pharmaceutical chemistry phd thesis

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Pharmaceutical Chemistry (Theses and Dissertations)

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Studies into the in vitro metabolism and antiplatelet effects of novel aspirin ester prodrugs 

Stability and hydrolysis studies of novel dual acting conjugate drugs with anitcancer activity 

Investigations of beta-lactams as novel bioactive compounds 

The design, synthesis and biological evaluation of novel barbiturate-based MMP inhibitors 

Characterisation and analysis of beta-aminoketones as potential prodrugs for amines 

Flexible estrogen receptor modulators 

Design and synthesis of 4-[1,3-diaryl-1H-pyrazole-4-yl]-2,6-dimethyl-1,4-dihydropyridine compounds and evaluation as anti-proliferative and multi-drug resistance reversal agents 

The synthesis and biochemical evaluation of novel isoquinoline derivatives 

Synthesis, biochemical evaluation and structural studies of novel antiproliferative βeta-lactams 

Studies in the synthesis and in vitro hydrolysis of novel aspirin prodrugs 

Design, synthesis and biochemical evaluation of novel antiproliferative agents for the treatement of Burkitt's Lymphoma 

The design, synthesis and biochemical evaluation of analogues of dehydroepiandrosterone (DHEA) and novel selective oestrogen receptor modulators (SERMs) 

Development, validation and optimisation of a vHTS protocol for identification of estrogen receptor modulators 

Dual acting nuclear receptor targeting conjugates : design, synthesis and biochemical evaluation 

Design, synthesis and biochemical evaluation of dual-acting, estrogen receptor ligand conjugates 

Studies in the synthesis and impurity profiling of Methylenedioxy and Alkylthioamphetamines 

Synthetic, photophysical and biological studies into new tools for investigating bile acid disposition and toxicity 

The design, synthesis and biochemical evaluation of novel flexible and conformationally restrained antiestrogens 

Design, synthesis and biochemical evaluation of novel 1,2,3,4-tetrahydroisoquinolines as anti-proliferative agents in breast cancer cells 

The design, synthesis, and evaluation of the Azetidin-2-one ring as a scaffold for novel combretastatin A4 analogues 

UKnowledge > College of Pharmacy > Theses & Dissertations

Theses and Dissertations--Pharmacy

Theses/dissertations from 2024 2024.

Investigating a New Drug Target in Alzheimer’s Disease: NOX2 , Tiffany Adams

Design of Kappa Opioid Receptor Agonists for Potential Treatment of Multiple Sclerosis , Lindsay Kornberger

Sensitizing KEAP1 loss non-small cell lung cancer to artesunate anti-cancer activity , Keng Hee Peh

INHIBITING PI3K/AKT TO ENHANCE BRAIN UPTAKE OF ANTICANCER AGENTS IN GLIOBLASTOMA , Louis Rodgers

Theses/Dissertations from 2023 2023

Self-Assembled Ternary Polypeptide Nanoparticles With Improved Biostability For Drug Delivery In Cancer Therapy , Preye Mike Agbana

Investigation of Folate-Poly(Glutamic Acid)/Polyethylenimine/DNA Complexes for in vitro Gene Delivery , Caleb Akers

POPULATION-BASED EVALUATION OF TREATMENT PATTERNS, DRUG-DRUG INTERACTIONS, AND CARDIOVASCULAR RISK IN PATIENTS WITH METASTATIC CASTRATION-RESISTANT PROSTATE CANCER , Yue Cheng

An Epidemiological and Pharmacokinetic-pharmacodynamic Investigation into the Impact of Carbapenem-resistant Enterobacterales , Justin Clark

STRIVING FOR APPROPRIATE ANTIBIOTIC USE: A BIOMARKER INITIATIVE, AND OUTCOMES ASSOCIATED WITH AZITHROMYCIN EXPOSURE , Amanda Gusovsky

New Tools for Biocatalysis: Studies on the Carminomycin 4-O-Methyltransferase DnrK , Elnaz Jalali

Optimization of Orally Bioavailable Inhibitors of Defective in Cullin Neddylation 1 (DCN-1) , Leah Kovalic

Genetic and Pharmacogenetics Associations of Cancer Disparities in Appalachia , Nan Lin

Design and Synthesis of Small Molecular Inhibitors of DCN1-UBE2M Interaction , Tucker J. Moseley

Effectiveness of a long-acting cocaine hydrolase in metabolizing cocaine and its physiologically active metabolites , Linyue Shang

Anti-Inflammatory and Analgesic Effects of Highly Selective Microsomal Prostaglandin E2 Synthase-1 (mPGES-1) Inhibitors , Madeline Stewart

INVESTIGATING THE USE OF mPGES-1 INHIBITORS FOR THE TREATMENT OF ABDOMINAL AORTIC ANEURYSMS , Lauren M. Weaver

DEVELOPING A BIOCATALYTIC TOOLBOX TO AID IN UNDERSTANDING NUCLEOSIDE ANTIBIOTICS , Jasmine Brianna Woods

BIOINFORMATIC ANALYSIS OF PROTEOMIC AND GENOMIC DATA FROM NSCLC TUMORS ON PROGNOSTIC AND PREDICTIVE FACTORS OF IMMUNOTHERAPY TREATMENT , Mark Wuenschel

Theses/Dissertations from 2022 2022

Response of Dopaminergic System to Cocaine Exposure, Recovery after Cocaine Abstinence, and Impact of a Long-acting Cocaine Hydrolase , Jing Deng

ANALYSIS OF POTENTIAL FACILITATORS TO USE OF HIV PRE-EXPOSURE PROPHYLAXIS (PrEP) IN A YOUNG TRANSGENDER POPULATION , Noah Dixon

Studies Toward the Development of an Improved Countermeasure for Synthetic Opioid Overdose , Sidnee L. Hedrick

Development of zafirlukast derivatives active against Porphyromonas gingivalis , Kaitlind C. Howard

Investigating the Physical Stability of Amorphous Pharmaceutical Formulations , Travis W. Jarrells

THE RELATIVE CONTRIBUTION OF LIVER AND INTESTINE IN REVERSE CHOLESTEROL TRANSPORT , Rupinder Kaur

LIPOSOMAL TECHNOLOGIES TO IMPROVE GENE DELIVERY , David Nardo Padron

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Academic Catalog 2024-2025

Medicinal chemistry and drug discovery, phd, journal club participation, colloquium attendance, internship requirements and regulations for department of pharmaceutical sciences, qualifying examination, doctoral candidacy status, doctoral dissertation committee, dissertation proposal defense, registration for dissertation, publications and presentations, phd dissertation preparation, pharmaceutical sciences colloquium, sopps professional code of conduct .

The PhD Program in Medicinal Chemistry and Drug Discovery educates and trains students in the design and synthesis of novel, biologically active compounds and in delineating their mechanisms of action using biochemical, biophysical, and pharmacological approaches. Research specializations are available in synthetic, biochemical/pharmacological, and biophysical aspects of medicinal chemistry. Doctoral research in these specializations will relate to faculty areas of research, which currently include substance use disorders and addiction; neuropathic pain; obesity and metabolic disorders; neuropsychiatric disorders (psychoses, ADHD, depression, anxiety, eating disorders); and neurodegenerative diseases.

The Department of Pharmaceutical Sciences sponsors weekly journal clubs, Pharmaceutical Science Seminar ( PHSC 6300 ) , at which students present and evaluate current scientific literature in their fields of study. Students must attend one of these journal clubs (Pharmaceutics & Drug Delivery Journal Club, Pharmacology Journal Club, or Medicinal Chemistry & Drug Discovery Journal Club), chosen in consultation with their advisors.

Attendance at one of these journal clubs is required each and every academic semester, as an integral part of the PhD curriculum, with the exception of the last year (year four) in the program. All PhD students must participate full-time in journal club for course credit, Pharmaceutical Science Seminar ( PHSC 6300 ) , for six semesters. Failure to attend journal club regularly may result in sanctions such as probation or dismissal from the PhD program. Any student who does not comply with these (or any other) conditions required in the PhD program faces potential dismissal.

All PhD students, regardless of program, are required to attend the weekly Pharmaceutical Science Colloquium series. Announcements of times and locations will be distributed weekly to students by email to their university email addresses. Attendance is recorded by sign-up sheet. One excused absence is permitted per semester. Failure to attend colloquia may result in sanctions such as probation or dismissal from the PhD program.

Internships provide an experiential component of the graduate curriculum that fosters professional development through work in the pharmaceutical and biotechnology industries.

After PhD candidates have completed their dissertation research and are working on their dissertations, they are able, with the express permission of their PhD advisor, to participate in an internship if they choose. They are never allowed to intern while they are serving as teaching assistants.

• Students are responsible for finding their own internship and must be honest and accurate representing their experiences on their resumés. Students are responsible for tracking this experience on their resumés as there will be no detailed record on students’ transcripts of these opportunities.
• In order to be eligible for internship, students must take Professional Development for Pharmaceutical Sciences ( PHSC 5305 ) a semester before internship.
• Students must not accept more than one position. They must honor the first offer accepted. Any student not adhering to this requirement will not be allowed to participate.
• International students must register for Pharmaceutical Science Internship ( PHSC 6401 )  and follow instructions to receive Curricular Practical Training authorization from the Office of Global Services every semester they work. This applies to part-time jobs and volunteer opportunities. International students cannot engage in full-time CPT authorization totaling more than 52 weeks. Doing so will eliminate the possibility of engaging in the postgraduation benefit of Post-Completion Optional Practical Training.
• In order to receive a grade for the course, students must write at least two learning goals within the first two weeks of the internship and a one- to two-page paper describing what they learned, mid- and end of semester. Supervisors for internships will reply to a questionnaire about students’ performance.
• Taking internship must not extend international students’ visas.
• There are no vacations on co-op/internships. Companies’ sick time policies may vary. Students should check with their employers. For all other matters, please see the Universitywide Academic Policies and Procedures and/or Bouvé College of Health Sciences Academic Policies and Procedures .

The PhD qualifying examination is required for students in all four programs under the auspices of the Department of Pharmaceutical Sciences: pharmacology, medicinal chemistry and drug discovery, biomedical sciences, and pharmaceutics and drug delivery. Students from each of the four programs will take the exams within the same time frame (below), regardless of specialty-area program focus.

Doctoral students should have selected a dissertation advisor by the end of their first year in the program and are expected to have begun research and demonstrated initial proficiency in the laboratory before taking the PhD qualifying examination.

The PhD qualifying examination tests the candidates’ knowledge and skills in core courses and program content areas. The overall PhD qualifying examination consists of two written exams and one oral exam. The qualifying examination is taken as a course,  Doctoral Training and Research ( PHSC 8940 ) , no later than during the fall semester of the student's second year, after having successfully completed all the core courses of their respective programs.

At least two departmental faculty will contribute questions for the written exams, and no one faculty member will write more than the equivalent of one entire exam. All students qualified to sit for the exams are expected to take them at the times announced.

The format for the written exams may vary (e.g., faculty may ask a series of comprehensive essay questions or provide research publications(s) from the biomedical literature and ask questions based upon the publications’ content). The first exam is given in the first week of fall semester, with the written portion of the second exam (i.e., the F31 written document) to be submitted to the student’s exam committee by the end of October, with the oral presentation to be completed by mid-November and graded by the providers of the question(s).

• For example, if the student is in the pharmaceutics and drug delivery PhD program, part 1 will be about pharmaceutics and drug delivery, and part 2 can focus either on pharmacology or medicinal chemistry and drug discovery.
• Written exam 2 requires that students write an NIH F31 grant proposal and have the proposal signed off as passing by their examination committee after an oral defense.

A score of at least 70% is required to pass the first written exam (two parts). Students must pass all written portions of the PhD qualifying examination prior to the oral defense of the F31 proposal. Students who fail one written exam will have one opportunity to retake and pass that examination. A student who fails the first exam twice will be required to withdraw from the PhD program.

During the oral exam, students defend their NIH F31 grant proposal before an examination committee of, minimally, four faculty members: the dissertation advisor, at least two other Department of Pharmaceutical Sciences faculty members, and at least one member from outside the department. This committee is convened only for the oral exam and does not need to be the same committee as the student's dissertation committee. 

Members of the oral examination committee are selected by the student, after consultation with the dissertation advisor and/or the director of graduate studies. The oral exam is graded on a pass/fail basis. Students who fail the oral exam on the first attempt may retake the exam within a time period designated by the examination committee not to exceed two months from the first oral exam. Those who fail twice will be dismissed from the program.

Doctoral students who have completed satisfactorily and thereby earned the credits for all required core courses (including those for their specialized area) and who have passed the written and oral qualifying examinations shall be admitted to candidacy status for the PhD degree.

Doctoral students must complete a dissertation that embodies the results of extended research and makes an original contribution to their field. This work should give evidence of candidates’ abilities to conduct independent investigation and interpret the results of their research in a professional manner. The doctoral dissertation advisor serves as chairperson of the Doctoral Dissertation Committee, which consists of no fewer than five members. Selection of an advisor is by mutual consent of the student and a member of the faculty, with approval by the director of graduate studies in the Department of Pharmaceutical Sciences. At least two members of the Doctoral Dissertation Committee must be faculty members in the Department of Pharmaceutical Sciences. At least one member is to be selected from outside the department. Committee members are chosen for their expertise in students’ research areas.

Within a year after successful completion of the PhD qualifying examination, but no later than the beginning of the fall semester of the third year, students must prepare and defend a written proposal detailing their planned dissertation project. Failure to do so will be regarded as a failure to progress in the PhD program and will result in a warning from the director of graduate studies of the Department of Pharmaceutical Sciences.

Students who do not correct this deficiency within one semester will be placed on academic probation. Students on academic probation must complete the dissertation proposal defense and return to nonprobationary status within one semester or be dismissed from the PhD program.

The dissertation proposal should be no more than 50 double-spaced pages (12-point font minimum and one-half-inch margins on all sides). This page limit excludes references but includes figures, figure legends, and tables. Aside from these exceptions, the proposal should otherwise conform to the format and structure of an NIH grant proposal with four main sections: specific aims, background and significance, preliminary studies, and experimental design and methods. The Department of Pharmaceutical Sciences Dissertation Proposal document provides detailed instructions on the preparation of a dissertation proposal. Associated required forms may be found on the SOPPS Student Portal Canvas site.

The dissertation proposal must be defended orally before the student's dissertation committee and signed by all dissertation committee members in approval of the student's planned dissertation research.  Upon dissertation approval, the copies of the signed proposal approval cover sheet must be submitted to the department’s director of graduate studies and to the Bouvé College of Health Sciences Graduate Office.

Biannual Review

Dissertation committees meet routinely at six-month intervals, but no less than once a year, to evaluate students’ research progress and to be presented with written and oral progress reports on the direction and status of the research. Progress reports should be written in a brief format, identical to that described for the formal dissertation (see instructions listed on the SOPPS Student Portal Canvas site). Unsatisfactory productivity provides the basis for a warning by the dissertation committee and/or the Graduate Committee. Two such warnings will result in a student’s dismissal from the program.

Advisor consent and completion of all coursework (with the exception of the colloquium course) must be documented before students register for the first dissertation course. Students must register for Dissertation Term 1 ( PHSC 9990 )  and Dissertation Term 2 ( PHSC 9991 ) . Students must register for Dissertation Continuation ( PHSC 9996 )  each semester thereafter until the dissertation has been successfully defended. The department strongly encourages PhD students to complete the program within five years after acceptance, i.e., by three years after establishing degree candidacy. According to university policy, no PhD students may remain in the program for more than seven years.

Prior to completion of PhD training, candidates must present their research either as a poster or podium presentation at a regional or national scientific conference. Also prior to completion, the student must have submitted (preferably, published) at least one manuscript in a peer-reviewed journal that reflects original findings and laboratory work from the candidate's dissertation research.

Detailed guidelines for the format and content of the written dissertation are given in Instructions for Preparation of the Dissertation found on the SOPPS Student Portal Canvas site. The completed dissertation document should be reviewed first by the dissertation advisor. Feedback from the advisor should be incorporated into the dissertation draft before its distribution to the dissertation committee. The completed dissertation should be delivered to all dissertation committee members no later than two weeks before the scheduled oral defense.

All PhD candidates nearing completion of their research are required to present their dissertation findings at the department’s Pharmaceutical Sciences Colloquium. These presentations should be scheduled at least six months before anticipated completion of the dissertation. In turn, the dissertation should be completed no later than one year after the colloquium presentation. Students must register for  Pharmaceutical Science Colloquium ( PHSC 6810 )  during the semester that the colloquium presentation is to be given.

Oral Dissertation Defense

The oral dissertation defense takes place after students complete their PhD dissertation research and all other requirements for the PhD degree. The oral defense deals with the subject matter of the dissertation, significant developments in the field, and students’ background knowledge in their field of concentration.

The dissertation committee conducts the final defense. The committee may recommend that the student clarify, amplify, or rewrite portions of the dissertation before the final defense is scheduled. Once the committee concurs that that written dissertation document is acceptable, a date is chosen for the final oral examination.

At least two weeks prior to the defense, students should inform the director of graduate studies in the Department of Pharmaceutical Sciences of the date of defense, so that advance announcement may be distributed. The final defense is open to anyone who wishes to attend and typically lasts at least two hours. After presentation of the work by the student in a seminar format, and responses to audience and committee questions, the committee meets first with the student for any follow-up discussion and then in executive session to decide whether the student has defended the dissertation successfully.

The committee’s decision is then announced to the student. If the committee’s vote is favorable, the student incorporates committee suggestions and corrections, if applicable, and the dissertation is signed and passed on to the department’s director of graduate studies. Requests for a second defense are highly irregular but may be permitted in the event that the previous oral defense was judged by the committee to be highly promising but inadequate in one critical aspect.

The final dissertation must be written, defended, and approved at least two weeks before the university commencement deadline. Students must submit signed copies of their dissertations to the website designated by the university and must abide by any embargo sanctioned by the student’s principal dissertation advisor and/or dissertation committee. The students should apply for graduation before the final dissertation defense, on the assumption that the dissertation will be approved. If the dissertation committee decides that more time is required to complete the dissertation beyond the commencement date, then the application for graduation can be withdrawn and a new one submitted pending final dissertation approval.

All SOPPS students (BSPS, Preprofessional, MS, and PhD) are expected to adhere to the Code of Conduct .

Please visit  Bouvé College of Health Sciences Program Learning Outcomes  for the specific student learning outcomes for this program.

• Concentrations and course offerings may vary by campus and/or by program modality.  Please consult with your advisor or admissions coach for the course availability each term at your campus or within your program modality.  
• Certain options within the program may be  required  at certain campuses or for certain program modalities.  Please consult with your advisor or admissions coach for requirements at your campus or for your program modality. 

Complete all courses and requirements listed below unless otherwise indicated.

Qualifying examination Doctoral candidacy status Doctoral dissertation committee Dissertation proposal Biannual review Pharmaceutical Sciences Colloquium Oral dissertation defense

Core Requirements

A grade of C– or higher is required in each course.

Research and Dissertation

Program Credit/GPA Requirements

32 total semester hours required Minimum 3.000 GPA required

Plan of Study

Scientific Writing: Thesis Proposal ( PHSC 7020 )  must be taken the summer before the qualifying exams.

Doctoral Proposal ( PHSC 9681 ) should be taken in summer of second year, but no later than fall of third year. 

Pharmaceutical Science Colloquium ( PHSC 6810 ) must be taken six months before dissertation defense.

PHSC 5305 & PHSC 6213 is suggested to be taken in the fourth year, but can be taken at any point before graduation. 

Plan of Study - Advanced Entry

Doctoral Proposal ( PHSC 9681 )  may be taken in spring of first year but must be taken before fall of second year.

Pharmaceutical Science Colloquium ( PHSC 6810 )  must be taken six months before dissertation defense.

Advanced entry into the Medicinal Chemistry and Drug Discovery PhD program requires a master's degree in pharmaceutical sciences or a related area and focuses on various advanced research courses and successful defense of the dissertation. An applicant's transcripts are required to be reviewed by the admissions committee to ensure they are eligible to be in the advanced entry program.

Annual review Qualifying examination Dissertation committee Dissertation proposal Dissertation defense

10 total semester hours required Minimum 3.000 GPA required

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Digital Commons @ USF > College of Arts and Sciences > Chemistry > Theses and Dissertations

Chemistry Theses and Dissertations

Theses/dissertations from 2024 2024.

Effects of Diminazene Aceturate on Drosophila melanogaster : A Lipidomic Analysis , Gabriela Suarez

Introductory Chemistry Student Success: Evaluating Peer-Led Team Learning and Describing Sense of Belonging , Jessica D. Young

Explorations on Non-Covalent Interactions: From Supramolecules to Drug-Like Molecules , Zhanpeng Zhang

Theses/Dissertations from 2023 2023

aPKCs role in Neuroblastoma cell signaling cascades and Implications of aPKCs inhibitors as potential therapeutics , Sloan Breedy

Protein Folding Kinetics Analysis Using Fluorescence Spectroscopy , Dhanya Dhananjayan

Affordances and Limitations of Molecular Representations in General and Organic Chemistry , Ayesha Farheen

Institutional and Individual Approaches to Change in Undergraduate STEM Education: Two Framework Analyses , Stephanie B. Feola

Applications in Opioid Analysis with FAIMS Through Control of Vapor Phase Solvent Modifiers , Nathan Grimes

Synthesis, Characterization, and Separation of Loaded Liposomes for Drug Delivery , Sandra Khalife

Supramolecular Architectures Generated by Self-assembly of Guanosine and Isoguanosine Derivatives , Mengjia Liu

Syntheses, Photophysics, & Application of Porphyrinic Metal-Organic Frameworks , Zachary L. Magnuson

Integration of Algae and Biomass Processes to Synthesize Renewable Bioproducts for the Circular Economy , Jessica Martin

Considerations for curricular reform in undergraduate chemistry: Cooperative adoption factors, modeling social influence, and focusing on specific populations , Jacob D. McAlpin

Chemical Analysis of Metabolites from Mangrove Endophytic Fungus , Sefat E Munjerin

Synthesis of Small Molecule Modulators of Non-Traditional Drug Targets , Jamie Nunziata

Conformational Dynamics and Free Energy Studies of DNA and Other Biomolecules , Paul B. Orndorff

Synthetic Studies of Potential New Ketogenic Molecules , Mohammad Nazmus Sakib

Coupling Chemical and Genomic Data of Marine Sediment-Associated Bacteria for Metabolite Profiling , Stephanie P. Suarez

Enhanced Methods in Forensic Mass Spectrometry for Targeted and Untargeted Drug Analysis , Dina M. Swanson

Investigation of Challenging Transformations in Gold Catalysis , Qi Tang

Diazirines and Oxaziridines as Nitrogen Transfer Reagents in Drug Discovery , Khalilia C. Tillett

Developing New Strategy toward Ruthenium and Gold Redox Catalysis , Chenhuan Wang

Gold-Catalyzed Diyne-ene Cyclization: Synthesis of Hetero Polyaromatic Hydrocarbons and 1,2-Dihydropyridines , Jingwen Wei

Development of Antiviral Peptidomimetics , Songyi Xue

Self-Assembly of Metallo-Supramolecules Based on Terpyridine and its Derivatives , Yu Yan

Theses/Dissertations from 2022 2022

Synthesis and Antibacterial Testing of Novel Thiosulfonate Compounds , Lindsay I. Blume

Investigating a Potential STING Modulator , Jaret J. Crews

Development of Lipidated Antimicrobial Polycarbonates , Ruixuan Gao

Exploring the Structure and Activity of Metallo-Tetracyclines , Shahedul Islam

Large Area Projection Sintering of Semicrystalline Polymers and Part Analysis of the Printed Specimens , Taranjot Kaur

Interfacing Computational Techniques with Synthetic and Spectroscopic Methods for Research and Education , Nicole Annette Miller

An Investigation into the Protein Dynamics and Proton Transfer Mechanism of Class-A β-lactamase (CTX-Ms) by NMR Spectroscopy , Radwan Ebna Noor

Effects of acid hydrolyzed chitosan derivatives on MHV infection , Krishna Sharma

Metabolomic Analysis, Identification and Antimicrobial Assay of Two Mangrove Endophytes , Stephen Thompson

Advanced Analytical Method Development: from Highly-Enrolled Classroom to Data-Intensive Proteomics , Laxmi Sinduri Vuppala

Measuring and Improving Student Attitude in College-level Chemistry: A Novel Survey Methodology and Social-psychological Interventions , Ying Wang

Targeting the Side-Chain Convergence of α-Helical Hot Spots to Design Small-Molecule Mimetics Disrupting Protein-Protein Interaction , Zhen Wang

Bioactivity of Suberitenones A and B , Jared G. Waters

Developing Efficient Transition Metal Catalyzed C-C & C-X Bond Construction , Chiyu Wei

Chemical Investigation and Drug Discovery Potential of Terpenoid Secondary Metabolites from Three Deep-Sea Irish Soft Corals , Joshua Thomas Welsch

Measurement in Chemistry, Mathematics, and Physics Education: Student Explanations of Organic Chemistry Reaction Mechanisms and Instructional Practices in Introductory Courses , Brandon J. Yik

Study on New Reactivity of Vinyl Gold and Its Sequential Transformations , Teng Yuan

Study on New Strategy toward Gold(I/III) Redox Catalysis , Shuyao Zhang

Theses/Dissertations from 2021 2021

Design, Synthesis and Testing of Bioactive Peptidomimetics , Sami Abdulkadir

Synthesis of Small Molecules for the Treatment of Infectious Diseases , Elena Bray

Social Constructivism in Chemistry Peer Leaders and Organic Chemistry Students , Aaron M. Clark

Synthesizing Laccol Based Polymers/Copolymers and Polyurethanes; Characterization and Their Applications , Imalka Marasinghe Arachchilage

The Photophysical Studies of Transition Metal Polyimines Encapsulated in Metal Organic Frameworks (MOF’s) , Jacob M. Mayers

Light Harvesting in Photoactive Guest-Based Metal-Organic Frameworks , Christopher R. McKeithan

Using Quantitative Methods to Investigate Student Attitudes Toward Chemistry: Women of Color Deserve the Spotlight , Guizella A. Rocabado Delgadillo

Simulations of H2 Sorption in Metal-Organic Frameworks , Shanelle Suepaul

Parallel Computation of Feynman Path Integrals and Many-Body Polarization with Application to Metal-Organic Materials , Brant H. Tudor

The Development of Bioactive Peptidomimetics Based on γ-AApeptides , Minghui Wang

Investigation of Immobilized Enzymes in Confined Environment of Mesoporous Host Matrices , Xiaoliang Wang

Novel Synthetic Ketogenic Compounds , Michael Scott Williams

Theses/Dissertations from 2020 2020

Biosynthetic Gene Clusters, Microbiomes, and Secondary Metabolites in Cold Water Marine Organisms , Nicole Elizabeth Avalon

Differential Mobility Spectrometry-Mass spectrometry (DMS-MS) for Forensic and Nuclear-Forensic applications , Ifeoluwa Ayodeji

Conversion from Metal Oxide to MOF Thin Films as a Platform of Chemical Sensing , Meng Chen

Asking Why : Analyzing Students' Explanations of Organic Chemistry Reaction Mechanisms using Lexical Analysis and Predictive Logistic Regression Models , Amber J. Dood

Development of Next-Generation, Fast, Accurate, Transferable, and Polarizable Force-fields for Heterogenous Material Simulations , Adam E. Hogan

Breakthroughs in Obtaining QM/MM Free Energies , Phillip S. Hudson

New Synthetic Methodology Using Base-Assisted Diazonium Salts Activation and Gold Redox Catalysis , Abiola Azeez Jimoh

Development and Application of Computational Models for Biochemical Systems , Fiona L. Kearns

Analyzing the Retention of Knowledge Among General Chemistry Students , James T. Kingsepp

A Chemical Investigation of Three Antarctic Tunicates of the Genus Synoicum , Sofia Kokkaliari

Construction of Giant 2D and 3D Metallo-Supramolecules Based on Pyrylium Salts Chemistry , Yiming Li

Assessing Many-Body van der Waals Contributions in Model Sorption Environments , Matthew K. Mostrom

Advancing Equity Amongst General Chemistry Students with Variable Preparations in Mathematics , Vanessa R. Ralph

Sustainable Non-Noble Metal based Catalysts for High Performance Oxygen Electrocatalysis , Swetha Ramani

The Role of aPKCs and aPKC Inhibitors in Cell Proliferation and Invasion in Breast and Ovarian Cancer , Tracess B. Smalley

Development of Ultrasonic-based Ambient Desorption Ionization Mass Spectrometry , Linxia Song

Covalent Organic Frameworks as an Organic Scaffold for Heterogeneous Catalysis including C-H Activation , Harsh Vardhan

Optimization of a Digital Ion Trap to Perform Isotope Ratio Analysis of Xenon for Planetary Studies , Timothy Vazquez

Multifunctional Metal-Organic Frameworks (MOFs) For Applications in Sustainability , Gaurav Verma

Design, Synthesis of Axial Chiral Triazole , Jing Wang

The Development of AApeptides , Lulu Wei

Chemical Investigation of Floridian Mangrove Endophytes and Antarctic Marine Organisms , Bingjie Yang

Theses/Dissertations from 2019 2019

An Insight into the Biological Functions, the Molecular Mechanism and the Nature of Interactions of a Set of Biologically Important Proteins. , Adam A. Aboalroub

Functional Porous Materials: Applications for Environmental Sustainability , Briana Amaris Aguila

Biomimetic Light Harvesting in Metalloporphyrins Encapsulated/Incorporated within Metal Organic Frameworks (MOFs). , Abdulaziz A. Alanazi

Design and Synthesis of Novel Agents for the Treatment of Tropical Diseases , Linda Corrinne Barbeto

Effect of Atypical protein kinase C inhibitor (DNDA) on Cell Proliferation and Migration of Lung Cancer Cells , Raja Reddy Bommareddy

The Activity and Structure of Cu2+ -Biomolecules in Disease and Disease Treatment , Darrell Cole Cerrato

Simulation and Software Development to Understand Interactions of Guest Molecules inPorous Materials , Douglas M. Franz

Construction of G-quadruplexes via Self-assembly: Enhanced Stability and Unique Properties , Ying He

The Role of Atypical Protein Kinase C in Colorectal Cancer Cells Carcinogenesis , S M Anisul Islam

Chemical Tools and Treatments for Neurological Disorders and Infectious Diseases , Andrea Lemus

Antarctic Deep Sea Coral and Tropical Fungal Endophyte: Novel Chemistry for Drug Discovery , Anne-Claire D. Limon

Constituent Partitioning Consensus Docking Models and Application in Drug Discovery , Rainer Metcalf

An Investigation into the Heterogeneity of Insect Arylalkylamine N -Acyltransferases , Brian G. O'Flynn

Evaluating the Evidence Base for Evidence-Based Instructional Practices in Chemistry through Meta-Analysis , Md Tawabur Rahman

Role of Oncogenic Protein Kinase C-iota in Melanoma Progression; A Study Based on Atypical Protein Kinase-C Inhibitors , Wishrawana Sarathi Bandara Ratnayake

Formulation to Application: Thermomechanical Characterization of Flexible Polyimides and The Improvement of Their Properties Via Chain Interaction , Alejandro Rivera Nicholls

The Chemical Ecology and Drug Discovery Potential of the Antarctic Red Alga Plocamium cartilagineum and the Antarctic Sponge Dendrilla membranosa , Andrew Jason Shilling

Synthesis, Discovery and Delivery of Therapeutic Natural Products and Analogs , Zachary P. Shultz

Development of α-AA peptides as Peptidomimetics for Antimicrobial Therapeutics and The Discovery of Nanostructures , Sylvia E. Singh

Self-Assembly of 2D and 3D Metallo-Supramolecules with Increasing Complexity , Bo Song

The Potential of Marine Microbes, Flora and Fauna in Drug Discovery , Santana Alexa Lavonia Thomas

Design, Synthesis, and Self-Assembly of Supramolecular Fractals Based on Terpyridine with Different Transition Metal Ions , Lei Wang

Theses/Dissertations from 2018 2018

Fatty Acid Amides and Their Biosynthetic Enzymes Found in Insect Model Systems , Ryan L. Anderson

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Defended PhD theses

• Cai LIn (2018-2021). PhD thesis: Enrichment of a purine nucleoside analog library towards activity against Leishmania and Trypanosoma cruzi species

Jakob Bouton (2015-2021). PhD thesis: Homoazanucleoside, purine nucleoside and hamamelitannin analogues: towards new therapeutics for infectious diseases

• Yanlin Jian (2017-2020). PhD thesis: "Design and synthesis of M. tuberculosis thymidylate kinase inhibitors towards active whole-cell antimycobacterial agents"
• Charlotte Courtens (2014-2018). PhD thesis: "Synthesis of prodrugs of a fosmidomycin surrogate as antimalarial and antitubercular agents"
• Jonas Janssens (2014-2019). Jonas Janssens (2014-2018). PhD thesis: "Galactosylceramide analogues as iNKT-cell antigens: synthesis, biological evaluation and structural analysis"
• Mingchen Qian (2013-2018). ”Synthesis and biological evaluation of new bivalent GPCR ligands”
• Fabian Hulpia (2013-2018).  ”Design and synthesis of a purine nucleoside library: phenotypic discovery of anti-kinetoplastid agents”
• Lijun Song (2012-2018). "Design and synthesis of non-nucleoside M. tuberculosis thymidylate kinase Inhibitors as antimycobacterial agents"
• Joren Guillaume (2010-2016). PhD thesis: "Synthesis of new glycosphingolipids as NKT cell ligands"
• Arno Vermote (2012-2015). PhD thesis: ”Quorum Sensing Modulating Hamamelitannin Analogues as Potentiators for Antibiotics against Staphylococcus aureus” 
• René Chofor (2009-2015). PhD defense highlights . PhD thesis: Synthesis and Evaluation of 1-Deoxy-D-xylulose 5-phosphate reductoisomerase Inhibitors as Antimalarial and Antituberculosis Agents
• Dries De Clercq (2011-2015) PhD thesis: Synthesis of chemical dimerizers for the optimization of MASPIT
• Kiran Toti (2009-2014) PhD thesis: Synthesis and biological evaluation of 4'-hydroxymethyl deleted, transposed and modified nucleosides
• Nora Pauwels (2008-2013) PhD thesis: Synthesis of new a-GalCer analogues as iNKT cell targeting agents
• Thomas Verbrugghen (2006-2012) PhD thesis: Synthesis of DXR inhibitors as antimalarials
• Sara Van Poecke (2007-2011) PhD thesis: Synthesis and biological evaluation of pyrimidine nucleosides and nucleoside phosphonates
• Matthias Trappeniers (2006-2010). PhD thesis: Synthesis of sphingosine- and sugar-modified alpha-GalCer analogues: towards new immunomodulatory agents
• Liesbet Cosyn (2003-2008) PhD thesis: Synthesis and Biological Evaluation of Purine and Pyrimidine Ligands for the A 3 and P2Y 2 Purinergic Receptors
• Ineke Van Daele (2003-2007) PhD thesis: Design of thymidine-based inhibitors of Mycobacterium tuberculosis thymidylate kinase
• Vincent Devreux (2003-2006) PhD thesis: Synthese van fosmidomycine-analogen met potentiële anti-malaria-activiteit
• Timothy Haemers (2002-2006) PhD thesis: Synthesis and Evaluation of Fosmidomycin Analogues as Antimalarial Agents
• Ulrik Hillaert (2000-2005) PhD thesis: Synthesis of Biologically Relevant Sphingolipid Analogues
• Philippe Van Rompaey (2000-2004) PhD thesis: Synthesis and Biological Evaluation of Modified Adenosine and Thymidine Nucleoside Analogues
• Veerle Vanheusden (1999-2004) PhD thesis: Structure-aided design of inhibitors of Mycobacterium tuberculosis thimydilate kinase
• Steven De Jonge (1997-2000) PhD thesis: Synthesis and Biological Evaluation of Dihydroceramide and Homoceramide Analogues
• Ilse Van Overmeire (1996-1999) PhD thesis: Synthesis of biologically relevant sphingoid- and ceramide-analogues

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• KU School of Pharmacy
• Doctor of Pharmacy (Pharm.D.)
• Pharmaceutical Chemistry
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Doctor of Philosophy (Ph.D.) in Medicinal Chemistry

The KU Department of Medicinal Chemistry provides Ph.D. students a strong foundation in organic and medicinal chemistry with flexibility for additional emphasis in aspects of biochemistry, pharmacology and other biological sciences.

Apply for Ph.D.

Ph.D. Program Overview

Standard ku graduate admission requirements —.

Students must meet all requirements for Graduate Admissions .

Prerequisites —

Previous degree requirement —.

B.S. or M.S. degree in pharmacy, medicinal chemistry, chemistry, biochemistry, or a closely-related field

Grade Point Average (GPA) —

Applicants must have a minimum cumulative GPA of a 3.0 on a 4.0 scale. 

Graduate Record Exam (GRE) Scores —

• GRE General Test  is recommended but not required.
• GRE scores should be sent directly to the University of Kansas and to the Department of Medicinal Chemistry (codes: KU-6871, Medicinal Chemistry - 0621). 
• Although not mandatory, applicants are encouraged to also take the subject test in chemistry.

English Proficiency Requirements —

Non-native English speakers must demonstrate proficiency in reading, writing and listening via English Proficiency Scores from the TOEFL, IELTS or PTE test. See  KU's English Proficiency Requirements  for detailed information, including minimum score requirements. Request that the testing agency send your official scores directly to KU (codes: KU-6871, Pharmacy-47).

Time to Complete —

The program typically takes five years to complete. Required core graduate courses for students who meet standard requirements can be completed within the first two years of study. Students attend year-round with time off for holidays and vacations.

Minimum Enrollment —

Students enroll in at least 9 credit hours in both the fall and spring semesters and 6 hours in the summer. Students must take all required courses, even if that requires more than the minimum hours a given term. Students must be enrolled in at least 1 hour of thesis or dissertation research each term (MDCM 895 or 999), regardless of other coursework.

Foundational Prerequisite Courses —

One year of organic chemistry with laboratory (equivalent to CHEM 624, 625, 626, 627) and at least one course in physical chemistry (equivalent to CHEM 640, 646) and one course biochemistry (see note below).

Note About Biochemistry A one-semester survey course in biochemistry is acceptable if the student received a grade of B or better in the course OR if the student scores a 70 or better on the ACS Biochemistry placement exam given to entering graduate students in the fall (one try only will be allowed). If neither of these applies, the student will take one semester of biochemistry through the Department of Medicinal Chemistry (MDCM 701).

See Courses - Ph.D. for details about required coursework, safety training and academic standing.

Research Requirements —

Graduate degrees in medicinal chemistry are research-based and awarded only after a student has made a significant, in-depth contribution of new knowledge to the field in the form of research publications and the M.S. Thesis or the Doctoral Dissertation.

Academic Standing —

At the end of the first semester, continuance in the program is dependent upon satisfactory academic program progress.

Comprehensive Written Examination —

After the spring semester of year one, students take a comprehensive written examination and must score 70% or higher. A score of 50%-69% qualifies students for one additional attempt, which must occur before fall semester of year two. A score below 50% will typically result in dismissal.

Comprehensive Oral Examination —

Students take a comprehensive oral exam after the first two years of coursework. Successful completion results in the student attaining the status of doctoral candidate. A non-thesis M.S. degree is automatically awarded to all students after the successful completion of their oral comprehensive examination.

Seminar Presentations —

Students must prepare and present two seminars in the departmental seminar series. The first is the Literature Seminar (MDCM 798) and presented during the spring semester of year two. The second seminar is the research seminar (MDCM 799), during the fall semester of year four and highlights research progress.

Original Research Proposal —

As part of the “Proposal Preparation” course (MDCM 980), during the fall semester of year three, students prepare an original proposal (NIH format), and submit it to the faculty for evaluation. This proposal is based on the same topic as their literature seminar.  

Research Rotations —

Students perform two research rotations during the first semester and are assigned a research advisor, both for rotations and the final research group assignment. Assignments are based on student’s preference as well as the availability of funding and research space.

Student Self-Assessment —

Starting in the third year, students are required to complete a yearly self-assessment of their goals and progress toward those goals.

Dissertation Defense —

The final requirements for the Ph.D. degree are the preparation and defense of a dissertation based on the original laboratory research conducted by the student.

Safety Training —

Students must comply with training required by the KU Department of Environment, Health and Safety and the Department of Medicinal Chemistry. Training can include research seminars, hands-on training and online training. Safety training specific to assigned labs must also be completed before students are allowed to begin laboratory work.

Director of Graduate Studies Course Mark Farrell Associate Professor [email protected] 785-864-1610

Graduate Student Recruiting Application [email protected] 785-864-4495

KU Graduate Admissions [email protected] 785-864-3140

We have 97 Pharmaceutical Chemistry PhD Research Projects PhD Projects, Programmes & Scholarships

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PhD Research Projects

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Pharmaceutical Chemistry PhD Research Projects PhD Projects, Programmes & Scholarships

Faculty of Biology, Medicine and Health

Tackle real world challenges, make a difference, and elevate your career with postgraduate research in the Faculty of Biology, Medicine and Health at Manchester. From biochemistry to neuroscience, cancer sciences to medicine, audiology to mental health and everything in between, we offer a wide range of postgraduate research projects, programmes and funding which will allow you to immerse yourself in an area of research you’re passionate about.

Understanding and preventing the denaturation of proteins on surfaces in manufacture, storage and delivery of biotherapeutics

Phd research project.

PhD Research Projects are advertised opportunities to examine a pre-defined topic or answer a stated research question. Some projects may also provide scope for you to propose your own ideas and approaches.

Self-Funded PhD Students Only

This project does not have funding attached. You will need to have your own means of paying fees and living costs and / or seek separate funding from student finance, charities or trusts.

PhD in Chemistry: Electrocatalysis: Development of Catalysts for the Electrochemical Transformation of Organic Biobased Molecules into Value-Added Products and Energy Harvesting

Drug development for parkinson's disease, funded phd project (students worldwide).

This project has funding attached, subject to eligibility criteria. Applications for the project are welcome from all suitably qualified candidates, but its funding may be restricted to a limited set of nationalities. You should check the project and department details for more information.

Competitive EPSRC funded PhD in Chemistry:Understanding interactions leading to pharmacological or biological activity through state-of-the-art biophysical techniques

Competition funded phd project (students worldwide).

This project is in competition for funding with other projects. Usually the project which receives the best applicant will be successful. Unsuccessful projects may still go ahead as self-funded opportunities. Applications for the project are welcome from all suitably qualified candidates, but potential funding may be restricted to a limited set of nationalities. You should check the project and department details for more information.

PhD in Chemistry: New antibiotics to kill 'Superbugs' by stopping them dividing

Phd in chemistry: design, synthesis and biological evaluation of molecules to tackle invasive fungal infections, competitive epsrc funded phd in chemistry: sustainable synthesis of antiviral and anticancer drugs through chemoenzymatic routes, nanocrystals-in-nanofibres as a promising strategy for the delivery of poorly soluble actives, competition funded phd project (uk students only).

This research project is one of a number of projects at this institution. It is in competition for funding with one or more of these projects. Usually the project which receives the best applicant will be awarded the funding. The funding is only available to UK citizens or those who have been resident in the UK for a period of 3 years or more. Some projects, which are funded by charities or by the universities themselves may have more stringent restrictions.

Ultra-long-acting microneedles for biologics delivery

Non-invasive therapy for soft tissue reconstruction: applications in cosmetics and wound healing, development of enzymes for the sustainable synthesis of pharmaceutically relevant amides under aqueous conditions., funded phd project (uk students only).

This research project has funding attached. It is only available to UK citizens or those who have been resident in the UK for a period of 3 years or more. Some projects, which are funded by charities or by the universities themselves may have more stringent restrictions.

Selective Extraction of Radiotherapeutic Metals for Targeted Alpha Cancer Therapy

Dexamethasone-releasing cochlear implants to reduce foreign body response, development of nano-formulation strategies to enhance the therapeutic potential of host defence peptides for the treatment of inflammatory bowel disease (project id sas0208), does the brain renin angiotensin system influence the occurrence of depression in alzheimer’s disease.

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Bulletin 2024-2025, pharmaceutical sciences/medicinal chemistry phd.

SCHOOL OF PHARMACY

Learn more about the Doctor of Philosophy in Pharmaceutical Sciences .

About the Program

The School of Pharmacy offers a graduate program leading to the MS and to the PhD in Pharmaceutical Sciences with a concentration in Medicinal Chemistry. The program is designed to prepare students for positions in the pharmaceutical industry, government agencies, and as faculty in schools of pharmacy.

Time Limit for Degree Completion: 7 years

Campus Location: Health Sciences Center, Main

Some courses may be offered at the Fort Washington campus. Research must be carried out at the Health Sciences Center campus under the supervision of an advisor who is a member of the Graduate Faculty.

Full-Time/Part-Time Status: Full-time status is recommended due to the nature of ongoing research.

Interdisciplinary Study: The program encourages interdisciplinary coursework, research and collaborations among faculty and students with interests in biochemistry, molecular modeling, organic chemistry and pharmacology.

Areas of Specialization: The focus is Medicinal and Pharmaceutical Chemistry, including design and synthesis of ligands for cholinergic receptors and ligands for retinoic acid receptors, novel anticonvulsants, and the development of analytical methodologies.

Job Prospects: The program primarily concentrates on providing research scientists for the pharmaceutical industry and government agencies, as well as faculty for schools of pharmacy.

Non-Matriculated Student Policy: Non-matriculated students are able to take up to 9 credits before formal application must be made to the program.

Financing Opportunities: Support options include University fellowships, teaching assistantships and research assistantships. Recipients are determined on a competitive basis during the admission process and receive a stipend and full tuition remission (up to 9 credits per term).

The principal duties of a Teaching Assistant (TA) include assisting faculty members in laboratory instruction, preparing apparatus or materials for PharmD students, conducting recitations, grading quizzes and reports, and proctoring exams. TAs are expected to work 20 hours per week.

A Research Assistant (RA) is expected to spend 20 hours per week engaged in research and is assigned to a specific faculty member. The research subjects are determined by consultation between the student and their research advisor.

Applications should include a statement of previous teaching and/or research experience, areas of interest, and future goals; official transcripts; and a curriculum vitae. The department attempts to make offers of assistantships on or before May 1. June 1 is the final date for acceptance or declination of department offers. Applications should be directed to:

Temple University School of Pharmacy 3307 North Broad Street, Suite 528 Philadelphia, PA 19140

Admission Requirements and Deadlines

Application Deadline:

Fall: December 15

All applications are evaluated together after the deadline.

APPLY ONLINE to this graduate program .

Letters of Reference: Number Required: 3

From Whom: Letters of recommendation should be obtained from college/university faculty members familiar with the applicant's academic competence and professionals in a supervisory position.

Coursework Required for Admission Consideration: It is recommended that applicants complete the courses (or their equivalent, as determined by the School of Pharmacy) to obtain a BS in Biochemistry, Chemistry (preferably Organic Chemistry), or Pharmacy before entering the program.

Master's Degree in Discipline/Related Discipline: A master's degree is not required.

Bachelor's Degree in Discipline/Related Discipline: A baccalaureate degree in Biochemistry, Chemistry (preferably Organic Chemistry), or Pharmacy is required.

Transcripts from all post-secondary institutions attended may be sent electronically to [email protected]. Alternately, unopened official transcripts bearing the school’s seal must be sent directly from the Registrar at each institution to the School of Pharmacy’s Office of Graduate Studies.

Applicants who earned a degree at a non-U.S. institution must submit an equivalency evaluation of their transcript(s) through a third-party provider, either World Education Services (WES) or Educational Credential Evaluators (ECE) .

Statement of Goals: In approximately 500 to 1,000 words, state your specific interest in Temple's program, research goals, future career goals, and academic and research achievements.

Standardized Test Scores: GRE: Scores are expected to be in the 65th percentile or above.

Applicants who earned their baccalaureate degree from an institution where the language of instruction was other than English, with the exception of those who subsequently earned a master’s degree at a U.S. institution, must report scores for a standardized test of English that meet these minimums:

• TOEFL iBT: 85
• IELTS Academic: 6.5
• PTE Academic: 58

Resume: Current resume or CV required.

Program Requirements

General Program Requirements: Number of Credits Required Beyond the Baccalaureate: 46

Required Courses:

Suggested electives include CHEM 4201 Organic Structure and Mechanisms , CHEM 5201 Physical Methods in Organic Chemistry , CHEM 5205 Organic Syntheses , and PS 8009 Advanced Medicinal Chemistry I . Electives should be taken primarily in Chemistry. Coursework in Biomedical Sciences, Computer and Information Science, and other disciplines is also permissible with guidance from the advisor.

Of the 6 required research credits, a minimum of 2 credits of PS 9999 must be taken. The other 4 credits may be taken in any combination of PS 9994 , PS 9998 , and PS 9999 .

Culminating Events: Preliminary Examination: The purpose of the preliminary examination is to demonstrate critical and interpretive knowledge in specialized areas of the discipline. The examination evaluates the student's ability to apply specific research foci to anticipated practical problems in the field. Students who accumulate 40 didactic credits are eligible to take the exam.

The preliminary exam consists of two sections. The first is a written section consisting of questions from the student’s Doctoral Advisory Committee (DAC). Each member of the DAC submits a question and then judges the quality of the student's answer based on criteria such as accuracy, thoroughness and originality. They then share that score and their rationale for it with the other members of the DAC. The evaluators look for a breadth and depth of understanding of concepts in the areas being tested, application of that knowledge, and the ability to write technical prose in a manner consistent with scientists in the field. The second section of the preliminary exam includes the preparation of a research proposal approved by the DAC and a 30-minute oral summary of the proposal followed by an oral defense of the proposal.

Students who are preparing to take their preliminary examination should confirm a time and date with the Director of Graduate Studies and register with the Administrative Assistant in the Office of Graduate Studies. The student and Director receive confirmation of the time, date, room and proctor for the examination.

Dissertation Proposal: The dissertation proposal demonstrates the student's knowledge of and ability to conduct the proposed research. The proposal should consist of:

• the context and background surrounding a particular research problem;
• an exhaustive survey and review of literature related to the problem; and
• a detailed methodological plan for investigating the problem.

The proposal should be completed and approved no more than one year after completing the preliminary exam. Upon approval, a doctoral student is promoted to PhD candidacy, and a timeline for completing the investigation and writing process are established.

Dissertation: The doctoral dissertation is an original, theoretical and/or empirical study that makes a significant contribution to the field. It should expand existing knowledge and demonstrate the student's knowledge of research methods and a mastery of their primary area of interest. The dissertation should be rigorously investigated; uphold the ethics and standards of the field; demonstrate an understanding of the relationship between the primary area of interest and the broader field; and be prepared for publication in a professional journal.

The Dissertation Examining Committee (DEC) is formed to oversee the student's doctoral research. It is charged with evaluating the student's dissertation and oral defense, including the student's ability to express verbally their research question, methodological approach, primary findings and implications. The DEC, which includes the members of the DAC, is comprised of at least three Graduate Faculty members. Two members, including the Chair, must be from the School of Pharmacy. The Chair is responsible for overseeing and guiding the student's progress, coordinating the responses of the Committee members, and informing the student of their academic progress. At least one additional Graduate Faculty member from outside the School of Pharmacy must be included on the DEC. This outside examiner should be identified no later than the beginning of the academic term in which the student will defend the dissertation. The DEC members vote to pass or fail the dissertation and the defense at the conclusion of the public presentation.

Committee compositions must be approved by the departmental graduate committee. If a student needs to change a member of a committee, the new member must be approved by the departmental graduate committee and by the Graduate School. The changes must be documented with the Administrative Assistant and the Graduate School using the "Request for Change in Dissertation Committee" form, found in TUportal under the Tools tab within "University Forms."

Students who are preparing to defend their dissertation should confirm a time and date with their DEC and register with the Office of Graduate Studies at least 15 days before the defense is to be scheduled. The Office of Graduate Studies arranges the time, date and room and forwards to the student the appropriate forms. After the Administrative Assistant has made the arrangements, the student must send the Graduate School a completed "Announcement of Dissertation Defense" form, found in TUportal under the Tools tab within "University Forms," at least 10 days before the defense date. The department posts announcements for the defense.

Program Web Address:

https://pharmacy.temple.edu/academics/phdms-pharmaceutical-sciences

Department Information:

Dept. of Pharmaceutical Sciences Office of Graduate Studies

School of Pharmacy

3307 N. Broad Street, Suite 528

Philadelphia, PA 19140

[email protected]

215-707-4972

Submission Address for Application Materials:

https://apply.temple.edu/PHARM_GRAD/

Department Contacts:

Admissions:

Program Coordinator:

Daniel J. Canney, PhD

Graduate Chairperson:

Swati Nagar, PhD

[email protected]

Department Chairperson:

Ellen Walker, PhD

[email protected]

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Medicinal Chemistry & Pharmacognosy Graduate Studies

Faculty in the Division of Medicinal Chemistry and Pharmacognosy have a broad range of expertise, which is echoed by the diversity of study of the graduate students. Graduate students receive instruction in individual and small group settings and perform original research to foster their technical abilities, increase the breadth and depth of their knowledge, and sharpen their critical thinking skills.

Students can specialize their research into one of the four tracks below:

• Synthetic Medicinal Chemistry – students receive training and perform original research regarding the design, synthesis, and structural optimization of biologically active molecules and potential drug candidates.  
• Natural Products Chemistry and Pharmacognosy – students are trained to perform the isolation, characterization, biological evaluation and derivatization of molecules from natural sources such as plants and microorganisms.  
• Biochemistry – students conduct the detailed pharmacological evaluation of drugs and drug candidates of interest to faculty members in the division, including exploration of the mechanism(s) of action of these candidates.  
• Computational Medicinal Chemistry – students investigate new approaches for computer-aided drug design, including the development of new computational methods.

Each student may take a slightly different path to complete the minimum core courses by the end of the second year. Electives necessary for research specialization may be taken during years two and three. Additional courses depend on research interests, and are taken during the second and/or third years as well.

The Division of Medicinal Chemistry & Pharmacognosy

Learn more about the faculty in the Division of Medicinal Chemistry & Pharmacognosy

General Examination and Oral Examination

A general examination is required for admission to candidacy for the PhD degree. It consists of written and oral components. The written portion of the general exam must be taken following the completion of the student's core coursework program, usually before the end of the third year of the program. The responsibility for the written exam rests with the student’s advisory committee. The written exam consists of an independent research proposal developed by the student. The proposal should not be in the dissertation research area of the student.

The oral portion of the general exam must be taken within four weeks of the approval of the written proposal by the advisory committee. The oral exam will consist of defense of the research proposal, written by the student as part of the general exam, as well as answering questions concerning the student's course work and research.

Doctoral students are required to present three formal seminars in order to complete the PhD.

Doctoral Dissertations

The doctoral dissertation defines the PhD and demonstrates the ability of the graduate student to perform independent research and scholarly activities. The dissertation details the research carried out, describes the results obtained, reports the relationship of the research to previous work in the field, and discusses the significance of the research in the further understanding the field.

Graduate Student Support

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• KU School of Pharmacy
• Doctor of Pharmacy (Pharm.D.)
• Medicinal Chemistry
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Research Proposal Guidelines

To satisfy the research requirement for the distance M.S. program in Pharmaceutical Chemistry, the aspiring student must define a research project and prepare a written proposal describing the nature and goals of the project.

It is suggested that the student in conjunction with their distance research mentor collaborate in the selection of and the definition of the proposed research. The proposal should consist of the following elements:

• Overall goal or hypotheses
• Statement of significance of the research
• Research plan consisting of several specific aims.

The following description serves to define expectations regarding proposal preparation.

Project Title

An appropriate title should be created that describes the overall research topic.

Overall Goal

Write a short statement that clearly defines the scope of the project.

Background and Significance

Become familiar with a published work that is related to your chosen research area. Provide a summary of the background in a manner that demonstrates a knowledge of the area and goes on to describe the significance of the proposed research in adding to and extending existing knowledge.

Specific Aims

The overall project should be envisioned as a series of sub-goals, which as they are individually accomplished, allows results in the achievement of the overall goal.  The specific aims should include a description of the experiments to be conducted. It should be clearly stated what is to be accomplished in each specific aim and how these results relate to the achievement of the overall research goal.

Bibliography

Appropriate literature citations should be provided in each section of the proposal, as justification for the proposed research, and to clearly indicate that the student has familiarized themselves with the research topic.

The M.S. research proposal should be limited to approximately four pages, excluding the bibliographic section.

The proposal preparation will satisfy one credit hour of the research requirement.

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Home > Dissertations and Theses > Pharmaceutical Sciences (MS) Theses

Pharmaceutical Sciences (MS) Theses

Below is a selection of dissertations from the Master of Science in Pharmaceutical Sciences program in the School of Pharmacy. Additional dissertations from years prior to 2019 are available through the Leatherby Libraries' print collection or in Proquest's Dissertations and Theses database.

Theses from 2024 2024

Design and Evaluation of Cyclic Peptide-Epirubicin Conjugate for Enhanced Anticancer Activity and Reduced Myocardial Toxicity , Dorna Davanidavari

Proteomic Identification of Hemp (Cannabis sativa) Seeds by Tandem Mass Spectrometry and Evaluation of Cytotoxic Activity , Taran Harris

Influence of Human and Viral IL-6 on KSHV Infection in Human Tonsil Lymphocytes , Wajd Zakir

Theses from 2023 2023

Renal Toxicity Warnings and Precautions of Drugs Marketed in the US , Mohammad Al Ghamdi

An Economic and Regulatory Analysis of Breast Cancer Drugs Approved by the US Food and Drug Administration , Abdullah Althomali

Cyclic and Linear Peptides Containing Tryptophan and Arginine Residues as Cell-Penetrating Peptides and Antifungal Agents , Khushbu Bhakta

Analyzing Functional Interactions of Designed Peptides by NMR Spectroscopy , Wonsuk Choi

Design, Synthesis, and Evaluation of Oleyl-WRH Peptides for siRNA Delivery , Mrigank S Rai

Theses from 2022 2022

Approvals and Prices of Systemic Antibiotics in Saudi Arabia and the United States , Saad Alharthi

Investigating Hybrid Cyclic/Linear and Linear Peptides as Vehicles for Nucleic Acid Delivery , Abdulelah Alhazza

Design, Synthesis, and Evaluation of N-Methylated H2R2W4 , Talal Alrubaie

Content and Activity of Cytochrome P450 3A in Rat Brain Microsomes and Mitochondria , Nouf Alshammari

Role of Macrophages in Ocular Surface Fibrosis , Alyanna Corpuz

Cyclic and Linear Cell-Penetarating Peptides Composed of Tryptophan (WW) and Arginine (RR) Residues as Molecular Transporters , Lois Kim

Effects of nNOS Inhibitors on Melanoma-Induced Immunosuppression , Kate Alison Lozada

The Development of a Novel Peptide-Drug Conjugate for Treating Triple-Negative Breast Cancer , Phi-Phung Than

Theses from 2021 2021

The Development of a Cancer-Targeting Peptide-Drug Conjugate for the Treatment of Melanoma , Cassandra Dill

Characterization of The Growth Factor Receptor Network Oncogenes in Lung Cancer , Ashley Duche

Hybrid Cyclic-Linear Cell-Penetrating Peptides Containing Alternative Positive and Hydrophobic Residues as Molecular Transporters , Sorour Khayyatnejad Shoushtari

Cost-Effectiveness Analysis of Tisagenlecleucel, Blinatumomab, and Clofarabine for Treatment of B-cell Precursor Acute Lymphoblastic Leukemia , Kamron Lotfi

Establishing the Role of DC-SIGN and Glycoprotein H for KSHV Entry in B Lymphocytes , Nancy Palmerin

Amphiphilic Cell-Penetrating Peptides Containing Natural and Unnatural Amino Acids as Drug Delivery Tools and Antimicrobial Agents , David Salehi

Modulation of Antibacterial Activity and Cytotoxicity in Amphipathic Cyclic Peptide [R4W4] Using Histidine Substitution , Ryan Stueber

Theses from 2020 2020

Hybrid Cyclic/Linear Peptides in a Multi-Component Lipid Structure as a siRNA Delivery System , Abdulaziz Alasmari

Effect of Diabetes Mellitus on Ocular Surface Tight Junctions and Glycocalyx , Saleh M. Alfuraih

Role of Protein Phosphatase-2A in Regulating Monocyte Activation by Soluble and Crystalline Uric Acid in Gout , Sandy ElSayed

Design and Evaluation of Peptide Lipid-Associated Nucleic Acids (PLANAs) for siRNA and CRISPR/Cas9 Delivery and Protein Silencing , Ryley Hall

Theses from 2019 2019

Targeting Primary Cilia Immune Receptor Proteins for the Treatment of Polycystic Kidney Disease Mechanisms , Nedaa Alomari

Identification of Molecules by Spectral Imaging , Qamar Alshammari

Proteomic Evaluation and Cytotoxicity of Red Maple (Acer rubrum) Leaves , Saud Alshammari

Trends in Prices of Insulin Marketed in the US , Hana Althobaiti

Proteomics and Biological Evaluation of Marshmallow (Althea officinalis) Seeds , Mahshid Amini

Altering the Regiospecificity of C6 Indole Prenyltransferase Enzymes Towards Drug Development , Ahmed R. Aoun

Gender Differences in Opioid Prescribing Patterns among Adults in the US , Salena Marie Preciado

The Development of Novel Apurinic/Aprymidinic Endonuclease/Redox-factor 1 Inhibitors for the Treatment of Human Melanoma , Bella Sharifi

Theses from 2018 2018

SK Channel Modulators as Drug Candidates and Pharmacological Tools , Razan Orfali

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