the Plan France 2030 set up by the French government and managed by the French National Research Agency. American authors acknowledge support from the Department of Energy (DOE), Office of Science, Basic Energy Sciences program, Division of Chemical Sciences, Geosciences, and Biosciences. This research used resources of the National Energy Research Scientific Computing Center, a DOE Office of Science user facility located at Lawrence Berkeley National Laboratory, operated under Contract No. DE-AC02-05CH11231.

Published: May 29, 2024

Leclaire, J., D. Heldebrant, et al. 2024. “Tetrameric self-assembling of water-lean solvents enables carbamate anhydride-based CO2 capture chemistry.” Nature Chemistry , DOI: 10.1038/s41557-024-01495-z

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300+ Chemistry Research Topics

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Chemistry is a fascinating and complex field that explores the composition, properties, and behavior of matter at the molecular and atomic level. As a result, there are numerous chemistry research topics that can be explored, ranging from the development of new materials and drugs to the study of natural compounds and the environment. In this rapidly evolving field, researchers are constantly uncovering new insights and pushing the boundaries of our understanding of chemistry. Whether you are a student, a professional researcher, or simply curious about the world around you, there is always something new to discover in the field of chemistry. In this post, we will explore some of the exciting and important research topics in chemistry today.

Chemistry Research Topics

Chemistry Research Topics are as follows:

Organic Chemistry Research Topics

Organic Chemistry Research Topics are as follows:

• Development of novel synthetic routes for the production of biologically active natural products
• Investigation of reaction mechanisms and kinetics for organic transformations
• Design and synthesis of new catalysts for asymmetric organic reactions
• Synthesis and characterization of chiral compounds for pharmaceutical applications
• Development of sustainable methods for the synthesis of organic molecules using renewable resources
• Discovery of new reaction pathways for the conversion of biomass into high-value chemicals
• Study of molecular recognition and host-guest interactions for drug design
• Design and synthesis of new materials for energy storage and conversion
• Development of efficient and selective methods for C-H functionalization reactions
• Exploration of the reactivity of reactive intermediates such as radicals and carbenes
• Study of supramolecular chemistry and self-assembly of organic molecules
• Development of new methods for the synthesis of heterocyclic compounds
• Investigation of the biological activities and mechanisms of action of natural products
• Synthesis of polymeric materials with controlled architecture and functionality
• Development of new synthetic methodologies for the preparation of bioconjugates
• Investigation of the mechanisms of enzyme catalysis and the design of enzyme inhibitors
• Synthesis and characterization of novel fluorescent probes for biological imaging
• Development of new synthetic strategies for the preparation of carbohydrates and glycoconjugates
• Study of the properties and reactivity of carbon nanomaterials
• Design and synthesis of novel drugs for the treatment of diseases such as cancer, diabetes, and Alzheimer’s disease.

Inorganic Chemistry Research Topics

Inorganic Chemistry Research Topics are as follows:

• Synthesis and characterization of new metal-organic frameworks (MOFs) for gas storage and separation applications
• Development of new catalysts for sustainable chemical synthesis reactions
• Investigation of the electronic and magnetic properties of transition metal complexes for spintronics applications
• Synthesis and characterization of novel nanomaterials for energy storage applications
• Development of new ligands for metal coordination complexes with potential medical applications
• Investigation of the mechanism of metal-catalyzed reactions using advanced spectroscopic techniques
• Synthesis and characterization of new inorganic materials for photocatalytic water splitting
• Development of new materials for electrochemical carbon dioxide reduction reactions
• Investigation of the properties of transition metal oxides for energy storage and conversion applications
• Synthesis and characterization of new metal chalcogenides for optoelectronic applications
• Development of new methods for the preparation of inorganic nanoparticles with controlled size and shape
• Investigation of the reactivity and catalytic properties of metal clusters
• Synthesis and characterization of new metal-organic polyhedra (MOPs) for gas storage and separation applications
• Development of new methods for the synthesis of metal nanoparticles using environmentally friendly reducing agents
• Investigation of the properties of metal-organic frameworks for gas sensing applications
• Synthesis and characterization of new coordination polymers with potential magnetic and electronic properties
• Development of new materials for electrocatalytic water oxidation reactions
• Investigation of the properties of metal-organic frameworks for carbon capture and storage applications
• Synthesis and characterization of new metal-containing polymers with potential applications in electronics and energy storage
• Development of new methods for the synthesis of metal-organic frameworks using green solvents and renewable resources.

Physical Chemistry Research Topics

Physical Chemistry Research Topics are as follows:

• Investigation of the properties and interactions of ionic liquids in aqueous and non-aqueous solutions.
• Development of advanced analytical techniques for the study of protein structure and dynamics.
• Investigation of the thermodynamic properties of supercritical fluids for use in industrial applications.
• Development of novel nanomaterials for energy storage applications.
• Studies of the surface chemistry of catalysts for the optimization of their performance in chemical reactions.
• Development of new methods for the synthesis of complex organic molecules with improved yields and selectivity.
• Investigation of the molecular mechanisms involved in the catalysis of biochemical reactions.
• Development of new strategies for the controlled release of drugs and other bioactive molecules.
• Studies of the interaction of nanoparticles with biological systems for biomedical applications.
• Investigation of the thermodynamic properties of materials under extreme conditions of temperature and pressure.
• Development of new methods for the characterization of materials at the nanoscale.
• Investigation of the electronic and magnetic properties of materials for use in spintronics.
• Development of new materials for energy conversion and storage.
• Studies of the kinetics and thermodynamics of adsorption processes on surfaces.
• Investigation of the transport properties of ionic liquids for use in energy storage and conversion devices.
• Development of new materials for the capture and sequestration of greenhouse gases.
• Studies of the structure and properties of biomolecules for use in drug design and development.
• Investigation of the dynamics of chemical reactions in solution using time-resolved spectroscopic techniques.
• Development of new approaches for the synthesis of metallic and semiconductor nanoparticles with controlled size and shape.
• Studies of the structure and properties of materials for use in electrochemical energy storage devices.

Analytical Chemistry Research Topics

Analytical Chemistry Research Topics are as follows:

• Development and optimization of analytical techniques for the quantification of trace elements in food and environmental samples.
• Design and synthesis of novel analytical probes for the detection of biomolecules in complex matrices.
• Investigation of the fundamental mechanisms involved in the separation and detection of complex mixtures using chromatographic techniques.
• Development of sensors and biosensors for the detection of chemical and biological species in real-time.
• Investigation of the chemical and structural properties of nanomaterials and their applications in analytical chemistry.
• Development and validation of analytical methods for the quantification of contaminants and pollutants in water, air, and soil.
• Investigation of the molecular mechanisms underlying drug metabolism and toxicity using mass spectrometry.
• Development of analytical tools for the identification and quantification of drugs of abuse in biological matrices.
• Investigation of the chemical composition and properties of natural products and their applications in medicine and food science.
• Development of advanced analytical techniques for the characterization of proteins and peptides.
• Investigation of the chemistry and mechanism of action of antioxidants in foods and their impact on human health.
• Development of analytical methods for the detection and quantification of microorganisms in food and environmental samples.
• Investigation of the molecular mechanisms involved in the biosynthesis and degradation of important biomolecules such as proteins, carbohydrates, and lipids.
• Development of analytical methods for the detection and quantification of environmental toxins and their impact on human health.
• Investigation of the structure and properties of biological membranes and their role in drug delivery and disease.
• Development of analytical techniques for the characterization of complex mixtures such as petroleum and crude oil.
• Investigation of the chemistry and mechanism of action of natural and synthetic dyes.
• Development of analytical techniques for the detection and quantification of pharmaceuticals and personal care products in water and wastewater.
• Investigation of the chemical composition and properties of biopolymers and their applications in biomedicine and biomaterials.
• Development of analytical methods for the identification and quantification of essential nutrients and vitamins in food and dietary supplements.

Biochemistry Research Topics

Biochemistry Research Topics are as follows:

• The role of enzymes in metabolic pathways
• The biochemistry of DNA replication and repair
• Protein folding and misfolding diseases
• Lipid metabolism and the pathogenesis of atherosclerosis
• The role of vitamins and minerals in human metabolism
• Biochemistry of cancer and the development of targeted therapies
• The biochemistry of signal transduction pathways and their regulation
• The mechanisms of antibiotic resistance in bacteria
• The biochemistry of neurotransmitters and their roles in behavior and disease
• The role of oxidative stress in aging and age-related diseases
• The biochemistry of microbial fermentation and its applications in industry
• The biochemistry of the immune system and its response to pathogens
• The biochemistry of plant metabolism and its regulation
• The molecular basis of genetic diseases and gene therapy
• The biochemistry of membrane transport and its role in cell function
• The biochemistry of muscle contraction and its regulation
• The role of lipids in membrane structure and function
• The biochemistry of photosynthesis and its regulation
• The biochemistry of RNA splicing and alternative splicing events
• The biochemistry of epigenetics and its regulation in gene expression.

Environmental Chemistry Research Topics

Environmental Chemistry Research Topics are as follows:

• Investigating the effects of microplastics on aquatic ecosystems and their potential impact on human health.
• Examining the impact of climate change on soil quality and nutrient availability in agricultural systems.
• Developing methods to improve the removal of heavy metals from contaminated soils and waterways.
• Assessing the effectiveness of natural and synthetic antioxidants in mitigating the effects of air pollution on human health.
• Investigating the potential for using algae and other microorganisms to sequester carbon dioxide from the atmosphere.
• Studying the role of biodegradable plastics in reducing plastic waste and their impact on the environment.
• Examining the impact of pesticides and other agricultural chemicals on water quality and the health of aquatic organisms.
• Investigating the effects of ocean acidification on marine organisms and ecosystems.
• Developing new materials and technologies to reduce carbon emissions from industrial processes.
• Evaluating the effectiveness of phytoremediation in cleaning up contaminated soils and waterways.
• Studying the impact of microplastics on terrestrial ecosystems and their potential to enter the food chain.
• Developing sustainable methods for managing and recycling electronic waste.
• Investigating the role of natural processes, such as weathering and erosion, in regulating atmospheric carbon dioxide levels.
• Assessing the impact of urbanization on air quality and developing strategies to mitigate pollution in cities.
• Examining the effects of climate change on the distribution and abundance of species in different ecosystems.
• Investigating the impact of ocean currents on the distribution of pollutants and other environmental contaminants.
• Developing new materials and technologies for renewable energy generation and storage.
• Studying the effects of deforestation on soil quality, water availability, and biodiversity.
• Assessing the potential for using waste materials, such as agricultural residues and municipal solid waste, as sources of renewable energy.
• Investigating the role of natural and synthetic chemicals in regulating ecosystem functions, such as nutrient cycling and carbon sequestration.

Polymer Chemistry Research Topics

Polymer Chemistry Research Topics are as follows:

• Development of new monomers for high-performance polymers
• Synthesis and characterization of biodegradable polymers for sustainable packaging
• Design of stimuli-responsive polymers for drug delivery applications
• Investigation of the properties and applications of conductive polymers
• Development of new catalysts for controlled/living polymerization
• Synthesis of polymers with tailored mechanical properties
• Characterization of the structure-property relationship in polymer nanocomposites
• Study of the impact of polymer architecture on material properties
• Design and synthesis of new polymeric materials for energy storage
• Development of high-throughput methods for polymer synthesis and characterization
• Exploration of new strategies for polymer recycling and upcycling
• Synthesis and characterization of responsive polymer networks for smart textiles
• Design of advanced polymer coatings with self-healing properties
• Investigation of the impact of processing conditions on the morphology and properties of polymer materials
• Study of the interactions between polymers and biological systems
• Development of biocompatible polymers for tissue engineering applications
• Synthesis and characterization of block copolymers for advanced membrane applications
• Exploration of the potential of polymer-based sensors and actuators
• Design of novel polymer electrolytes for advanced batteries and fuel cells
• Study of the behavior of polymers under extreme conditions, such as high pressure or temperature.

Materials Chemistry Research Topics

Materials Chemistry Research Topics are as follows:

• Development of new advanced materials for energy storage and conversion
• Synthesis and characterization of nanomaterials for environmental remediation
• Design and fabrication of stimuli-responsive materials for drug delivery
• Investigation of electrocatalytic materials for fuel cells and electrolysis
• Fabrication of flexible and stretchable electronic materials for wearable devices
• Development of novel materials for high-performance electronic devices
• Exploration of organic-inorganic hybrid materials for optoelectronic applications
• Study of corrosion-resistant coatings for metallic materials
• Investigation of biomaterials for tissue engineering and regenerative medicine
• Synthesis and characterization of metal-organic frameworks for gas storage and separation
• Design and fabrication of new materials for water purification
• Investigation of carbon-based materials for supercapacitors and batteries
• Synthesis and characterization of self-healing materials for structural applications
• Development of new materials for catalysis and chemical reactions
• Exploration of magnetic materials for spintronic devices
• Investigation of thermoelectric materials for energy conversion
• Study of 2D materials for electronic and optoelectronic applications
• Development of sustainable and eco-friendly materials for packaging
• Fabrication of advanced materials for sensors and actuators
• Investigation of materials for high-temperature applications such as aerospace and nuclear industries.

Nuclear Chemistry Research Topics

Nuclear Chemistry Research Topics are as follows:

• Nuclear fission and fusion reactions
• Nuclear power plant safety and radiation protection
• Radioactive waste management and disposal
• Nuclear fuel cycle and waste reprocessing
• Nuclear energy and its impact on climate change
• Radiation therapy for cancer treatment
• Radiopharmaceuticals for medical imaging
• Nuclear medicine and its role in diagnostics
• Nuclear forensics and nuclear security
• Isotopic analysis in environmental monitoring and pollution control
• Nuclear magnetic resonance (NMR) spectroscopy
• Nuclear magnetic resonance imaging (MRI)
• Radiation damage in materials and radiation effects on electronic devices
• Nuclear data evaluation and validation
• Nuclear reactors design and optimization
• Nuclear fuel performance and irradiation behavior
• Nuclear energy systems integration and optimization
• Neutron and gamma-ray detection and measurement techniques
• Nuclear astrophysics and cosmology
• Nuclear weapons proliferation and disarmament.

Medicinal Chemistry Research Topics

Medicinal Chemistry Research Topics are as follows:

• Drug discovery and development
• Design and synthesis of novel drugs
• Medicinal chemistry of natural products
• Structure-activity relationships (SAR) of drugs
• Rational drug design using computational methods
• Target identification and validation
• Drug metabolism and pharmacokinetics (DMPK)
• Drug delivery systems
• Development of new antibiotics
• Design of drugs for the treatment of cancer
• Development of drugs for the treatment of neurological disorders
• Medicinal chemistry of peptides and proteins
• Development of drugs for the treatment of infectious diseases
• Discovery of new antiviral agents
• Design of drugs for the treatment of cardiovascular diseases
• Medicinal chemistry of enzyme inhibitors
• Development of drugs for the treatment of inflammatory diseases
• Design of drugs for the treatment of metabolic disorders
• Medicinal chemistry of anti-cancer agents
• Development of drugs for the treatment of rare diseases.

Food Chemistry Research Topics

Food Chemistry Research Topics are as follows:

• Investigating the effect of cooking methods on the nutritional value of food.
• Analyzing the role of antioxidants in preventing food spoilage and degradation.
• Examining the effect of food processing techniques on the nutritional value of fruits and vegetables.
• Studying the chemistry of food additives and their impact on human health.
• Evaluating the role of enzymes in food digestion and processing.
• Investigating the chemical properties and functional uses of food proteins.
• Analyzing the effect of food packaging materials on the quality and safety of food products.
• Examining the chemistry of food flavorings and the impact of flavor on consumer acceptance.
• Studying the role of carbohydrates in food texture and structure.
• Investigating the chemistry of food lipids and their impact on human health.
• Analyzing the chemical properties and functional uses of food gums and emulsifiers.
• Examining the effect of processing on the flavor and aroma of food products.
• Studying the chemistry of food preservatives and their impact on food safety.
• Investigating the chemical properties and functional uses of food fibers.
• Analyzing the effect of food processing on the bioavailability of nutrients.
• Examining the chemistry of food colorants and their impact on consumer acceptance.
• Studying the role of vitamins and minerals in food and their impact on human health.
• Investigating the chemical properties and functional uses of food hydrocolloids.
• Analyzing the effect of food processing on the allergenicity of food products.
• Examining the chemistry of food sweeteners and their impact on human health.

Industrial Chemistry Research Topics

Industrial Chemistry Research Topics are as follows:

• Development of catalysts for selective hydrogenation reactions in the petrochemical industry.
• Green chemistry approaches for the synthesis of biodegradable polymers from renewable sources.
• Optimization of solvent extraction processes for the separation of rare earth elements from ores.
• Development of novel materials for energy storage applications, such as lithium-ion batteries.
• Production of biofuels from non-food sources, such as algae or waste biomass.
• Application of computational chemistry to optimize the design of new catalysts and materials.
• Design and optimization of continuous flow processes for large-scale chemical production.
• Development of new synthetic routes for the production of pharmaceutical intermediates.
• Investigation of the environmental impact of industrial processes and development of sustainable alternatives.
• Development of innovative water treatment technologies for industrial wastewater.
• Synthesis of functionalized nanoparticles for use in drug delivery and other biomedical applications.
• Optimization of processes for the production of high-performance polymers, such as polyamides or polyesters.
• Design and optimization of process control strategies for efficient and safe chemical production.
• Development of new methods for the detection and removal of heavy metal ions from industrial effluents.
• Investigation of the behavior of surfactants in complex mixtures, such as crude oil or food products.
• Development of new materials for catalytic oxidation reactions, such as the removal of volatile organic compounds from air.
• Investigation of the properties and behavior of materials under extreme conditions, such as high pressure or high temperature.
• Development of new processes for the production of chemicals from renewable resources, such as bio-based building blocks.
• Study of the kinetics and mechanism of chemical reactions in complex systems, such as multi-phase reactors.
• Optimization of the production of fine chemicals, such as flavors and fragrances, using biocatalytic processes.

Computational Chemistry Research Topics

Computational Chemistry Research Topics are as follows:

• Development and application of machine learning algorithms for predicting chemical reactions and properties.
• Investigation of the role of solvents in chemical reactions using molecular dynamics simulations.
• Modeling and simulation of protein-ligand interactions to aid drug design.
• Study of the electronic structure and reactivity of catalysts for sustainable energy production.
• Analysis of the thermodynamics and kinetics of complex chemical reactions using quantum chemistry methods.
• Exploration of the mechanism and kinetics of enzyme-catalyzed reactions using molecular dynamics simulations.
• Investigation of the properties and behavior of nanoparticles using computational modeling.
• Development of computational tools for the prediction of chemical toxicity and environmental impact.
• Study of the electronic properties of graphene and other 2D materials for applications in electronics and energy storage.
• Investigation of the mechanisms of protein folding and aggregation using molecular dynamics simulations.
• Development and optimization of computational methods for calculating thermodynamic properties of liquids and solids.
• Study of the properties of supercritical fluids for applications in separation and extraction processes.
• Development of new methods for the calculation of electron transfer rates in complex systems.
• Investigation of the electronic and mechanical properties of carbon nanotubes for applications in nanoelectronics and nanocomposites.
• Development of new approaches for modeling the interaction of biomolecules with biological membranes.
• Study of the mechanisms of charge transfer in molecular and hybrid solar cells.
• Analysis of the structural and mechanical properties of materials under extreme conditions using molecular dynamics simulations.
• Development of new approaches for the calculation of free energy differences in complex systems.
• Investigation of the reaction mechanisms of metalloenzymes using quantum mechanics/molecular mechanics (QM/MM) methods.
• Study of the properties of ionic liquids for applications in catalysis and energy storage.

Theoretical Chemistry Research Topics

Theoretical Chemistry Research Topics are as follows:

• Quantum Chemical Studies of Excited State Processes in Organic Molecules
• Theoretical Investigation of Structure and Reactivity of Metal-Organic Frameworks
• Computational Modeling of Reaction Mechanisms and Kinetics in Enzyme Catalysis
• Theoretical Investigation of Non-Covalent Interactions in Supramolecular Chemistry
• Quantum Chemical Studies of Photochemical Processes in Organic Molecules
• Theoretical Analysis of Charge Transport in Organic and Inorganic Materials
• Computational Modeling of Protein Folding and Dynamics
• Quantum Chemical Investigations of Electron Transfer Processes in Complex Systems
• Theoretical Studies of Surface Chemistry and Catalysis
• Computational Design of Novel Materials for Energy Storage Applications
• Theoretical Analysis of Chemical Bonding and Molecular Orbital Theory
• Quantum Chemical Investigations of Magnetic Properties of Complex Systems
• Computational Modeling of Biological Membranes and Transport Processes
• Theoretical Studies of Nonlinear Optical Properties of Molecules and Materials
• Quantum Chemical Studies of Spectroscopic Properties of Molecules
• Theoretical Investigations of Reaction Mechanisms in Organometallic Chemistry
• Computational Modeling of Heterogeneous Catalysis
• Quantum Chemical Studies of Excited State Dynamics in Photosynthesis
• Theoretical Analysis of Chemical Reaction Networks
• Computational Design of Nanomaterials for Biomedical Applications

Astrochemistry Research Topics

Astrochemistry Research Topics are as follows:

• Investigating the chemical composition of protoplanetary disks and its implications for planet formation
• Examining the role of magnetic fields in the formation of complex organic molecules in space
• Studying the effects of interstellar radiation on the chemical evolution of molecular clouds
• Exploring the chemistry of comets and asteroids to better understand the early solar system
• Investigating the origin and evolution of interstellar dust and its relationship to organic molecules
• Examining the formation and destruction of interstellar molecules in shocked gas
• Studying the chemical processes that occur in the atmospheres of planets and moons in our solar system
• Exploring the possibility of life on other planets through astrobiology and astrochemistry
• Investigating the chemistry of planetary nebulae and their role in the evolution of stars
• Studying the chemical properties of exoplanets and their potential habitability
• Examining the chemical reactions that occur in the interstellar medium
• Investigating the chemical composition of supernova remnants and their impact on the evolution of galaxies
• Studying the chemical composition of interstellar grains and their role in the formation of stars and planets
• Exploring the chemistry of astrocytes and their role in the evolution of galaxies
• Investigating the formation of interstellar ice and its implications for the origin of life
• Examining the chemistry of molecular clouds and its relationship to star formation
• Studying the chemical composition of the interstellar medium in different galaxies and how it varies
• Investigating the role of cosmic rays in the formation of complex organic molecules in space
• Exploring the chemical properties of interstellar filaments and their relationship to star formation
• Studying the chemistry of protostars and the role of turbulence in the formation of stars.

Geochemistry Research Topics

Geochemistry Research Topics are as follows:

• Understanding the role of mineralogical and geochemical factors on metal mobility in contaminated soils
• Investigating the sources and fate of dissolved organic matter in aquatic systems
• Exploring the geochemical signatures of ancient sedimentary rocks to reconstruct Earth’s past atmospheric conditions
• Studying the impacts of land-use change on soil organic matter content and quality
• Investigating the impact of acid mine drainage on water quality and ecosystem health
• Examining the processes controlling the behavior and fate of emerging contaminants in the environment
• Characterizing the organic matter composition of shale gas formations to better understand hydrocarbon storage and migration
• Evaluating the potential for carbon capture and storage in geologic formations
• Investigating the geochemical processes controlling the formation and evolution of ore deposits
• Studying the geochemistry of geothermal systems to better understand energy production potential and environmental impacts
• Exploring the impacts of climate change on the biogeochemistry of terrestrial ecosystems
• Investigating the geochemical cycling of nutrients in coastal marine environments
• Characterizing the isotopic composition of minerals and fluids to understand Earth’s evolution
• Developing new analytical techniques to better understand the chemistry of natural waters
• Studying the impact of anthropogenic activities on the geochemistry of urban soils
• Investigating the role of microbial processes in geochemical cycling of elements in soils and sediments
• Examining the impact of wildfires on soil and water chemistry
• Characterizing the geochemistry of mineral dust and its impact on climate and biogeochemical cycles
• Investigating the geochemical factors controlling the release and transport of contaminants from mine tailings
• Exploring the biogeochemistry of wetlands and their role in carbon sequestration and nutrient cycling.

Electrochemistry Research Topics

Electrochemistry Research Topics are as follows:

• Development of high-performance electrocatalysts for efficient electrochemical conversion of CO2 to fuels and chemicals
• Investigation of electrode-electrolyte interfaces in lithium-ion batteries for enhanced battery performance and durability
• Design and synthesis of novel electrolytes for high-energy-density and stable lithium-sulfur batteries
• Development of advanced electrochemical sensors for the detection of trace-levels of analytes in biological and environmental samples
• Analysis of the electrochemical behavior of new materials and their electrocatalytic properties in fuel cells
• Study of the kinetics of electrochemical reactions and their effect on the efficiency and selectivity of electrochemical processes
• Development of novel strategies for the electrochemical synthesis of value-added chemicals from biomass and waste materials
• Analysis of the electrochemical properties of metal-organic frameworks (MOFs) for energy storage and conversion applications
• Investigation of the electrochemical degradation mechanisms of polymer electrolyte membranes in fuel cells
• Study of the electrochemical properties of 2D materials and their applications in energy storage and conversion devices
• Development of efficient electrochemical systems for desalination and water treatment applications
• Investigation of the electrochemical properties of metal-oxide nanoparticles for energy storage and conversion applications
• Analysis of the electrochemical behavior of redox-active organic molecules and their application in energy storage and conversion devices
• Study of the electrochemical behavior of metal-organic frameworks (MOFs) for the catalytic conversion of CO2 to value-added chemicals
• Development of novel electrode materials for electrochemical capacitors with high energy density and fast charge/discharge rates
• Investigation of the electrochemical properties of perovskite materials for energy storage and conversion applications
• Study of the electrochemical behavior of enzymes and their application in bioelectrochemical systems
• Development of advanced electrochemical techniques for the characterization of interfacial processes in electrochemical systems
• Analysis of the electrochemical behavior of nanocarbons and their application in electrochemical energy storage devices
• Investigation of the electrochemical properties of ionic liquids for energy storage and conversion applications.

Surface Chemistry Research Topics

Surface Chemistry Research Topics are as follows:

• Surface modification of nanoparticles for enhanced catalytic activity
• Investigating the effect of surface roughness on the wetting behavior of materials
• Development of new materials for solar cell applications through surface chemistry techniques
• Surface chemistry of graphene and its applications in electronic devices
• Surface functionalization of biomaterials for biomedical applications
• Characterization of surface defects and their effect on material properties
• Surface modification of carbon nanotubes for energy storage applications
• Developing surface coatings for corrosion protection of metals
• Synthesis of self-assembled monolayers on surfaces for sensor applications
• Surface chemistry of metal-organic frameworks for gas storage and separation
• Investigating the role of surface charge in protein adsorption
• Developing surfaces with superhydrophobic or superoleophobic properties for self-cleaning applications
• Surface functionalization of nanoparticles for drug delivery applications
• Surface chemistry of semiconductors and its effect on photovoltaic properties
• Development of surface-enhanced Raman scattering (SERS) substrates for trace analyte detection
• Surface functionalization of graphene oxide for water purification applications
• Investigating the role of surface tension in emulsion formation and stabilization
• Surface modification of membranes for water desalination and purification
• Synthesis and characterization of metal nanoparticles for catalytic applications
• Development of surfaces with controlled wettability for microfluidic applications.

Atmospheric Chemistry Research Topics

Atmospheric Chemistry Research Topics are as follows:

• The impact of wildfires on atmospheric chemistry
• The role of aerosols in atmospheric chemistry
• The chemistry and physics of ozone depletion in the stratosphere
• The chemistry and dynamics of the upper atmosphere
• The impact of anthropogenic emissions on atmospheric chemistry
• The role of clouds in atmospheric chemistry
• The chemistry of atmospheric particulate matter
• The impact of nitrogen oxides on atmospheric chemistry and air quality
• The effects of climate change on atmospheric chemistry
• The impact of atmospheric chemistry on climate change
• The chemistry and physics of atmospheric mercury cycling
• The impact of volcanic eruptions on atmospheric chemistry
• The chemistry and physics of acid rain formation and effects
• The role of halogen chemistry in the atmosphere
• The chemistry of atmospheric radicals and their impact on air quality and health
• The impact of urbanization on atmospheric chemistry
• The chemistry and physics of stratospheric polar vortex dynamics
• The role of natural sources (e.g. ocean, plants) in atmospheric chemistry
• The impact of atmospheric chemistry on the biosphere
• The chemistry and dynamics of the ozone hole over Antarctica.

Photochemistry Research Topics

Photochemistry Research Topics are as follows:

• Investigating the mechanisms of photoinduced electron transfer reactions in organic photovoltaic materials.
• Developing novel photoredox catalysts for photochemical reactions.
• Understanding the effects of light on DNA and RNA stability and replication.
• Studying the photochemistry of atmospheric pollutants and their impact on air quality.
• Designing new photoresponsive materials for advanced photonic and electronic devices.
• Exploring the photochemistry of metalloporphyrins for potential applications in catalysis.
• Investigating the photochemistry of transition metal complexes and their use as photodynamic therapy agents.
• Developing new photocatalytic systems for sustainable energy production.
• Studying the photochemistry of natural products and their potential pharmaceutical applications.
• Investigating the role of light in the formation and degradation of environmental contaminants.
• Designing new photochromic materials for smart windows and displays.
• Exploring the photochemistry of carbon nanomaterials for energy storage and conversion.
• Developing new light-driven molecular machines for nanotechnology applications.
• Investigating the photochemistry of organic dyes for potential applications in dye-sensitized solar cells.
• Studying the effects of light on the behavior of biological macromolecules.
• Designing new photoresponsive hydrogels for drug delivery applications.
• Exploring the photochemistry of semiconductor nanoparticles for potential applications in quantum computing.
• Investigating the mechanisms of photochemical reactions in ionic liquids.
• Developing new photonic sensors for chemical and biological detection.
• Studying the photochemistry of transition metal complexes for potential applications in water splitting and hydrogen production.

About the author

Muhammad Hassan

Researcher, Academic Writer, Web developer

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