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Weight-loss drug Saxenda effective for kids as young as 6, study showsJonel Aleccia Associated Press A drug approved to treat obesity in adults and teens is safe and effective for use in kids as young as 6 when combined with diet and exercise, a small new study shows. Liraglutide lowered body mass, slowed weight gain and improved health markers in kids ages 6 through 11, according to research presented Tuesday at a medical conference and published in the New England Journal of Medicine. Recommended Videos Based on the results of the trial, drugmaker Novo Nordisk has asked U.S. regulators to expand use of the medication for kids in that age group, a company spokesperson said Tuesday. If approved, the drug would be the first authorized to treat the most common type of obesity that affects more than 20% of U.S. kids ages 6 through 11, according to the U.S. Centers for Disease Control and Prevention. “To date, children have had virtually no options for treating obesity,” said Dr. Claudia Fox, a pediatric obesity expert at the University of Minnesota who led the study. “They have been told to ‘try harder’ with diet and exercise." Side effects were common among those given the drug, particularly gastrointestinal effects such as nausea, vomiting and diarrhea. And experts said doctors and parents would need to carefully consider those risks and the lack of data about the long-term use of such drugs in young kids. “Having a medication for that age group, if approved, would be a really nice tool to have, but we're also going to have to be careful about how widely we start using it," said Dr. Melissa Crocker, a pediatric obesity specialist at Boston Children's Hospital who wasn't involved in the study. “And I would answer that differently at 6 than I would at 11.” Liraglutide is in a class of so-called GLP-1 drugs that include blockbuster medications like Wegovy and Mounjaro. The medications mimic hormones that affect appetite, feelings of fullness and digestion. It’s taken as a daily injection and is approved under the brand name Victoza to treat diabetes in adults and children ages 10 and older and as Saxenda to treat obesity in adults and children ages 12 to 17. The new study, paid for by Novo Nordisk, included 82 children with a mean age of 10 and a baseline weight of about 155 pounds (70 kilograms). The average starting BMI was 31, above the threshold for childhood obesity. More than half the children had obesity-related health problems such as insulin resistance, asthma or early puberty. The results were presented at the annual meeting of the European Association for the Study of Diabetes in Madrid. In the trial, 56 children received daily injections of up to 3 milligrams of liraglutide for nearly 13 months, while 26 got dummy medications. The kids were followed for six months afterward. All the children received individual counseling to help them follow a plan that called for a healthy diet and 60 minutes a day of moderate to high-intensity exercise. Researchers found that kids who took the drug for more than a year reduced their body mass index -- a measure of height and weight that can account for a child’s natural growth – by 5.8%. Children who received the dummy medication saw their BMI increase by 1.6%. At the same time, children who received the drug slowed weight gain to 1.6% of their body weight during that period, compared with a 10% gain for those who got sham drugs. The study found that 46% of kids who got the drug lowered their BMI by at least 5%, an amount that has been linked to improvements in health problems tied to obesity. In kids who received placebo, 9% met that mark. Lower measures of blood pressure and blood sugar were detected in children who received the drug, researchers noted. Side effects, mostly mild to moderate, were reported in nearly 90% of both groups of participants. Gastrointestinal side effects including nausea and vomiting were reported in 80% of kids who received the drug, compared with 54% who received sham medications. Serious side effects were reported in seven children using liraglutide and two who took placebo. Six participants taking the drug left the trial because of the side effects, while no one taking placebo stopped treatment. In the six-month follow-up, children in both groups who stopped treatment increased BMI and gained weight, the study found. The trial has been extended to include more treatment and follow up, with results expected in 2027. Fox receives research funding from Novo Nordisk and drugmaker Eli Lilly paid directly to her institution. Those companies are also conducting trials with more powerful weekly injections of Novo's Wegovy and Lilly's Zepbound in kids as young as 6. Dr. Alaina Vidmar, a pediatric obesity specialist at Children's Hospital Los Angeles who wasn't involved in the new study, said she has used liraglutide off-label to treat young kids and would welcome approval of the drug to increase flexibility and access. The drug treats the underlying physiology of obesity, which is a complex, chronic disease that can occur at any age. Early use can prevent obesity and life-threatening health problems from extending into the teen years — and adulthood. “We want these kids to have long, healthy lives,” Vidmar said. “The sooner that we can start, the more likely we can stop them from getting early onset diabetes, early onset heart disease, sleep apnea, all of those things. Doing nothing is not the right answer.” The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Science and Educational Media Group. The AP is solely responsible for all content. Copyright 2024 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed without permission. |
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Kids Encyclopedia Facts. A case study is an in-depth, detailed examination of a particular case (or cases) within a real-world context. For example, case studies in medicine may focus on an individual patient or ailment; case studies in business might cover a particular firm 's strategy or a broader market; similarly, case studies in politics ...
The Narrative portion of your case study assignment should be written in APA style, double-spaced, and follow the format below: Introduction: Background information about the child (if any is known), setting, age, physical appearance, and other relevant details.There should be an overall feel for what this child and his/her family is like. Remember that the child's neighborhood, school ...
Scientific Definition. A child case study is a research method that involves an in-depth, comprehensive examination of a particular child, typically one with special needs or a developmental disability. The case study aims to provide a holistic understanding of the child's unique challenges, strengths, and experiences within their social ...
A Case Study is a method of detailed research and examination that focuses on 1 specific case. This can then be used to draw conclusions, comparisons and similarities to other research, facts or beliefs. To break this down into simpler terms, a case can be defined as a person, a group of people, an event or a situation.
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The meaning of CASE STUDY is an intensive analysis of an individual unit (such as a person or community) stressing developmental factors in relation to environment. How to use case study in a sentence.
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A case study is a research method that involves an in-depth examination and analysis of a particular phenomenon or case, such as an individual, organization, community, event, or situation. It is a qualitative research approach that aims to provide a detailed and comprehensive understanding of the case being studied.
Case studies are chosen for teaching based on how rich the narrative is, and whether the people in the study are required to make a decision or solve a problem. When using case studies, the focus is not on the data or the analysis. The students analyze the case and try to find ways to find solutions and solve problems.
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CASE STUDY meaning: 1. a detailed account giving information about the development of a person, group, or thing…. Learn more.
Researchers, economists, and others frequently use case studies to answer questions across a wide spectrum of disciplines, from analyzing decades of climate data for conservation efforts to developing new theoretical frameworks in psychology. Learn about the different types of case studies, their benefits, and examples of successful case studies.
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The purpose of case study research is twofold: (1) to provide descriptive information and (2) to suggest theoretical relevance. Rich description enables an in-depth or sharpened understanding of the case. It is unique given one characteristic: case studies draw from more than one data source. Case studies are inherently multimodal or mixed ...
Case study - Wikipedia ... Case study
A case study is a particular research h method involving an up-close and in-depth investigation of any subject, and it is related to a contextual position. These are produced by following a research form. The case study helps in bringing the understanding of any complex issue. This can extend experience or add strength to the already existing ...
Case study definition: a study of an individual unit, as a person, family, or social group, usually emphasizing developmental issues and relationships with the environment, especially in order to compare a larger group to the individual unit.. See examples of CASE STUDY used in a sentence.
The meaning of case. Definition of case. Best online English dictionaries for children, with kid-friendly definitions, integrated thesaurus for kids, images, and animations. Spanish and Chinese language support available
The case study was conducted by keen observations of the special needed child by involving and getting information directly from different reliable sources like,concerned teachers, peer groups from the school, parents, family members and peer groups of the child from the home environment. The tools used in the study were 1. Qustionnaire. 2.
Study with Quizlet and memorize flashcards containing terms like Tim is a 34-year-old computer programmer who is married with three children. He was always a little overweight as a kid and young adult, but his weight has now become a health concern for him. Standing at 5 feet 8 inches, he weighs 280 pounds and looks "apple-shaped," meaning that ...
The new study, paid for by Novo Nordisk, included 82 children with a mean age of 10 and a baseline weight of about 155 pounds (70 kilograms). The average starting BMI was 31, above the threshold ...