Influenza, also known as the flu, is a highly contagious respiratory illness caused by a number of RNA influenza viruses that can infect humans. Complications from influenza can cause significant morbidity and mortality. 1 Globally, as many as 500,000 people die annually from complications related to influenza.
Influenza Vaccine Effectiveness: New Insights and Challenges
Abstract. Methods for assessing influenza vaccine efficacy and effectiveness have evolved over six decades. Randomized trials remain the gold standard for licensure, but observational studies are needed for annual assessment of vaccine effectiveness (VE). The test-negative design (TND) has become the de facto standard for these field studies.
Examining the potential benefits of the influenza vaccine ...
Introduction Recently, several single center studies have suggested a protective effect of the influenza vaccine against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). This study utilizes a continuously updated Electronic Medical Record (EMR) network to assess the possible benefits of influenza vaccination mitigating critical adverse outcomes in SARS-CoV-2 positive patients from ...
Current and future influenza vaccines
Abstract. Although antiviral drugs and vaccines have reduced the economic and healthcare burdens of influenza, influenza epidemics continue to take a toll. Over the past decade, research on ...
Does repeated influenza vaccination attenuate effectiveness? A
We identified 4979 publications, selected 681 for full review, and included 83 in the systematic review and 41 in meta-analyses. ΔVE for vaccination in both seasons compared with the current season was -9% (95% CI -16 to -1, I 2 =0%; low certainty) for influenza A(H1N1)pdm09, -18% (-26 to -11, I 2 =7%; low certainty) for influenza A(H3N2), and -7% (-14 to 0, I 2 =0%; low ...
The effect of influenza vaccine in reducing the severity of ...
Future research of high-quality randomized controlled trials is recommended to further assess the efficacy of the influenza vaccine in COVID-19 patients. The regular updating of the influenza ...
Efficacy and effectiveness of influenza vaccines: a systematic review
Influenza vaccines can provide moderate protection against virologically confirmed influenza, but such protection is greatly reduced or absent in some seasons. Evidence for protection in adults aged 65 years or older is lacking. LAIVs consistently show highest efficacy in young children (aged 6 months to 7 years). New vaccines with improved clinical efficacy and effectiveness are needed to ...
Efficacy of High-Dose versus Standard-Dose Influenza Vaccine in Older
As compared with a standard-dose vaccine, a high-dose, trivalent, inactivated influenza vaccine (IIV3-HD) improves antibody responses to influenza among adults 65 years of age or older. This study ...
CDC Seasonal Flu Vaccine Effectiveness Studies
Supporting Research; U.S. Flu Vaccine Effectiveness Networks. ... **2020-2021 flu vaccine effectiveness was not estimated due to low influenza virus circulation during the 2020-2021 flu season. ***In a Wisconsin study among patients aged 6 months to 64 years, VE was 54% against medically attended outpatient acute respiratory illness (ARI ...
Influenza
Annual seasonal influenza epidemics of variable severity caused by influenza A and B virus infections result in substantial disease burden worldwide. Seasonal influenza virus circulation declined markedly in 2020-21 after SARS-CoV-2 emerged but increased in 2021-22. Most people with influenza have abrupt onset of respiratory symptoms and myalgia with or without fever and recover within 1 ...
Pfizer Initiates Phase 3 Study of mRNA-Based Influenza Vaccine
First Phase 3 efficacy study to be conducted using an mRNA-based influenza vaccine; study will enroll 25,000 U.S. adults 18 years and older Influenza causes 140,000 to 710,000 hospitalizations and 12,000 to 52,000 deaths in the U.S. every year1 mRNA-based vaccines require only the genetic sequences of the viruses, enabling more flexible, rapid manufacturing which may lead to improved strain ...
New Strategy Could Lead to Universal, Long-Lasting Flu Shot
After a shot of the highly variant vaccine was administered in some experiments, 100 percent of the mice avoided illness or death from what should have been a lethal dose of flu viruses. The next steps of the research will attempt to understand whether the same level of immunity can be achieved by presenting fewer than 80,000 hemagglutinin ...
Daily briefing: Flu vaccine might also prevent COVID-19
Influenza vaccines might prevent COVID-19, particularly in its most severe forms. A preprint study of more than 30,000 health-care workers in Qatar found that those who got a flu shot were nearly ...
Flu shot: Researchers inch closer to a long lasting universal vaccine
Developing a long lasting flu vaccine could be highly beneficial for the health of society, and research is getting closer to this goal.. A study published in Science Translational Medicinefound ...
A Flu Shot Might Reduce Coronavirus Infections, Early Research Suggests
Workers who received a flu vaccine, the researchers found, were 39 percent less likely to test positive for the coronavirus as of June 1, 2020. While 2.23 percent of nonvaccinated employees tested ...
Advances in Flu Vaccine Technology Over the Years
When it comes to public health, revolutionary measures have advanced to combat the spread of illness with preventative vaccines. Influenza, otherwise known as the flu, was originally thought to be caused by a bacterial infection, according to the World Health Organization.Because of this, early attempts at creating a vaccine during the 1918 influenza pandemic were unsuccessful and resulted in ...
A revolutionary new weapon in the battle against influenza
Influenza kills up to 650,000 people around the world each year, with 99% of deaths in children under five years of age in developing countries due to influenza-related infections, according to the World Health Organisation.. The current crop of influenza vaccines has limitations in effectively combating the billion cases of seasonal influenza each year, as they provide immunity against only ...
Penn Researchers Develop Experimental mRNA Avian Flu Vaccine
The vaccine could potentially help manage the outbreak of the H5N1 virus currently circulating in birds and cattle in the United States, and prevent human infections with the virus, according to research from the Perelman School of Medicine at the University of Pennsylvania, published today in Nature Communications.
A Revolutionary Approach to Flu Prevention: New Molecules Stop
Scientists at Scripps Research have developed a drug-like molecule that potentially blocks the initial stage of type A influenza infection. Currently, flu medications work by tackling the virus once it has already infected the body. However, researchers at Scripps Research and the Albert Einstein College of Medicine are taking a proactive approach. They have developed drug-like molecules aimed ...
Drug-like inhibitor shows promise in preventing flu
Scripps Research Institute. (2024, May 21). Drug-like inhibitor shows promise in preventing flu. ScienceDaily. Retrieved May 24, 2024 from www.sciencedaily.com / releases / 2024 / 05 ...
Influenza
Influenza, commonly known as "the flu" or just "flu", is an infectious disease caused by influenza viruses.Symptoms range from mild to severe and often include fever, runny nose, sore throat, muscle pain, headache, coughing, and fatigue.These symptoms begin one to four (typically two) days after exposure to the virus and last for about two to eight days.
Influenza A virus subtype H5N1
Influenza A virus subtype H5N1 (A/H5N1) is a subtype of the influenza A virus, which causes influenza (flu), predominantly in birds. It is enzootic (maintained in the population) in many bird populations, and also panzootic (affecting animals of many species over a wide area). A/H5N1 virus can also infect mammals (including humans) which have been exposed to infected birds; in these cases ...
Swine influenza
Swine influenza is an infection caused by any of several types of swine influenza viruses. Swine influenza virus (SIV) or swine-origin influenza virus (S-OIV) refers to any strain of the influenza family of viruses that is endemic in pigs. As of 2009, identified SIV strains include influenza C and the subtypes of influenza A known as H1N1, H1N2, H2N1, H3N1, H3N2, and H2N3.
Scientists Developing mRNA-Based Vaccine Against H5N1 Bird Flu
TUESDAY, May 28, 2024 (HealthDay News) -- An experimental mRNA vaccine against the H5N1 avian flu is highly effective in preventing severe illness and death in lab animals, researchers report. The ...
COMMENTS
Influenza, also known as the flu, is a highly contagious respiratory illness caused by a number of RNA influenza viruses that can infect humans. Complications from influenza can cause significant morbidity and mortality. 1 Globally, as many as 500,000 people die annually from complications related to influenza.
Abstract. Methods for assessing influenza vaccine efficacy and effectiveness have evolved over six decades. Randomized trials remain the gold standard for licensure, but observational studies are needed for annual assessment of vaccine effectiveness (VE). The test-negative design (TND) has become the de facto standard for these field studies.
Introduction Recently, several single center studies have suggested a protective effect of the influenza vaccine against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). This study utilizes a continuously updated Electronic Medical Record (EMR) network to assess the possible benefits of influenza vaccination mitigating critical adverse outcomes in SARS-CoV-2 positive patients from ...
Abstract. Although antiviral drugs and vaccines have reduced the economic and healthcare burdens of influenza, influenza epidemics continue to take a toll. Over the past decade, research on ...
We identified 4979 publications, selected 681 for full review, and included 83 in the systematic review and 41 in meta-analyses. ΔVE for vaccination in both seasons compared with the current season was -9% (95% CI -16 to -1, I 2 =0%; low certainty) for influenza A(H1N1)pdm09, -18% (-26 to -11, I 2 =7%; low certainty) for influenza A(H3N2), and -7% (-14 to 0, I 2 =0%; low ...
Future research of high-quality randomized controlled trials is recommended to further assess the efficacy of the influenza vaccine in COVID-19 patients. The regular updating of the influenza ...
Influenza vaccines can provide moderate protection against virologically confirmed influenza, but such protection is greatly reduced or absent in some seasons. Evidence for protection in adults aged 65 years or older is lacking. LAIVs consistently show highest efficacy in young children (aged 6 months to 7 years). New vaccines with improved clinical efficacy and effectiveness are needed to ...
As compared with a standard-dose vaccine, a high-dose, trivalent, inactivated influenza vaccine (IIV3-HD) improves antibody responses to influenza among adults 65 years of age or older. This study ...
Supporting Research; U.S. Flu Vaccine Effectiveness Networks. ... **2020-2021 flu vaccine effectiveness was not estimated due to low influenza virus circulation during the 2020-2021 flu season. ***In a Wisconsin study among patients aged 6 months to 64 years, VE was 54% against medically attended outpatient acute respiratory illness (ARI ...
Annual seasonal influenza epidemics of variable severity caused by influenza A and B virus infections result in substantial disease burden worldwide. Seasonal influenza virus circulation declined markedly in 2020-21 after SARS-CoV-2 emerged but increased in 2021-22. Most people with influenza have abrupt onset of respiratory symptoms and myalgia with or without fever and recover within 1 ...
First Phase 3 efficacy study to be conducted using an mRNA-based influenza vaccine; study will enroll 25,000 U.S. adults 18 years and older Influenza causes 140,000 to 710,000 hospitalizations and 12,000 to 52,000 deaths in the U.S. every year1 mRNA-based vaccines require only the genetic sequences of the viruses, enabling more flexible, rapid manufacturing which may lead to improved strain ...
After a shot of the highly variant vaccine was administered in some experiments, 100 percent of the mice avoided illness or death from what should have been a lethal dose of flu viruses. The next steps of the research will attempt to understand whether the same level of immunity can be achieved by presenting fewer than 80,000 hemagglutinin ...
Influenza vaccines might prevent COVID-19, particularly in its most severe forms. A preprint study of more than 30,000 health-care workers in Qatar found that those who got a flu shot were nearly ...
Developing a long lasting flu vaccine could be highly beneficial for the health of society, and research is getting closer to this goal.. A study published in Science Translational Medicinefound ...
Workers who received a flu vaccine, the researchers found, were 39 percent less likely to test positive for the coronavirus as of June 1, 2020. While 2.23 percent of nonvaccinated employees tested ...
When it comes to public health, revolutionary measures have advanced to combat the spread of illness with preventative vaccines. Influenza, otherwise known as the flu, was originally thought to be caused by a bacterial infection, according to the World Health Organization.Because of this, early attempts at creating a vaccine during the 1918 influenza pandemic were unsuccessful and resulted in ...
Influenza kills up to 650,000 people around the world each year, with 99% of deaths in children under five years of age in developing countries due to influenza-related infections, according to the World Health Organisation.. The current crop of influenza vaccines has limitations in effectively combating the billion cases of seasonal influenza each year, as they provide immunity against only ...
The vaccine could potentially help manage the outbreak of the H5N1 virus currently circulating in birds and cattle in the United States, and prevent human infections with the virus, according to research from the Perelman School of Medicine at the University of Pennsylvania, published today in Nature Communications.
Scientists at Scripps Research have developed a drug-like molecule that potentially blocks the initial stage of type A influenza infection. Currently, flu medications work by tackling the virus once it has already infected the body. However, researchers at Scripps Research and the Albert Einstein College of Medicine are taking a proactive approach. They have developed drug-like molecules aimed ...
Scripps Research Institute. (2024, May 21). Drug-like inhibitor shows promise in preventing flu. ScienceDaily. Retrieved May 24, 2024 from www.sciencedaily.com / releases / 2024 / 05 ...
Influenza, commonly known as "the flu" or just "flu", is an infectious disease caused by influenza viruses.Symptoms range from mild to severe and often include fever, runny nose, sore throat, muscle pain, headache, coughing, and fatigue.These symptoms begin one to four (typically two) days after exposure to the virus and last for about two to eight days.
Influenza A virus subtype H5N1 (A/H5N1) is a subtype of the influenza A virus, which causes influenza (flu), predominantly in birds. It is enzootic (maintained in the population) in many bird populations, and also panzootic (affecting animals of many species over a wide area). A/H5N1 virus can also infect mammals (including humans) which have been exposed to infected birds; in these cases ...
Swine influenza is an infection caused by any of several types of swine influenza viruses. Swine influenza virus (SIV) or swine-origin influenza virus (S-OIV) refers to any strain of the influenza family of viruses that is endemic in pigs. As of 2009, identified SIV strains include influenza C and the subtypes of influenza A known as H1N1, H1N2, H2N1, H3N1, H3N2, and H2N3.
TUESDAY, May 28, 2024 (HealthDay News) -- An experimental mRNA vaccine against the H5N1 avian flu is highly effective in preventing severe illness and death in lab animals, researchers report. The ...